| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bruno A Marichal-Cancino, Alain H Altamirano-Espinoza, Guadalupe Manrique-Maldonado, Antoinette MaassenVanDenBrink, Carlos M Villaló. Role of pre-junctional CB1, but not CB2 , TRPV1 or GPR55 receptors in anandamide-induced inhibition of the vasodepressor sensory CGRPergic outflow in pithed rats. Basic & clinical pharmacology & toxicology. vol 114. issue 3. 2015-09-28. PMID:24118786. |
yet, as no publication has reported whether this mechanism is operative in the healthy systemic vasculature, this study has specifically analysed the receptors mediating the potential inhibitory effects of the cannabinoid (cb) receptor agonists anandamide (non-selective), jwh-015 (cb2 ) and lysophosphatidylinositol (gpr55) on the rat vasodepressor sensory cgrpergic outflow (an index of systemic vasodilatation). |
2015-09-28 |
2023-08-12 |
rat |
| Jeremiah J Harnett, Christine Dolo, Isabelle Viossat, Florence Auger, Eric Ferrandis, Dennis Bigg, Michel Auguet, Serge Auvin, Pierre-E Chabrie. Novel azoles as potent and selective cannabinoid CB2 receptor agonists. Bioorganic & medicinal chemistry letters. vol 25. issue 1. 2015-09-24. PMID:25466197. |
novel azoles as potent and selective cannabinoid cb2 receptor agonists. |
2015-09-24 |
2023-08-13 |
Not clear |
| Anton Reiner, Scott A Heldt, Chaela S Presley, Natalie H Guley, Andrea J Elberger, Yunping Deng, Lauren D'Surney, Joshua T Rogers, Jessica Ferrell, Wei Bu, Nobel Del Mar, Marcia G Honig, Steven N Gurley, Bob M Moor. Motor, visual and emotional deficits in mice after closed-head mild traumatic brain injury are alleviated by the novel CB2 inverse agonist SMM-189. International journal of molecular sciences. vol 16. issue 1. 2015-09-14. PMID:25561230. |
because microglial activation can worsen brain damage after a concussive event and because microglia can be modulated by their cannabinoid type 2 receptors (cb2), we evaluated the effectiveness of the novel cb2 receptor inverse agonist smm-189 in altering microglial activation and mitigating deficits after mild tbi. |
2015-09-14 |
2023-08-13 |
mouse |
| Xiaopan Chen, Congxia Zheng, Jing Qian, Steven W Sutton, Zhen Wang, Jianxin Lv, Changlu Liu, Naiming Zho. Involvement of β-arrestin-2 and clathrin in agonist-mediated internalization of the human cannabinoid CB2 receptor. Current molecular pharmacology. vol 7. issue 1. 2015-09-10. PMID:25023974. |
involvement of β-arrestin-2 and clathrin in agonist-mediated internalization of the human cannabinoid cb2 receptor. |
2015-09-10 |
2023-08-13 |
human |
| L Latini, E Bisicchia, V Sasso, V Chiurchiù, V Cavallucci, M Molinari, M Maccarrone, M T Viscom. Cannabinoid CB2 receptor (CB2R) stimulation delays rubrospinal mitochondrial-dependent degeneration and improves functional recovery after spinal cord hemisection by ERK1/2 inactivation. Cell death & disease. vol 5. 2015-09-08. PMID:25188514. |
cannabinoid cb2 receptor (cb2r) stimulation delays rubrospinal mitochondrial-dependent degeneration and improves functional recovery after spinal cord hemisection by erk1/2 inactivation. |
2015-09-08 |
2023-08-13 |
rat |
| Francesca Borrelli, Barbara Romano, Stefania Petrosino, Ester Pagano, Raffaele Capasso, Diana Coppola, Giovanni Battista, Pierangelo Orlando, Vincenzo Di Marzo, Angelo A Izz. Palmitoylethanolamide, a naturally occurring lipid, is an orally effective intestinal anti-inflammatory agent. British journal of pharmacology. vol 172. issue 1. 2015-09-04. PMID:25205418. |
palmitoylethanolamide (pea) acts via several targets, including cannabinoid cb1 and cb2 receptors, transient receptor potential vanilloid type-1 (trpv1) ion channels, peroxisome proliferator-activated receptor alpha (ppar α) and orphan g protein-coupled receptor 55 (grr55), all involved in the control of intestinal inflammation. |
2015-09-04 |
2023-08-13 |
Not clear |
| Fabricio A Moreira, Bianca Jupp, David Belin, Jeffrey W Dalle. Endocannabinoids and striatal function: implications for addiction-related behaviours. Behavioural pharmacology. vol 26. issue 1-2. 2015-09-03. PMID:25369747. |
we highlight the potential of selective inhibitors of endocannabinoid metabolism, directed at fatty acid amide hydrolase and monoacylglycerol lipase, to reduce anxiety and stress responses, and discuss novel mechanisms underlying the modulation of the endocannabinoid system, including the attenuation of impulsivity, anxiety, and drug reward by selective cb2 receptor agonists. |
2015-09-03 |
2023-08-13 |
Not clear |
| Sari Yrjölä, Mirkka Sarparanta, Anu J Airaksinen, Maria Hytti, Anu Kauppinen, Sanna Pasonen-Seppänen, Barbara Adinolfi, Paola Nieri, Clementina Manera, Outi Keinänen, Antti Poso, Tapio J Nevalainen, Teija Parkkar. Synthesis, in vitro and in vivo evaluation of 1,3,5-triazines as cannabinoid CB2 receptor agonists. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. vol 67. 2015-08-31. PMID:25447744. |
synthesis, in vitro and in vivo evaluation of 1,3,5-triazines as cannabinoid cb2 receptor agonists. |
2015-08-31 |
2023-08-13 |
human |
| Antonio Ortega-Álvaro, Alexander Ternianov, Auxiliadora Aracil-Fernández, Francisco Navarrete, Maria Salud García-Gutiérrez, Jorge Manzanare. Role of cannabinoid CB2 receptor in the reinforcing actions of ethanol. Addiction biology. vol 20. issue 1. 2015-08-24. PMID:23855434. |
role of cannabinoid cb2 receptor in the reinforcing actions of ethanol. |
2015-08-24 |
2023-08-12 |
mouse |
| Antonio Ortega-Álvaro, Alexander Ternianov, Auxiliadora Aracil-Fernández, Francisco Navarrete, Maria Salud García-Gutiérrez, Jorge Manzanare. Role of cannabinoid CB2 receptor in the reinforcing actions of ethanol. Addiction biology. vol 20. issue 1. 2015-08-24. PMID:23855434. |
this study examines the role of the cannabinoid cb2 receptor (cb2 r) on the vulnerability to ethanol consumption. |
2015-08-24 |
2023-08-12 |
mouse |
| Gulis Saglam, Ozgur Gunduz, Ahmet Ulugo. Blockade of cannabinoid CB1 and CB2 receptors does not prevent the antipruritic effect of systemic paracetamol. Acta neurologica Belgica. vol 114. issue 4. 2015-08-24. PMID:24399199. |
blockade of cannabinoid cb1 and cb2 receptors does not prevent the antipruritic effect of systemic paracetamol. |
2015-08-24 |
2023-08-12 |
mouse |
| Gulis Saglam, Ozgur Gunduz, Ahmet Ulugo. Blockade of cannabinoid CB1 and CB2 receptors does not prevent the antipruritic effect of systemic paracetamol. Acta neurologica Belgica. vol 114. issue 4. 2015-08-24. PMID:24399199. |
since itch and pain sensations share many similarities, the purpose of the present study was to investigate whether blockade of cannabinoid cb1 and cb2 receptors participates in the antipruritic activity of paracetamol in mice. |
2015-08-24 |
2023-08-12 |
mouse |
| Ana Bagüés, M Isabel Martín, Eva M Sánchez-Roble. Involvement of central and peripheral cannabinoid receptors on antinociceptive effect of tetrahydrocannabinol in muscle pain. European journal of pharmacology. vol 745. 2015-08-24. PMID:25446925. |
the drugs used were the non-selective agonist thc and two selective cannabinoid antagonists, am251 (cb1) and am630 (cb2). |
2015-08-24 |
2023-08-13 |
rat |
| N A Balenga, E Martínez-Pinilla, J Kargl, R Schröder, M Peinhaupt, W Platzer, Z Bálint, M Zamarbide, I G Dopeso-Reyes, A Ricobaraza, J M Pérez-Ortiz, E Kostenis, M Waldhoer, A Heinemann, R Franc. Heteromerization of GPR55 and cannabinoid CB2 receptors modulates signalling. British journal of pharmacology. vol 171. issue 23. 2015-08-14. PMID:25048571. |
heteromerization of gpr55 and cannabinoid cb2 receptors modulates signalling. |
2015-08-14 |
2023-08-13 |
human |
| Iryna A Khasabova, Xu Yao, Justin Paz, Cutler T Lewandowski, Amy E Lindberg, Lia Coicou, Natasha Burlakova, Don A Simone, Virginia S Seybol. JZL184 is anti-hyperalgesic in a murine model of cisplatin-induced peripheral neuropathy. Pharmacological research. vol 90. 2015-08-13. PMID:25304184. |
acute injection of a cannabinoid (cb)-1 but not a cb2 receptor antagonist reversed the anti-hyperalgesic effect of jzl184 indicating that downstream activation of cb1 receptors suppressed the expression of mechanical hyperalgesia. |
2015-08-13 |
2023-08-13 |
Not clear |
| D I Abrams, M Guzma. Cannabis in cancer care. Clinical pharmacology and therapeutics. vol 97. issue 6. 2015-08-12. PMID:25777363. |
cannabinoids, the active components of cannabis sativa, mimic the effects of the endogenous cannabinoids (endocannabinoids), activating specific cannabinoid receptors, particularly cb1 found predominantly in the central nervous system and cb2 found predominantly in cells involved with immune function. |
2015-08-12 |
2023-08-13 |
Not clear |
| V Kiran Vemuri, A Makriyanni. Medicinal chemistry of cannabinoids. Clinical pharmacology and therapeutics. vol 97. issue 6. 2015-08-12. PMID:25801236. |
the endocannabinoid system comprises the two well characterized gi/o -protein coupled receptors (cannabinoid receptor 1 (cb1) and cb2), their endogenous lipid ligands, and the enzymes involved in their biosynthesis and biotransformation. |
2015-08-12 |
2023-08-13 |
Not clear |
| Ruth M Concannon, Bright N Okine, David P Finn, Eilís Dow. Differential upregulation of the cannabinoid CB₂ receptor in neurotoxic and inflammation-driven rat models of Parkinson's disease. Experimental neurology. vol 269. 2015-08-11. PMID:25895887. |
the cannabinoid cb2 receptor has recently emerged as a potential anti-inflammatory target to break the self-sustaining cycle of neuroinflammation and neurodegeneration that is associated with neurodegenerative diseases. |
2015-08-11 |
2023-08-13 |
rat |
| Liting Deng, Benjamin L Cornett, Ken Mackie, Andrea G Hohman. CB1 Knockout Mice Unveil Sustained CB2-Mediated Antiallodynic Effects of the Mixed CB1/CB2 Agonist CP55,940 in a Mouse Model of Paclitaxel-Induced Neuropathic Pain. Molecular pharmacology. vol 88. issue 1. 2015-08-11. PMID:25904556. |
cannabinoids suppress neuropathic pain through activation of cannabinoid cb1 and/or cb2 receptors; however, unwanted cb1-mediated cannabimimetic effects limit clinical use. |
2015-08-11 |
2023-08-13 |
mouse |
| Liting Deng, Benjamin L Cornett, Ken Mackie, Andrea G Hohman. CB1 Knockout Mice Unveil Sustained CB2-Mediated Antiallodynic Effects of the Mixed CB1/CB2 Agonist CP55,940 in a Mouse Model of Paclitaxel-Induced Neuropathic Pain. Molecular pharmacology. vol 88. issue 1. 2015-08-11. PMID:25904556. |
we asked whether cp55,940 [(-)-3-[2-hydroxy-4-(1,1-dimethylheptyl)phenyl]-4-(3-hydroxypropyl)cyclohexanol], a potent cannabinoid that binds with similar affinity to cb1 and cb2 in vitro, produces functionally separable cb1- and cb2-mediated pharmacological effects in vivo. |
2015-08-11 |
2023-08-13 |
mouse |