| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Liting Deng, Benjamin L Cornett, Ken Mackie, Andrea G Hohman. CB1 Knockout Mice Unveil Sustained CB2-Mediated Antiallodynic Effects of the Mixed CB1/CB2 Agonist CP55,940 in a Mouse Model of Paclitaxel-Induced Neuropathic Pain. Molecular pharmacology. vol 88. issue 1. 2015-08-11. PMID:25904556. |
our study highlights the therapeutic potential of targeting cannabinoid cb2 receptors to bypass unwanted central effects associated with cb1 receptor activation. |
2015-08-11 |
2023-08-13 |
mouse |
| Hiroko Ikeda, Megumi Ikegami, Misa Kai, Junzo Kame. Cannabinoid functions in the amygdala contribute to conditioned fear memory in streptozotocin-induced diabetic mice: Interaction with glutamatergic functions. Experimental neurology. vol 269. 2015-08-11. PMID:25929688. |
this effect was significantly inhibited by the cannabinoid cb1 receptor antagonist am 251 (3mg/kg, s.c.), but not by the cannabinoid cb2 receptor antagonist am 630 (1mg/kg, s.c.). |
2015-08-11 |
2023-08-13 |
mouse |
| Hiroko Ikeda, Megumi Ikegami, Misa Kai, Junzo Kame. Cannabinoid functions in the amygdala contribute to conditioned fear memory in streptozotocin-induced diabetic mice: Interaction with glutamatergic functions. Experimental neurology. vol 269. 2015-08-11. PMID:25929688. |
in contrast, the protein levels of cannabinoid cb2 receptors and diacylglycerol lipase α, the enzyme that synthesizes endocannabinoid 2-arachidonoylglycerol, in the amygdala did not differ between non-diabetic and stz-induced diabetic mice. |
2015-08-11 |
2023-08-13 |
mouse |
| María Concepción García, Valentina Cinquina, Cristina Palomo-Garo, Alberto Rábano, Javier Fernández-Rui. Identification of CB₂ receptors in human nigral neurons that degenerate in Parkinson's disease. Neuroscience letters. vol 587. 2015-08-10. PMID:25481767. |
it is well-demonstrated that cannabinoid cb2 receptors located in glial cells are up-regulated in neurodegenerative disorders serving as a target to control glial influences to neurons. |
2015-08-10 |
2023-08-13 |
human |
| Tian-Cheng Wang, Jing Wang, Xu Xu, Jing-Lin Ma, Xue-Feng Wan. Tonic modulation of nociceptive behavior and allodynia by cannabinoid receptors in formalin test in rats. The Chinese journal of physiology. vol 58. issue 1. 2015-08-06. PMID:25687494. |
the current study investigated the role of cannabinoid (cb1 and cb2) receptors in modulating formalin-induced nociceptive behavior and mechanical allodynia in the rat. |
2015-08-06 |
2023-08-13 |
rat |
| Ramy Khella, Jennifer L Short, Daniel T Malon. CB2 receptor agonism reverses MK-801-induced disruptions of prepulse inhibition in mice. Psychopharmacology. vol 231. issue 16. 2015-08-04. PMID:24705902. |
whilst cannabinoid cb2 receptors were thought to exist predominantly in immune cells in the periphery, the recent discovery of cb2 receptors in the brain has led to an increased interest in the role of these central cb2 receptors. |
2015-08-04 |
2023-08-13 |
mouse |
| Joëlle Nader, Cinzia Rapino, Benjamin Gennequin, Francois Chavant, Maureen Francheteau, Alexandros Makriyannis, Andrea Duranti, Mauro Maccarrone, Marcello Solinas, Nathalie Thirie. Prior stimulation of the endocannabinoid system prevents methamphetamine-induced dopaminergic neurotoxicity in the striatum through activation of CB2 receptors. Neuropharmacology. vol 87. 2015-08-04. PMID:24709540. |
prior stimulation of the endocannabinoid system prevents methamphetamine-induced dopaminergic neurotoxicity in the striatum through activation of cb2 receptors. |
2015-08-04 |
2023-08-13 |
Not clear |
| Joëlle Nader, Cinzia Rapino, Benjamin Gennequin, Francois Chavant, Maureen Francheteau, Alexandros Makriyannis, Andrea Duranti, Mauro Maccarrone, Marcello Solinas, Nathalie Thirie. Prior stimulation of the endocannabinoid system prevents methamphetamine-induced dopaminergic neurotoxicity in the striatum through activation of CB2 receptors. Neuropharmacology. vol 87. 2015-08-04. PMID:24709540. |
Δ(9)-tetrahydrocannabinol (thc), a cannabis-derived agonist of both cb1 and cb2 cannabinoid receptors, or inhibitors of the main enzymes responsible for the degradation of aea and 2-ag (urb597 and jzl184, respectively), blunted the decrease in striatal protein levels of tyrosine hydroxylase induced by methamphetamine. |
2015-08-04 |
2023-08-13 |
Not clear |
| Alexander I Bondarenk. Endothelial atypical cannabinoid receptor: do we have enough evidence? British journal of pharmacology. vol 171. issue 24. 2015-07-28. PMID:25073723. |
more studies are needed to differentiate gi/o protein-dependent endothelial cannabinoid signalling from that involving the classical cb1 and cb2 receptors as well as its relevance for pathophysiological conditions. |
2015-07-28 |
2023-08-13 |
human |
| Stephen G Woodhams, Devi Rani Sagar, James J Burston, Victoria Chapma. The role of the endocannabinoid system in pain. Handbook of experimental pharmacology. vol 227. 2015-07-27. PMID:25846617. |
the ec system is composed of two main cannabinoid receptors (cb1 and cb2) and two main classes of endogenous ligands or endocannabinoids (ecs). |
2015-07-27 |
2023-08-13 |
Not clear |
| Anna Maria Malfitano, Sreemanti Basu, Katarzyna Maresz, Maurizio Bifulco, Bonnie N Ditte. What we know and do not know about the cannabinoid receptor 2 (CB2). Seminars in immunology. vol 26. issue 5. 2015-07-15. PMID:24877594. |
it has been well appreciated that the endocannabinoid system can regulate immune responses via the cannabinoid receptor 2 (cb2), which is primarily expressed by cells of the hematopoietic system. |
2015-07-15 |
2023-08-13 |
mouse |
| Anna Maria Malfitano, Sreemanti Basu, Katarzyna Maresz, Maurizio Bifulco, Bonnie N Ditte. What we know and do not know about the cannabinoid receptor 2 (CB2). Seminars in immunology. vol 26. issue 5. 2015-07-15. PMID:24877594. |
along with endocannabinoids, both plant-derived and synthetic cannabinoids have been shown to bind to and signal through cb2 via g proteins leading to both inhibitory and stimulatory signals depending on the biological process. |
2015-07-15 |
2023-08-13 |
mouse |
| Anna Maria Malfitano, Sreemanti Basu, Katarzyna Maresz, Maurizio Bifulco, Bonnie N Ditte. What we know and do not know about the cannabinoid receptor 2 (CB2). Seminars in immunology. vol 26. issue 5. 2015-07-15. PMID:24877594. |
because no cannabinoid ligand has been identified that only binds to cb2, the generation of mice deficient in cb2 has greatly expanded our knowledge of how cb2 contributes to immune cell development and function in health and disease. |
2015-07-15 |
2023-08-13 |
mouse |
| Anna Maria Malfitano, Sreemanti Basu, Katarzyna Maresz, Maurizio Bifulco, Bonnie N Ditte. What we know and do not know about the cannabinoid receptor 2 (CB2). Seminars in immunology. vol 26. issue 5. 2015-07-15. PMID:24877594. |
here, we review the endocannabinoid system with an emphasis on cb2 and its role in the immune system. |
2015-07-15 |
2023-08-13 |
mouse |
| Federico Carbone, François Mach, Nicolas Vuilleumier, Fabrizio Montecucc. Cannabinoid receptor type 2 activation in atherosclerosis and acute cardiovascular diseases. Current medicinal chemistry. vol 21. issue 35. 2015-07-02. PMID:25245379. |
different from the other cannabinoid receptors in which controversial results are reported, the selective activation of the cannabinoid receptor type 2 (cb2) has been shown to play antiinflammatory and protective actions within atherosclerotic vessels and downstream ischemic peripheral organs. |
2015-07-02 |
2023-08-13 |
human |
| Gilson Gonçalves dos Santos, Elayne Vieira Dias, Juliana Maia Teixeira, Maria Carolina Pedro Athie, Ivan José Magayewski Bonet, Cláudia Herrera Tambeli, Carlos Amilcar Parad. The analgesic effect of dipyrone in peripheral tissue involves two different mechanisms: neuronal K(ATP) channel opening and CB(1) receptor activation. European journal of pharmacology. vol 741. 2015-06-22. PMID:25058903. |
the aim of this study was to investigate the participation of peripheral cb1 and cb2 cannabinoid receptors activation in the anti-hyperalgesic effect of dipyrone, 4-maa or 4-aa. |
2015-06-22 |
2023-08-13 |
rat |
| Richard S Priestley, Sarah A Nickolls, Stephen P H Alexander, David A Kendal. A potential role for cannabinoid receptors in the therapeutic action of fenofibrate. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 29. issue 4. 2015-06-22. PMID:25550466. |
radio-ligand binding and functional assays were conducted using human recombinant cannabinoid type 1 (cb1) or cannabinoid type 2 (cb2) receptors, as well as the guinea pig isolated ileum, using the full agonist cp55940 as a positive control. |
2015-06-22 |
2023-08-13 |
human |
| Miriam Fishbein-Kaminietsky, Mikhal Gafni, Yosef Sarn. Ultralow doses of cannabinoid drugs protect the mouse brain from inflammation-induced cognitive damage. Journal of neuroscience research. vol 92. issue 12. 2015-06-19. PMID:25042014. |
the protective effect of thc was blocked by the cannabinoid (cb) 1 receptor antagonist sr14176a but not by the cb2 receptor antagonist sr141528 and was mimicked by the cb1 agonist acea but not by the cb2 agonist hu308. |
2015-06-19 |
2023-08-13 |
mouse |
| Yahiya Y Syed, Kate McKeage, Lesley J Scot. Delta-9-tetrahydrocannabinol/cannabidiol (Sativex®): a review of its use in patients with moderate to severe spasticity due to multiple sclerosis. Drugs. vol 74. issue 5. 2015-06-15. PMID:24671907. |
the main active substance, thc, acts as a partial agonist at human cannabinoid receptors (cb1 and cb2), and thus, may modulate the effects of excitatory (glutamate) and inhibitory (gamma-aminobutyric acid) neurotransmitters. |
2015-06-15 |
2023-08-12 |
human |
| Ornelio Rosati, Federica Messina, Azzurra Pelosi, Massimo Curini, Vanessa Petrucci, Jürg Gertsch, Andrea Chicc. One-pot heterogeneous synthesis of Δ(3)-tetrahydrocannabinol analogues and xanthenes showing differential binding to CB(1) and CB(2) receptors. European journal of medicinal chemistry. vol 85. 2015-06-02. PMID:25072877. |
four Δ(3)-thc analogues and corresponding Δ(4a)-tetrahydroxanthenes (Δ(4a)-thxs) were synthesized regioselectively and showed differential binding affinities for cb1 and cb2 cannabinoid receptors. |
2015-06-02 |
2023-08-13 |
Not clear |