| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Weisi Fu, Bradley K Taylo. Activation of cannabinoid CB2 receptors reduces hyperalgesia in an experimental autoimmune encephalomyelitis mouse model of multiple sclerosis. Neuroscience letters. vol 595. 2015-10-20. PMID:25849525. |
activation of cannabinoid cb2 receptors reduces hyperalgesia in an experimental autoimmune encephalomyelitis mouse model of multiple sclerosis. |
2015-10-20 |
2023-08-13 |
mouse |
| Patricia Rivera, Eduardo Blanco, Laura Bindila, Francisco Alen, Antonio Vargas, Leticia Rubio, Francisco J Pavón, Antonia Serrano, Beat Lutz, Fernando Rodríguez de Fonseca, Juan Suáre. Pharmacological activation of CB2 receptors counteracts the deleterious effect of ethanol on cell proliferation in the main neurogenic zones of the adult rat brain. Frontiers in cellular neuroscience. vol 9. 2015-10-20. PMID:26483633. |
we evaluated the protective effects of the selective cb1 receptor agonist acea, the selective cb2 receptor agonist jwh133 and the fatty-acid amide-hydrolase (faah) inhibitor urb597, which enhances endocannabinoid receptor activity, on npc proliferation in rats with forced consumption of ethanol (10%) or sucrose liquid diets for 2 weeks. |
2015-10-20 |
2023-08-13 |
rat |
| Esmée Vendel, Elizabeth C M de Lang. Functions of the CB1 and CB 2 receptors in neuroprotection at the level of the blood-brain barrier. Neuromolecular medicine. vol 16. issue 3. 2015-10-15. PMID:24929655. |
cannabinoids and the bbb share the same mechanisms of neuroprotection and both protect against excitotoxicity (cb1), cell death (cb1), inflammation (cb2) and oxidative stress (possibly cb independent)-all processes that also damage the bbb. |
2015-10-15 |
2023-08-13 |
Not clear |
| Zubair Malik, Daniel Baik, Ron Sche. The role of cannabinoids in regulation of nausea and vomiting, and visceral pain. Current gastroenterology reports. vol 17. issue 2. 2015-10-13. PMID:25715910. |
several cannabinoid receptors, which include the cannabinoid receptor 1 (cb1), cb2, and possibly gpr55, have been identified throughout the gi tract. |
2015-10-13 |
2023-08-13 |
Not clear |
| G Bellini, A N Olivieri, A Grandone, M Alessio, M F Gicchino, B Nobili, L Perrone, S Maione, E Miraglia del Giudice, F Ross. Association between cannabinoid receptor type 2 Q63R variant and oligo/polyarticular juvenile idiopathic arthritis. Scandinavian journal of rheumatology. vol 44. issue 4. 2015-10-08. PMID:25974389. |
to investigate whether the functional variant q63r of the cannabinoid 2 (cb2) receptor is associated with susceptibility to oligo/poly-articular juvenile idiopathic arthritis (jia) and with its clinical features. |
2015-10-08 |
2023-08-13 |
Not clear |
| Takayo Haruna, Masahiko Soga, Yasuhide Morioka, Ichiro Hikita, Kinichi Imura, Yoko Furue, Mina Yamamoto, Chihiro Imura, Minoru Ikeda, Akira Yamauchi, Masashi Deguchi, Michitaka Shichijo, Akinori Arimura, Kiyoshi Yasu. S-777469, a novel cannabinoid type 2 receptor agonist, suppresses itch-associated scratching behavior in rodents through inhibition of itch signal transmission. Pharmacology. vol 95. issue 1-2. 2015-10-06. PMID:25721168. |
we have previously reported that s-777469 [1-([6-ethyl-1-(4-fluorobenzyl)-5-methyl-2-oxo-1,2-dihydropyridine-3-carbonyl]amino)-cyclohexanecarboxylic acid], a novel cannabinoid type 2 receptor (cb2) agonist, significantly suppressed compound 48/80-induced scratching behavior in mice in a dose-dependent manner when it was administered orally. |
2015-10-06 |
2023-08-13 |
mouse |
| Oya Yonal, Fatih Eren, Yusuf Yılmaz, Özlen Atuğ, Hülya Hamzaoğlu Öve. No association between the functional cannabinoid receptor type 2 Q63R variants and inflammatory bowel disease in Turkish subjects. The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology. vol 25. issue 6. 2015-10-01. PMID:25599774. |
the endocannabinoid system can exert beneficial effects on gastrointestinal inflammation, and cannabinoid receptor-2 (cb2) agonists may represent a new therapeutic approach in inflammatory bowel disease (ibd). |
2015-10-01 |
2023-08-13 |
human |
| Bruno A Marichal-Cancino, Alain H Altamirano-Espinoza, Guadalupe Manrique-Maldonado, Antoinette MaassenVanDenBrink, Carlos M Villaló. Role of pre-junctional CB1, but not CB2 , TRPV1 or GPR55 receptors in anandamide-induced inhibition of the vasodepressor sensory CGRPergic outflow in pithed rats. Basic & clinical pharmacology & toxicology. vol 114. issue 3. 2015-09-28. PMID:24118786. |
yet, as no publication has reported whether this mechanism is operative in the healthy systemic vasculature, this study has specifically analysed the receptors mediating the potential inhibitory effects of the cannabinoid (cb) receptor agonists anandamide (non-selective), jwh-015 (cb2 ) and lysophosphatidylinositol (gpr55) on the rat vasodepressor sensory cgrpergic outflow (an index of systemic vasodilatation). |
2015-09-28 |
2023-08-12 |
rat |
| Jeremiah J Harnett, Christine Dolo, Isabelle Viossat, Florence Auger, Eric Ferrandis, Dennis Bigg, Michel Auguet, Serge Auvin, Pierre-E Chabrie. Novel azoles as potent and selective cannabinoid CB2 receptor agonists. Bioorganic & medicinal chemistry letters. vol 25. issue 1. 2015-09-24. PMID:25466197. |
novel azoles as potent and selective cannabinoid cb2 receptor agonists. |
2015-09-24 |
2023-08-13 |
Not clear |
| Anton Reiner, Scott A Heldt, Chaela S Presley, Natalie H Guley, Andrea J Elberger, Yunping Deng, Lauren D'Surney, Joshua T Rogers, Jessica Ferrell, Wei Bu, Nobel Del Mar, Marcia G Honig, Steven N Gurley, Bob M Moor. Motor, visual and emotional deficits in mice after closed-head mild traumatic brain injury are alleviated by the novel CB2 inverse agonist SMM-189. International journal of molecular sciences. vol 16. issue 1. 2015-09-14. PMID:25561230. |
because microglial activation can worsen brain damage after a concussive event and because microglia can be modulated by their cannabinoid type 2 receptors (cb2), we evaluated the effectiveness of the novel cb2 receptor inverse agonist smm-189 in altering microglial activation and mitigating deficits after mild tbi. |
2015-09-14 |
2023-08-13 |
mouse |
| Xiaopan Chen, Congxia Zheng, Jing Qian, Steven W Sutton, Zhen Wang, Jianxin Lv, Changlu Liu, Naiming Zho. Involvement of β-arrestin-2 and clathrin in agonist-mediated internalization of the human cannabinoid CB2 receptor. Current molecular pharmacology. vol 7. issue 1. 2015-09-10. PMID:25023974. |
involvement of β-arrestin-2 and clathrin in agonist-mediated internalization of the human cannabinoid cb2 receptor. |
2015-09-10 |
2023-08-13 |
human |
| L Latini, E Bisicchia, V Sasso, V Chiurchiù, V Cavallucci, M Molinari, M Maccarrone, M T Viscom. Cannabinoid CB2 receptor (CB2R) stimulation delays rubrospinal mitochondrial-dependent degeneration and improves functional recovery after spinal cord hemisection by ERK1/2 inactivation. Cell death & disease. vol 5. 2015-09-08. PMID:25188514. |
cannabinoid cb2 receptor (cb2r) stimulation delays rubrospinal mitochondrial-dependent degeneration and improves functional recovery after spinal cord hemisection by erk1/2 inactivation. |
2015-09-08 |
2023-08-13 |
rat |
| Francesca Borrelli, Barbara Romano, Stefania Petrosino, Ester Pagano, Raffaele Capasso, Diana Coppola, Giovanni Battista, Pierangelo Orlando, Vincenzo Di Marzo, Angelo A Izz. Palmitoylethanolamide, a naturally occurring lipid, is an orally effective intestinal anti-inflammatory agent. British journal of pharmacology. vol 172. issue 1. 2015-09-04. PMID:25205418. |
palmitoylethanolamide (pea) acts via several targets, including cannabinoid cb1 and cb2 receptors, transient receptor potential vanilloid type-1 (trpv1) ion channels, peroxisome proliferator-activated receptor alpha (ppar α) and orphan g protein-coupled receptor 55 (grr55), all involved in the control of intestinal inflammation. |
2015-09-04 |
2023-08-13 |
Not clear |
| Fabricio A Moreira, Bianca Jupp, David Belin, Jeffrey W Dalle. Endocannabinoids and striatal function: implications for addiction-related behaviours. Behavioural pharmacology. vol 26. issue 1-2. 2015-09-03. PMID:25369747. |
we highlight the potential of selective inhibitors of endocannabinoid metabolism, directed at fatty acid amide hydrolase and monoacylglycerol lipase, to reduce anxiety and stress responses, and discuss novel mechanisms underlying the modulation of the endocannabinoid system, including the attenuation of impulsivity, anxiety, and drug reward by selective cb2 receptor agonists. |
2015-09-03 |
2023-08-13 |
Not clear |
| Sari Yrjölä, Mirkka Sarparanta, Anu J Airaksinen, Maria Hytti, Anu Kauppinen, Sanna Pasonen-Seppänen, Barbara Adinolfi, Paola Nieri, Clementina Manera, Outi Keinänen, Antti Poso, Tapio J Nevalainen, Teija Parkkar. Synthesis, in vitro and in vivo evaluation of 1,3,5-triazines as cannabinoid CB2 receptor agonists. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. vol 67. 2015-08-31. PMID:25447744. |
synthesis, in vitro and in vivo evaluation of 1,3,5-triazines as cannabinoid cb2 receptor agonists. |
2015-08-31 |
2023-08-13 |
human |
| Antonio Ortega-Álvaro, Alexander Ternianov, Auxiliadora Aracil-Fernández, Francisco Navarrete, Maria Salud García-Gutiérrez, Jorge Manzanare. Role of cannabinoid CB2 receptor in the reinforcing actions of ethanol. Addiction biology. vol 20. issue 1. 2015-08-24. PMID:23855434. |
role of cannabinoid cb2 receptor in the reinforcing actions of ethanol. |
2015-08-24 |
2023-08-12 |
mouse |
| Antonio Ortega-Álvaro, Alexander Ternianov, Auxiliadora Aracil-Fernández, Francisco Navarrete, Maria Salud García-Gutiérrez, Jorge Manzanare. Role of cannabinoid CB2 receptor in the reinforcing actions of ethanol. Addiction biology. vol 20. issue 1. 2015-08-24. PMID:23855434. |
this study examines the role of the cannabinoid cb2 receptor (cb2 r) on the vulnerability to ethanol consumption. |
2015-08-24 |
2023-08-12 |
mouse |
| Gulis Saglam, Ozgur Gunduz, Ahmet Ulugo. Blockade of cannabinoid CB1 and CB2 receptors does not prevent the antipruritic effect of systemic paracetamol. Acta neurologica Belgica. vol 114. issue 4. 2015-08-24. PMID:24399199. |
blockade of cannabinoid cb1 and cb2 receptors does not prevent the antipruritic effect of systemic paracetamol. |
2015-08-24 |
2023-08-12 |
mouse |
| Gulis Saglam, Ozgur Gunduz, Ahmet Ulugo. Blockade of cannabinoid CB1 and CB2 receptors does not prevent the antipruritic effect of systemic paracetamol. Acta neurologica Belgica. vol 114. issue 4. 2015-08-24. PMID:24399199. |
since itch and pain sensations share many similarities, the purpose of the present study was to investigate whether blockade of cannabinoid cb1 and cb2 receptors participates in the antipruritic activity of paracetamol in mice. |
2015-08-24 |
2023-08-12 |
mouse |
| Ana Bagüés, M Isabel Martín, Eva M Sánchez-Roble. Involvement of central and peripheral cannabinoid receptors on antinociceptive effect of tetrahydrocannabinol in muscle pain. European journal of pharmacology. vol 745. 2015-08-24. PMID:25446925. |
the drugs used were the non-selective agonist thc and two selective cannabinoid antagonists, am251 (cb1) and am630 (cb2). |
2015-08-24 |
2023-08-13 |
rat |