| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhenning Liu, Yu Wang, Hongyu Zhao, Qiang Zheng, Li Xiao, Min Zha. CB2 receptor activation ameliorates the proinflammatory activity in acute lung injury induced by paraquat. BioMed research international. vol 2014. 2015-02-12. PMID:24963491. |
in the present study, we investigated the possible underlying mechanisms of cannabinoid receptor-2 (cb2) activation to ameliorate the proinflammatory activity induced by pq in rats. |
2015-02-12 |
2023-08-13 |
rat |
| Magdalena Florek-Luszczki, Aleksandra Wlaz, Maria W Kondrat-Wrobel, Piotr Tutka, Jarogniew J Luszczk. Effects of WIN 55,212-2 (a non-selective cannabinoid CB1 and CB 2 receptor agonist) on the protective action of various classical antiepileptic drugs in the mouse 6 Hz psychomotor seizure model. Journal of neural transmission (Vienna, Austria : 1996). vol 121. issue 7. 2015-02-02. PMID:24549572. |
the aim of this study was to characterize the influence of win 55,212-2 (win--a non-selective cannabinoid cb1 and cb2 receptor agonist) on the anticonvulsant effects of various classical antiepileptic drugs (clobazam, clonazepam, phenobarbital and valproate) in the mouse 6 hz-induced psychomotor seizure model. |
2015-02-02 |
2023-08-12 |
mouse |
| Teresa Auguet, Alba Berlanga, Esther Guiu-Jurado, Ximena Terra, Salomé Martinez, Carmen Aguilar, Elisa Filiu, Ajla Alibalic, Fàtima Sabench, Mercé Hernández, Daniel Del Castillo, Cristóbal Richar. Endocannabinoid receptors gene expression in morbidly obese women with nonalcoholic fatty liver disease. BioMed research international. vol 2014. 2015-01-19. PMID:24864249. |
the aim of this study was to investigate the relationship between liver expression of cannabinoid (cb) receptor subtypes, cb1 and cb2, in morbidly obese (mo) women with different histological stages of nafld. |
2015-01-19 |
2023-08-13 |
Not clear |
| János Haskó, Csilla Fazakas, Judit Molnár, Ádám Nyúl-Tóth, Hildegard Herman, Anca Hermenean, Imola Wilhelm, Yuri Persidsky, István A Krizba. CB2 receptor activation inhibits melanoma cell transmigration through the blood-brain barrier. International journal of molecular sciences. vol 15. issue 5. 2015-01-16. PMID:24815068. |
extravasation of leukocytes through the bbb is decreased by the activation of type 2 cannabinoid receptors (cb2); therefore, in the present study we sought to investigate the role of cb2 receptors in the interaction of melanoma cells with the brain endothelium. |
2015-01-16 |
2023-08-13 |
Not clear |
| M Paola Castelli, Camilla Madeddu, Alberto Casti, Angelo Casu, Paola Casti, Maria Scherma, Liana Fattore, Paola Fadda, M Grazia Enna. Δ9-tetrahydrocannabinol prevents methamphetamine-induced neurotoxicity. PloS one. vol 9. issue 5. 2015-01-15. PMID:24844285. |
preclinical studies have shown that natural (Δ9-tetrahydrocannabinol, Δ9-thc) and synthetic cannabinoid cb1 and cb2 receptor agonists exert neuroprotective effects on different models of cerebral damage. |
2015-01-15 |
2023-08-13 |
rat |
| b' Ana C Pascual, Virginia L Gaveglio, Norma M Giusto, Susana J Pasquar\\xc3\\xa. Cannabinoid receptor-dependent metabolism of 2-arachidonoylglycerol during aging. Experimental gerontology. vol 55. 2015-01-12. PMID:24768821.' |
cannabinoids primarily interact with the seven-segment transmembrane cannabinoid receptor 1 (cb1) and cannabinoid receptor 2 (cb2), both of which are expressed in the central nervous system (cns). |
2015-01-12 |
2023-08-13 |
rat |
| b' Ana C Pascual, Virginia L Gaveglio, Norma M Giusto, Susana J Pasquar\\xc3\\xa. Cannabinoid receptor-dependent metabolism of 2-arachidonoylglycerol during aging. Experimental gerontology. vol 55. 2015-01-12. PMID:24768821.' |
taken together, the results of the present study show that cb1 and/or cb2 receptor antagonists trigger a significant modulation of 2-ag metabolism, underlining their relevance as therapeutic strategy for controlling endocannabinoid levels in physiological aging. |
2015-01-12 |
2023-08-13 |
rat |
| Ningyang Jia, Shaojuan Zhang, Pin Shao, Christina Bagia, Jelena M Janjic, Ying Ding, Mingfeng Ba. Cannabinoid CB2 receptor as a new phototherapy target for the inhibition of tumor growth. Molecular pharmaceutics. vol 11. issue 6. 2015-01-12. PMID:24779700. |
cannabinoid cb2 receptor as a new phototherapy target for the inhibition of tumor growth. |
2015-01-12 |
2023-08-13 |
Not clear |
| Ningyang Jia, Shaojuan Zhang, Pin Shao, Christina Bagia, Jelena M Janjic, Ying Ding, Mingfeng Ba. Cannabinoid CB2 receptor as a new phototherapy target for the inhibition of tumor growth. Molecular pharmaceutics. vol 11. issue 6. 2015-01-12. PMID:24779700. |
in the current study, we chose a cannabinoid cb2 receptor (cb2r) as a new target and used a cb2r-targeted photosensitizer, ir700dx-mbc94, for phototherapy treatment. |
2015-01-12 |
2023-08-13 |
Not clear |
| James J Burston, Devi Rani Sagar, Pin Shao, Mingfeng Bai, Emma King, Louis Brailsford, Jenna M Turner, Gareth J Hathway, Andrew J Bennett, David A Walsh, David A Kendall, Aron Lichtman, Victoria Chapma. Cannabinoid CB2 receptors regulate central sensitization and pain responses associated with osteoarthritis of the knee joint. PloS one. vol 8. issue 11. 2015-01-02. PMID:24282543. |
cannabinoid cb2 receptors regulate central sensitization and pain responses associated with osteoarthritis of the knee joint. |
2015-01-02 |
2023-08-12 |
human |
| James J Burston, Devi Rani Sagar, Pin Shao, Mingfeng Bai, Emma King, Louis Brailsford, Jenna M Turner, Gareth J Hathway, Andrew J Bennett, David A Walsh, David A Kendall, Aron Lichtman, Victoria Chapma. Cannabinoid CB2 receptors regulate central sensitization and pain responses associated with osteoarthritis of the knee joint. PloS one. vol 8. issue 11. 2015-01-02. PMID:24282543. |
inhibitory cannabinoid 2 (cb2) receptors attenuate peripheral immune cell function and modulate central neuro-immune responses in models of neurodegeneration. |
2015-01-02 |
2023-08-12 |
human |
| Marta Baranowska-Kuczko, Hanna Kozłowska, Mirosław Kozłowski, Eberhard Schlicker, Monika Kloza, Arkadiusz Surażyński, Emilia Grzęda, Barbara Malinowsk. Mechanisms of endothelium-dependent relaxation evoked by anandamide in isolated human pulmonary arteries. Naunyn-Schmiedeberg's archives of pharmacology. vol 387. issue 5. 2015-01-02. PMID:24682422. |
in experiments performed in the presence of urb597 to exclude effects of anandamide metabolites, the antagonist of the endothelial cannabinoid receptor, o-1918, diminished the anandamide-evoked relaxation whereas the antagonists of cannabinoid cb1, cb2 and vanilloid trpv1 receptors, am251, sr144528 and capsazepine, respectively, had no effect. |
2015-01-02 |
2023-08-12 |
human |
| S Zoppi, J L Madrigal, J R Caso, M S García-Gutiérrez, J Manzanares, J C Leza, B García-Buen. Regulatory role of the cannabinoid CB2 receptor in stress-induced neuroinflammation in mice. British journal of pharmacology. vol 171. issue 11. 2014-12-28. PMID:24467609. |
regulatory role of the cannabinoid cb2 receptor in stress-induced neuroinflammation in mice. |
2014-12-28 |
2023-08-12 |
mouse |
| S Zoppi, J L Madrigal, J R Caso, M S García-Gutiérrez, J Manzanares, J C Leza, B García-Buen. Regulatory role of the cannabinoid CB2 receptor in stress-induced neuroinflammation in mice. British journal of pharmacology. vol 171. issue 11. 2014-12-28. PMID:24467609. |
here, we have assessed the possible regulatory role of cannabinoid cb2 receptors in stress-induced excitotoxicity and neuroinflammation. |
2014-12-28 |
2023-08-12 |
mouse |
| Tapio Nevalaine. Recent development of CB2 selective and peripheral CB1/CB2 cannabinoid receptor ligands. Current medicinal chemistry. vol 21. issue 2. 2014-12-22. PMID:24164198. |
separating the therapeutic effects of cannabinoid agonists from their undesired cns effects can be achieved by either increasing the selectivity of the ligands for the cb2 receptor or by developing peripherally restricted cb1/cb2 ligands. |
2014-12-22 |
2023-08-12 |
Not clear |
| Jana Kucerova, Katarina Tabiova, Filippo Drago, Vincenzo Mical. Therapeutic potential of cannabinoids in schizophrenia. Recent patents on CNS drug discovery. vol 9. issue 1. 2014-12-22. PMID:24605939. |
the endocannabinoid system comprises of two g protein-coupled receptors (the cannabinoid receptors 1 and 2 [cb1 and cb2] for marijuana's psychoactive principle Δ(9)-tetrahydrocannabinol), their endogenous small lipid ligands (namely anandamide [aea] and 2-arachidonoylglycerol [2-ag], also known as endocannabinoids), and proteins for endocannabinoid biosynthesis and degradation. |
2014-12-22 |
2023-08-12 |
Not clear |
| Jana Kucerova, Katarina Tabiova, Filippo Drago, Vincenzo Mical. Therapeutic potential of cannabinoids in schizophrenia. Recent patents on CNS drug discovery. vol 9. issue 1. 2014-12-22. PMID:24605939. |
consistently, preclinical and clinical studies have found a dysregulation in the endocannabinoid system such as changed expression of cb1 and cb2 receptors or altered levels of aea and 2-ag . |
2014-12-22 |
2023-08-12 |
Not clear |
| Carmen Rodríguez-Cueto, Cristina Benito, Julián Romero, Mariluz Hernández-Gálvez, María Gómez-Ruiz, Javier Fernández-Rui. Endocannabinoid-hydrolysing enzymes in the post-mortem cerebellum of humans affected by hereditary autosomal dominant ataxias. Pathobiology : journal of immunopathology, molecular and cellular biology. vol 81. issue 3. 2014-12-17. PMID:24642775. |
we recently found important changes in cannabinoid cb1 and cb2 receptors in the post-mortem cerebellum of patients affected by different scas. |
2014-12-17 |
2023-08-12 |
Not clear |
| Shuang Han, Jiong-Jiong Chen, Jian-Zhong Che. Latest progress in the identification of novel synthetic ligands for the cannabinoid CB2 receptor. Mini reviews in medicinal chemistry. vol 14. issue 5. 2014-12-17. PMID:24766386. |
latest progress in the identification of novel synthetic ligands for the cannabinoid cb2 receptor. |
2014-12-17 |
2023-08-13 |
Not clear |
| Shuang Han, Jiong-Jiong Chen, Jian-Zhong Che. Latest progress in the identification of novel synthetic ligands for the cannabinoid CB2 receptor. Mini reviews in medicinal chemistry. vol 14. issue 5. 2014-12-17. PMID:24766386. |
cannabinoid cb2 receptor, which mainly locates in peripheral tissues, represents as a promising drug target for the treatment of pain, osteoporosis, liver disorders, and so on without serious cns side effects. |
2014-12-17 |
2023-08-13 |
Not clear |