| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J T Toguri, C Lehmann, R B Laprairie, A M Szczesniak, J Zhou, E M Denovan-Wright, M E M Kell. Anti-inflammatory effects of cannabinoid CB(2) receptor activation in endotoxin-induced uveitis. British journal of pharmacology. vol 171. issue 6. 2014-11-05. PMID:24308861. |
cannabinoid cb2 receptors mediate immunomodulation. |
2014-11-05 |
2023-08-12 |
Not clear |
| John C Ashton, Yiwen Zheng, Cynthia Darlington, Jean-Ha Baek, Paul F Smit. Cannabinoid CB2 receptor immunolabelling in the healthy brain--still a live possibility. Naunyn-Schmiedeberg's archives of pharmacology. vol 387. issue 3. 2014-10-28. PMID:24346059. |
cannabinoid cb2 receptor immunolabelling in the healthy brain--still a live possibility. |
2014-10-28 |
2023-08-12 |
Not clear |
| Aurélien Tourteau, Natascha Leleu-Chavain, Mathilde Body-Malapel, Virginie Andrzejak, Amélie Barczyk, Madjid Djouina, Benoit Rigo, Pierre Desreumaux, Philippe Chavatte, Régis Mille. Switching cannabinoid response from CB(2) agonists to FAAH inhibitors. Bioorganic & medicinal chemistry letters. vol 24. issue 5. 2014-10-28. PMID:24508127. |
the pharmacological results led to identify structure-activity relationships enabling to switch cannabinoid response from cb2 agonists to faah inhibitors. |
2014-10-28 |
2023-08-12 |
mouse |
| Jaime Mella-Raipán, Santiago Hernández-Pino, César Morales-Verdejo, David Pessoa-Mahan. 3D-QSAR/CoMFA-based structure-affinity/selectivity relationships of aminoalkylindoles in the cannabinoid CB1 and CB2 receptors. Molecules (Basel, Switzerland). vol 19. issue 3. 2014-10-28. PMID:24603555. |
3d-qsar/comfa-based structure-affinity/selectivity relationships of aminoalkylindoles in the cannabinoid cb1 and cb2 receptors. |
2014-10-28 |
2023-08-12 |
Not clear |
| Jaime Mella-Raipán, Santiago Hernández-Pino, César Morales-Verdejo, David Pessoa-Mahan. 3D-QSAR/CoMFA-based structure-affinity/selectivity relationships of aminoalkylindoles in the cannabinoid CB1 and CB2 receptors. Molecules (Basel, Switzerland). vol 19. issue 3. 2014-10-28. PMID:24603555. |
a 3d-qsar (comfa) study was performed in an extensive series of aminoalkylindoles derivatives with affinity for the cannabinoid receptors cb1 and cb2. |
2014-10-28 |
2023-08-12 |
Not clear |
| Simone Macrì, Lara Lanuzza, Gustavo Merola, Chiara Ceci, Stefano Gentili, Antonella Valli, Teodora Macchia, Giovanni Laviol. Behavioral responses to acute and sub-chronic administration of the synthetic cannabinoid JWH-018 in adult mice prenatally exposed to corticosterone. Neurotoxicity research. vol 24. issue 1. 2014-10-26. PMID:23296549. |
among them, the aminoalkylindole-derivative jwh-018 is widely distributed due to its capability of binding the cannabinoid receptors cb1 and cb2 thereby mimicking the effects of classical drug agonists. |
2014-10-26 |
2023-08-12 |
mouse |
| M A Costa, B M Fonseca, E Keating, N A Teixeira, G Correia-da-Silv. 2-arachidonoylglycerol effects in cytotrophoblasts: metabolic enzymes expression and apoptosis in BeWo cells. Reproduction (Cambridge, England). vol 147. issue 3. 2014-10-21. PMID:24324206. |
moreover, whereas Δψm loss and ros/rns generation were significantly attenuated by the antagonists of both the cannabinoid receptors 1 and 2 (cb1 and cb2), the increase in caspase 3/7 and 9 activities and loss of cell viability were reversed only by the antagonist of cb2 receptor; the blockage of the ecb membrane transporter and the depletion of cholesterol failed to reverse the effects of 2-ag. |
2014-10-21 |
2023-08-12 |
human |
| Elizabeth J Rahn, Liting Deng, Ganesh A Thakur, Kiran Vemuri, Alexander M Zvonok, Yvonne Y Lai, Alexandros Makriyannis, Andrea G Hohman. Prophylactic cannabinoid administration blocks the development of paclitaxel-induced neuropathic nociception during analgesic treatment and following cessation of drug delivery. Molecular pain. vol 10. 2014-10-17. PMID:24742127. |
the impact of chronic drug infusion on transcriptional regulation of mrna markers of astrocytes (gfap), microglia (cd11b) and cannabinoid receptors (cb1, cb2) was assessed in lumbar spinal cords of paclitaxel and vehicle-treated rats. |
2014-10-17 |
2023-08-13 |
rat |
| Pietro Marini, Maria-Grazia Cascio, Angela King, Roger G Pertwee, Ruth A Ros. Characterization of cannabinoid receptor ligands in tissues natively expressing cannabinoid CB2 receptors. British journal of pharmacology. vol 169. issue 4. 2014-10-08. PMID:23711022. |
characterization of cannabinoid receptor ligands in tissues natively expressing cannabinoid cb2 receptors. |
2014-10-08 |
2023-08-12 |
mouse |
| Pedro González-Naranjo, Natalia Pérez-Macias, Nuria E Campillo, Concepción Pérez, Vicente J Arán, Rocio Girón, Eva Sánchez-Robles, María Isabel Martín, María Gómez-Cañas, Moisés García-Arencibia, Javier Fernández-Ruiz, Juan A Páe. Cannabinoid agonists showing BuChE inhibition as potential therapeutic agents for Alzheimer's disease. European journal of medicinal chemistry. vol 73. 2014-10-07. PMID:24378710. |
in this work, new indazole ethers that possess dual activity as both cannabinoid agonists cb2 and inhibitors of buche have been designed by computational methods. |
2014-10-07 |
2023-08-12 |
Not clear |
| Pedro González-Naranjo, Natalia Pérez-Macias, Nuria E Campillo, Concepción Pérez, Vicente J Arán, Rocio Girón, Eva Sánchez-Robles, María Isabel Martín, María Gómez-Cañas, Moisés García-Arencibia, Javier Fernández-Ruiz, Juan A Páe. Cannabinoid agonists showing BuChE inhibition as potential therapeutic agents for Alzheimer's disease. European journal of medicinal chemistry. vol 73. 2014-10-07. PMID:24378710. |
the results of pharmacological tests have revealed that three of these derivatives behave as cb2 cannabinoid agonists and simultaneously show buche inhibition. |
2014-10-07 |
2023-08-12 |
Not clear |
| Jagjeet S Mnpotra, Zhuanhong Qiao, Jian Cai, Diane L Lynch, Alan Grossfield, Nicholas Leioatts, Dow P Hurst, Michael C Pitman, Zhao-Hui Song, Patricia H Reggi. Structural basis of G protein-coupled receptor-Gi protein interaction: formation of the cannabinoid CB2 receptor-Gi protein complex. The Journal of biological chemistry. vol 289. issue 29. 2014-10-06. PMID:24855641. |
structural basis of g protein-coupled receptor-gi protein interaction: formation of the cannabinoid cb2 receptor-gi protein complex. |
2014-10-06 |
2023-08-13 |
Not clear |
| Richard F Cox, Vincent Ras. Characterization of cannabinoid receptors. Current protocols in pharmacology. vol 63. 2014-09-26. PMID:24510753. |
this unit describes the use of cannabinoid radioligands in competitive binding assays for determining affinity parameters (ic50, ki ) of unlabeled compounds at transfected cb1 and cb2 receptors expressed in cell lines. |
2014-09-26 |
2023-08-12 |
Not clear |
| G Cristina Brailoiu, Elena Deliu, Jahan Marcu, Nicholas E Hoffman, Linda Console-Bram, Pingwei Zhao, Muniswamy Madesh, Mary E Abood, Eugen Brailoi. Differential activation of intracellular versus plasmalemmal CB2 cannabinoid receptors. Biochemistry. vol 53. issue 30. 2014-09-26. PMID:25033246. |
differential activation of intracellular versus plasmalemmal cb2 cannabinoid receptors. |
2014-09-26 |
2023-08-13 |
Not clear |
| G Cristina Brailoiu, Elena Deliu, Jahan Marcu, Nicholas E Hoffman, Linda Console-Bram, Pingwei Zhao, Muniswamy Madesh, Mary E Abood, Eugen Brailoi. Differential activation of intracellular versus plasmalemmal CB2 cannabinoid receptors. Biochemistry. vol 53. issue 30. 2014-09-26. PMID:25033246. |
the type 2 receptor for cannabinoids (cb2) has emerged as an important therapeutic target in several pathologies, as it mediates beneficial effects of cannabinoids while having little if any psychotropic activity. |
2014-09-26 |
2023-08-13 |
Not clear |
| Gabriele Murineddu, Francesco Deligia, Antonio Dore, Giovanni Pinna, Battistina Asproni, Gerard A Pinn. Different classes of CB2 ligands potentially useful in the treatment of pain. Recent patents on CNS drug discovery. vol 8. issue 1. 2014-09-25. PMID:23477308. |
in this context, since the modulation of the endocannabinoid system with the non selective phytocannabinoid Δ9-thc produces analgesia and potentiates opioid analgesia in animal models, cb2 ligands studies aimed to explore the involvement of endocannabinoid system in management of pain were started. |
2014-09-25 |
2023-08-12 |
Not clear |
| J J Xu, P Diaz, B Bie, F Astruc-Diaz, J Wu, H Yang, D L Brown, M Nagui. Spinal gene expression profiling and pathways analysis of a CB2 agonist (MDA7)-targeted prevention of paclitaxel-induced neuropathy. Neuroscience. vol 260. 2014-09-25. PMID:24361916. |
we found that a novel selective cannabinoid cb2 receptor agonist (mda7) prevents paclitaxel-induced mechanical allodynia in rats and mice. |
2014-09-25 |
2023-08-12 |
mouse |
| Isabel Devesa, Antonio Ferrer-Montie. Neurotrophins, endocannabinoids and thermo-transient receptor potential: a threesome in pain signalling. The European journal of neuroscience. vol 39. issue 3. 2014-09-25. PMID:24494676. |
although pain is multifactorial at cellular and molecular levels, it is widely accepted that neurotrophin (trka, p75ntr, ret and gfrs), cannabinoid (cb1 and cb2), and thermo-transient receptor potential (trps; trpv1, trpa1 and trpm8) receptors play a pivotal role. |
2014-09-25 |
2023-08-12 |
Not clear |
| Livio Luongo, Sabatino Maione, Vincenzo Di Marz. Endocannabinoids and neuropathic pain: focus on neuron-glia and endocannabinoid-neurotrophin interactions. The European journal of neuroscience. vol 39. issue 3. 2014-09-25. PMID:24494680. |
although originally described as a signalling system encompassing the cannabinoid cb1 and cb2 receptors, their endogenous agonists (the endocannabinoids), and metabolic enzymes regulating the levels of such agonists, the endocannabinoid system is now viewed as being more complex, and including metabolically related endocannabinoid-like mediators and their molecular targets as well. |
2014-09-25 |
2023-08-12 |
Not clear |
| Sherry Shu-Jung Hu, Yu-Cheng Ho, Lih-Chu Chio. No more pain upon Gq-protein-coupled receptor activation: role of endocannabinoids. The European journal of neuroscience. vol 39. issue 3. 2014-09-25. PMID:24494686. |
the analgesic mechanism of its constituents, the cannabinoids, was only revealed after the discovery of cannabinoid receptors (cb1 and cb2) two decades ago. |
2014-09-25 |
2023-08-12 |
Not clear |