| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alessandro Orrù, Giorgio Marchese, Gianluca Casu, Maria Antonietta Casu, Sanjay Kasture, Filippo Cottiglia, Elio Acquas, Maria Paola Mascia, Nicola Anzani, Stefania Rui. Withania somnifera root extract prolongs analgesia and suppresses hyperalgesia in mice treated with morphine. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 21. issue 5. 2014-12-15. PMID:24268297. |
further, to characterize the receptor(s) involved in these effects, we studied, by receptor-binding assay, the affinity of wse for opioid (μ, δ, k), cannabinoid (cb1, cb2), glutamatergic (nmda), gabaergic (gabaa, gabab), serotoninergic (5ht2a) and adrenergic (α2) receptors. |
2014-12-15 |
2023-08-12 |
mouse |
| J R Rivers-Auty, P F Smith, J C Ashto. The cannabinoid CB2 receptor agonist GW405833 does not ameliorate brain damage induced by hypoxia-ischemia in rats. Neuroscience letters. vol 569. 2014-12-09. PMID:24721671. |
the cannabinoid cb2 receptor agonist gw405833 does not ameliorate brain damage induced by hypoxia-ischemia in rats. |
2014-12-09 |
2023-08-13 |
rat |
| J R Rivers-Auty, P F Smith, J C Ashto. The cannabinoid CB2 receptor agonist GW405833 does not ameliorate brain damage induced by hypoxia-ischemia in rats. Neuroscience letters. vol 569. 2014-12-09. PMID:24721671. |
the cannabinoid cb2 receptor has been under investigation as a potential target for neuroprotection with the suppression of neuroinflammation as the proposed mechanism of action. |
2014-12-09 |
2023-08-13 |
rat |
| Simone Tambaro, Maria Antonietta Casu, Andrea Mastinu, Paolo Lazzar. Evaluation of selective cannabinoid CB(1) and CB(2) receptor agonists in a mouse model of lipopolysaccharide-induced interstitial cystitis. European journal of pharmacology. vol 729. 2014-12-03. PMID:24561047. |
in this study, we evaluated the anti-inflammatory effect of selective cannabinoid cb1 and cb2 receptor agonists in a mouse model of interstitial cystitis. |
2014-12-03 |
2023-08-12 |
mouse |
| Simone Tambaro, Maria Antonietta Casu, Andrea Mastinu, Paolo Lazzar. Evaluation of selective cannabinoid CB(1) and CB(2) receptor agonists in a mouse model of lipopolysaccharide-induced interstitial cystitis. European journal of pharmacology. vol 729. 2014-12-03. PMID:24561047. |
additionally, anti-inflammatory activity was studied by evaluation, leukocytes mucosa infiltration, myeloperoxidase activity, and mrna expression of pro-inflammatory interleukin (il-1α and il-1β), tumor necrosis factor-alpha (tnf-α) and cannabinoid cb1 and cb2 receptors. |
2014-12-03 |
2023-08-12 |
mouse |
| Simone Tambaro, Maria Antonietta Casu, Andrea Mastinu, Paolo Lazzar. Evaluation of selective cannabinoid CB(1) and CB(2) receptor agonists in a mouse model of lipopolysaccharide-induced interstitial cystitis. European journal of pharmacology. vol 729. 2014-12-03. PMID:24561047. |
taken together, these findings strongly suggest that modulation of the cannabinoid cb2 receptors might be a promising therapeutic strategy for the treatment of bladder diseases and conditions characterized by inflammation, such as interstitial cystitis. |
2014-12-03 |
2023-08-12 |
mouse |
| Elisa Borsani, Alessandra Majorana, Marco Angelo Cocchi, Giulio Conti, Sara Bonadeo, Alessandro Padovani, Giuseppe Lauria, Elena Bardellini, Rita Rezzani, Luigi Fabrizio Rodell. Epithelial expression of vanilloid and cannabinoid receptors: a potential role in burning mouth syndrome pathogenesis. Histology and histopathology. vol 29. issue 4. 2014-12-01. PMID:24190005. |
the aim of this study was to assess the epithelial alteration of transient receptor potential vanilloid channel type 1 (trpv1) and cannabinoid receptors type 1 (cb1) and type 2 (cb2) in the human tongue. |
2014-12-01 |
2023-08-12 |
human |
| Cristina Fernández-Fernández, Luis F Callado, Rocío Girón, Eva Sánchez, Amaia M Erdozain, José Antonio López-Moreno, Paula Morales, Fernando Rodríguez de Fonseca, Javier Fernández-Ruiz, Pilar Goya, J Javier Meana, M Isabel Martín, Nadine Jagerovi. Combining rimonabant and fentanyl in a single entity: preparation and pharmacological results. Drug design, development and therapy. vol 8. 2014-11-24. PMID:24591816. |
the new compounds have been tested for their affinity and functionality regarding cb1 and cb2 cannabinoid and μ opioid receptors. |
2014-11-24 |
2023-08-12 |
human |
| L C R Silva, T R L Romero, L S Guzzo, I D G Duart. Participation of cannabinoid receptors in peripheral nociception induced by some NSAIDs. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 45. issue 12. 2014-11-12. PMID:22983178. |
this effect was not antagonized by ipl cb1 cannabinoid antagonist to dipyrone (mean = 5.00 ± 0.9815 g), diclofenac (mean = 2.50 ± 0.8337 g) and indomethacin (mean = 6.650 ± 4.069 g) or cb2 cannabinoid antagonist to dipyrone (mean = 1.050 ± 6.436 g), diclofenac (mean = 6.675 ± 1.368 g) and indomethacin (mean = 2.85 ± 5.01 g). |
2014-11-12 |
2023-08-12 |
rat |
| Amey Dhopeshwarkar, Ken Macki. CB2 Cannabinoid receptors as a therapeutic target-what does the future hold? Molecular pharmacology. vol 86. issue 4. 2014-11-07. PMID:25106425. |
cb2 cannabinoid receptors as a therapeutic target-what does the future hold? |
2014-11-07 |
2023-08-13 |
human |
| Amey Dhopeshwarkar, Ken Macki. CB2 Cannabinoid receptors as a therapeutic target-what does the future hold? Molecular pharmacology. vol 86. issue 4. 2014-11-07. PMID:25106425. |
the past decades have seen an exponential rise in our understanding of the endocannabinoid system, comprising cb1 and cb2 cannabinoid receptors, endogenous cannabinoids (endocannabinoids), and the enzymes that synthesize and degrade endocannabinoids. |
2014-11-07 |
2023-08-13 |
human |
| Ya Zhou, Katarzyna Falenta, Giovanna Lall. Endocannabinoid signalling in neuronal migration. The international journal of biochemistry & cell biology. vol 47. 2014-11-06. PMID:24361301. |
the endocannabinoid (ecb) system consists of several endogenous lipids, their target cb1 and cb2 receptors and enzymes responsible for their synthesis and degradation. |
2014-11-06 |
2023-08-12 |
Not clear |
| S G Fagan, V A Campbel. The influence of cannabinoids on generic traits of neurodegeneration. British journal of pharmacology. vol 171. issue 6. 2014-11-05. PMID:24172185. |
signalling from the cb1 and cb2 receptors are known to be involved in the regulation of ca(2+) homeostasis, mitochondrial function, trophic support and inflammatory status, respectively, while other receptors gated by cannabinoids such as pparγ, are gaining interest in their anti-inflammatory properties. |
2014-11-05 |
2023-08-12 |
Not clear |
| J T Toguri, C Lehmann, R B Laprairie, A M Szczesniak, J Zhou, E M Denovan-Wright, M E M Kell. Anti-inflammatory effects of cannabinoid CB(2) receptor activation in endotoxin-induced uveitis. British journal of pharmacology. vol 171. issue 6. 2014-11-05. PMID:24308861. |
cannabinoid cb2 receptors mediate immunomodulation. |
2014-11-05 |
2023-08-12 |
Not clear |
| John C Ashton, Yiwen Zheng, Cynthia Darlington, Jean-Ha Baek, Paul F Smit. Cannabinoid CB2 receptor immunolabelling in the healthy brain--still a live possibility. Naunyn-Schmiedeberg's archives of pharmacology. vol 387. issue 3. 2014-10-28. PMID:24346059. |
cannabinoid cb2 receptor immunolabelling in the healthy brain--still a live possibility. |
2014-10-28 |
2023-08-12 |
Not clear |
| Aurélien Tourteau, Natascha Leleu-Chavain, Mathilde Body-Malapel, Virginie Andrzejak, Amélie Barczyk, Madjid Djouina, Benoit Rigo, Pierre Desreumaux, Philippe Chavatte, Régis Mille. Switching cannabinoid response from CB(2) agonists to FAAH inhibitors. Bioorganic & medicinal chemistry letters. vol 24. issue 5. 2014-10-28. PMID:24508127. |
the pharmacological results led to identify structure-activity relationships enabling to switch cannabinoid response from cb2 agonists to faah inhibitors. |
2014-10-28 |
2023-08-12 |
mouse |
| Jaime Mella-Raipán, Santiago Hernández-Pino, César Morales-Verdejo, David Pessoa-Mahan. 3D-QSAR/CoMFA-based structure-affinity/selectivity relationships of aminoalkylindoles in the cannabinoid CB1 and CB2 receptors. Molecules (Basel, Switzerland). vol 19. issue 3. 2014-10-28. PMID:24603555. |
3d-qsar/comfa-based structure-affinity/selectivity relationships of aminoalkylindoles in the cannabinoid cb1 and cb2 receptors. |
2014-10-28 |
2023-08-12 |
Not clear |
| Jaime Mella-Raipán, Santiago Hernández-Pino, César Morales-Verdejo, David Pessoa-Mahan. 3D-QSAR/CoMFA-based structure-affinity/selectivity relationships of aminoalkylindoles in the cannabinoid CB1 and CB2 receptors. Molecules (Basel, Switzerland). vol 19. issue 3. 2014-10-28. PMID:24603555. |
a 3d-qsar (comfa) study was performed in an extensive series of aminoalkylindoles derivatives with affinity for the cannabinoid receptors cb1 and cb2. |
2014-10-28 |
2023-08-12 |
Not clear |
| Simone Macrì, Lara Lanuzza, Gustavo Merola, Chiara Ceci, Stefano Gentili, Antonella Valli, Teodora Macchia, Giovanni Laviol. Behavioral responses to acute and sub-chronic administration of the synthetic cannabinoid JWH-018 in adult mice prenatally exposed to corticosterone. Neurotoxicity research. vol 24. issue 1. 2014-10-26. PMID:23296549. |
among them, the aminoalkylindole-derivative jwh-018 is widely distributed due to its capability of binding the cannabinoid receptors cb1 and cb2 thereby mimicking the effects of classical drug agonists. |
2014-10-26 |
2023-08-12 |
mouse |
| M A Costa, B M Fonseca, E Keating, N A Teixeira, G Correia-da-Silv. 2-arachidonoylglycerol effects in cytotrophoblasts: metabolic enzymes expression and apoptosis in BeWo cells. Reproduction (Cambridge, England). vol 147. issue 3. 2014-10-21. PMID:24324206. |
moreover, whereas Δψm loss and ros/rns generation were significantly attenuated by the antagonists of both the cannabinoid receptors 1 and 2 (cb1 and cb2), the increase in caspase 3/7 and 9 activities and loss of cell viability were reversed only by the antagonist of cb2 receptor; the blockage of the ecb membrane transporter and the depletion of cholesterol failed to reverse the effects of 2-ag. |
2014-10-21 |
2023-08-12 |
human |