| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Aurélien Tourteau, Virginie Andrzejak, Mathilde Body-Malapel, Lucas Lemaire, Amélie Lemoine, Roxane Mansouri, Madjid Djouina, Nicolas Renault, Jamal El Bakali, Pierre Desreumaux, Giulio G Muccioli, Didier M Lambert, Philippe Chavatte, Benoît Rigo, Natascha Leleu-Chavain, Régis Mille. 3-Carboxamido-5-aryl-isoxazoles as new CB2 agonists for the treatment of colitis. Bioorganic & medicinal chemistry. vol 21. issue 17. 2014-03-18. PMID:23849204. |
recent investigations showed that anandamide, the main endogenous ligand of cb1 and cb2 cannabinoid receptors, possesses analgesic, antidepressant and anti-inflammatory effects. |
2014-03-18 |
2023-08-12 |
mouse |
| Sangdon Han, Jayant Thatte, Daniel J Buzard, Robert M Jone. Therapeutic utility of cannabinoid receptor type 2 (CB(2)) selective agonists. Journal of medicinal chemistry. vol 56. issue 21. 2014-03-18. PMID:23865723. |
cb2 was identified among cdnas based on its similarity in amino acid sequence to the cb1 receptor and helped provide an explanation for the established effects of cannabinoids on the immune system. |
2014-03-18 |
2023-08-12 |
Not clear |
| Sangdon Han, Jayant Thatte, Daniel J Buzard, Robert M Jone. Therapeutic utility of cannabinoid receptor type 2 (CB(2)) selective agonists. Journal of medicinal chemistry. vol 56. issue 21. 2014-03-18. PMID:23865723. |
several "mixed" cannabinoid agonists are currently in clinical use primarily for controlling pain, and it is believed that selective cb2 agonism may afford a superior analgesic agent devoid of the centrally mediated cb1 effects. |
2014-03-18 |
2023-08-12 |
Not clear |
| S Valdeolivas, M R Pazos, T Bisogno, F Piscitelli, F A Iannotti, M Allarà, O Sagredo, V Di Marzo, J Fernández-Rui. The inhibition of 2-arachidonoyl-glycerol (2-AG) biosynthesis, rather than enhancing striatal damage, protects striatal neurons from malonate-induced death: a potential role of cyclooxygenase-2-dependent metabolism of 2-AG. Cell death & disease. vol 4. 2014-03-12. PMID:24136226. |
the cannabinoid cb2 receptor, which is activated by the endocannabinoid 2-arachidonoyl-glycerol (2-ag), protects striatal neurons from apoptotic death caused by the local administration of malonate, a rat model of huntington's disease (hd). |
2014-03-12 |
2023-08-12 |
rat |
| Khalid A Alswa. The role of endocannabinoids system in fatty liver disease and therapeutic potentials. Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association. vol 19. issue 4. 2014-03-11. PMID:23828743. |
this system refers to the cannabinoid receptors type 1 (cb1) and type 2 (cb2), with both their endogenous ligands and machinery dedicated to ec synthesis and degradation. |
2014-03-11 |
2023-08-12 |
Not clear |
| Weimin Kong, Hongbo Li, Ronald F Tuma, Doina Gane. Selective CB2 receptor activation ameliorates EAE by reducing Th17 differentiation and immune cell accumulation in the CNS. Cellular immunology. vol 287. issue 1. 2014-03-10. PMID:24342422. |
cb2, the cannabinoid receptor expressed primarily on hematopoietic cells and activated microglia, mediates the immunoregulatory functions of cannabinoids. |
2014-03-10 |
2023-08-12 |
Not clear |
| I Dando, M Donadelli, C Costanzo, E Dalla Pozza, A D'Alessandro, L Zolla, M Palmier. Cannabinoids inhibit energetic metabolism and induce AMPK-dependent autophagy in pancreatic cancer cells. Cell death & disease. vol 4. 2014-02-25. PMID:23764845. |
we used cannabinoids specific for the cb1 (acpa) and cb2 (gw) receptors and metabolomic analyses to unravel the potential pathways mediating cannabinoid-dependent inhibition of pancreatic cancer cell growth. |
2014-02-25 |
2023-08-12 |
Not clear |
| Ken-ichi Tomiyama, Masahiko Funad. Cytotoxicity of synthetic cannabinoids on primary neuronal cells of the forebrain: the involvement of cannabinoid CB1 receptors and apoptotic cell death. Toxicology and applied pharmacology. vol 274. issue 1. 2014-02-24. PMID:24211273. |
our results indicate that the cytotoxicity of synthetic cannabinoids towards primary neuronal cells is mediated by the cb1 receptor, but not by the cb2 receptor, and further suggest that caspase cascades may play an important role in the apoptosis induced by these synthetic cannabinoids. |
2014-02-24 |
2023-08-12 |
mouse |
| Evangelia Bakali, Ruth A Elliott, Anthony H Taylor, Jon Willets, Justin C Konje, Douglas G Tincell. Distribution and function of the endocannabinoid system in the rat and human bladder. International urogynecology journal. vol 24. issue 5. 2014-02-10. PMID:23081739. |
our aim was to compare expression and distribution of cannabinoid receptors cb1 and cb2, transient receptor potential vanilloid receptor 1 (trpv1), and modulating enzymes in human and rat bladder. |
2014-02-10 |
2023-08-12 |
human |
| Evangelia Bakali, Ruth A Elliott, Anthony H Taylor, Jon Willets, Justin C Konje, Douglas G Tincell. Distribution and function of the endocannabinoid system in the rat and human bladder. International urogynecology journal. vol 24. issue 5. 2014-02-10. PMID:23081739. |
we also evaluated effects of cannabinoid agonists (acea, agonist of cb1; gp1a, agonist of cb2) on contractile responses of rat bladder strips. |
2014-02-10 |
2023-08-12 |
human |
| John C M Brus. Spice, pot, and stroke. Neurology. vol 81. issue 24. 2014-02-10. PMID:24212392. |
the endocannabinoid system includes 2 types of g-protein coupled receptors: cb1 (mostly in the brain) and cb2 (in peripheral lymphoid tissue). |
2014-02-10 |
2023-08-12 |
Not clear |
| Rachel Ribeiro, Jie Wen, Shihe Li, Yumin Zhan. Involvement of ERK1/2, cPLA2 and NF-κB in microglia suppression by cannabinoid receptor agonists and antagonists. Prostaglandins & other lipid mediators. vol 100-101. 2014-01-24. PMID:23219970. |
however, the underlying molecular mechanisms and whether the action of cannabinoids is coupled to the activation of cannabinoid type 1 (cb1) and type 2 (cb2) receptors are still poorly defined. |
2014-01-24 |
2023-08-12 |
Not clear |
| Rachel Ribeiro, Jie Wen, Shihe Li, Yumin Zhan. Involvement of ERK1/2, cPLA2 and NF-κB in microglia suppression by cannabinoid receptor agonists and antagonists. Prostaglandins & other lipid mediators. vol 100-101. 2014-01-24. PMID:23219970. |
taken together, these results indicate that both cannabinoid receptor agonists and antagonists might suppress microglia activation by cb1 and cb2 receptor independent mechanisms, and provide a new insight into the mechanisms of microglia inhibition by cannabinoids. |
2014-01-24 |
2023-08-12 |
Not clear |
| J M Franklin, T Vasiljevik, T E Prisinzano, G A Carrasc. Cannabinoid 2 receptor- and beta Arrestin 2-dependent upregulation of serotonin 2A receptors. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 23. issue 7. 2014-01-23. PMID:22841827. |
here, we present experimental evidence that sustained treatment with a non-selective cannabinoid agonist (cp55,940) or selective cb2 receptor agonists (jwh133 or gp1a) upregulate 5-ht(2a) receptors in a neuronal cell line. |
2014-01-23 |
2023-08-12 |
Not clear |
| J M Franklin, T Vasiljevik, T E Prisinzano, G A Carrasc. Cannabinoid 2 receptor- and beta Arrestin 2-dependent upregulation of serotonin 2A receptors. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 23. issue 7. 2014-01-23. PMID:22841827. |
our results indicate that cannabinoid agonists might upregulate 5-ht(2a) receptors by a mechanism that requires cb2 receptors and β-arrestin 2 in cells that express both cb2 and 5-ht(2a) receptors. |
2014-01-23 |
2023-08-12 |
Not clear |
| Dow P Hurst, Marianne Schmeisser, Patricia H Reggi. Endogenous lipid activated G protein-coupled receptors: emerging structural features from crystallography and molecular dynamics simulations. Chemistry and physics of lipids. vol 169. 2014-01-15. PMID:23485612. |
however, there is a growing sub-group of class a gpcrs that bind lipid-derived endogenous ligands, such as the cannabinoid cb1 and cb2 receptors (with endogenous ligands, n-arachidonoylethanolamine (anandamide) and sn-2-arachidonylglycerol (2-ag)) and the s1p1-5 receptors (with endogenous ligand, sphingosine-1-phosphate). |
2014-01-15 |
2023-08-12 |
Not clear |
| Joseph Bouskila, Pasha Javadi, Christian Casanova, Maurice Ptito, Jean-François Bouchar. Müller cells express the cannabinoid CB2 receptor in the vervet monkey retina. The Journal of comparative neurology. vol 521. issue 11. 2014-01-13. PMID:23630038. |
müller cells express the cannabinoid cb2 receptor in the vervet monkey retina. |
2014-01-13 |
2023-08-12 |
monkey |
| Eduardo Blanco-Calvo, Patricia Rivera, Sergio Arrabal, Antonio Vargas, Francisco Javier Pavón, Antonia Serrano, Estela Castilla-Ortega, Pablo Galeano, Leticia Rubio, Juan Suárez, Fernando Rodriguez de Fonsec. Pharmacological blockade of either cannabinoid CB1 or CB2 receptors prevents both cocaine-induced conditioned locomotion and cocaine-induced reduction of cell proliferation in the hippocampus of adult male rat. Frontiers in integrative neuroscience. vol 7. 2014-01-10. PMID:24409127. |
pharmacological blockade of either cannabinoid cb1 or cb2 receptors prevents both cocaine-induced conditioned locomotion and cocaine-induced reduction of cell proliferation in the hippocampus of adult male rat. |
2014-01-10 |
2023-08-12 |
rat |
| Eduardo Blanco-Calvo, Patricia Rivera, Sergio Arrabal, Antonio Vargas, Francisco Javier Pavón, Antonia Serrano, Estela Castilla-Ortega, Pablo Galeano, Leticia Rubio, Juan Suárez, Fernando Rodriguez de Fonsec. Pharmacological blockade of either cannabinoid CB1 or CB2 receptors prevents both cocaine-induced conditioned locomotion and cocaine-induced reduction of cell proliferation in the hippocampus of adult male rat. Frontiers in integrative neuroscience. vol 7. 2014-01-10. PMID:24409127. |
the endogenous cannabinoid system modulates this proliferative response as demonstrated by the finding that pharmacological activation/blockade of cannabinoid cb1 and cb2 receptors not only modulates neurogenesis but also modulates cell death in the brain. |
2014-01-10 |
2023-08-12 |
rat |
| B S Harvey, L L Nicotra, M Vu, S D Smi. Cannabinoid CB2 receptor activation attenuates cytokine-evoked mucosal damage in a human colonic explant model without changing epithelial permeability. Cytokine. vol 63. issue 2. 2014-01-08. PMID:23706402. |
cannabinoid cb2 receptor activation attenuates cytokine-evoked mucosal damage in a human colonic explant model without changing epithelial permeability. |
2014-01-08 |
2023-08-12 |
human |