| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Vincenzo Di Marzo, Luciano De Petrocelli. Why do cannabinoid receptors have more than one endogenous ligand? Philosophical transactions of the Royal Society of London. Series B, Biological sciences. vol 367. issue 1607. 2013-04-08. PMID:23108541. |
the endocannabinoid system was revealed following the understanding of the mechanism of action of marijuana's major psychotropic principle, Δ(9)-tetrahydrocannabinol, and includes two g-protein-coupled receptors (gpcrs; the cannabinoid cb1 and cb2 receptors), their endogenous ligands (the endocannabinoids, the best studied of which are anandamide and 2-arachidonoylglycerol (2-ag)), and the proteins that regulate the levels and activity of these receptors and ligands. |
2013-04-08 |
2023-08-12 |
human |
| Claudia Grimaldi, Anna Capass. Role of lipid rafts/caveolae in the anticancer effect of endocannabinoids. Mini reviews in medicinal chemistry. vol 12. issue 11. 2013-04-01. PMID:22625418. |
the endocannabinoid system comprises the cannabinoid receptors type 1 (cb1) and type 2 (cb2), their endogenous ligands (endocannabinoids) and the whole apparatus appointed of their synthesis and degradation. |
2013-04-01 |
2023-08-12 |
Not clear |
| C Mugnaini, S Pasquini, F Corell. The bioisosteric concept applied to cannabinoid ligands. Current medicinal chemistry. vol 19. issue 28. 2013-03-28. PMID:22830341. |
two different cannabinoid receptors have been cloned from mammalian tissues, the cb1 receptor, mostly expressed in brain, and the cb2 receptor, mostly expressed in the immune system, both regulating a variety of physiological functions. |
2013-03-28 |
2023-08-12 |
Not clear |
| Dan Wang, Bing-Xu Ren, Cheng-Long Liu, Jie Zhu, Juan Zhang, Wei Zhang, Feng-Mei Mei, Xiao-Ping Gu, Zheng-Liang M. [Role of cannabinoid 2 receptor in the development of bone cancer pain]. Zhonghua yi xue za zhi. vol 92. issue 7. 2013-01-31. PMID:22490961. |
to explore the effects of cannabinoid 2 receptor (cb2) in the development of bone cancer pain in mice. |
2013-01-31 |
2023-08-12 |
mouse |
| Jade M Franklin, Gonzalo A Carrasc. Cannabinoid-induced enhanced interaction and protein levels of serotonin 5-HT(2A) and dopamine D₂ receptors in rat prefrontal cortex. Journal of psychopharmacology (Oxford, England). vol 26. issue 10. 2013-01-30. PMID:22791651. |
to date, two cannabinoids receptors have been found in brain, cb1 and cb2 receptors. |
2013-01-30 |
2023-08-12 |
rat |
| Bharati Prasad, Miodrag G Radulovacki, David W Carle. Proof of concept trial of dronabinol in obstructive sleep apnea. Frontiers in psychiatry. vol 4. 2013-01-25. PMID:23346060. |
on this basis, we examined the safety, tolerability, and efficacy of dronabinol (Δ(9)thc), an exogenous cannabinoid type 1 and type 2 (cb1 and cb2) receptor agonist in patients with obstructive sleep apnea (osa). |
2013-01-25 |
2023-08-12 |
Not clear |
| S E M Lewis, R Paro, L Borriello, L Simon, L Robinson, Z Dincer, G Riedel, N Battista, M Maccarron. Long-term use of HU210 adversely affects spermatogenesis in rats by modulating the endocannabinoid system. International journal of andrology. vol 35. issue 5. 2013-01-22. PMID:22435752. |
hu210, a selective agonist for cb1 and cb2 cannabinoid receptors impairs spermatogenesis and sperm motility and deregulates the endocannabinoid system. |
2013-01-22 |
2023-08-12 |
rat |
| Katrin Palumbo-Zerr, Angelika Horn, Alfiya Distler, Pawel Zerr, Clara Dees, Christian Beyer, Enrico Selvi, Benjamin F Cravatt, Oliver Distler, Georg Schett, Jörg H W Distle. Inactivation of fatty acid amide hydrolase exacerbates experimental fibrosis by enhanced endocannabinoid-mediated activation of CB1. Annals of the rheumatic diseases. vol 71. issue 12. 2013-01-14. PMID:22915616. |
selective targeting of the cannabinoid receptors cb1 and cb2 by synthetic compounds has revealed opposing roles of both receptors in fibrosis. |
2013-01-14 |
2023-08-12 |
Not clear |
| Cristoforo Silvestri, Vincenzo Di Marz. Second generation CB1 receptor blockers and other inhibitors of peripheral endocannabinoid overactivity and the rationale of their use against metabolic disorders. Expert opinion on investigational drugs. vol 21. issue 9. 2013-01-04. PMID:22780328. |
the endocannabinoid system (ecs) is composed of neutral lipids which signal through the g-protein coupled cannabinoid receptors cb1 and cb2. |
2013-01-04 |
2023-08-12 |
Not clear |
| Jarogniew J Luszczki, Magdalena Florek-Łuszczk. Synergistic interaction of pregabalin with the synthetic cannabinoid WIN 55,212-2 mesylate in the hot-plate test in mice: an isobolographic analysis. Pharmacological reports : PR. vol 64. issue 3. 2013-01-04. PMID:22814025. |
the aim of the study was to determine the type of interaction between pregabalin (a 3(rd)-generation antiepileptic drug) and win 55,212-2 mesylate (win - a highly potent non-selective cannabinoid cb1 and cb2 receptor agonist) administered in combination at a fixed ratio of 1:1, in the acute thermal pain model (hot-plate test) in mice. |
2013-01-04 |
2023-08-12 |
mouse |
| Jonathon C Arnold, Phoebe Hone, Michelle L Holland, John D Alle. CB2 and TRPV1 receptors mediate cannabinoid actions on MDR1 expression in multidrug resistant cells. Pharmacological reports : PR. vol 64. issue 3. 2013-01-04. PMID:22814029. |
cb2 and trpv1 receptors mediate cannabinoid actions on mdr1 expression in multidrug resistant cells. |
2013-01-04 |
2023-08-12 |
Not clear |
| Gracious R Ross, Aron Lichtman, William L Dewey, Hamid I Akbaral. Evidence for the putative cannabinoid receptor (GPR55)-mediated inhibitory effects on intestinal contractility in mice. Pharmacology. vol 90. issue 1-2. 2012-12-27. PMID:22759743. |
cannabinoids inhibit intestinal motility via presynaptic cannabinoid receptor type i (cb1) in enteric neurons while cannabinoid receptor type ii (cb2) receptors are located mainly in immune cells. |
2012-12-27 |
2023-08-12 |
mouse |
| Heather L Hutchins-Wiese, Yong Li, Kevin Hannon, Bruce A Watkin. Hind limb suspension and long-chain omega-3 PUFA increase mRNA endocannabinoid system levels in skeletal muscle. The Journal of nutritional biochemistry. vol 23. issue 8. 2012-12-07. PMID:22051448. |
arachidonic acid (aa) is the substrate for anandamide (aea) and 2-arachidonylgycerol (2-ag), which act as agonists for cannabinoid receptors cb1 and cb2 found in muscle. |
2012-12-07 |
2023-08-12 |
mouse |
| Alessandro Pini, Guido Mannaioni, Domenico Pellegrini-Giampietro, Maria Beatrice Passani, Rosanna Mastroianni, Daniele Bani, Emanuela Masin. The role of cannabinoids in inflammatory modulation of allergic respiratory disorders, inflammatory pain and ischemic stroke. Current drug targets. vol 13. issue 7. 2012-12-06. PMID:22420307. |
two types of cannabinoid receptors, cb1 and cb2, which belong to the g protein-coupled receptor family, have been identified and are targeted by numerous exogenous and endogenous ligands. |
2012-12-06 |
2023-08-12 |
Not clear |
| Alessandro Pini, Guido Mannaioni, Domenico Pellegrini-Giampietro, Maria Beatrice Passani, Rosanna Mastroianni, Daniele Bani, Emanuela Masin. The role of cannabinoids in inflammatory modulation of allergic respiratory disorders, inflammatory pain and ischemic stroke. Current drug targets. vol 13. issue 7. 2012-12-06. PMID:22420307. |
moreover, pharmacologic interference with endocannabinoid metabolism has been demonstrated to result in anti-nociceptive activity, mediated by cb1 and cb2 receptors, in animal models of inflammatory pain. |
2012-12-06 |
2023-08-12 |
Not clear |
| Linda Console-Bram, Jahan Marcu, Mary E Aboo. Cannabinoid receptors: nomenclature and pharmacological principles. Progress in neuro-psychopharmacology & biological psychiatry. vol 38. issue 1. 2012-12-03. PMID:22421596. |
the cb1 and cb2 cannabinoid receptors are members of the g protein-coupled receptor (gpcr) family that are pharmacologically well defined. |
2012-12-03 |
2023-08-12 |
Not clear |
| Darryl D Dixon, Marcus A Tius, Ganesh A Thakur, Han Zhou, Anna L Bowman, Vidyanand G Shukla, Yan Peng, Alexandros Makriyanni. C3-heteroaroyl cannabinoids as photolabeling ligands for the CB2 cannabinoid receptor. Bioorganic & medicinal chemistry letters. vol 22. issue 16. 2012-11-30. PMID:22796181. |
c3-heteroaroyl cannabinoids as photolabeling ligands for the cb2 cannabinoid receptor. |
2012-11-30 |
2023-08-12 |
Not clear |
| Darryl D Dixon, Marcus A Tius, Ganesh A Thakur, Han Zhou, Anna L Bowman, Vidyanand G Shukla, Yan Peng, Alexandros Makriyanni. C3-heteroaroyl cannabinoids as photolabeling ligands for the CB2 cannabinoid receptor. Bioorganic & medicinal chemistry letters. vol 22. issue 16. 2012-11-30. PMID:22796181. |
a series of tricyclic cannabinoids incorporating a heteroaroyl group at c3 were prepared as probes to explore the binding site(s) of the cb1 and cb2 receptors. |
2012-11-30 |
2023-08-12 |
Not clear |
| Nima Naderi, Mohsen Majidi, Zahra Mousavi, Solaleh Khoramian Tusi, Zahra Mansouri, Fariba Khodaghol. The interaction between intrathecal administration of low doses of palmitoylethanolamide and AM251 in formalin-induced pain related behavior and spinal cord IL1-β expression in rats. Neurochemical research. vol 37. issue 4. 2012-11-26. PMID:22201038. |
most of the modulating effects of cannabinoids on pain are through putative cannabinoid cb1 and cb2 receptors. |
2012-11-26 |
2023-08-12 |
rat |
| Nima Naderi, Mohsen Majidi, Zahra Mousavi, Solaleh Khoramian Tusi, Zahra Mansouri, Fariba Khodaghol. The interaction between intrathecal administration of low doses of palmitoylethanolamide and AM251 in formalin-induced pain related behavior and spinal cord IL1-β expression in rats. Neurochemical research. vol 37. issue 4. 2012-11-26. PMID:22201038. |
cannabinoid compounds with analgesic activity such as palmitoylethanolamide (pea) show low affinity to cb1 and cb2 receptors, yet selectively activate gpr55 receptors. |
2012-11-26 |
2023-08-12 |
rat |