| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jade M Franklin, Gonzalo A Carrasc. Cannabinoid receptor agonists upregulate and enhance serotonin 2A (5-HT(2A)) receptor activity via ERK1/2 signaling. Synapse (New York, N.Y.). vol 67. issue 3. 2013-06-28. PMID:23151877. |
two cannabinoids receptors are found in brain, cb1 and cb2 receptors, but the molecular mechanism by which cannabinoid receptors would regulate 5-ht(2a) receptor neurotransmission remains unknown. |
2013-06-28 |
2023-08-12 |
rat |
| Francesca Rossi, Giulia Bellini, Livio Luongo, Silvia Mancusi, Marco Torella, Chiara Tortora, Iolanda Manzo, Francesca Guida, Bruno Nobili, Vito de Novellis, Sabatino Maion. The 17-β-oestradiol inhibits osteoclast activity by increasing the cannabinoid CB2 receptor expression. Pharmacological research. vol 68. issue 1. 2013-06-20. PMID:23142558. |
the 17-β-oestradiol inhibits osteoclast activity by increasing the cannabinoid cb2 receptor expression. |
2013-06-20 |
2023-08-12 |
human |
| Carmen La Porta, Simona Andreea Bura, Auxiliadora Aracil-Fernández, Jorge Manzanares, Rafael Maldonad. Role of CB1 and CB2 cannabinoid receptors in the development of joint pain induced by monosodium iodoacetate. Pain. vol 154. issue 1. 2013-06-18. PMID:23199705. |
role of cb1 and cb2 cannabinoid receptors in the development of joint pain induced by monosodium iodoacetate. |
2013-06-18 |
2023-08-12 |
mouse |
| Carmen La Porta, Simona Andreea Bura, Auxiliadora Aracil-Fernández, Jorge Manzanares, Rafael Maldonad. Role of CB1 and CB2 cannabinoid receptors in the development of joint pain induced by monosodium iodoacetate. Pain. vol 154. issue 1. 2013-06-18. PMID:23199705. |
the purpose of this study was to investigate the role of cb1 and cb2 cannabinoid receptors in the behavioral, histological, and neurochemical alterations associated with joint pain. |
2013-06-18 |
2023-08-12 |
mouse |
| Carmen La Porta, Simona Andreea Bura, Auxiliadora Aracil-Fernández, Jorge Manzanares, Rafael Maldonad. Role of CB1 and CB2 cannabinoid receptors in the development of joint pain induced by monosodium iodoacetate. Pain. vol 154. issue 1. 2013-06-18. PMID:23199705. |
the murine model of monosodium iodoacetate (mia) was used to induce joint pain in knockout mice for cb1 (cb1ko) and cb2 cannabinoid receptors (cb2ko) and transgenic mice overexpressing cb2 receptors (cb2xp). |
2013-06-18 |
2023-08-12 |
mouse |
| Carmen La Porta, Simona Andreea Bura, Auxiliadora Aracil-Fernández, Jorge Manzanares, Rafael Maldonad. Role of CB1 and CB2 cannabinoid receptors in the development of joint pain induced by monosodium iodoacetate. Pain. vol 154. issue 1. 2013-06-18. PMID:23199705. |
in addition, we evaluated the changes induced by mia in gene expression of cb1 and cb2 cannabinoid receptors and μ-, δ- and κ-opioid receptors in the lumbar spinal cord of these mice. |
2013-06-18 |
2023-08-12 |
mouse |
| Natsuo Ueda, Kazuhito Tsuboi, Toru Uyam. Metabolism of endocannabinoids and related N-acylethanolamines: canonical and alternative pathways. The FEBS journal. vol 280. issue 9. 2013-06-18. PMID:23425575. |
endocannabinoids are endogenous ligands of the cannabinoid receptors cb1 and cb2. |
2013-06-18 |
2023-08-12 |
Not clear |
| Lucian Del Fabbro, Carlos Borges Filho, Leandro Cattelan Souza, Lucielli Savegnago, Diego Alves, Paulo Henrique Schneider, Helena Domingues de Salles, Cristiano R Jess. Effects of Se-phenyl thiazolidine-4-carboselenoate on mechanical and thermal hyperalgesia in brachial plexus avulsion in mice: mediation by cannabinoid CB1 and CB2 receptors. Brain research. vol 1475. 2013-06-14. PMID:22902772. |
effects of se-phenyl thiazolidine-4-carboselenoate on mechanical and thermal hyperalgesia in brachial plexus avulsion in mice: mediation by cannabinoid cb1 and cb2 receptors. |
2013-06-14 |
2023-08-12 |
mouse |
| John C Ashto. The atypical cannabinoid O-1602: targets, actions, and the central nervous system. Central nervous system agents in medicinal chemistry. vol 12. issue 3. 2013-06-13. PMID:22831390. |
o-1602 is a cannabidiol analogue that does not bind with high affinity to either the cannabinoid cb1 receptor or cb2 receptor. |
2013-06-13 |
2023-08-12 |
Not clear |
| Raphael Mechoulam, Linda A Parke. The endocannabinoid system and the brain. Annual review of psychology. vol 64. 2013-06-10. PMID:22804774. |
the psychoactive constituent in cannabis, Δ(9)-tetrahydrocannabinol (thc), was isolated in the mid-1960s, but the cannabinoid receptors, cb1 and cb2, and the major endogenous cannabinoids (anandamide and 2-arachidonoyl glycerol) were identified only 20 to 25 years later. |
2013-06-10 |
2023-08-12 |
Not clear |
| Rahman Md Mostafeezur, Hossain Md Zakir, Hanako Takatsuji, Yoshiaki Yamada, Kensuke Yamamura, Junichi Kitagaw. Cannabinoids facilitate the swallowing reflex elicited by the superior laryngeal nerve stimulation in rats. PloS one. vol 7. issue 11. 2013-05-22. PMID:23209814. |
cannabinoids have been reported to be involved in affecting various biological functions through binding with cannabinoid receptors type 1 (cb1) and 2 (cb2). |
2013-05-22 |
2023-08-12 |
rat |
| Andrea Rotter, Kristina Bayerlein, Max Hansbauer, Judith Weiland, Wolfgang Sperling, Johannes Kornhuber, Teresa Bierman. CB1 and CB2 receptor expression and promoter methylation in patients with cannabis dependence. European addiction research. vol 19. issue 1. 2013-05-17. PMID:22948261. |
cb1 and cb2 receptors are influenced via exogenous and endogenous cannabinoids. |
2013-05-17 |
2023-08-12 |
human |
| Serena Pasquini, Maria De Rosa, Alessia Ligresti, Claudia Mugnaini, Antonella Brizzi, Nicola P Caradonna, Maria Grazia Cascio, Daniele Bolognini, Roger G Pertwee, Vincenzo Di Marzo, Federico Corell. Investigations on the 4-quinolone-3-carboxylic acid motif. 6. Synthesis and pharmacological evaluation of 7-substituted quinolone-3-carboxamide derivatives as high affinity ligands for cannabinoid receptors. European journal of medicinal chemistry. vol 58. 2013-05-16. PMID:23085772. |
within our studies on structure-activity relationships of 4-quinolone-3-carboxamides as cannabinoid ligands, a new series of compounds characterized by a fluoro or phenylthio group at 7-position and different substituents at n1 and carboxamide nitrogen were synthesized and evaluated for their binding ability to cannabinoid type 1 (cb1) and type 2 (cb2) receptors. |
2013-05-16 |
2023-08-12 |
Not clear |
| Serena Pasquini, Maria De Rosa, Alessia Ligresti, Claudia Mugnaini, Antonella Brizzi, Nicola P Caradonna, Maria Grazia Cascio, Daniele Bolognini, Roger G Pertwee, Vincenzo Di Marzo, Federico Corell. Investigations on the 4-quinolone-3-carboxylic acid motif. 6. Synthesis and pharmacological evaluation of 7-substituted quinolone-3-carboxamide derivatives as high affinity ligands for cannabinoid receptors. European journal of medicinal chemistry. vol 58. 2013-05-16. PMID:23085772. |
most of the compounds showed affinity for one or both cannabinoid receptors at nanomolar concentration, with k(i)(cb1) and k(i)(cb2) values ranging from 2.45 to >10,000 nm and from 0.09 to 957 nm, respectively. |
2013-05-16 |
2023-08-12 |
Not clear |
| Fang He, Akhilesh Kumar, Zhao-Hui Son. Heat shock protein 90 is an essential molecular chaperone for CB2 cannabinoid receptor-mediated signaling in trabecular meshwork cells. Molecular vision. vol 18. 2013-05-14. PMID:23233786. |
heat shock protein 90 is an essential molecular chaperone for cb2 cannabinoid receptor-mediated signaling in trabecular meshwork cells. |
2013-05-14 |
2023-08-12 |
Not clear |
| W Schmidt, F Schäfer, V Striggow, K Fröhlich, F Striggo. Cannabinoid receptor subtypes 1 and 2 mediate long-lasting neuroprotection and improve motor behavior deficits after transient focal cerebral ischemia. Neuroscience. vol 227. 2013-05-09. PMID:23069763. |
we have investigated the localization of cannabinoid cb1 and cb2 receptors in adult rat brains before and after focal cerebral ischemia due to endothelin-induced transient occlusion of the middle cerebral artery (emcao). |
2013-05-09 |
2023-08-12 |
rat |
| Antonella Contartese, Massimo Valoti, Federico Corelli, Serena Pasquini, Claudia Mugnaini, Federica Pessina, Carlo Aldinucci, Giampietro Sgaragli, Maria Frosin. A novel CB2 agonist, COR167, potently protects rat brain cortical slices against OGD and reperfusion injury. Pharmacological research. vol 66. issue 6. 2013-05-07. PMID:23036353. |
cannabinoid cb2 receptor activation has been shown to have many pharmacological but not psychotropic effects. |
2013-05-07 |
2023-08-12 |
rat |
| Angel Arevalo-Martin, Daniel Garcia-Ovejero, Yolanda Sierra-Palomares, Beatriz Paniagua-Torija, Ines Gonzalez-Gil, Silvia Ortega-Gutierrez, Eduardo Molina-Holgad. Early endogenous activation of CB1 and CB2 receptors after spinal cord injury is a protective response involved in spontaneous recovery. PloS one. vol 7. issue 11. 2013-05-07. PMID:23152849. |
since 2-ag and aea act through cb1 and cb2 cannabinoid receptors, we administered at 20 minutes after lesion a single injection of their respective antagonists am281 and am630 alone or in combination to block the effects of this early endocannabinoid accumulation. |
2013-05-07 |
2023-08-12 |
rat |
| A M Sanchez, P Vigano, A Mugione, P Panina-Bordignon, M Candian. The molecular connections between the cannabinoid system and endometriosis. Molecular human reproduction. vol 18. issue 12. 2013-05-06. PMID:22923487. |
the endocannabinoid system consists of an array of endogenously produced bioactive lipids that activate cannabinoid 1 (cb1) and 2 (cb2) receptors. |
2013-05-06 |
2023-08-12 |
Not clear |
| A M Sanchez, P Vigano, A Mugione, P Panina-Bordignon, M Candian. The molecular connections between the cannabinoid system and endometriosis. Molecular human reproduction. vol 18. issue 12. 2013-05-06. PMID:22923487. |
the components of the endocannabinoid system, cb1 and cb2 receptors and the enzymes n-acylphosphatidylethanolamine-phospholipase d and fatty acid amide hydrolase are differentially regulated throughout the menstrual cycle in the endometrium and are expressed in deep endometriotic nodules and in sensory and sympathetic neurons innervating the lesions. |
2013-05-06 |
2023-08-12 |
Not clear |