| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Pál Pacher, Ken Macki. Interplay of cannabinoid 2 (CB2) receptors with nitric oxide synthases, oxidative and nitrative stress, and cell death during remote neurodegeneration. Journal of molecular medicine (Berlin, Germany). vol 90. issue 4. 2012-08-17. PMID:22371074. |
interplay of cannabinoid 2 (cb2) receptors with nitric oxide synthases, oxidative and nitrative stress, and cell death during remote neurodegeneration. |
2012-08-17 |
2023-08-12 |
Not clear |
| Nima Naderi, Leila Ahmad-Molaei, Ali Mazar-Atabaki, Abdolaziz Ronaghi, Zahra Shirazi-zand, Seyed Mehrdad Motiei-Langroudi, Somayeh Eslahka. L-type calcium channel mediates anticonvulsant effect of cannabinoids in acute and chronic murine models of seizure. Neurochemical research. vol 37. issue 2. 2012-08-13. PMID:21928146. |
moreover, (r)-(+)-[2,3-dihydro-5-methyl-3[(4-morpholinyl)methyl]pyrrolo[1,2,3-de]-1,4-benzoxazinyl]-(1-naphthalenyl) methanone mesylate (win55,212-2), the non-selective cannabinoid cb1 and cb2 receptor agonist showed anticonvulsant effect in amygdala-kindled rats. |
2012-08-13 |
2023-08-12 |
mouse |
| Wei Xiong, Tanxing Cui, Kejun Cheng, Fei Yang, Shao-Rui Chen, Dan Willenbring, Yun Guan, Hui-Lin Pan, Ke Ren, Yan Xu, Li Zhan. Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors. The Journal of experimental medicine. vol 209. issue 6. 2012-08-13. PMID:22585736. |
in contrast, the cannabinoid analgesia is neither correlated with their binding affinity for cb1 and cb2 receptors nor with their psychoactive side effects. |
2012-08-13 |
2023-08-12 |
mouse |
| Peng-Fei Wang, Li-Sheng Jiang, Jun Bu, Xiao-Jin Huang, Wei Song, Yong-Ping Du, Ben H. Cannabinoid-2 receptor activation protects against infarct and ischemia-reperfusion heart injury. Journal of cardiovascular pharmacology. vol 59. issue 4. 2012-08-10. PMID:22113346. |
in conclusion, the endocannabinoid system was activated during ami and ir, and cb2 receptor activation produces a protective role, thus offering a novel pharmaceutical target for treating these diseases. |
2012-08-10 |
2023-08-12 |
mouse |
| Eleonora Patsenker, Matthias Stoll, Gunda Millonig, Abbas Agaimy, Till Wissniowski, Vreni Schneider, Sebastian Mueller, Rudolf Brenneisen, Helmut K Seitz, Matthias Ocker, Felix Sticke. Cannabinoid receptor type I modulates alcohol-induced liver fibrosis. Molecular medicine (Cambridge, Mass.). vol 17. issue 11-12. 2012-08-03. PMID:21863215. |
the cannabinoid system (cs) is implicated in the regulation of hepatic fibrosis, steatosis and inflammation, with cannabinoid receptors 1 and 2 (cb1 and cb2) being involved in regulation of pro- and antifibrogenic effects. |
2012-08-03 |
2023-08-12 |
mouse |
| T-F Su, Y-Q Zhao, L-H Zhang, M Peng, C-H Wu, L Pei, B Tian, J Zhang, J Shi, H-L Pan, M L. Electroacupuncture reduces the expression of proinflammatory cytokines in inflamed skin tissues through activation of cannabinoid CB2 receptors. European journal of pain (London, England). vol 16. issue 5. 2012-08-01. PMID:22337285. |
electroacupuncture reduces the expression of proinflammatory cytokines in inflamed skin tissues through activation of cannabinoid cb2 receptors. |
2012-08-01 |
2023-08-12 |
rat |
| T-F Su, Y-Q Zhao, L-H Zhang, M Peng, C-H Wu, L Pei, B Tian, J Zhang, J Shi, H-L Pan, M L. Electroacupuncture reduces the expression of proinflammatory cytokines in inflamed skin tissues through activation of cannabinoid CB2 receptors. European journal of pain (London, England). vol 16. issue 5. 2012-08-01. PMID:22337285. |
endogenous cannabinoids and peripheral cannabinoid cb2 receptors (cb2rs) are involved in the antinociceptive effect of electroacupuncture (ea) on inflammatory pain. |
2012-08-01 |
2023-08-12 |
rat |
| Bėla Horváth, Lital Magid, Partha Mukhopadhyay, Sándor Bátkai, Mohanraj Rajesh, Ogyi Park, Galin Tanchian, Rachel Y Gao, Catherine E Goodfellow, Michelle Glass, Raphael Mechoulam, Pál Pache. A new cannabinoid CB2 receptor agonist HU-910 attenuates oxidative stress, inflammation and cell death associated with hepatic ischaemia/reperfusion injury. British journal of pharmacology. vol 165. issue 8. 2012-07-27. PMID:21449982. |
a new cannabinoid cb2 receptor agonist hu-910 attenuates oxidative stress, inflammation and cell death associated with hepatic ischaemia/reperfusion injury. |
2012-07-27 |
2023-08-12 |
Not clear |
| Sándor Bátkai, Partha Mukhopadhyay, Bėla Horváth, Mohanraj Rajesh, Rachel Y Gao, Anu Mahadevan, Mukkanti Amere, Natalia Battista, Aron H Lichtman, Lisa A Gauson, Mauro Maccarrone, Roger G Pertwee, Pál Pache. Δ8-Tetrahydrocannabivarin prevents hepatic ischaemia/reperfusion injury by decreasing oxidative stress and inflammatory responses through cannabinoid CB2 receptors. British journal of pharmacology. vol 165. issue 8. 2012-07-27. PMID:21470208. |
Δ8-tetrahydrocannabivarin prevents hepatic ischaemia/reperfusion injury by decreasing oxidative stress and inflammatory responses through cannabinoid cb2 receptors. |
2012-07-27 |
2023-08-12 |
Not clear |
| Lamont Booker, Steven G Kinsey, Rehab A Abdullah, Jacqueline L Blankman, Jonathan Z Long, Cyrine Ezzili, Dale L Boger, Benjamin F Cravatt, Aron H Lichtma. The fatty acid amide hydrolase (FAAH) inhibitor PF-3845 acts in the nervous system to reverse LPS-induced tactile allodynia in mice. British journal of pharmacology. vol 165. issue 8. 2012-07-27. PMID:21506952. |
one potential target to treat inflammatory pain is the endogenous cannabinoid (endocannabinoid) system, which is comprised of cb1 and cb2 cannabinoid receptors and several endogenous ligands, including anandamide (aea). |
2012-07-27 |
2023-08-12 |
mouse |
| Daniele Bolognini, Maria Grazia Cascio, Daniela Parolaro, Roger G Pertwe. AM630 behaves as a protean ligand at the human cannabinoid CB2 receptor. British journal of pharmacology. vol 165. issue 8. 2012-07-27. PMID:21615724. |
am630 behaves as a protean ligand at the human cannabinoid cb2 receptor. |
2012-07-27 |
2023-08-12 |
human |
| Takayuki Mimura, Yoshifumi Ueda, Yoshihiro Watanabe, Takayuki Sugiur. The cannabinoid receptor-2 is involved in allergic inflammation. Life sciences. vol 90. issue 21-22. 2012-07-23. PMID:22525379. |
to investigate the role of cannabinoid receptor-2 (cb2) in allergic inflammation in cb2 knockout (cb2-ko) mice. |
2012-07-23 |
2023-08-12 |
mouse |
| P W Brownjohn, J C Ashto. Spinal cannabinoid CB2 receptors as a target for neuropathic pain: an investigation using chronic constriction injury. Neuroscience. vol 203. 2012-07-19. PMID:22210507. |
spinal cannabinoid cb2 receptors as a target for neuropathic pain: an investigation using chronic constriction injury. |
2012-07-19 |
2023-08-12 |
rat |
| P W Brownjohn, J C Ashto. Spinal cannabinoid CB2 receptors as a target for neuropathic pain: an investigation using chronic constriction injury. Neuroscience. vol 203. 2012-07-19. PMID:22210507. |
agonists for the cannabinoid cb2 receptor are antinociceptive in several rodent models and several reports have suggested that the target for these drugs is cb2 expressed in the spinal cord pain pathway. |
2012-07-19 |
2023-08-12 |
rat |
| Christine Börner, Elisa Martella, Volker Höllt, Jürgen Krau. Regulation of opioid and cannabinoid receptor genes in human neuroblastoma and T cells by the epigenetic modifiers trichostatin A and 5-aza-2'-deoxycytidine. Neuroimmunomodulation. vol 19. issue 3. 2012-07-17. PMID:22262103. |
the aim of this study was to investigate the effect of the epigenetic modifiers trichostatin a and 5-aza-2'-deoxycytidine on the expression of the cannabinoid receptors cb1 and cb2 and μ-opioid receptors in human sh sy5y neuroblastoma cells and human jurkat t lymphocytes. |
2012-07-17 |
2023-08-12 |
human |
| Tannia Gutierrez, Jonathon D Crystal, Alexander M Zvonok, Alexandros Makriyannis, Andrea G Hohman. Self-medication of a cannabinoid CB2 agonist in an animal model of neuropathic pain. Pain. vol 152. issue 9. 2012-06-04. PMID:21550725. |
self-medication of a cannabinoid cb2 agonist in an animal model of neuropathic pain. |
2012-06-04 |
2023-08-12 |
rat |
| Benjamin S Harvey, Katharina S Ohlsson, Jesper L V Mååg, Ian F Musgrave, Scott D Smi. Contrasting protective effects of cannabinoids against oxidative stress and amyloid-β evoked neurotoxicity in vitro. Neurotoxicology. vol 33. issue 1. 2012-06-04. PMID:22233683. |
in this study we compared the effects of cb1 and cb2 receptor-selective ligands, the endocannabinoid anandamide and the phytocannabinoid cannabidiol, against oxidative stress and the toxic hallmark alzheimer's protein, β-amyloid (aβ) in neuronal cell lines. |
2012-06-04 |
2023-08-12 |
Not clear |
| Benjamin S Harvey, Katharina S Ohlsson, Jesper L V Mååg, Ian F Musgrave, Scott D Smi. Contrasting protective effects of cannabinoids against oxidative stress and amyloid-β evoked neurotoxicity in vitro. Neurotoxicology. vol 33. issue 1. 2012-06-04. PMID:22233683. |
in conclusion, the endocannabinoid anandamide protects neuronal cells from aβ exposure via a pathway unrelated to cb1 or cb2 receptor activation. |
2012-06-04 |
2023-08-12 |
Not clear |
| Gabriele Murineddu, Battistina Asproni, Gerard A Pinn. A survey of recent patents on CB2 agonists in the management of pain. Recent patents on CNS drug discovery. vol 7. issue 1. 2012-06-04. PMID:22280338. |
the different types of receptors in the cns involved in the mediation of analgesia include the cannabinoid receptors: in particular, cb2 modulators seem to represent a new potential class of analgesic. |
2012-06-04 |
2023-08-12 |
Not clear |
| Islam Gamaleddin, Alexander Zvonok, Alexandros Makriyannis, Steven R Goldberg, Bernard Le Fol. Effects of a selective cannabinoid CB2 agonist and antagonist on intravenous nicotine self administration and reinstatement of nicotine seeking. PloS one. vol 7. issue 1. 2012-06-04. PMID:22291896. |
effects of a selective cannabinoid cb2 agonist and antagonist on intravenous nicotine self administration and reinstatement of nicotine seeking. |
2012-06-04 |
2023-08-12 |
human |