| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alexandre Louvet, Fatima Teixeira-Clerc, Marie-Noële Chobert, Vanessa Deveaux, Catherine Pavoine, Andreas Zimmer, Françoise Pecker, Ariane Mallat, Sophie Lotersztaj. Cannabinoid CB2 receptors protect against alcoholic liver disease by regulating Kupffer cell polarization in mice. Hepatology (Baltimore, Md.). vol 54. issue 4. 2011-11-29. PMID:21735467. |
cannabinoid cb2 receptors protect against alcoholic liver disease by regulating kupffer cell polarization in mice. |
2011-11-29 |
2023-08-12 |
mouse |
| Alexandre Louvet, Fatima Teixeira-Clerc, Marie-Noële Chobert, Vanessa Deveaux, Catherine Pavoine, Andreas Zimmer, Françoise Pecker, Ariane Mallat, Sophie Lotersztaj. Cannabinoid CB2 receptors protect against alcoholic liver disease by regulating Kupffer cell polarization in mice. Hepatology (Baltimore, Md.). vol 54. issue 4. 2011-11-29. PMID:21735467. |
because cannabinoid cb2 receptors (cb2) display potent anti-inflammatory properties, we investigated their role in the pathogenesis of alcoholic liver disease, focusing on the impact of cb2 on kupffer cell polarization and the consequences on liver steatosis. |
2011-11-29 |
2023-08-12 |
mouse |
| Micaela S Sordelli, Jimena S Beltrame, Juliana Burdet, Elsa Zotta, Romina Pardo, Maximiliano Cella, Ana M Franchi, Maria Laura Ribeir. The effect of anandamide on uterine nitric oxide synthase activity depends on the presence of the blastocyst. PloS one. vol 6. issue 4. 2011-11-28. PMID:21559512. |
anandamide (aea), an endocannabinoid, binds to cannabinoid receptors type 1 (cb1) and type 2 (cb2), and high concentrations are toxic for implantation and embryo development. |
2011-11-28 |
2023-08-12 |
rat |
| Steven G Kinsey, Anu Mahadevan, Bingjun Zhao, Hang Sun, Pattipati S Naidu, Raj K Razdan, Dana E Selley, M Imad Damaj, Aron H Lichtma. The CB2 cannabinoid receptor-selective agonist O-3223 reduces pain and inflammation without apparent cannabinoid behavioral effects. Neuropharmacology. vol 60. issue 2-3. 2011-11-22. PMID:20849866. |
the cb2 cannabinoid receptor-selective agonist o-3223 reduces pain and inflammation without apparent cannabinoid behavioral effects. |
2011-11-22 |
2023-08-12 |
Not clear |
| Giuseppina Chianese, Ernesto Fattorusso, Orazio Taglialatela-Scafati, Giorgio Bavestrello, Barbara Calcinai, Henny A Dien, Alessia Ligresti, Vincenzo Di Marz. Desulfohaplosamate, a new phosphate-containing steroid from Dasychalina sp., is a selective cannabinoid CB2 receptor ligand. Steroids. vol 76. issue 10-11. 2011-11-15. PMID:21530566. |
desulfohaplosamate, a new phosphate-containing steroid from dasychalina sp., is a selective cannabinoid cb2 receptor ligand. |
2011-11-15 |
2023-08-12 |
Not clear |
| John C Ashto. Knockout controls and the specificity of cannabinoid CB2 receptor antibodies. British journal of pharmacology. vol 163. issue 6. 2011-11-15. PMID:21707587. |
knockout controls and the specificity of cannabinoid cb2 receptor antibodies. |
2011-11-15 |
2023-08-12 |
Not clear |
| Mariagrazia Rita Scuderi, Giuseppina Cantarella, Mimmo Scollo, Laurence Lempereur, Marco Palumbo, Gloria Saccani-Jotti, Renato Bernardin. The antimitogenic effect of the cannabinoid receptor agonist WIN55212-2 on human melanoma cells is mediated by the membrane lipid raft. Cancer letters. vol 310. issue 2. 2011-11-15. PMID:21807457. |
here are reported the antiproliferative effects of the cannabinoid agonist win upon human melanoma cells expressing mrna and protein for both cb1 and cb2 receptors. |
2011-11-15 |
2023-08-12 |
human |
| Y Okahisa, M Kodama, M Takaki, T Inada, N Uchimura, M Yamada, N Iwata, M Iyo, I Sora, N Ozaki, H Ujik. Association Study of Two Cannabinoid Receptor Genes, CNR1 and CNR2, with Methamphetamine Dependence. Current neuropharmacology. vol 9. issue 1. 2011-11-10. PMID:21886587. |
to examine the possible association of the cnr1 and cnr2 genes, which encode cannabinoid receptors cb1 and cb2, with methamphetamine dependence, we investigated three single nucleotide polymorphisms (snps) (rs806379, rs1535255, rs2023239) in intron 2 of the cnr1 gene and a nonsynonymous snp, q63r, in the cnr2 gene. |
2011-11-10 |
2023-08-12 |
Not clear |
| E S Onaiv. Commentary: Functional Neuronal CB2 Cannabinoid Receptors in the CNS. Current neuropharmacology. vol 9. issue 1. 2011-11-10. PMID:21886591. |
commentary: functional neuronal cb2 cannabinoid receptors in the cns. |
2011-11-10 |
2023-08-12 |
human |
| Sarah A Maher, Eric D Dubuis, Maria G Belvis. G-protein coupled receptors regulating cough. Current opinion in pharmacology. vol 11. issue 3. 2011-11-08. PMID:21727026. |
activation of the β2-adrenoceptor and cannabinoid cb2 receptors can inhibit sensory nerves and prevent cough. |
2011-11-08 |
2023-08-12 |
Not clear |
| M A Cosenza-Nashat, A Bauman, M-L Zhao, S Morgello, H-S Suh, S C Le. Cannabinoid receptor expression in HIV encephalitis and HIV-associated neuropathologic comorbidities. Neuropathology and applied neurobiology. vol 37. issue 5. 2011-11-07. PMID:21450051. |
the expression of cannabinoid receptors (cb1 and cb2) has been reported in neurodegenerative diseases and in simian immunodeficiency virus encephalitis, yet the receptor expression in the central nervous system of hiv+ individuals is not known. |
2011-11-07 |
2023-08-12 |
Not clear |
| M Donadelli, I Dando, T Zaniboni, C Costanzo, E Dalla Pozza, M T Scupoli, A Scarpa, S Zappavigna, M Marra, A Abbruzzese, M Bifulco, M Caraglia, M Palmier. Gemcitabine/cannabinoid combination triggers autophagy in pancreatic cancer cells through a ROS-mediated mechanism. Cell death & disease. vol 2. 2011-11-01. PMID:21525939. |
here, we show that gem induces both cannabinoid receptor-1 (cb1) and cannabinoid receptor-2 (cb2) receptors by an nf-κb-dependent mechanism and that its association with cannabinoids synergistically inhibits pancreatic adenocarcinoma cell growth and increases reactive oxygen species (ros) induced by single treatments. |
2011-11-01 |
2023-08-12 |
mouse |
| Rupal Pandey, Venkatesh L Hegde, Mitzi Nagarkatti, Prakash S Nagarkatt. Targeting cannabinoid receptors as a novel approach in the treatment of graft-versus-host disease: evidence from an experimental murine model. The Journal of pharmacology and experimental therapeutics. vol 338. issue 3. 2011-10-31. PMID:21673072. |
the ability of thc to reduce the clinical gvhd was reversed, at least in part, by administration of cannabinoid receptor (cb) 1 and cb2 antagonists, thereby demonstrating that thc-mediated amelioration of gvhd was cannabinoid receptor-dependent. |
2011-10-31 |
2023-08-12 |
mouse |
| Jonel Trebicka, Ildiko Racz, Sören V Siegmund, Erlind Cara, Michaela Granzow, Robert Schierwagen, Sabine Klein, Alexandra Wojtalla, Martin Hennenberg, Sebastian Huss, Hans-Peter Fischer, Jörg Heller, Andreas Zimmer, Tilman Sauerbruc. Role of cannabinoid receptors in alcoholic hepatic injury: steatosis and fibrogenesis are increased in CB2 receptor-deficient mice and decreased in CB1 receptor knockouts. Liver international : official journal of the International Association for the Study of the Liver. vol 31. issue 6. 2011-10-07. PMID:21645218. |
role of cannabinoid receptors in alcoholic hepatic injury: steatosis and fibrogenesis are increased in cb2 receptor-deficient mice and decreased in cb1 receptor knockouts. |
2011-10-07 |
2023-08-12 |
mouse |
| Xiaoping Gu, FengMei Mei, Yue Liu, Rui Zhang, Juan Zhang, ZhengLiang M. Intrathecal administration of the cannabinoid 2 receptor agonist JWH015 can attenuate cancer pain and decrease mRNA expression of the 2B subunit of N-methyl-D-aspartic acid. Anesthesia and analgesia. vol 113. issue 2. 2011-09-28. PMID:21519057. |
because of the pain-relieving effects of cannabinoid 2 (cb2) receptor agonists in inflammation pain, incision pain, and neuropathic pain models, we tested whether spinal cb2 receptor activation would induce antihyperalgesia in cancer pain. |
2011-09-28 |
2023-08-12 |
mouse |
| Young-Jun Seo, Min-Soo Kwon, Seung-Min Choi, Jin-Koo Lee, Soo-Hyun Park, Jun-Sub Jung, Yun-Beom Sim, Hong-Won Su. Differential cross-tolerance development between single and repeated immobilization stress on the antinociceptive effect induced by β-endorphin, 5-hydroxytryptamine, morphine, and WIN55,212-2 in the inflammatory mouse pain mode. Archives of pharmacal research. vol 34. issue 2. 2011-09-23. PMID:21380811. |
meanwhile, we did not find any changes in the opioid receptors' (mu-, delta- and kappa-receptor) and the cannabinoid receptors' (cb1 and cb2) expressions in the midbrain regions elicited by single or repeated stress. |
2011-09-23 |
2023-08-12 |
mouse |
| Giuseppina Cantarella, Mimmo Scollo, Laurence Lempereur, Gloria Saccani-Jotti, Francesco Basile, Renato Bernardin. Endocannabinoids inhibit release of nerve growth factor by inflammation-activated mast cells. Biochemical pharmacology. vol 82. issue 4. 2011-09-13. PMID:21601562. |
none of the two cannabinoid cb1 and cb2 receptors was expressed by hmc-1 cells, which on the other hand expressed the orphan receptor gpr55. |
2011-09-13 |
2023-08-12 |
human |
| B M Fonseca, N A Teixeira, M Almada, A H Taylor, J C Konje, G Correia-da-Silv. Modulation of the novel cannabinoid receptor - GPR55 - during rat fetoplacental development. Placenta. vol 32. issue 6. 2011-09-12. PMID:21497900. |
two cannabinoid receptors have been described so far, cb1 and cb2, though a third has been suggested, cb3. |
2011-09-12 |
2023-08-12 |
rat |
| Jin Hua Cui, Woong Mo Kim, Hyung Gon Lee, Ye Ok Kim, Chang Mo Kim, Myung Ha Yoo. Antinociceptive effect of intrathecal cannabinoid receptor agonist WIN 55,212-2 in a rat bone tumor pain model. Neuroscience letters. vol 493. issue 3. 2011-09-01. PMID:21195743. |
this study evaluated the efficacy of a cannabinoid (cb) receptor agonist (win 55,212-2) on bone tumor pain in the spinal cords of rats, and clarified the roles of the cb1 and cb2 receptors in win 55,212-2-induced antinociception at the spinal level. |
2011-09-01 |
2023-08-12 |
rat |
| K Z Myint, C Ma, L Wang, X-Q Xi. Fragment-similarity-based QSAR (FS-QSAR) algorithm for ligand biological activity predictions. SAR and QSAR in environmental research. vol 22. issue 3. 2011-08-31. PMID:21598200. |
for validation studies, the fs-qsar algorithm was applied to several case studies, including a dataset of cox2 inhibitors and a dataset of cannabinoid cb2 triaryl bis-sulfone antagonist analogues, to build predictive models achieving average coefficient of determination (r(2)) of 0.62 and 0.68, respectively. |
2011-08-31 |
2023-08-12 |
Not clear |