| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ling Tong, B B Shankar, Lei Chen, Razia Rizvi, Joseph Kelly, Eric Gilbert, Chunli Huang, De-Yi Yang, Joseph A Kozlowski, N-Y Shih, W Gonsiorek, R William Hipkin, Asra Malikzay, Charles A Lunn, Daniel J Lundel. Expansion of SAR studies on triaryl bis sulfone cannabinoid CB2 receptor ligands. Bioorganic & medicinal chemistry letters. vol 20. issue 22. 2011-03-29. PMID:20850969. |
expansion of sar studies on triaryl bis sulfone cannabinoid cb2 receptor ligands. |
2011-03-29 |
2023-08-12 |
rat |
| Alexandra Kibbl. American Chemical Society - 240th national meeting - chemistry for preventing and combating disease: part 2. IDrugs : the investigational drugs journal. vol 13. issue 10. 2011-03-29. PMID:20878583. |
this conference report highlights selected presentations on (s)-adenosylhomocysteine (ahcy) inhibitors for the treatment of alzheimer's disease, 2,4-diphenyl-1h-imidazole analogs as cannabinoid cb2 agonists for the treatment of pain, checkpoint kinase 1 (chk1) and aurora kinase b as therapeutic targets for cancer treatment, pyridylmethylthio derivatives as vegfr2 inhibitors, and janus kinase 2 (jak2) for the treatment of myeloproliferative disorders. |
2011-03-29 |
2023-08-12 |
Not clear |
| Jing Zhang, Lin Chen, Tangfeng Su, Fuyuan Cao, Xianfang Meng, Lei Pei, Jing Shi, Hui-Lin Pan, Man L. Electroacupuncture increases CB2 receptor expression on keratinocytes and infiltrating inflammatory cells in inflamed skin tissues of rats. The journal of pain. vol 11. issue 12. 2011-03-21. PMID:20627823. |
endogenous cannabinoids and peripheral cannabinoid cb2 receptors (cb2rs) are involved in the antinociceptive effect of electroacupuncture (ea) on inflammatory pain. |
2011-03-21 |
2023-08-12 |
rat |
| Noha A Osman, Amr H Mahmoud, Marco Allarà, Raimund Niess, Khaled A Abouzid, Vincenzo Di Marzo, Ashraf H Abad. Synthesis, binding studies and molecular modeling of novel cannabinoid receptor ligands. Bioorganic & medicinal chemistry. vol 18. issue 24. 2011-03-08. PMID:21074998. |
the novel compounds had been evaluated for their binding affinity to cb1/cb2 cannabinoid receptors, binding studies showed that some of the newly developed compounds have measurable affinity and selectivity for the cb2 receptor. |
2011-03-08 |
2023-08-12 |
Not clear |
| Bruce A Watkins, Heather Hutchins, Yong Li, Mark F Seifer. The endocannabinoid signaling system: a marriage of PUFA and musculoskeletal health. The Journal of nutritional biochemistry. vol 21. issue 12. 2011-02-28. PMID:20934863. |
this signaling system consists of the g-protein coupled cannabinoid receptors, cb1 and cb2, expressed in central and peripheral tissues and cells, which are variably activated by the production and on demand release of endogenous and synthetic agonists and antagonists. |
2011-02-28 |
2023-08-12 |
Not clear |
| N Schuelert, C Zhang, A J Mogg, L M Broad, D L Hepburn, E S Nisenbaum, M P Johnson, J J McDougal. Paradoxical effects of the cannabinoid CB2 receptor agonist GW405833 on rat osteoarthritic knee joint pain. Osteoarthritis and cartilage. vol 18. issue 11. 2011-02-24. PMID:20863899. |
paradoxical effects of the cannabinoid cb2 receptor agonist gw405833 on rat osteoarthritic knee joint pain. |
2011-02-24 |
2023-08-12 |
rat |
| Andrea De Gottardi, Laurent Spahr, Florence Ravier-Dall'Antonia, Antoine Hadengu. Cannabinoid receptor 1 and 2 agonists increase lipid accumulation in hepatocytes. Liver international : official journal of the International Association for the Study of the Liver. vol 30. issue 10. 2011-02-11. PMID:20602678. |
cannabinoid receptors cb1 and cb2 are expressed in the liver, but their regulation in fatty hepatocytes is poorly documented. |
2011-02-11 |
2023-08-12 |
Not clear |
| Sharleen Yuan, Brian D Burrel. Endocannabinoid-dependent LTD in a nociceptive synapse requires activation of a presynaptic TRPV-like receptor. Journal of neurophysiology. vol 104. issue 5. 2011-02-11. PMID:20884761. |
recent studies have found that some forms of endocannabinoid-dependent synaptic plasticity in the hippocampus are mediated through activation of transient potential receptor vanilloid (trpv) receptors instead of cannabinoid receptors cb1 or cb2. |
2011-02-11 |
2023-08-12 |
Not clear |
| Ana Crespillo, Juan Suárez, Francisco J Bermúdez-Silva, Patricia Rivera, Margarita Vida, Monica Alonso, Ana Palomino, Miguel A Lucena, Antonia Serrano, Margarita Pérez-Martín, Manuel Macias, Pedro Fernández-Llébrez, Fernando Rodríguez de Fonsec. Expression of the cannabinoid system in muscle: effects of a high-fat diet and CB1 receptor blockade. The Biochemical journal. vol 433. issue 1. 2011-02-10. PMID:20955176. |
cb2 (cannabinoid type 2) receptor and pparα (peroxisome-proliferator-activated receptor α) gene expression was decreased in hfd-fed rats, whereas magl (monoglyceride lipase) gene expression was up-regulated. |
2011-02-10 |
2023-08-12 |
rat |
| Lankun Wu, Eric W Rowe, Ksenija Jeftinija, Srdija Jeftinija, Ludmila Rizshsky, Basil J Nikolau, Jodi McKay, Marian Kohut, Eve Syrkin Wurtel. Echinacea-induced cytosolic Ca2+ elevation in HEK293. BMC complementary and alternative medicine. vol 10. 2011-01-20. PMID:21092239. |
one likely mode of action is that alkamides from echinacea bind to cannabinoid type 2 (cb2) receptors and induce a transient increase in intracellular ca2+. |
2011-01-20 |
2023-08-12 |
Not clear |
| Elena Cichero, Sara Cesarini, Luisa Mosti, Paola Foss. CoMFA and CoMSIA analyses on 1,2,3,4-tetrahydropyrrolo[3,4-b]indole and benzimidazole derivatives as selective CB2 receptor agonists. Journal of molecular modeling. vol 16. issue 9. 2011-01-03. PMID:20174844. |
novel classes of cannabinoid 2 receptor (cb2) agonists based on 1,2,3,4-tetrahydropyrrolo[3,4-b]indole and benzimidazole scaffolds have shown high binding affinity toward cb2 receptor and good selectivity over cannabinoid 1 receptor (cb1). |
2011-01-03 |
2023-08-12 |
Not clear |
| Pranab K Chanda, Ying Gao, Lilly Mark, Joan Btesh, Brian W Strassle, Peimin Lu, Michael J Piesla, Mei-Yi Zhang, Brendan Bingham, Albert Uveges, Dianne Kowal, David Garbe, Evguenia V Kouranova, Robert H Ring, Brian Bates, Menelas N Pangalos, Jeffrey D Kennedy, Garth T Whiteside, Tarek A Sama. Monoacylglycerol lipase activity is a critical modulator of the tone and integrity of the endocannabinoid system. Molecular pharmacology. vol 78. issue 6. 2010-12-17. PMID:20855465. |
endocannabinoids are lipid molecules that serve as natural ligands for the cannabinoid receptors cb1 and cb2. |
2010-12-17 |
2023-08-12 |
mouse |
| Chen Li, Peter M Jones, Shanta J Persau. Cannabinoid receptors are coupled to stimulation of insulin secretion from mouse MIN6 beta-cells. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 26. issue 2. 2010-12-08. PMID:20798502. |
endocannabinoid lipids are known to exert orexigenic effects via central cannabinoid cb1 and cb2 receptors, which have also been identified in islet endocrine cells. |
2010-12-08 |
2023-08-12 |
mouse |
| Chen Li, Peter M Jones, Shanta J Persau. Cannabinoid receptors are coupled to stimulation of insulin secretion from mouse MIN6 beta-cells. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 26. issue 2. 2010-12-08. PMID:20798502. |
min6 beta-cells express the cannabinoid synthesising enzyme diacylglycerol lipase and cb1 and cb2 receptors, which are coupled to inhibition of beta-cell cyclic amp generation and stimulation of intracellular calcium levels. |
2010-12-08 |
2023-08-12 |
mouse |
| Chen Li, Peter M Jones, Shanta J Persau. Cannabinoid receptors are coupled to stimulation of insulin secretion from mouse MIN6 beta-cells. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 26. issue 2. 2010-12-08. PMID:20798502. |
synthesis of endocannabinoids by beta-cells may provide an additional mechanism for stimulation of insulin secretion through activation of beta-cell cb1 and/or cb2 cannabinoid receptors. |
2010-12-08 |
2023-08-12 |
mouse |
| C E Pinto, E Moura, M P Serrão, M J Martins, M A Vieira-Coelh. Effect of (-)-Delta(9)-tetrahydrocannabinoid on the hepatic redox state of mice. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 43. issue 4. 2010-12-06. PMID:20445947. |
the levels of mrna of the cannabinoid receptors cb1 and cb2 were also monitored. |
2010-12-06 |
2023-08-12 |
mouse |
| Amélie Servettaz, Niloufar Kavian, Carole Nicco, Vanessa Deveaux, Christiane Chéreau, Andrew Wang, Andreas Zimmer, Sophie Lotersztajn, Bernard Weill, Frédéric Batteu. Targeting the cannabinoid pathway limits the development of fibrosis and autoimmunity in a mouse model of systemic sclerosis. The American journal of pathology. vol 177. issue 1. 2010-12-06. PMID:20508030. |
balb/c mice injected subcutaneously every day for 6 weeks with pbs or hypochlorite were treated intraperitoneally with either win-55,212, an agonist of the cannabinoid receptors 1 (cb1) and receptors 2 (cb2), with jwh-133, a selective agonist of cb2, or with pbs. |
2010-12-06 |
2023-08-12 |
mouse |
| R Talevi, V Barbato, S De Iorio, V Mollo, T Capriglione, L Ricchiari, A Samo, R Gualtier. Is there a role for endocannabinoids in sperm-oviduct interaction? Reproduction (Cambridge, England). vol 140. issue 2. 2010-12-03. PMID:20511399. |
data showed that 1) the endocannabinoid receptors 1 and 2 (cb1 and cb2) are present in bovine spermatozoa both in the initial ejaculate and in spermatozoa bound to the oviduct in vitro; 2) cb1 receptor is still detectable in spermatozoa released from the oviduct through penicillamine but not in those released through heparin; 3) arachidonylethanolamide (aea) does not affect sperm viability, whereas it depresses sperm progressive motility and kinetic values; 4) sperm-oviduct binding and release in vitro are not influenced by aea; 5) aea depresses sperm-zona pellucida (zp) binding; 6) binding of heparin-capacitated spermatozoa to the zp is not affected by aea; 7) n-acylphosphatidylethanolamine-selective phospholipase d, the main enzyme involved in anandamide synthesis, is expressed in oviductal epithelial cells. |
2010-12-03 |
2023-08-12 |
cattle |
| Sieglinde Marquart, Pawel Zerr, Alfiya Akhmetshina, Katrin Palumbo, Nicole Reich, Michal Tomcik, Angelika Horn, Clara Dees, Matthias Engel, Jochen Zwerina, Oliver Distler, Georg Schett, Jörg H W Distle. Inactivation of the cannabinoid receptor CB1 prevents leukocyte infiltration and experimental fibrosis. Arthritis and rheumatism. vol 62. issue 11. 2010-11-30. PMID:20617520. |
cannabinoids are derivates of the marijuana component Δ(9) -tetrahydrocannabinol that exert their effects on mesenchymal cells and immune cells via cb1 and cb2 receptors. |
2010-11-30 |
2023-08-12 |
Not clear |
| Andrew G Horti, Yongjun Gao, Hayden T Ravert, Paige Finley, Heather Valentine, Dean F Wong, Christopher J Endres, Alena V Savonenko, Robert F Dannal. Synthesis and biodistribution of [11C]A-836339, a new potential radioligand for PET imaging of cannabinoid type 2 receptors (CB2). Bioorganic & medicinal chemistry. vol 18. issue 14. 2010-11-23. PMID:20554448. |
synthesis and biodistribution of [11c]a-836339, a new potential radioligand for pet imaging of cannabinoid type 2 receptors (cb2). |
2010-11-23 |
2023-08-12 |
mouse |