| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C Grimaldi, A Capass. The endocannabinoid system in the cancer therapy: an overview. Current medicinal chemistry. vol 18. issue 11. 2011-08-18. PMID:21428888. |
the endocannabinoid system comprises the cannabinoid receptors type 1 (cb1) and type 2 (cb2), their endogenous ligands (endocannabinoids), and the proteins responsible for their biosynthesis and degradation. |
2011-08-18 |
2023-08-12 |
Not clear |
| V Di Marzo, F Piscitell. Gut feelings about the endocannabinoid system. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 23. issue 5. 2011-07-20. PMID:21481098. |
in this article, some of the most recent developments in this field are discussed, with particular emphasis on new data, most of which are published in neurogastroenterology & motility, on the potential tonic endocannabinoid control of intestinal motility, the function of cannabinoid type-1 (cb1) receptors in gastric function, visceral pain, inflammation and sepsis, the emerging role of cannabinoid type-2 (cb2) receptors in the gut, and the pharmacology of endocannabinoid-related molecules and plant cannabinoids not necessarily acting via cannabinoid cb1 and cb2 receptors. |
2011-07-20 |
2023-08-12 |
Not clear |
| María S García-Gutiérrez, Jorge Manzanare. Overexpression of CB2 cannabinoid receptors decreased vulnerability to anxiety and impaired anxiolytic action of alprazolam in mice. Journal of psychopharmacology (Oxford, England). vol 25. issue 1. 2011-07-18. PMID:20837564. |
overexpression of cb2 cannabinoid receptors decreased vulnerability to anxiety and impaired anxiolytic action of alprazolam in mice. |
2011-07-18 |
2023-08-12 |
mouse |
| Yan Sun, Andy Bennet. Cannabinoids: a new group of agonists of PPARs. PPAR research. vol 2007. 2011-07-14. PMID:18288264. |
an increasing number of therapeutic actions of cannabinoid are being reported that do not appear to be mediated by either cb1 or cb2, and recently nuclear receptor superfamily ppars (peroxisome-proliferator-activated receptors) have been suggested as the target of certain cannabinoids. |
2011-07-14 |
2023-08-12 |
Not clear |
| Mark A Ware, Paul Daeninck, Vincent Maid. A review of nabilone in the treatment of chemotherapy-induced nausea and vomiting. Therapeutics and clinical risk management. vol 4. issue 1. 2011-07-14. PMID:18728826. |
the cannabinoids exert antiemetic effects via agonism of cannabinoid receptors (cb1 and cb2). |
2011-07-14 |
2023-08-12 |
Not clear |
| Aymen I Idri. Cannabinoid receptors as target for treatment of osteoporosis: a tale of two therapies. Current neuropharmacology. vol 8. issue 3. 2011-07-14. PMID:21358974. |
the endocannabinoids anandamide and 2-arachidonylglycerol are found in the skeleton and numerous studies also showed that bone cells express the cannabinoid receptors cb1 and cb2 and the orphan receptor gpr55. |
2011-07-14 |
2023-08-12 |
mouse |
| Prakash Nagarkatti, Rupal Pandey, Sadiye Amcaoglu Rieder, Venkatesh L Hegde, Mitzi Nagarkatt. Cannabinoids as novel anti-inflammatory drugs. Future medicinal chemistry. vol 1. issue 7. 2011-07-11. PMID:20191092. |
cannabinoid receptors include cb1, which is predominantly expressed in the brain, and cb2, which is primarily found on the cells of the immune system. |
2011-07-11 |
2023-08-12 |
mouse |
| Prakash Nagarkatti, Rupal Pandey, Sadiye Amcaoglu Rieder, Venkatesh L Hegde, Mitzi Nagarkatt. Cannabinoids as novel anti-inflammatory drugs. Future medicinal chemistry. vol 1. issue 7. 2011-07-11. PMID:20191092. |
the fact that both cb1 and cb2 receptors have been found on immune cells suggests that cannabinoids play an important role in the regulation of the immune system. |
2011-07-11 |
2023-08-12 |
mouse |
| Jarogniew J Luszczki, Marta Misiuta-Krzesinska, Magdalena Florek, Piotr Tutka, Stanislaw J Czuczwa. Synthetic cannabinoid WIN 55,212-2 mesylate enhances the protective action of four classical antiepileptic drugs against maximal electroshock-induced seizures in mice. Pharmacology, biochemistry, and behavior. vol 98. issue 2. 2011-07-08. PMID:21238473. |
the aim of this study was to determine the effect of win 55,212-2 mesylate (win--a non-selective cannabinoid cb1 and cb2 receptor agonist) on the protective action of four classical antiepileptic drugs (carbamazepine, phenytoin, phenobarbital, and valproate) in the mouse maximal electroshock seizure (mes) model. |
2011-07-08 |
2023-08-12 |
mouse |
| G Appendino, G Chianese, O Taglialatela-Scafat. Cannabinoids: occurrence and medicinal chemistry. Current medicinal chemistry. vol 18. issue 7. 2011-07-04. PMID:21254969. |
many of the potential therapeutic uses of cannabinoids are related to the interaction with (at least) two cannabinoid g-protein coupled receptors (cb1 and cb2). |
2011-07-04 |
2023-08-12 |
Not clear |
| Nicole M Tsutahara, Yoshie S Weems, J Alejandro Arreguin-Arevalo, Torrance M Nett, Magen E LaPorte, Janelle Uchida, Janelle Pang, Tonya McBride, Ronald D Randel, Charles W Weem. Effects of endocannabinoid 1 and 2 (CB1; CB2) receptor agonists on luteal weight, circulating progesterone, luteal mRNA for luteinizing hormone (LH) receptors, and luteal unoccupied and occupied receptors for LH in vivo in ewes. Prostaglandins & other lipid mediators. vol 94. issue 1-2. 2011-06-28. PMID:21109016. |
effects of endocannabinoid 1 and 2 (cb1; cb2) receptor agonists on luteal weight, circulating progesterone, luteal mrna for luteinizing hormone (lh) receptors, and luteal unoccupied and occupied receptors for lh in vivo in ewes. |
2011-06-28 |
2023-08-12 |
cattle |
| Nicole M Tsutahara, Yoshie S Weems, J Alejandro Arreguin-Arevalo, Torrance M Nett, Magen E LaPorte, Janelle Uchida, Janelle Pang, Tonya McBride, Ronald D Randel, Charles W Weem. Effects of endocannabinoid 1 and 2 (CB1; CB2) receptor agonists on luteal weight, circulating progesterone, luteal mRNA for luteinizing hormone (LH) receptors, and luteal unoccupied and occupied receptors for LH in vivo in ewes. Prostaglandins & other lipid mediators. vol 94. issue 1-2. 2011-06-28. PMID:21109016. |
cannabinoid (cb) type 1 (cb1) or type 2 (cb2) receptor agonists and an inhibitor of the enzyme fatty acid amide hydrolase, which catabolizes endocannabinoids, decreased luteal progesterone, prostaglandin e (pge), and prostaglandin f(2α) (pgf(2α)) secretion by the bovine corpus luteum in vitro by 30 percent. |
2011-06-28 |
2023-08-12 |
cattle |
| Raquel Taléns-Visconti, Irene Sanchez-Vera, Jelena Kostic, Maria Amparo Perez-Arago, Slaven Erceg, Miodrag Stojkovic, Consuelo Guerr. Neural differentiation from human embryonic stem cells as a tool to study early brain development and the neuroteratogenic effects of ethanol. Stem cells and development. vol 20. issue 2. 2011-06-24. PMID:20491543. |
we further demonstrate, for the first time, that human nps express the endocannabinoid receptors (cb1 and cb2) and the enzymes involved in endocannabinoids synthesis (nape-pld) and degradation (faah). |
2011-06-24 |
2023-08-12 |
human |
| Ester M López, Patricia Tagliaferro, Emmanuel S Onaivi, Juan J López-Cost. Distribution of CB2 cannabinoid receptor in adult rat retina. Synapse (New York, N.Y.). vol 65. issue 5. 2011-06-23. PMID:20803619. |
cannabinoid effects are mediated through two receptors, cb1 and cb2. |
2011-06-23 |
2023-08-12 |
rat |
| R Moaddel, A Rosenberg, K Spelman, J Frazier, C Frazier, S Nocerino, A Brizzi, C Mugnaini, I W Waine. Development and characterization of immobilized cannabinoid receptor (CB1/CB2) open tubular column for on-line screening. Analytical biochemistry. vol 412. issue 1. 2011-06-20. PMID:21215722. |
cannabinoid receptors, cb1 and cb2, are therapeutic targets in the treatment of anxiety, obesity, movement disorders, glaucoma, and pain. |
2011-06-20 |
2023-08-12 |
Not clear |
| Simone Brogi, Federico Corelli, Vincenzo Di Marzo, Alessia Ligresti, Claudia Mugnaini, Serena Pasquini, Andrea Taf. Three-dimensional quantitative structure-selectivity relationships analysis guided rational design of a highly selective ligand for the cannabinoid receptor 2. European journal of medicinal chemistry. vol 46. issue 2. 2011-06-08. PMID:21183257. |
this paper describes a three-dimensional quantitative structure-selectivity relationships (3d-qssr) study for selectivity of a series of ligands for cannabinoid cb1 and cb2 receptors. |
2011-06-08 |
2023-08-12 |
Not clear |
| Simone Brogi, Federico Corelli, Vincenzo Di Marzo, Alessia Ligresti, Claudia Mugnaini, Serena Pasquini, Andrea Taf. Three-dimensional quantitative structure-selectivity relationships analysis guided rational design of a highly selective ligand for the cannabinoid receptor 2. European journal of medicinal chemistry. vol 46. issue 2. 2011-06-08. PMID:21183257. |
the identification of a new selective cb2 receptor ligand lends support for the practicability of quantitative ligand-based selectivity models for cannabinoid receptors. |
2011-06-08 |
2023-08-12 |
Not clear |
| De-chun Geng, Yao-zeng Xu, Hui-lin Yang, Guang-ming Zhu, Xian-bin Wang, Xue-song Zh. Cannabinoid receptor-2 selective antagonist negatively regulates receptor activator of nuclear factor kappa B ligand mediated osteoclastogenesis. Chinese medical journal. vol 124. issue 4. 2011-06-08. PMID:21362286. |
the cannabinoid receptor-2 (cb2) is important for bone remodeling. |
2011-06-08 |
2023-08-12 |
Not clear |
| Barbara Rossi, Elena Zenaro, Stefano Angiari, Linda Ottoboni, Simona Bach, Laura Piccio, Enrica C Pietronigro, Elio Scarpini, Mariella Fusco, Alberta Leon, Gabriela Constanti. Inverse agonism of cannabinoid CB1 receptor blocks the adhesion of encephalitogenic T cells in inflamed brain venules by a protein kinase A-dependent mechanism. Journal of neuroimmunology. vol 233. issue 1-2. 2011-06-07. PMID:21216016. |
cannabinoid receptors cb1 and cb2 are expressed on t lymphocytes and mediate the immunomodulatory effects of cannabinoids on t cell functions. |
2011-06-07 |
2023-08-12 |
Not clear |
| Javier Ramos, Víctor L Cruz, Javier Martínez-Salazar, Nuria E Campillo, Juan A Páe. Dissimilar interaction of CB1/CB2 with lipid bilayers as revealed by molecular dynamics simulation. Physical chemistry chemical physics : PCCP. vol 13. issue 9. 2011-06-03. PMID:21173968. |
cannabinoid receptors cb1 and cb2 are a striking class of transmembrane proteins involved in a high number of important biological processes. |
2011-06-03 |
2023-08-12 |
Not clear |