| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ganesh A Thakur, Ritesh Tichkule, Shama Bajaj, Alexandros Makriyanni. Latest advances in cannabinoid receptor agonists. Expert opinion on therapeutic patents. vol 19. issue 12. 2010-02-02. PMID:19939187. |
the last decade has witnessed remarkable advances in the development of cannabinergic ligands displaying high selectivity and potency towards two subtypes of cannabinoid receptors, namely cb1 and cb2. |
2010-02-02 |
2023-08-12 |
Not clear |
| Asma Al-Shamahi, Konrad Kirkham, Livia Hooke. Society for Neuroscience - 39th Annual Meeting. Part 1 - Novel therapies for the treatment of CNS disorders and pain. IDrugs : the investigational drugs journal. vol 12. issue 12. 2010-01-28. PMID:19943210. |
this conference report highlights selected presentations on nicotinic ach receptor alpha7 agonists, cannabinoid cb2 receptor agonists, transient receptor potential channel antagonists, spinal mechanotransmission modulation, a cox-1 inhibitor, a nav/cav blocker, an opioid modulator and a novel triple reuptake inhibitor with potential antidepressant, anxiolytic and analgesic activity. |
2010-01-28 |
2023-08-12 |
Not clear |
| Javier Palazuelos, Tania Aguado, M Ruth Pazos, Boris Julien, Carolina Carrasco, Eva Resel, Onintza Sagredo, Cristina Benito, Julián Romero, Iñigo Azcoitia, Javier Fernández-Ruiz, Manuel Guzmán, Ismael Galve-Roper. Microglial CB2 cannabinoid receptors are neuroprotective in Huntington's disease excitotoxicity. Brain : a journal of neurology. vol 132. issue Pt 11. 2010-01-15. PMID:19805493. |
microglial cb2 cannabinoid receptors are neuroprotective in huntington's disease excitotoxicity. |
2010-01-15 |
2023-08-12 |
mouse |
| H Ishiguro, O Carpio, Y Horiuchi, A Shu, S Higuchi, N Schanz, R Benno, T Arinami, E S Onaiv. A nonsynonymous polymorphism in cannabinoid CB2 receptor gene is associated with eating disorders in humans and food intake is modified in mice by its ligands. Synapse (New York, N.Y.). vol 64. issue 1. 2010-01-08. PMID:19768813. |
a nonsynonymous polymorphism in cannabinoid cb2 receptor gene is associated with eating disorders in humans and food intake is modified in mice by its ligands. |
2010-01-08 |
2023-08-12 |
mouse |
| H Ishiguro, O Carpio, Y Horiuchi, A Shu, S Higuchi, N Schanz, R Benno, T Arinami, E S Onaiv. A nonsynonymous polymorphism in cannabinoid CB2 receptor gene is associated with eating disorders in humans and food intake is modified in mice by its ligands. Synapse (New York, N.Y.). vol 64. issue 1. 2010-01-08. PMID:19768813. |
we investigated the association between cnr2 gene, which encodes cannabinoid cb2 receptor (cb2-r) and eating disorders in 204 subjects with eating disorders and 1876 healthy volunteers in japanese population. |
2010-01-08 |
2023-08-12 |
mouse |
| Emmanuel S Onaiv. Cannabinoid receptors in brain: pharmacogenetics, neuropharmacology, neurotoxicology, and potential therapeutic applications. International review of neurobiology. vol 88. 2010-01-08. PMID:19897083. |
a major breakthrough in marijuana-cannabinoid research has been the discovery of a previously unknown but elaborate endogenous endocannabinoid system (ecs), complete with endocannabinoids and enzymes for their biosynthesis and degradation with genes encoding two distinct cannabinoid (cb1 and cb2) receptors (cbrs) that are activated by endocannabinoids, cannabinoids, and marijuana use. |
2010-01-08 |
2023-08-12 |
human |
| Martin A Storr, Catherine M Keenan, Hong Zhang, Kamala D Patel, Alexandros Makriyannis, Keith A Sharke. Activation of the cannabinoid 2 receptor (CB2) protects against experimental colitis. Inflammatory bowel diseases. vol 15. issue 11. 2010-01-07. PMID:19408320. |
activation of the cannabinoid 2 receptor (cb2) protects against experimental colitis. |
2010-01-07 |
2023-08-12 |
mouse |
| Christine Börner, Michal Smida, Volker Höllt, Burkhart Schraven, Jürgen Krau. Cannabinoid receptor type 1- and 2-mediated increase in cyclic AMP inhibits T cell receptor-triggered signaling. The Journal of biological chemistry. vol 284. issue 51. 2010-01-06. PMID:19858202. |
the aim of this study was to characterize inhibitory mechanisms on t cell receptor signaling mediated by the cannabinoid receptors cb1 and cb2. |
2010-01-06 |
2023-08-12 |
human |
| Christine Börner, Michal Smida, Volker Höllt, Burkhart Schraven, Jürgen Krau. Cannabinoid receptor type 1- and 2-mediated increase in cyclic AMP inhibits T cell receptor-triggered signaling. The Journal of biological chemistry. vol 284. issue 51. 2010-01-06. PMID:19858202. |
all of the effects of the cannabinoids were blocked by the cb1 and cb2 antagonists am281 and am630. |
2010-01-06 |
2023-08-12 |
human |
| Qing Liu, Manjunatha Bhat, Wayne D Bowen, Jianguo Chen. Signaling pathways from cannabinoid receptor-1 activation to inhibition of N-methyl-D-aspartic acid mediated calcium influx and neurotoxicity in dorsal root ganglion neurons. The Journal of pharmacology and experimental therapeutics. vol 331. issue 3. 2009-12-22. PMID:19752241. |
these effects were blocked by selective cannabinoid cb1 receptor antagonists n-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1h-pyrazole-3-carboxamide (sr141716a) or n-(piperidin-1-yl)-5-(4-iodophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1h-pyrazole-3-carboxamide (am251), but not cb2 receptor antagonist n-[(1s)-endo-1,3,3,-trimethylbicyclo[2.2.1]heptan-2-yl]-5-(4-chloro-3-methylphenyl)-1-(4-methyl-benzyl)-pyrazole-3-carboxamide (sr144528). |
2009-12-22 |
2023-08-12 |
Not clear |
| Stefania Merighi, Carolina Simioni, Stefania Gessi, Katia Varani, Pier Andrea Bore. Binding thermodynamics at the human cannabinoid CB1 and CB2 receptors. Biochemical pharmacology. vol 79. issue 3. 2009-12-22. PMID:19766600. |
binding thermodynamics at the human cannabinoid cb1 and cb2 receptors. |
2009-12-22 |
2023-08-12 |
human |
| Ahmed Helm. Endocannabinoids and non-alcoholic steatohepatitis. Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association. vol 12. issue 1. 2009-12-14. PMID:19858584. |
recently, two g-proteins coupled, and specific receptors, to cannabinoids, cb1 & cb2, which act via adenylate cyclase and calcium channels, were described. |
2009-12-14 |
2023-08-12 |
mouse |
| I R Dinu, Simona Popa, Mihaela Bîcu, E Moţa, Maria Moţ. The implication of CNR1 gene's polymorphisms in the modulation of endocannabinoid system effects. Romanian journal of internal medicine = Revue roumaine de medecine interne. vol 47. issue 1. 2009-12-11. PMID:19886064. |
it is composed of cannabinoid receptors cb1 and cb2, and their genes (cnr1 and cnr2), their endogenous ligands and the enzymes which mediate endogenous ligands' biosynthesis and degradation. |
2009-12-11 |
2023-08-12 |
Not clear |
| Nova M H Sain, Annie Liang, Stefanie A Kane, Mark O Urba. Antinociceptive effects of the non-selective cannabinoid receptor agonist CP 55,940 are absent in CB1(-/-) and not CB2(-/-) mice in models of acute and persistent pain. Neuropharmacology. vol 57. issue 3. 2009-11-27. PMID:19538975. |
previous studies have suggested a role for both cb1 and cb2 cannabinoid receptors in modulation of nociception. |
2009-11-27 |
2023-08-12 |
mouse |
| Cassandra I Saunders, Robert G Fassett, Dominic P Geraght. Up-regulation of TRPV1 in mononuclear cells of end-stage kidney disease patients increases susceptibility to N-arachidonoyl-dopamine (NADA)-induced cell death. Biochimica et biophysica acta. vol 1792. issue 10. 2009-11-25. PMID:19619644. |
trpv1 (5'-iodoresiniferatoxin) and cannabinoid (cb2; am630) receptor antagonists blocked the cytotoxic effect of nada. |
2009-11-25 |
2023-08-12 |
Not clear |
| Nicola H Morgan, Ian M Stanford, Gavin L Woodhal. Functional CB2 type cannabinoid receptors at CNS synapses. Neuropharmacology. vol 57. issue 4. 2009-11-24. PMID:19616018. |
functional cb2 type cannabinoid receptors at cns synapses. |
2009-11-24 |
2023-08-12 |
rat |
| Nicola H Morgan, Ian M Stanford, Gavin L Woodhal. Functional CB2 type cannabinoid receptors at CNS synapses. Neuropharmacology. vol 57. issue 4. 2009-11-24. PMID:19616018. |
however, evidence for the expression of cb2 type cannabinoid receptors at neuronal sites in the cns is building through anatomical localization of receptors and mrna in neurons and behavioural studies of central effects of cb2r agonists. |
2009-11-24 |
2023-08-12 |
rat |
| J J Galliga. Cannabinoid signalling in the enteric nervous system. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 21. issue 9. 2009-11-23. PMID:19689654. |
exogenous cannabinoids and endocannabinoids act on cb1 and cb2 receptors. |
2009-11-23 |
2023-08-12 |
Not clear |
| J J Galliga. Cannabinoid signalling in the enteric nervous system. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 21. issue 9. 2009-11-23. PMID:19689654. |
cb2 receptors are expressed by immune cells and cannabinoids can suppress immune function. |
2009-11-23 |
2023-08-12 |
Not clear |
| Vanessa Deveaux, Thomas Cadoudal, Yasukatsu Ichigotani, Fatima Teixeira-Clerc, Alexandre Louvet, Sylvie Manin, Jeanne Tran-Van Nhieu, Marie Pierre Belot, Andreas Zimmer, Patrick Even, Patrice D Cani, Claude Knauf, Remy Burcelin, Adeline Bertola, Yannick Le Marchand-Brustel, Philippe Gual, Ariane Mallat, Sophie Lotersztaj. Cannabinoid CB2 receptor potentiates obesity-associated inflammation, insulin resistance and hepatic steatosis. PloS one. vol 4. issue 6. 2009-11-17. PMID:19513120. |
cannabinoid cb2 receptor potentiates obesity-associated inflammation, insulin resistance and hepatic steatosis. |
2009-11-17 |
2023-08-12 |
Not clear |