| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yannick Marchalant, Holly M Brothers, Greg J Norman, Kate Karelina, A Courtney DeVries, Gary L Wen. Cannabinoids attenuate the effects of aging upon neuroinflammation and neurogenesis. Neurobiology of disease. vol 34. issue 2. 2009-08-04. PMID:19385063. |
the current study was designed to determine the differential role of the endocannabinoid receptor sub-types 1 (cb1) and 2 (cb2) and transient receptor potential vanilloid 1 receptor (trpv1) in the reduction of age-associated brain inflammation and their effects on neurogenesis in the dentate gyrus of aged rats. |
2009-08-04 |
2023-08-12 |
rat |
| Kathryn A Seely, Mark S Levi, Paul L Prathe. The dietary polyphenols trans-resveratrol and curcumin selectively bind human CB1 cannabinoid receptors with nanomolar affinities and function as antagonists/inverse agonists. The Journal of pharmacology and experimental therapeutics. vol 330. issue 1. 2009-07-27. PMID:19359525. |
it is interesting that cannabinoids, derived from the marijuana plant (cannabis sativa), produce similar protective effects via cb1 and cb2 receptors. |
2009-07-27 |
2023-08-12 |
mouse |
| Paola Grimaldi, Pierangelo Orlando, Sara Di Siena, Francesca Lolicato, Stefania Petrosino, Tiziana Bisogno, Raffaele Geremia, Luciano De Petrocellis, Vincenzo Di Marz. The endocannabinoid system and pivotal role of the CB2 receptor in mouse spermatogenesis. Proceedings of the National Academy of Sciences of the United States of America. vol 106. issue 27. 2009-07-27. PMID:19541620. |
the endocannabinoid system and pivotal role of the cb2 receptor in mouse spermatogenesis. |
2009-07-27 |
2023-08-12 |
mouse |
| C Robin Hile. Endocannabinoids and the heart. Journal of cardiovascular pharmacology. vol 53. issue 4. 2009-07-16. PMID:19276990. |
they activate cannabinoid cb1 and cb2 receptors, transient receptor potential v1 (trpv1), peroxisome proliferator-activated receptors, and perhaps a novel vascular g-protein-coupled receptor. |
2009-07-16 |
2023-08-12 |
mouse |
| C Robin Hile. Endocannabinoids and the heart. Journal of cardiovascular pharmacology. vol 53. issue 4. 2009-07-16. PMID:19276990. |
endocannabinoids are largely protective; they decrease tissue damage and arrhythmia in myocardial infarction and may reduce progression of atherosclerosis (cb2 receptor stimulation inhibits lesion progression), and fatty acid amide hydrolase knockout mice (which have enhanced endocannabinoid levels) show decreased cardiac dysfunction with age compared with wild types. |
2009-07-16 |
2023-08-12 |
mouse |
| Guilherme B L De Freitas, Leandro L da Silva, Nelilma C Romeiro, Carlos A M Frag. Development of CoMFA and CoMSIA models of affinity and selectivity for indole ligands of cannabinoid CB1 and CB2 receptors. European journal of medicinal chemistry. vol 44. issue 6. 2009-07-15. PMID:19249138. |
development of comfa and comsia models of affinity and selectivity for indole ligands of cannabinoid cb1 and cb2 receptors. |
2009-07-15 |
2023-08-12 |
Not clear |
| Guilherme B L De Freitas, Leandro L da Silva, Nelilma C Romeiro, Carlos A M Frag. Development of CoMFA and CoMSIA models of affinity and selectivity for indole ligands of cannabinoid CB1 and CB2 receptors. European journal of medicinal chemistry. vol 44. issue 6. 2009-07-15. PMID:19249138. |
this paper describes comfa and comsia studies for affinity and selectivity of a series of indole ligands to cannabinoid cb1 and cb2 receptors. |
2009-07-15 |
2023-08-12 |
Not clear |
| Saoirse E O'Sullivan, Yan Sun, Andrew J Bennett, Michael D Randall, David A Kendal. Time-dependent vascular actions of cannabidiol in the rat aorta. European journal of pharmacology. vol 612. issue 1-3. 2009-07-09. PMID:19285060. |
the vascular effects of cannabidiol were not affected by endothelial denudation, nitric oxide synthase inhibition, pertussis toxin, cannabinoid cb1 or cannabinoid cb2 receptor antagonism, or capsaicin pre-treatment. |
2009-07-09 |
2023-08-12 |
rat |
| N E Campillo, J A Páe. Cannabinoid system in neurodegeneration: new perspectives in Alzheimer's disease. Mini reviews in medicinal chemistry. vol 9. issue 5. 2009-07-08. PMID:19456285. |
the presence of functional cannabinoid cb2 receptors in central nervous system (cns) has provoked that this receptor and its agonist ligands are now considered as promising pharmacological targets for neurological diseases. |
2009-07-08 |
2023-08-12 |
Not clear |
| Varadarajan Sudhahar, Sean Shaw, John D Imi. Mechanisms involved in oleamide-induced vasorelaxation in rat mesenteric resistance arteries. European journal of pharmacology. vol 607. issue 1-3. 2009-07-07. PMID:19326479. |
the cannabinoid type 1 (cb1) receptor antagonist, am251 and the non-cb1/cb2 cannabinoid receptor antagonist, o-1918, attenuated the oleamide vasodilatory response, however the cannabinoid cb2 receptor antagonist, am630, did not affect the vascular response. |
2009-07-07 |
2023-08-12 |
rat |
| Varadarajan Sudhahar, Sean Shaw, John D Imi. Mechanisms involved in oleamide-induced vasorelaxation in rat mesenteric resistance arteries. European journal of pharmacology. vol 607. issue 1-3. 2009-07-07. PMID:19326479. |
in agreement with the vascular functional data, the cannabinoid cb1 and trpv1 receptor proteins were expressed in mesenteric resistance arteries but cannabinoid cb2 receptors and the faah enzyme were not. |
2009-07-07 |
2023-08-12 |
rat |
| Balapal S Basavarajappa, Ralph A Nixon, Ottavio Aranci. Endocannabinoid system: emerging role from neurodevelopment to neurodegeneration. Mini reviews in medicinal chemistry. vol 9. issue 4. 2009-06-23. PMID:19356123. |
many of the effects of cannabinoids and ecs are mediated by two g protein-coupled receptors (gpcrs), cb1 and cb2, although additional receptors may be implicated. |
2009-06-23 |
2023-08-12 |
human |
| L De Petrocellis, R Deva, F Mainieri, M Schaefer, T Bisogno, R Ciccoli, A Ligresti, K Hill, S Nigam, G Appendino, V Di Marz. Chemical synthesis, pharmacological characterization, and possible formation in unicellular fungi of 3-hydroxy-anandamide. Journal of lipid research. vol 50. issue 4. 2009-06-22. PMID:19017617. |
both enantiomers of 3-haea were as active as anandamide at elevating intracellular ca2+ via trpv1 receptors overexpressed in hek-293 cells, while a approximately 70-90-fold and approximately 45-60-fold lower affinity at cannabinoid cb1 and cb2 receptors was instead observed. |
2009-06-22 |
2023-08-12 |
Not clear |
| María Gracia Gervasi, Maximiliano Rapanelli, María Laura Ribeiro, Mariana Farina, Silvia Billi, Ana María Franchi, Silvina Perez Martine. The endocannabinoid system in bull sperm and bovine oviductal epithelium: role of anandamide in sperm-oviduct interaction. Reproduction (Cambridge, England). vol 137. issue 3. 2009-06-15. PMID:19042982. |
we observed that bull sperm and bovine oviductal epithelial cells express cannabinoid receptors, cb1 and cb2, and fatty acid amide hydrolase, the enzyme that controls intracellular anandamide levels. |
2009-06-15 |
2023-08-12 |
cattle |
| Sanjai Saxen. Fungal biotransformation of cannabinoids: potential for new effective drugs. Current opinion in drug discovery & development. vol 12. issue 2. 2009-06-04. PMID:19333876. |
the discovery of the cannabinoid receptors cb1 and cb2 led to the development of agonists and antagonists of these receptors for the treatment of a variety of diseases. |
2009-06-04 |
2023-08-12 |
Not clear |
| Alicia Brusco, Patricia Tagliaferro, Trinidad Saez, Emmanuel S Onaiv. Postsynaptic localization of CB2 cannabinoid receptors in the rat hippocampus. Synapse (New York, N.Y.). vol 62. issue 12. 2009-05-26. PMID:18798269. |
postsynaptic localization of cb2 cannabinoid receptors in the rat hippocampus. |
2009-05-26 |
2023-08-12 |
rat |
| Alicia Brusco, Patricia Tagliaferro, Trinidad Saez, Emmanuel S Onaiv. Postsynaptic localization of CB2 cannabinoid receptors in the rat hippocampus. Synapse (New York, N.Y.). vol 62. issue 12. 2009-05-26. PMID:18798269. |
the expression of cb2 cannabinoid receptors (cb2-rs) in the brain and their neuronal function has now attracted research interest, since we and others have demonstrated the presence of cb2-rs in neuronal and glial cells in the brain. |
2009-05-26 |
2023-08-12 |
rat |
| Paolo Caraceni, Marco Domenicali, Ferdinando Giannone, Mauro Bernard. The role of the endocannabinoid system in liver diseases. Best practice & research. Clinical endocrinology & metabolism. vol 23. issue 1. 2009-05-26. PMID:19285261. |
endogenous cannabinoids (ecs) are ubiquitous lipid signaling molecules provided by a number of central and peripheral effects, which are mediated mainly by the specific receptors cb1 and cb2. |
2009-05-26 |
2023-08-12 |
Not clear |
| Debra McGuinness, Asra Malikzay, Richard Visconti, Karen Lin, Marvin Bayne, Frederick Monsma, Charles A Lun. Characterizing cannabinoid CB2 receptor ligands using DiscoveRx PathHunter beta-arrestin assay. Journal of biomolecular screening. vol 14. issue 1. 2009-05-22. PMID:19171920. |
characterizing cannabinoid cb2 receptor ligands using discoverx pathhunter beta-arrestin assay. |
2009-05-22 |
2023-08-12 |
human |
| David R Janero, Alexandros Makriyanni. Cannabinoid receptor antagonists: pharmacological opportunities, clinical experience, and translational prognosis. Expert opinion on emerging drugs. vol 14. issue 1. 2009-05-22. PMID:19249987. |
the endogenous cannabinoid (cb) (endocannabinoid) signaling system is involved in a variety of (patho)physiological processes, primarily by virtue of natural, arachidonic acid-derived lipids (endocannabinoids) that activate g protein-coupled cb1 and cb2 receptors. |
2009-05-22 |
2023-08-12 |
human |