| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Francesca Comelli, Gabriella Giagnoni, Isabella Bettoni, Mariapia Colleoni, Barbara Cost. Antihyperalgesic effect of a Cannabis sativa extract in a rat model of neuropathic pain: mechanisms involved. Phytotherapy research : PTR. vol 22. issue 8. 2008-10-02. PMID:18618522. |
the results also demonstrated that such an antihyperalgesic effect did not involve the cannabinoid cb1 and cb2 receptors, whereas it was mediated by vanilloid receptors trpv1. |
2008-10-02 |
2023-08-12 |
rat |
| L Bellocchio, C Cervino, R Pasquali, U Pagott. The endocannabinoid system and energy metabolism. Journal of neuroendocrinology. vol 20. issue 6. 2008-09-29. PMID:18601709. |
cannabinoid receptors [cannabinoid receptor type 1 (cb1) and cb2] participate in the physiological modulation of many central and peripheral functions. |
2008-09-29 |
2023-08-12 |
Not clear |
| Barbara L F Kaplan, Alison E B Springs, Norbert E Kaminsk. The profile of immune modulation by cannabidiol (CBD) involves deregulation of nuclear factor of activated T cells (NFAT). Biochemical pharmacology. vol 76. issue 6. 2008-09-29. PMID:18656454. |
cannabidiol (cbd) is a cannabinoid compound derived from cannabis sativa that does not possess high affinity for either the cb1 or cb2 cannabinoid receptors. |
2008-09-29 |
2023-08-12 |
mouse |
| Denise Richardson, Richard G Pearson, Nisha Kurian, M Liaque Latif, Michael J Garle, David A Barrett, David A Kendall, Brigitte E Scammell, Alison J Reeve, Victoria Chapma. Characterisation of the cannabinoid receptor system in synovial tissue and fluid in patients with osteoarthritis and rheumatoid arthritis. Arthritis research & therapy. vol 10. issue 2. 2008-09-23. PMID:18416822. |
the endocannabinoid receptor system, including the cannabinoid receptor 1 (cb1) and receptor 2 (cb2) and the endocannabinoids, are implicated in a wide range of physiological and pathophysiological processes. |
2008-09-23 |
2023-08-12 |
Not clear |
| Nikolai Zvonok, John Williams, Meghan Johnston, Lakshmipathi Pandarinathan, David R Janero, Jing Li, Srinivasan C Krishnan, Alexandros Makriyanni. Full mass spectrometric characterization of human monoacylglycerol lipase generated by large-scale expression and single-step purification. Journal of proteome research. vol 7. issue 5. 2008-09-22. PMID:18452279. |
the serine hydrolase monoacylglycerol lipase (mgl) modulates endocannabinoid signaling in vivo by inactivating 2-arachidonoylglycerol (2-ag), the main endogenous agonist for central cb1 and peripheral cb2 cannabinoid receptors. |
2008-09-22 |
2023-08-12 |
human |
| Wibke Reinhard, Klaus Stark, Katharina Neureuther, Kamil Sedlacek, Marcus Fischer, Andrea Baessler, Stefan Weber, Bernhard Kaess, Silke Wiedmann, Jeanette Erdmann, Wolfgang Lieb, Andreas Jeron, Guenter Riegger, Christian Hengstenber. Common polymorphisms in the cannabinoid CB2 receptor gene (CNR2) are not associated with myocardial infarction and cardiovascular risk factors. International journal of molecular medicine. vol 22. issue 2. 2008-09-18. PMID:18636169. |
common polymorphisms in the cannabinoid cb2 receptor gene (cnr2) are not associated with myocardial infarction and cardiovascular risk factors. |
2008-09-18 |
2023-08-12 |
Not clear |
| Paul W Wacnik, Katarina M Luhr, Russell H Hill, Hans-Gustaf Ljunggren, Krister Kristensson, Mattias Svensso. Cannabinoids affect dendritic cell (DC) potassium channel function and modulate DC T cell stimulatory capacity. Journal of immunology (Baltimore, Md. : 1950). vol 181. issue 5. 2008-09-15. PMID:18713976. |
cannabinoids stimulate g protein-coupled cannabinoid receptors cb1 and cb2. |
2008-09-15 |
2023-08-12 |
Not clear |
| Maurizio Bifulco, Anna Maria Malfitano, Simona Pisanti, Chiara Laezz. Endocannabinoids in endocrine and related tumours. Endocrine-related cancer. vol 15. issue 2. 2008-09-11. PMID:18508995. |
the 'endocannabinoid system', comprising the cannabinoid cb1 and cb2 receptors, their endogenous ligands, endocannabinoids and the enzymes that regulate their biosynthesis and degradation, has drawn a great deal of scientist attention during the last two decades. |
2008-09-11 |
2023-08-12 |
Not clear |
| Marnie Duncan, Abdeslam Mouihate, Ken Mackie, Catherine M Keenan, Nancy E Buckley, Joseph S Davison, Kamala D Patel, Quentin J Pittman, Keith A Sharke. Cannabinoid CB2 receptors in the enteric nervous system modulate gastrointestinal contractility in lipopolysaccharide-treated rats. American journal of physiology. Gastrointestinal and liver physiology. vol 295. issue 1. 2008-09-09. PMID:18483180. |
cannabinoid cb2 receptors in the enteric nervous system modulate gastrointestinal contractility in lipopolysaccharide-treated rats. |
2008-09-09 |
2023-08-12 |
rat |
| Gabriella Aviello, Isabel Matias, Raffaele Capasso, Stefania Petrosino, Francesca Borrelli, Pierangelo Orlando, Barbara Romano, Francesco Capasso, Vincenzo Di Marzo, Angelo A Izz. Inhibitory effect of the anorexic compound oleoylethanolamide on gastric emptying in control and overweight mice. Journal of molecular medicine (Berlin, Germany). vol 86. issue 4. 2008-08-25. PMID:18278475. |
the effect of oea was unaffected by rimonabant (cannabinoid cb1 receptor antagonist), sr144528 (cannabinoid cb2 receptor antagonist), 5'-iodoresiniferatoxin (transient receptor potential vanilloid type 1 antagonist), or mk886 (peroxisome proliferator-activated receptor-alpha) antagonist. |
2008-08-25 |
2023-08-12 |
mouse |
| Jürg Gertsc. Immunomodulatory lipids in plants: plant fatty acid amides and the human endocannabinoid system. Planta medica. vol 74. issue 6. 2008-08-21. PMID:18275004. |
potently activate cb2 cannabinoid receptors we have focused our interest on plant fatty acid amides (faas) and their overall cannabinomodulatory effects. |
2008-08-21 |
2023-08-12 |
human |
| John C Ashton, Jason L Wright, John M McPartland, Joel D A Tyndal. Cannabinoid CB1 and CB2 receptor ligand specificity and the development of CB2-selective agonists. Current medicinal chemistry. vol 15. issue 14. 2008-08-14. PMID:18537620. |
cannabinoid cb1 and cb2 receptor ligand specificity and the development of cb2-selective agonists. |
2008-08-14 |
2023-08-12 |
mouse |
| John C Ashton, Jason L Wright, John M McPartland, Joel D A Tyndal. Cannabinoid CB1 and CB2 receptor ligand specificity and the development of CB2-selective agonists. Current medicinal chemistry. vol 15. issue 14. 2008-08-14. PMID:18537620. |
cannabinoids in current use such as nabilone activate both cb1 and cb2 receptors. |
2008-08-14 |
2023-08-12 |
mouse |
| John C Ashton, Jason L Wright, John M McPartland, Joel D A Tyndal. Cannabinoid CB1 and CB2 receptor ligand specificity and the development of CB2-selective agonists. Current medicinal chemistry. vol 15. issue 14. 2008-08-14. PMID:18537620. |
selective cb2 activation may provide some of the therapeutic effects of cannabinoids, such as their immuno-modulatory properties, without the psychoactive effects of cb1 activation. |
2008-08-14 |
2023-08-12 |
mouse |
| John C Ashton, Jason L Wright, John M McPartland, Joel D A Tyndal. Cannabinoid CB1 and CB2 receptor ligand specificity and the development of CB2-selective agonists. Current medicinal chemistry. vol 15. issue 14. 2008-08-14. PMID:18537620. |
therefore, cannabinoid cb2 receptors represent an attractive target for drug development. |
2008-08-14 |
2023-08-12 |
mouse |
| John C Ashton, Jason L Wright, John M McPartland, Joel D A Tyndal. Cannabinoid CB1 and CB2 receptor ligand specificity and the development of CB2-selective agonists. Current medicinal chemistry. vol 15. issue 14. 2008-08-14. PMID:18537620. |
mutational and ligand binding studies, functional mapping, and computer modelling have revealed key residues and domains in cannabinoid receptors that are involved in agonist and antagonist binding to cb1 and cb2. |
2008-08-14 |
2023-08-12 |
mouse |
| Christine Börner, Volker Höllt, Jürgen Krau. Activation of human T cells induces upregulation of cannabinoid receptor type 1 transcription. Neuroimmunomodulation. vol 14. issue 6. 2008-07-22. PMID:18287809. |
effects of cannabinoids are mediated by cb1 and cb2 receptors. |
2008-07-22 |
2023-08-12 |
human |
| Daniela Accorsi-Mendonça, Carlos E L Almado, André L A Dagostin, Benedito H Machado, Ricardo M Leã. Inhibition of spontaneous neurotransmission in the nucleus of solitary tract of the rat by the cannabinoid agonist WIN 55212-2 is not via CB1 or CB2 receptors. Brain research. vol 1200. 2008-07-18. PMID:18308297. |
inhibition of spontaneous neurotransmission in the nucleus of solitary tract of the rat by the cannabinoid agonist win 55212-2 is not via cb1 or cb2 receptors. |
2008-07-18 |
2023-08-12 |
rat |
| Daniela Accorsi-Mendonça, Carlos E L Almado, André L A Dagostin, Benedito H Machado, Ricardo M Leã. Inhibition of spontaneous neurotransmission in the nucleus of solitary tract of the rat by the cannabinoid agonist WIN 55212-2 is not via CB1 or CB2 receptors. Brain research. vol 1200. 2008-07-18. PMID:18308297. |
both cb1 and cb2 cannabinoid receptors have been described in the nucleus tractus solitarius (nts), which receives direct afferent projections of cardiovascular reflexes. |
2008-07-18 |
2023-08-12 |
rat |
| Kristin Gustafsson, Xiao Wang, Denise Severa, Maeve Eriksson, Eva Kimby, Mats Merup, Birger Christensson, Jenny Flygare, Birgitta Sande. Expression of cannabinoid receptors type 1 and type 2 in non-Hodgkin lymphoma: growth inhibition by receptor activation. International journal of cancer. vol 123. issue 5. 2008-07-18. PMID:18546271. |
in this study, we evaluated the expression of cannabinoid receptors type 1 and type 2 (cb1 and cb2) in non-hodgkin lymphomas of b cell type (n = 62). |
2008-07-18 |
2023-08-12 |
mouse |