| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| John Ashto. Pro-drugs for indirect cannabinoids as therapeutic agents. Current drug delivery. vol 5. issue 4. 2008-11-04. PMID:18855592. |
these include the psychoactivity of cannabinoid cb1 receptor agonists and the lack of availability of highly selective cannabinoid receptor full agonists (for the cb1 or cb2 receptor), as well as problems of pharmacokinetics. |
2008-11-04 |
2023-08-12 |
Not clear |
| b' N\\xc3\\xb3ra Dobrosi, Bal\\xc3\\xa1zs I T\\xc3\\xb3th, Georgina Nagy, Anik\\xc3\\xb3 D\\xc3\\xb3zsa, Tam\\xc3\\xa1s G\\xc3\\xa9czy, L\\xc3\\xa1szl\\xc3\\xb3 Nagy, Christos C Zouboulis, Ralf Paus, L\\xc3\\xa1szl\\xc3\\xb3 Kov\\xc3\\xa1cs, Tam\\xc3\\xa1s B\\xc3\\xadr\\xc3\\xb. Endocannabinoids enhance lipid synthesis and apoptosis of human sebocytes via cannabinoid receptor-2-mediated signaling. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 22. issue 10. 2008-10-21. PMID:18596221.' |
because cells with "silenced" cb2 exhibited significantly suppressed basal lipid production, our results collectively suggest that human sebocytes utilize a paracrine-autocrine, endogenously active, cb2-mediated endocannabinoid signaling system for positively regulating lipid production and cell death. |
2008-10-21 |
2023-08-12 |
human |
| Jian-Kang Chen, Jianchun Chen, John D Imig, Shouzuo Wei, David L Hachey, Jagadeesh Setti Guthi, John R Falck, Jorge H Capdevila, Raymond C Harri. Identification of novel endogenous cytochrome p450 arachidonate metabolites with high affinity for cannabinoid receptors. The Journal of biological chemistry. vol 283. issue 36. 2008-10-20. PMID:18606824. |
both 2-11,12-eg and 2-14,15-eg activated the two cannabinoid (cb) receptor subtypes, cb1 and cb2, with high affinity and elicited biological responses in cultured cells expressing cb receptors and in intact animals. |
2008-10-20 |
2023-08-12 |
Not clear |
| María Iribarne, Vanesa Torbidoni, Karina Julián, Juan P Prestifilippo, Debasish Sinha, Valeria Rettori, Alejandro Berra, Angela M Subur. Cannabinoid receptors in conjunctival epithelium: identification and functional properties. Investigative ophthalmology & visual science. vol 49. issue 10. 2008-10-10. PMID:18566465. |
therefore, the authors explored the presence and properties of cannabinoid receptors (cb1 and cb2) in conjunctival epithelial cells. |
2008-10-10 |
2023-08-12 |
Not clear |
| Erinn S Raborn, Francine Marciano-Cabral, Nancy E Buckley, Billy R Martin, Guy A Cabra. The cannabinoid delta-9-tetrahydrocannabinol mediates inhibition of macrophage chemotaxis to RANTES/CCL5: linkage to the CB2 receptor. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 3. issue 2. 2008-10-08. PMID:18247131. |
the cannabinoid delta-9-tetrahydrocannabinol mediates inhibition of macrophage chemotaxis to rantes/ccl5: linkage to the cb2 receptor. |
2008-10-08 |
2023-08-12 |
mouse |
| Erinn S Raborn, Francine Marciano-Cabral, Nancy E Buckley, Billy R Martin, Guy A Cabra. The cannabinoid delta-9-tetrahydrocannabinol mediates inhibition of macrophage chemotaxis to RANTES/CCL5: linkage to the CB2 receptor. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 3. issue 2. 2008-10-08. PMID:18247131. |
collectively, these results suggest that cannabinoids act through the cb2 receptor to transdeactivate migratory responsiveness to rantes/ccl5. |
2008-10-08 |
2023-08-12 |
mouse |
| Jian Zhang, Chu Che. Endocannabinoid 2-arachidonoylglycerol protects neurons by limiting COX-2 elevation. The Journal of biological chemistry. vol 283. issue 33. 2008-10-03. PMID:18534982. |
2-arachidonoylglycerol (2-ag), the most abundant endogenous cannabinoid and a full agonist for cannabinoid receptors (cb1 and cb2), is a substrate for cyclooxygenase-2 (cox-2) and can be metabolized by cox-2. |
2008-10-03 |
2023-08-12 |
Not clear |
| Francesca Comelli, Gabriella Giagnoni, Isabella Bettoni, Mariapia Colleoni, Barbara Cost. Antihyperalgesic effect of a Cannabis sativa extract in a rat model of neuropathic pain: mechanisms involved. Phytotherapy research : PTR. vol 22. issue 8. 2008-10-02. PMID:18618522. |
the results also demonstrated that such an antihyperalgesic effect did not involve the cannabinoid cb1 and cb2 receptors, whereas it was mediated by vanilloid receptors trpv1. |
2008-10-02 |
2023-08-12 |
rat |
| L Bellocchio, C Cervino, R Pasquali, U Pagott. The endocannabinoid system and energy metabolism. Journal of neuroendocrinology. vol 20. issue 6. 2008-09-29. PMID:18601709. |
cannabinoid receptors [cannabinoid receptor type 1 (cb1) and cb2] participate in the physiological modulation of many central and peripheral functions. |
2008-09-29 |
2023-08-12 |
Not clear |
| Barbara L F Kaplan, Alison E B Springs, Norbert E Kaminsk. The profile of immune modulation by cannabidiol (CBD) involves deregulation of nuclear factor of activated T cells (NFAT). Biochemical pharmacology. vol 76. issue 6. 2008-09-29. PMID:18656454. |
cannabidiol (cbd) is a cannabinoid compound derived from cannabis sativa that does not possess high affinity for either the cb1 or cb2 cannabinoid receptors. |
2008-09-29 |
2023-08-12 |
mouse |
| Denise Richardson, Richard G Pearson, Nisha Kurian, M Liaque Latif, Michael J Garle, David A Barrett, David A Kendall, Brigitte E Scammell, Alison J Reeve, Victoria Chapma. Characterisation of the cannabinoid receptor system in synovial tissue and fluid in patients with osteoarthritis and rheumatoid arthritis. Arthritis research & therapy. vol 10. issue 2. 2008-09-23. PMID:18416822. |
the endocannabinoid receptor system, including the cannabinoid receptor 1 (cb1) and receptor 2 (cb2) and the endocannabinoids, are implicated in a wide range of physiological and pathophysiological processes. |
2008-09-23 |
2023-08-12 |
Not clear |
| Nikolai Zvonok, John Williams, Meghan Johnston, Lakshmipathi Pandarinathan, David R Janero, Jing Li, Srinivasan C Krishnan, Alexandros Makriyanni. Full mass spectrometric characterization of human monoacylglycerol lipase generated by large-scale expression and single-step purification. Journal of proteome research. vol 7. issue 5. 2008-09-22. PMID:18452279. |
the serine hydrolase monoacylglycerol lipase (mgl) modulates endocannabinoid signaling in vivo by inactivating 2-arachidonoylglycerol (2-ag), the main endogenous agonist for central cb1 and peripheral cb2 cannabinoid receptors. |
2008-09-22 |
2023-08-12 |
human |
| Wibke Reinhard, Klaus Stark, Katharina Neureuther, Kamil Sedlacek, Marcus Fischer, Andrea Baessler, Stefan Weber, Bernhard Kaess, Silke Wiedmann, Jeanette Erdmann, Wolfgang Lieb, Andreas Jeron, Guenter Riegger, Christian Hengstenber. Common polymorphisms in the cannabinoid CB2 receptor gene (CNR2) are not associated with myocardial infarction and cardiovascular risk factors. International journal of molecular medicine. vol 22. issue 2. 2008-09-18. PMID:18636169. |
common polymorphisms in the cannabinoid cb2 receptor gene (cnr2) are not associated with myocardial infarction and cardiovascular risk factors. |
2008-09-18 |
2023-08-12 |
Not clear |
| Paul W Wacnik, Katarina M Luhr, Russell H Hill, Hans-Gustaf Ljunggren, Krister Kristensson, Mattias Svensso. Cannabinoids affect dendritic cell (DC) potassium channel function and modulate DC T cell stimulatory capacity. Journal of immunology (Baltimore, Md. : 1950). vol 181. issue 5. 2008-09-15. PMID:18713976. |
cannabinoids stimulate g protein-coupled cannabinoid receptors cb1 and cb2. |
2008-09-15 |
2023-08-12 |
Not clear |
| Maurizio Bifulco, Anna Maria Malfitano, Simona Pisanti, Chiara Laezz. Endocannabinoids in endocrine and related tumours. Endocrine-related cancer. vol 15. issue 2. 2008-09-11. PMID:18508995. |
the 'endocannabinoid system', comprising the cannabinoid cb1 and cb2 receptors, their endogenous ligands, endocannabinoids and the enzymes that regulate their biosynthesis and degradation, has drawn a great deal of scientist attention during the last two decades. |
2008-09-11 |
2023-08-12 |
Not clear |
| Marnie Duncan, Abdeslam Mouihate, Ken Mackie, Catherine M Keenan, Nancy E Buckley, Joseph S Davison, Kamala D Patel, Quentin J Pittman, Keith A Sharke. Cannabinoid CB2 receptors in the enteric nervous system modulate gastrointestinal contractility in lipopolysaccharide-treated rats. American journal of physiology. Gastrointestinal and liver physiology. vol 295. issue 1. 2008-09-09. PMID:18483180. |
cannabinoid cb2 receptors in the enteric nervous system modulate gastrointestinal contractility in lipopolysaccharide-treated rats. |
2008-09-09 |
2023-08-12 |
rat |
| Gabriella Aviello, Isabel Matias, Raffaele Capasso, Stefania Petrosino, Francesca Borrelli, Pierangelo Orlando, Barbara Romano, Francesco Capasso, Vincenzo Di Marzo, Angelo A Izz. Inhibitory effect of the anorexic compound oleoylethanolamide on gastric emptying in control and overweight mice. Journal of molecular medicine (Berlin, Germany). vol 86. issue 4. 2008-08-25. PMID:18278475. |
the effect of oea was unaffected by rimonabant (cannabinoid cb1 receptor antagonist), sr144528 (cannabinoid cb2 receptor antagonist), 5'-iodoresiniferatoxin (transient receptor potential vanilloid type 1 antagonist), or mk886 (peroxisome proliferator-activated receptor-alpha) antagonist. |
2008-08-25 |
2023-08-12 |
mouse |
| Jürg Gertsc. Immunomodulatory lipids in plants: plant fatty acid amides and the human endocannabinoid system. Planta medica. vol 74. issue 6. 2008-08-21. PMID:18275004. |
potently activate cb2 cannabinoid receptors we have focused our interest on plant fatty acid amides (faas) and their overall cannabinomodulatory effects. |
2008-08-21 |
2023-08-12 |
human |
| John C Ashton, Jason L Wright, John M McPartland, Joel D A Tyndal. Cannabinoid CB1 and CB2 receptor ligand specificity and the development of CB2-selective agonists. Current medicinal chemistry. vol 15. issue 14. 2008-08-14. PMID:18537620. |
cannabinoid cb1 and cb2 receptor ligand specificity and the development of cb2-selective agonists. |
2008-08-14 |
2023-08-12 |
mouse |
| John C Ashton, Jason L Wright, John M McPartland, Joel D A Tyndal. Cannabinoid CB1 and CB2 receptor ligand specificity and the development of CB2-selective agonists. Current medicinal chemistry. vol 15. issue 14. 2008-08-14. PMID:18537620. |
cannabinoids in current use such as nabilone activate both cb1 and cb2 receptors. |
2008-08-14 |
2023-08-12 |
mouse |