| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jenell M Eckert, Stephanie J Byer, Buffie J Clodfelder-Miller, Steven L Carrol. Neuregulin-1 beta and neuregulin-1 alpha differentially affect the migration and invasion of malignant peripheral nerve sheath tumor cells. Glia. vol 57. issue 14. 2009-12-09. PMID:19306381. |
while nrg-1 beta potently and persistently activated erk 1/2, sapk/jnk, akt and src family kinases, nrg-1 alpha did not activate akt and activated these other kinases with kinetics distinct from those evident in nrg-1 beta-stimulated cells. |
2009-12-09 |
2023-08-12 |
human |
| Dong Bai, Lynn Ueno, Peter K Vog. Akt-mediated regulation of NFkappaB and the essentialness of NFkappaB for the oncogenicity of PI3K and Akt. International journal of cancer. vol 125. issue 12. 2009-12-02. PMID:19609947. |
our data suggest that the stimulation of nfkappab by akt is dependent on the phosphorylation of p65 at s534, mediated by ikk (ikappab kinase) alpha and beta. |
2009-12-02 |
2023-08-12 |
chicken |
| Quan-Guang Zhang, Limor Raz, Ruimin Wang, Dong Han, Liesl De Sevilla, Fang Yang, Ratna K Vadlamudi, Darrell W Bran. Estrogen attenuates ischemic oxidative damage via an estrogen receptor alpha-mediated inhibition of NADPH oxidase activation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 44. 2009-11-17. PMID:19889994. |
e(2) neuroprotection was shown to involve a profound attenuation of nadph oxidase activation and superoxide production in hippocampal ca1 pyramidal neurons after stroke, an effect mediated by extranuclear estrogen receptor alpha (eralpha)-mediated nongenomic signaling, involving akt activation and subsequent phosphorylation/inactivation of rac1, a factor critical for activation of nox2 nadph oxidase. |
2009-11-17 |
2023-08-12 |
Not clear |
| Yong Gyu Lee, Benjamin M Chain, Jae Youl Ch. Distinct role of spleen tyrosine kinase in the early phosphorylation of inhibitor of kappaB alpha via activation of the phosphoinositide-3-kinase and Akt pathways. The international journal of biochemistry & cell biology. vol 41. issue 4. 2009-10-23. PMID:18775507. |
distinct role of spleen tyrosine kinase in the early phosphorylation of inhibitor of kappab alpha via activation of the phosphoinositide-3-kinase and akt pathways. |
2009-10-23 |
2023-08-12 |
Not clear |
| Rama P Cherla, Sang-Yun Lee, Renée A Mulder, Moo-Seung Lee, Vernon L Tes. Shiga toxin 1-induced proinflammatory cytokine production is regulated by the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin signaling pathway. Infection and immunity. vol 77. issue 9. 2009-09-03. PMID:19596774. |
pi3k, akt, and mtor inhibitors and small interfering rna knockdown of akt expression all increased, whereas a gsk-3alpha/beta inhibitor decreased, stx1-induced soluble tumor necrosis factor alpha and interleukin-1beta production. |
2009-09-03 |
2023-08-12 |
Not clear |
| Gouse M Shaik, Lubica Dráberová, Petr Heneberg, Petr Drábe. Vacuolin-1-modulated exocytosis and cell resealing in mast cells. Cellular signalling. vol 21. issue 8. 2009-07-10. PMID:19376224. |
this inhibition was not reflected by decreased phosphorylation of the fcepsilonri alpha and beta subunits, linker for activation of t cells, non-t cell activation linker, akt and map kinase erk, and uptake of extracellular ca2+, indicating that early activation events are not affected. |
2009-07-10 |
2023-08-12 |
mouse |
| Mercè Pallàs, Gemma Casadesús, Mark A Smith, Ana Coto-Montes, Carme Pelegri, Jordi Vilaplana, Antoni Camin. Resveratrol and neurodegenerative diseases: activation of SIRT1 as the potential pathway towards neuroprotection. Current neurovascular research. vol 6. issue 1. 2009-06-25. PMID:19355928. |
one hypothesis is that by activating sirtuin 1, resveratrol modulates the activity of numerous proteins, including peroxisome proliferator-activated receptor coactivator-1alpha (pgc-1 alpha), the foxo family, akt (protein kinase b) and nuclear factor-kappabeta (nfkappabeta). |
2009-06-25 |
2023-08-12 |
rat |
| Ramasamy Tamizhselvi, Jia Sun, Yung-Hua Koh, Madhav Bhati. Effect of hydrogen sulfide on the phosphatidylinositol 3-kinase-protein kinase B pathway and on caerulein-induced cytokine production in isolated mouse pancreatic acinar cells. The Journal of pharmacology and experimental therapeutics. vol 329. issue 3. 2009-06-23. PMID:19258518. |
the pi3k inhibitor ly294002 [2-(4-morpholinyl)-8-phenyl-1(4h)-benzopyran-4-one hydrochloride] abolished the h(2)s-mediated activation of akt and increases tumor necrosis factor alpha and interleukin 1beta levels in caerulein-treated acinar cells. |
2009-06-23 |
2023-08-12 |
mouse |
| Xiao-Yan Xu, Zhe Zhang, Wen-Hui Su, Yang Zhang, Chen Feng, Hong-Mei Zhao, Zhi-Hong Zong, Cheng Cui, Bing-Zhi Y. Involvement of the p110 alpha isoform of PI3K in early development of mouse embryos. Molecular reproduction and development. vol 76. issue 4. 2009-05-04. PMID:18932194. |
silencing of p110 alpha by microinjection of p110 alpha shrna into one-cell embryos resulted in a g2/m arrest and prevented the activation of akt and m-phase promoting factor (mpf). |
2009-05-04 |
2023-08-12 |
mouse |
| Xiao-Yan Xu, Zhe Zhang, Wen-Hui Su, Yang Zhang, Chen Feng, Hong-Mei Zhao, Zhi-Hong Zong, Cheng Cui, Bing-Zhi Y. Involvement of the p110 alpha isoform of PI3K in early development of mouse embryos. Molecular reproduction and development. vol 76. issue 4. 2009-05-04. PMID:18932194. |
taken together, this study demonstrates that p110 alpha is significant for g2/m transition of mouse one-cell embryos and further emphasizes the importance of akt in pi3k pathway. |
2009-05-04 |
2023-08-12 |
mouse |
| Jianfen Guo, Zoya Gertsberg, Nazira Ozgen, Susan F Steinber. p66Shc links alpha1-adrenergic receptors to a reactive oxygen species-dependent AKT-FOXO3A phosphorylation pathway in cardiomyocytes. Circulation research. vol 104. issue 5. 2009-04-06. PMID:19168439. |
p66shc links alpha(1)-ars to an akt signaling pathway that selectively phosphorylates/inactivates foxo transcription factors and downregulates the ros-scavenging protein manganese superoxide dismutase (mnsod); the alpha(1)-ar-p66shc-dependent pathway involving akt does not regulate gsk3. |
2009-04-06 |
2023-08-12 |
Not clear |
| Mikel Garcia-Marcos, Pradipta Ghosh, Marilyn G Farquha. GIV is a nonreceptor GEF for G alpha i with a unique motif that regulates Akt signaling. Proceedings of the National Academy of Sciences of the United States of America. vol 106. issue 9. 2009-04-01. PMID:19211784. |
giv is a nonreceptor gef for g alpha i with a unique motif that regulates akt signaling. |
2009-04-01 |
2023-08-12 |
Not clear |
| Rajarshi Sengupta, Silvia Burbassi, Saori Shimizu, Silvia Cappello, Richard B Vallee, Joshua B Rubin, Olimpia Meucc. Morphine increases brain levels of ferritin heavy chain leading to inhibition of CXCR4-mediated survival signaling in neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 8. 2009-03-16. PMID:19244528. |
cxcr4-induced g alpha(i)/g betagamma activities were suppressed after 24 h treatment of cortical neurons with morphine or the selective mu-opioid agonist damgo (d-ala2-n-me-phe(4)-glycol(5)-enkephalin), as shown by analysis of downstream targets of cxcr4 (i.e., camp, akt, and erk1/2). |
2009-03-16 |
2023-08-12 |
rat |
| Hong Im Kim, Huang Huang, Satish Cheepala, Shile Huang, Jun Chun. Curcumin inhibition of integrin (alpha6beta4)-dependent breast cancer cell motility and invasion. Cancer prevention research (Philadelphia, Pa.). vol 1. issue 5. 2009-03-05. PMID:19138983. |
consistent with this finding, curcumin also blocked alpha(6)beta(4)-dependent akt activation and expression of the cell motility-promoting factor enpp2 in mda-mb-435/beta4 cell line. |
2009-03-05 |
2023-08-12 |
Not clear |
| Alfredo Toschi, Evan Lee, Noga Gadir, Michael Ohh, David A Foste. Differential dependence of hypoxia-inducible factors 1 alpha and 2 alpha on mTORC1 and mTORC2. The Journal of biological chemistry. vol 283. issue 50. 2009-02-19. PMID:18945681. |
we also examined the dependence of hif alpha expression on the mtorc2 substrate akt, which exists as three different isoforms, akt1, akt2, and akt3. |
2009-02-19 |
2023-08-12 |
human |
| J K Morris, H Zhang, A A Gupte, G L Bomhoff, J A Stanford, P C Geige. Measures of striatal insulin resistance in a 6-hydroxydopamine model of Parkinson's disease. Brain research. vol 1240. 2009-02-17. PMID:18805403. |
decreased phosphorylation of akt and expression of the kinase glycogen synthase kinase-3 alpha (gsk3-alpha) was also measured in the striatum of severely da-depleted animals. |
2009-02-17 |
2023-08-12 |
rat |
| Marc Morissette, Sara Al Sweidi, Sophie Callier, Thérèse Di Paol. Estrogen and SERM neuroprotection in animal models of Parkinson's disease. Molecular and cellular endocrinology. vol 290. issue 1-2. 2009-02-11. PMID:18515001. |
striatal da neurons of estrogen receptor alpha knockout mice are more susceptible to mptp toxicity than wild-type mice and neuroprotection by estradiol is associated with the activation of the pi3-k pathway involving akt, gsk3beta, bcl2 and bad. |
2009-02-11 |
2023-08-12 |
mouse |
| Gang Song, Yanlin Ming, Yubin Mao, Shideng Bao, Gaoliang Ouyan. Osteopontin prevents curcumin-induced apoptosis and promotes survival through Akt activation via alpha v beta 3 integrins in human gastric cancer cells. Experimental biology and medicine (Maywood, N.J.). vol 233. issue 12. 2009-01-22. PMID:18849546. |
osteopontin prevents curcumin-induced apoptosis and promotes survival through akt activation via alpha v beta 3 integrins in human gastric cancer cells. |
2009-01-22 |
2023-08-12 |
human |
| Gang Song, Yanlin Ming, Yubin Mao, Shideng Bao, Gaoliang Ouyan. Osteopontin prevents curcumin-induced apoptosis and promotes survival through Akt activation via alpha v beta 3 integrins in human gastric cancer cells. Experimental biology and medicine (Maywood, N.J.). vol 233. issue 12. 2009-01-22. PMID:18849546. |
moreover, inhibiting the binding of opn to alpha(v)beta(3) integrins reduced activation of akt. |
2009-01-22 |
2023-08-12 |
human |
| Poornima Bhat-Nakshatri, Guohua Wang, Hitesh Appaiah, Nikhil Luktuke, Jason S Carroll, Tim R Geistlinger, Myles Brown, Sunil Badve, Yunlong Liu, Harikrishna Nakshatr. AKT alters genome-wide estrogen receptor alpha binding and impacts estrogen signaling in breast cancer. Molecular and cellular biology. vol 28. issue 24. 2009-01-09. PMID:18838536. |
akt alters genome-wide estrogen receptor alpha binding and impacts estrogen signaling in breast cancer. |
2009-01-09 |
2023-08-12 |
Not clear |