| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L Arbibe, J P Mira, N Teusch, L Kline, M Guha, N Mackman, P J Godowski, R J Ulevitch, U G Knau. Toll-like receptor 2-mediated NF-kappa B activation requires a Rac1-dependent pathway. Nature immunology. vol 1. issue 6. 2001-04-12. PMID:11101877. |
a signaling cascade composed of rac1, pi3k and akt targets nuclear p65 transactivation independently of i kappa b alpha degradation. |
2001-04-12 |
2023-08-12 |
human |
| B B Whitlock, S Gardai, V Fadok, D Bratton, P M Henso. Differential roles for alpha(M)beta(2) integrin clustering or activation in the control of apoptosis via regulation of akt and ERK survival mechanisms. The Journal of cell biology. vol 151. issue 6. 2001-01-17. PMID:11121444. |
differential roles for alpha(m)beta(2) integrin clustering or activation in the control of apoptosis via regulation of akt and erk survival mechanisms. |
2001-01-17 |
2023-08-12 |
Not clear |
| B B Whitlock, S Gardai, V Fadok, D Bratton, P M Henso. Differential roles for alpha(M)beta(2) integrin clustering or activation in the control of apoptosis via regulation of akt and ERK survival mechanisms. The Journal of cell biology. vol 151. issue 6. 2001-01-17. PMID:11121444. |
clustered, inactive alpha(m)beta(2) was capable of stimulating the kinases erk and akt. |
2001-01-17 |
2023-08-12 |
Not clear |
| B B Whitlock, S Gardai, V Fadok, D Bratton, P M Henso. Differential roles for alpha(M)beta(2) integrin clustering or activation in the control of apoptosis via regulation of akt and ERK survival mechanisms. The Journal of cell biology. vol 151. issue 6. 2001-01-17. PMID:11121444. |
activated alpha(m)beta(2) stimulated akt, but not erk. |
2001-01-17 |
2023-08-12 |
Not clear |
| B B Whitlock, S Gardai, V Fadok, D Bratton, P M Henso. Differential roles for alpha(M)beta(2) integrin clustering or activation in the control of apoptosis via regulation of akt and ERK survival mechanisms. The Journal of cell biology. vol 151. issue 6. 2001-01-17. PMID:11121444. |
when proapoptotic stimuli were combined with either alpha(m)beta(2) clustering or activation, akt activity was blocked, allowing integrin activation to enhance apoptosis. |
2001-01-17 |
2023-08-12 |
Not clear |
| K B Sandau, H G Faus, B Brün. Induction of hypoxia-inducible-factor 1 by nitric oxide is mediated via the PI 3K pathway. Biochemical and biophysical research communications. vol 278. issue 1. 2001-01-04. PMID:11071882. |
whereas mitogen-activated protein kinases were not involved, we noticed phosphorylation/activation of akt in correlation with hif-1 alpha stabilization. |
2001-01-04 |
2023-08-12 |
Not clear |
| B H Rauch, A Weber, M Braun, N Zimmermann, K Schrö. PDGF-induced Akt phosphorylation does not activate NF-kappa B in human vascular smooth muscle cells and fibroblasts. FEBS letters. vol 481. issue 1. 2000-10-02. PMID:10984605. |
in contrast, stimulation with pdgf resulted in a marked phosphorylation of akt, but no akt phosphorylation occurred after stimulation with tnf alpha. |
2000-10-02 |
2023-08-12 |
human |
| M E Burow, C B Weldon, L I Melnik, B N Duong, B M Collins-Burow, B S Beckman, J A McLachla. PI3-K/AKT regulation of NF-kappaB signaling events in suppression of TNF-induced apoptosis. Biochemical and biophysical research communications. vol 271. issue 2. 2000-06-13. PMID:10799299. |
we found that in mcf-7 breast carcinoma cells, pi3k and akt suppressed a dose-dependent induction of apoptosis by tumor necrosis factor alpha (tnf). |
2000-06-13 |
2023-08-12 |
Not clear |
| A Toker, A C Newto. Akt/protein kinase B is regulated by autophosphorylation at the hypothetical PDK-2 site. The Journal of biological chemistry. vol 275. issue 12. 2000-04-27. PMID:10722653. |
second, we show that akt autophosphorylates on the hydrophobic site in vitro: phosphorylation of the activation loop by pdk-1 triggers the phosphorylation of the hydrophobic site in kinase-active, but not thermally inactivated, akt alpha. |
2000-04-27 |
2023-08-12 |
Not clear |
| L M Ballou, M E Cross, S Huang, E M McReynolds, B X Zhang, R Z Li. Differential regulation of the phosphatidylinositol 3-kinase/Akt and p70 S6 kinase pathways by the alpha(1A)-adrenergic receptor in rat-1 fibroblasts. The Journal of biological chemistry. vol 275. issue 7. 2000-03-21. PMID:10671514. |
treatment of the cells with phenylephrine, a specific alpha(1)-adrenergic receptor agonist, activated p70 s6 kinase but did not activate pi 3-kinase or any of the three known isoforms of akt. |
2000-03-21 |
2023-08-12 |
human |
| Y Lu, Y Z Lin, R LaPushin, B Cuevas, X Fang, S X Yu, M A Davies, H Khan, T Furui, M Mao, R Zinner, M C Hung, P Steck, K Siminovitch, G B Mill. The PTEN/MMAC1/TEP tumor suppressor gene decreases cell growth and induces apoptosis and anoikis in breast cancer cells. Oncogene. vol 18. issue 50. 2000-01-04. PMID:10597304. |
in the presence of low concentrations of serum, enforced pten expression results in a marked increase in cellular apoptosis, a finding which is consistent with the capacity of pten to alter the phosphorylation, and presumably function, of the akt, bad, p70s6 kinase and gsk3 alpha apoptosis regulators. |
2000-01-04 |
2023-08-12 |
Not clear |
| S Kafert, S Luther, I Böll, K Wagner, A Ganser, M Ede. Functional analysis of a single chain chimeric alpha/beta-granulocyte-macrophage colony-stimulating factor receptor. Importance of a glutamate residue in the transmembrane region. The Journal of biological chemistry. vol 274. issue 46. 2000-01-03. PMID:10551876. |
to further compare the functions of wild type and chimeric receptors, we now report that this alpha/beta-gmr is sufficient to mediate morphological changes, expression of alpha(4)- and beta(1)-integrin receptor subunits, and serine-phosphorylation of akt kinase. |
2000-01-03 |
2023-08-12 |
Not clear |
| M Shaw, P Cohen, D R Aless. Further evidence that the inhibition of glycogen synthase kinase-3beta by IGF-1 is mediated by PDK1/PKB-induced phosphorylation of Ser-9 and not by dephosphorylation of Tyr-216. FEBS letters. vol 416. issue 3. 1997-12-08. PMID:9373175. |
coexpression of wt-gsk3beta in 293 cells with either pkb alpha (also known as akt) or pdk1 (the 'upstream' activator of pkb) mimicked the igf-1- or insulin-induced phosphorylation of ser-9 and inactivation of gsk3beta. |
1997-12-08 |
2023-08-12 |
Not clear |
| D R Alessi, F B Caudwell, M Andjelkovic, B A Hemmings, P Cohe. Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase-1 and p70 S6 kinase. FEBS letters. vol 399. issue 3. 1997-01-30. PMID:8985174. |
the substrate specificity of protein kinase-b alpha (pkbalpha, also known as rac kinase or akt) was investigated using synthetic peptide substrates related to the sequence surrounding the phosphorylation site on glycogen synthase kinase-3 (gsk3). |
1997-01-30 |
2023-08-12 |
Not clear |