| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Katherine Conant, Coryse St Hillaire, Hideaki Nagase, Rob Visse, Devin Gary, Norman Haughey, Carol Anderson, Jadwiga Turchan, Avindra Nat. Matrix metalloproteinase 1 interacts with neuronal integrins and stimulates dephosphorylation of Akt. The Journal of biological chemistry. vol 279. issue 9. 2004-05-03. PMID:14679206. |
moreover, mmp-1-associated dephosphorylation of akt is inhibited by a blocking antibody to the alpha(2) integrin, but not by batimastat, an inhibitor of mmp-1 enzymatic activity. |
2004-05-03 |
2023-08-12 |
human |
| Ching-Hu Chung, Wen-Bin Wu, Tur-Fu Huan. Aggretin, a snake venom-derived endothelial integrin alpha 2 beta 1 agonist, induces angiogenesis via expression of vascular endothelial growth factor. Blood. vol 103. issue 6. 2004-04-15. PMID:14630793. |
in conclusion, aggretin induces endothelial cell proliferation, migration, and angiogenesis by interacting with integrin alpha 2 beta 1 leading to activation of pi3k, akt, and erk1/2 pathways, and the increased expression of vegf may be responsible for its angiogenic activity. |
2004-04-15 |
2023-08-12 |
human |
| Jason A Gustin, Osman N Ozes, Hakan Akca, Roxana Pincheira, Lindsey D Mayo, Qiutang Li, Javier Rivera Guzman, Chandrashekhar K Korgaonkar, David B Donne. Cell type-specific expression of the IkappaB kinases determines the significance of phosphatidylinositol 3-kinase/Akt signaling to NF-kappa B activation. The Journal of biological chemistry. vol 279. issue 3. 2004-02-12. PMID:14585846. |
cells with a high proportion of ikk alpha (the ikk kinase activated by akt) to ikk beta were most sensitive to pi 3-kinase inhibitors. |
2004-02-12 |
2023-08-12 |
human |
| Vassiliki Poulaki, Constantine S Mitsiades, Ciaran McMullan, Despoina Sykoutri, Galinos Fanourakis, Vassiliki Kotoula, Sophia Tseleni-Balafouta, Demetrios A Koutras, Nicholas Mitsiade. Regulation of vascular endothelial growth factor expression by insulin-like growth factor I in thyroid carcinomas. The Journal of clinical endocrinology and metabolism. vol 88. issue 11. 2003-12-09. PMID:14602779. |
the igf-i-induced up-regulation of vegf production was associated with activation of ap-1 and hif-1 alpha and was abrogated by phosphatidylinositol 3-kinase inhibitors (wortmannin and ly294002); jun kinase inhibitor (sp600125); hif-1 alpha antisense oligonucleotide; or geldanamycin, an inhibitor of the heat shock protein 90 molecular chaperone, which regulates the three-dimensional conformation and function of igf-i-receptor and akt. |
2003-12-09 |
2023-08-12 |
Not clear |
| Nihal Kaplan-Albuquerque, Chrystelle Garat, Christina Desseva, Peter L Jones, Raphael A Nemenof. Platelet-derived growth factor-BB-mediated activation of Akt suppresses smooth muscle-specific gene expression through inhibition of mitogen-activated protein kinase and redistribution of serum response factor. The Journal of biological chemistry. vol 278. issue 41. 2003-12-02. PMID:12882977. |
expression of a gain-of-function pi3k or myristoylated akt (myr-akt) mimicked the inhibitory effect of pdgf on sm-alpha-actin and sm22 alpha expression. |
2003-12-02 |
2023-08-12 |
Not clear |
| Suzanne Kovacic, Carrie-Lynn M Soltys, Amy J Barr, Ichiro Shiojima, Kenneth Walsh, Jason R B Dyc. Akt activity negatively regulates phosphorylation of AMP-activated protein kinase in the heart. The Journal of biological chemistry. vol 278. issue 41. 2003-12-02. PMID:12890675. |
in addition, insulin caused an increase in akt phosphorylation and a decrease in ampk phosphorylation at its major regulatory site (threonine 172 of the alpha catalytic subunit). |
2003-12-02 |
2023-08-12 |
mouse |
| Yuichi Tanaka, M Veronica Gavrielides, Yasuhiro Mitsuuchi, Teruhiko Fujii, Marcelo G Kazaniet. Protein kinase C promotes apoptosis in LNCaP prostate cancer cells through activation of p38 MAPK and inhibition of the Akt survival pathway. The Journal of biological chemistry. vol 278. issue 36. 2003-10-07. PMID:12824193. |
in addition, the diacylglycerol mimetic agent hk654, which selectively stimulates pkc alpha in lncap cells, also induced the dephosphorylation of akt in lncap cells. |
2003-10-07 |
2023-08-12 |
Not clear |
| Angela M Valverde, Deborah J Burks, Isabel Fabregat, Tracey L Fisher, José Carretero, Morris F White, Manuel Benit. Molecular mechanisms of insulin resistance in IRS-2-deficient hepatocytes. Diabetes. vol 52. issue 9. 2003-10-07. PMID:12941762. |
downstream pi 3-kinase, activation of akt, glycogen synthase kinase (gsk)-3 (alpha and beta isoforms), foxo1, and atypical protein kinase c were blunted in insulin-stimulated irs-2(-/-) cells. |
2003-10-07 |
2023-08-12 |
mouse |
| Jason J Wilkes, Andrea Hevener, Jerrold Olefsk. Chronic endothelin-1 treatment leads to insulin resistance in vivo. Diabetes. vol 52. issue 8. 2003-09-15. PMID:12882904. |
with respect to insulin signaling, chronic in vivo et-1 treatment led to a 30-40% decrease in irs-i protein content, irs-i-associated p110(alpha), and akt activation. |
2003-09-15 |
2023-08-12 |
rat |
| Lisa M Ballou, Hong-Ying Lin, Gaofeng Fan, Ya-Ping Jiang, Richard Z Li. Activated G alpha q inhibits p110 alpha phosphatidylinositol 3-kinase and Akt. The Journal of biological chemistry. vol 278. issue 26. 2003-08-20. PMID:12704201. |
activated g alpha q inhibits p110 alpha phosphatidylinositol 3-kinase and akt. |
2003-08-20 |
2023-08-12 |
human |
| Marcin Kortylewski, Florian Feld, Klaus-Dieter Krüger, Gregor Bahrenberg, Richard A Roth, Hans-Georg Joost, Peter C Heinrich, Iris Behrmann, Andreas Barthe. Akt modulates STAT3-mediated gene expression through a FKHR (FOXO1a)-dependent mechanism. The Journal of biological chemistry. vol 278. issue 7. 2003-04-30. PMID:12456685. |
the transient expression of constitutively active akt inhibited the il-6-dependent activity of the alpha(2)-macroglobulin promoter in hepg2 cells, whereas expression of an inactive mutant of phosphatidylinositol-dependent kinase 1 had the opposite effect. |
2003-04-30 |
2023-08-12 |
Not clear |
| Tommaso Simoncini, Elena Rabkin, James K Lia. Molecular basis of cell membrane estrogen receptor interaction with phosphatidylinositol 3-kinase in endothelial cells. Arteriosclerosis, thrombosis, and vascular biology. vol 23. issue 2. 2003-03-14. PMID:12588759. |
by interacting with phosphatidylinositol 3-kinase (pi3k), estrogen receptor (er) alpha leads to activation of protein kinase akt and to subsequent increase in endothelial nitric oxide synthase activity. |
2003-03-14 |
2023-08-12 |
Not clear |
| Devin S Gary, Ollivier Milhavet, Simonetta Camandola, Mark P Mattso. Essential role for integrin linked kinase in Akt-mediated integrin survival signaling in hippocampal neurons. Journal of neurochemistry. vol 84. issue 4. 2003-03-05. PMID:12562530. |
activation of integrins using a peptide containing the amino acid sequence eikllis derived from the alpha chain of laminin protected hippocampal neurons from apoptosis induced by glutamate or staurosporine, and increased akt activity in a beta1 integrin-dependent manner. |
2003-03-05 |
2023-08-12 |
Not clear |
| Kip A West, John Brognard, Amy S Clark, Ilona R Linnoila, Xiaowei Yang, Sandra M Swain, Curtis Harris, Steven Belinsky, Phillip A Denni. Rapid Akt activation by nicotine and a tobacco carcinogen modulates the phenotype of normal human airway epithelial cells. The Journal of clinical investigation. vol 111. issue 1. 2003-03-03. PMID:12511591. |
activation of akt by nicotine or nnk occurred within minutes at concentrations achievable by smokers and depended upon alpha(3)-/alpha(4)-containing or alpha(7)-containing nicotinic acetylcholine receptors, respectively. |
2003-03-03 |
2023-08-12 |
mouse |
| Guoqiang Jiang, Qing Dallas-Yang, Franklin Liu, David E Moller, Bei B Zhan. Salicylic acid reverses phorbol 12-myristate-13-acetate (PMA)- and tumor necrosis factor alpha (TNFalpha)-induced insulin receptor substrate 1 (IRS1) serine 307 phosphorylation and insulin resistance in human embryonic kidney 293 (HEK293) cells. The Journal of biological chemistry. vol 278. issue 1. 2003-02-10. PMID:12409308. |
protein kinase c isoforms and tumor necrosis factor alpha (tnfalpha) signaling pathways are well described mediators of insulin resistance; they are implicated in the activation of ikkbeta and the subsequent inhibition of proximal insulin signaling via insulin receptor substrate 1 (irs1) and akt. |
2003-02-10 |
2023-08-12 |
human |
| Steven Bozinovski, Jessica E Jones, Ross Vlahos, John A Hamilton, Gary P Anderso. Granulocyte/macrophage-colony-stimulating factor (GM-CSF) regulates lung innate immunity to lipopolysaccharide through Akt/Erk activation of NFkappa B and AP-1 in vivo. The Journal of biological chemistry. vol 277. issue 45. 2003-02-06. PMID:12208854. |
we investigated the role of akt and erk1/2 as lps intensely stimulates granulocyte/macrophage-colony-stimulating factor (gm-csf) release, and neutralizing gm-csf profoundly suppressed lps-induced inflammation, suppressed expression and activity of lung proteases, significantly reduced gm-csf and tumor necrosis factor alpha (tnfalpha) mrna expression, and dampened nuclear localization of both nfkappab (p50/65) and ap-1. |
2003-02-06 |
2023-08-12 |
mouse |
| Dirk Haller, Maria P Russo, R Balfour Sartor, Christian Jobi. IKK beta and phosphatidylinositol 3-kinase/Akt participate in non-pathogenic Gram-negative enteric bacteria-induced RelA phosphorylation and NF-kappa B activation in both primary and intestinal epithelial cell lines. The Journal of biological chemistry. vol 277. issue 41. 2002-11-25. PMID:12140289. |
we report that b. vulgatus induced interleukin-1 receptor-associated kinase-1 degradation, i kappa b alpha phosphorylation/degradation, rela and akt phosphorylation, as well as nf-kappa b dna binding and nf-kappa b transcriptional activity in rat non-transformed iec-6 cells. |
2002-11-25 |
2023-08-12 |
rat |
| Fanyin Meng, Li Liu, Paul C Chin, Santosh R D'Mell. Akt is a downstream target of NF-kappa B. The Journal of biological chemistry. vol 277. issue 33. 2002-09-20. PMID:12052823. |
treatment of nih3t3 cells with the nf-kappa b activators, tumor necrosis factor (tnf) alpha and lipopolysaccharide, results in the stimulation of akt phosphorylation. |
2002-09-20 |
2023-08-12 |
Not clear |
| Len Necker. Hsp90 inhibitors as novel cancer chemotherapeutic agents. Trends in molecular medicine. vol 8. issue 4 Suppl. 2002-08-19. PMID:11927289. |
hsp90 client proteins include mutated p53, bcr-abl, raf-1, akt, erbb2 and hypoxia-inducible factor 1 alpha (hif-1 alpha). |
2002-08-19 |
2023-08-12 |
Not clear |
| Jun Chung, Robin E Bachelder, Elizabeth A Lipscomb, Leslie M Shaw, Arthur M Mercuri. Integrin (alpha 6 beta 4) regulation of eIF-4E activity and VEGF translation: a survival mechanism for carcinoma cells. The Journal of cell biology. vol 158. issue 1. 2002-08-08. PMID:12105188. |
importantly, we show that this alpha 6 beta 4-dependent regulation of vegf translation plays an important role in the survival of metastatic breast carcinoma cells by sustaining a vegf autocrine signaling pathway that involves activation of pi-3k and akt. |
2002-08-08 |
2023-08-12 |
Not clear |