| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Franck Vandermoere, Ikram El Yazidi-Belkoura, Yohann Demont, Christian Slomianny, Johann Antol, Jérôme Lemoine, Hubert Hondermarc. Proteomics exploration reveals that actin is a signaling target of the kinase Akt. Molecular & cellular proteomics : MCP. vol 6. issue 1. 2007-02-22. PMID:17088265. |
mass spectrometry analysis (maldi-tof and ms-ms) of sds-page-separated akt co-immunoprecipitates allowed the identification of 10 proteins: alpha -actinin, valosin-containing protein, inhibitor kappab kinase, mortalin, tubulin beta, cytokeratin 8, actin, 14-3-3sigma, proliferating cell nuclear antigen, and heat shock protein hsp27. |
2007-02-22 |
2023-08-12 |
Not clear |
| Jin Hee Lee, Louis Ragoli. AKT phosphorylation is essential for insulin-induced relaxation of rat vascular smooth muscle cells. American journal of physiology. Cell physiology. vol 291. issue 6. 2007-02-15. PMID:16855220. |
siaktc treatment resulted in increased insulin and ang ii-stimulated phosphorylation of contractile apparatus, such as mbp substrate (mypt1) and myosin light chain (mlc20), accompanied by increased rho-associated kinase alpha (rokalpha) activity, demonstrating the requirement of akt for insulin-induced vasorelaxation. |
2007-02-15 |
2023-08-12 |
rat |
| Chaodong Wu, Salmaan A Khan, Li-Jen Peng, Alex J Lang. Roles for fructose-2,6-bisphosphate in the control of fuel metabolism: beyond its allosteric effects on glycolytic and gluconeogenic enzymes. Advances in enzyme regulation. vol 46. 2007-01-17. PMID:16860376. |
although some effects may be secondary to changes in metabolite levels, high levels of f26p2 have been shown to regulate protein amount and/or phosphorylation state of hepatic nuclear factor 1-alpha (hnf1alpha), carbohydrate response element binding protein (chrebp), peroxisome proliferators-activated receptor alpha (pparalpha), and peroxisome proliferators-activated receptor gamma co-activator 1beta (pgc1beta), as well as akt and amp-activated protein kinase (ampk). |
2007-01-17 |
2023-08-12 |
Not clear |
| Shehla Hashim, Yuan Li, Madhu B Anand-Srivastav. Small cytoplasmic domain peptides of natriuretic peptide receptor-C attenuate cell proliferation through Gialpha protein/MAP kinase/PI3-kinase/AKT pathways. American journal of physiology. Heart and circulatory physiology. vol 291. issue 6. 2007-01-16. PMID:16920814. |
in addition, peptide 1 also inhibited vasoactive peptide-induced phosphorylation of erk1/2 and akt and enhanced expression of g(i)alpha proteins. |
2007-01-16 |
2023-08-12 |
Not clear |
| Tomohiro Kawaguchi, Yoji Yamashita, Masayuki Kanamori, Raelene Endersby, Krystof S Bankiewicz, Suzanne J Baker, Gabriele Bergers, Russell O Piepe. The PTEN/Akt pathway dictates the direct alphaVbeta3-dependent growth-inhibitory action of an active fragment of tumstatin in glioma cells in vitro and in vivo. Cancer research. vol 66. issue 23. 2007-01-10. PMID:17145879. |
the collagen type iv cleavage fragment tumstatin and its active subfragments bind to integrin alpha(v)beta(3) and inhibit activation of focal adhesion kinase, phophoinositol-3 kinase, akt, and mammalian target of rapamycin (mtor) in what is thought to be an endothelial cell-specific manner. |
2007-01-10 |
2023-08-12 |
mouse |
| Tomohiro Kawaguchi, Yoji Yamashita, Masayuki Kanamori, Raelene Endersby, Krystof S Bankiewicz, Suzanne J Baker, Gabriele Bergers, Russell O Piepe. The PTEN/Akt pathway dictates the direct alphaVbeta3-dependent growth-inhibitory action of an active fragment of tumstatin in glioma cells in vitro and in vivo. Cancer research. vol 66. issue 23. 2007-01-10. PMID:17145879. |
consistent with this idea, several integrin alpha(v)beta(3)-expressing glioma cell lines with pten mutations and high levels of phospho-akt (pakt) were unaffected by exposure to an active fragment of tumstatin (t3), whereas alpha(v)beta(3)-expressing glioma cell lines with a functional pten/low levels of pakt exhibited t3-induced growth suppression that could be bypassed by small interfering rna-mediated suppression of pten, introduction of a constitutively expressed akt, or introduction of the akt and mtor target eukaryotic translation initiation factor 4e. |
2007-01-10 |
2023-08-12 |
mouse |
| Jianfen Guo, Abdelkarim Sabri, Hasnae Elouardighi, Vitalyi Rybin, Susan F Steinber. Alpha1-adrenergic receptors activate AKT via a Pyk2/PDK-1 pathway that is tonically inhibited by novel protein kinase C isoforms in cardiomyocytes. Circulation research. vol 99. issue 12. 2007-01-05. PMID:17110596. |
akt is a potent antiapoptotic kinase, but its role in the cardioprotective actions of alpha(1)-adrenergic receptors (ars) remains uncertain, because alpha(1)-ars typically induce little-to-no akt activation in most cardiomyocyte models. |
2007-01-05 |
2023-08-12 |
rat |
| Jianfen Guo, Abdelkarim Sabri, Hasnae Elouardighi, Vitalyi Rybin, Susan F Steinber. Alpha1-adrenergic receptors activate AKT via a Pyk2/PDK-1 pathway that is tonically inhibited by novel protein kinase C isoforms in cardiomyocytes. Circulation research. vol 99. issue 12. 2007-01-05. PMID:17110596. |
this study identifies a prominent alpha(1)-ar-dependent akt activation pathway that is under tonic inhibitory control by novel protein kinase cs (npkcs) in neonatal rat cardiomyocyte cultures. |
2007-01-05 |
2023-08-12 |
rat |
| Jianfen Guo, Abdelkarim Sabri, Hasnae Elouardighi, Vitalyi Rybin, Susan F Steinber. Alpha1-adrenergic receptors activate AKT via a Pyk2/PDK-1 pathway that is tonically inhibited by novel protein kinase C isoforms in cardiomyocytes. Circulation research. vol 99. issue 12. 2007-01-05. PMID:17110596. |
we also implicate pyk2, pyk2 complex formation with pdk-1 and paxillin, and increased pdk-1-y373/376 phosphorylation as the mechanism that links alpha(1)-ar activation to increased akt phosphorylation. |
2007-01-05 |
2023-08-12 |
rat |
| Jianfen Guo, Abdelkarim Sabri, Hasnae Elouardighi, Vitalyi Rybin, Susan F Steinber. Alpha1-adrenergic receptors activate AKT via a Pyk2/PDK-1 pathway that is tonically inhibited by novel protein kinase C isoforms in cardiomyocytes. Circulation research. vol 99. issue 12. 2007-01-05. PMID:17110596. |
npkcs (which are prominent alpha(1)-ar effectors) interfere with this alpha(1)-ar-dependent akt activation by blocking pyk2/pdk-1/paxillin complex formation and pdk-1-y373/376 phosphorylation. |
2007-01-05 |
2023-08-12 |
rat |
| Jianfen Guo, Abdelkarim Sabri, Hasnae Elouardighi, Vitalyi Rybin, Susan F Steinber. Alpha1-adrenergic receptors activate AKT via a Pyk2/PDK-1 pathway that is tonically inhibited by novel protein kinase C isoforms in cardiomyocytes. Circulation research. vol 99. issue 12. 2007-01-05. PMID:17110596. |
collectively, these studies identify jnk and akt as functionally distinct downstream components of the alpha(1)-ar/pyk2 signaling pathway. |
2007-01-05 |
2023-08-12 |
rat |
| Samarjit Das, Cesar G Fraga, Dipak K Da. Cardioprotective effect of resveratrol via HO-1 expression involves p38 map kinase and PI-3-kinase signaling, but does not involve NFkappaB. Free radical research. vol 40. issue 10. 2006-11-08. PMID:17015251. |
resveratrol induced the activation of nuclear factor kappa-beta(nfkappab), the phosphorylation of p38map kinase beta and akt, as well as the inhibition of p38 map kinase alpha; all these effects but the activation of nfkappab, were completely reversed by treatment with snpp. |
2006-11-08 |
2023-08-12 |
rat |
| François Saller, Laurent Burnier, Marc Schapira, Anne Angelillo-Scherre. Role of the growth arrest-specific gene 6 (gas6) product in thrombus stabilization. Blood cells, molecules & diseases. vol 36. issue 3. 2006-11-03. PMID:16564713. |
the early release of gas6 by agonists perpetuates platelet activation through its three receptors, reinforcing outside-in alpha(iib)beta(3) signaling by activation of pi3k and akt signaling and stimulation of tyrosine phosphorylation of the beta(3) integrin. |
2006-11-03 |
2023-08-12 |
mouse |
| Richard D Patten, Richard H Kara. Estrogen replacement and cardiomyocyte protection. Trends in cardiovascular medicine. vol 16. issue 3. 2006-09-29. PMID:16546686. |
in vitro, physiologic concentrations of e(2) rapidly activated akt via estrogen receptor alpha (eralpha) and phosphoinositide-3 (pi3)-kinase-dependent mechanisms. |
2006-09-29 |
2023-08-12 |
mouse |
| Eddy H T Wu, Becky H L Tam, Yung H Won. Constitutively active alpha subunits of G(q/11) and G(12/13) families inhibit activation of the pro-survival Akt signaling cascade. The FEBS journal. vol 273. issue 11. 2006-08-23. PMID:16704413. |
constitutively active alpha subunits of g(q/11) and g(12/13) families inhibit activation of the pro-survival akt signaling cascade. |
2006-08-23 |
2023-08-12 |
human |
| Eddy H T Wu, Becky H L Tam, Yung H Won. Constitutively active alpha subunits of G(q/11) and G(12/13) families inhibit activation of the pro-survival Akt signaling cascade. The FEBS journal. vol 273. issue 11. 2006-08-23. PMID:16704413. |
in contrast, basal akt phosphorylation was unaffected by the overexpression of a constitutively active g alpha(s) mutant (g alpha(s)ql). |
2006-08-23 |
2023-08-12 |
human |
| Anne-Maj Samuelsson, Entela Bollano, Reza Mobini, Britt-Mari Larsson, Elmir Omerovic, Michael Fu, Finn Waagstein, Agneta Holmän. Hyperinsulinemia: effect on cardiac mass/function, angiotensin II receptor expression, and insulin signaling pathways. American journal of physiology. Heart and circulatory physiology. vol 291. issue 2. 2006-08-18. PMID:16565309. |
we also characterized insulin signaling pathways believed to promote myocyte growth and interact with proliferative responses mediated by g protein-coupled receptors, and we assessed myocardial insulin receptor substrate-1 (irs-1) and p110 alpha catalytic and p85 regulatory subunits of phospatidylinositol 3 kinase (pi3k), akt, mek, erk1/2, and s6 kinase-1 (s6k1). |
2006-08-18 |
2023-08-12 |
rat |
| Anne-Maj Samuelsson, Entela Bollano, Reza Mobini, Britt-Mari Larsson, Elmir Omerovic, Michael Fu, Finn Waagstein, Agneta Holmän. Hyperinsulinemia: effect on cardiac mass/function, angiotensin II receptor expression, and insulin signaling pathways. American journal of physiology. Heart and circulatory physiology. vol 291. issue 2. 2006-08-18. PMID:16565309. |
insulin decreased at1a-r mrna expression but increased protein levels and increased at2-r mrna and protein levels and phosphorylation of irs-1 (ser374/tyr989), mek1/2 (ser218/ser222), erk1/2 (thr202/tyr204), s6k1 (thr421/ser424/thr389), akt (thr308/thr308), and pi3k p110 alpha but not of p85 (tyr508). |
2006-08-18 |
2023-08-12 |
rat |
| Meng-Ru Shen, Yueh-Mei Hsu, Keng-Fu Hsu, Yih-Fung Chen, Ming-Jer Tang, Cheng-Yang Cho. Insulin-like growth factor 1 is a potent stimulator of cervical cancer cell invasiveness and proliferation that is modulated by alphavbeta3 integrin signaling. Carcinogenesis. vol 27. issue 5. 2006-07-31. PMID:16400188. |
the modulation of alpha(v)beta3 occupancy also affected the activation of igf-1r downstream-signaling elements, including activation of akt and extracellular signal-regulated protein kinases 1/2 (erk1/2). |
2006-07-31 |
2023-08-12 |
mouse |
| Meng-Ru Shen, Yueh-Mei Hsu, Keng-Fu Hsu, Yih-Fung Chen, Ming-Jer Tang, Cheng-Yang Cho. Insulin-like growth factor 1 is a potent stimulator of cervical cancer cell invasiveness and proliferation that is modulated by alphavbeta3 integrin signaling. Carcinogenesis. vol 27. issue 5. 2006-07-31. PMID:16400188. |
immunoblots of tumor tissues confirmed that the phosphorylation of igf-1r and downstream targets of akt and erk1/2 were remarkably decreased in scid mice treated with blocking antibodies of alpha(v)beta3 or igf-1r. |
2006-07-31 |
2023-08-12 |
mouse |