| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| b' M Kostrouchov\\xc3\\xa1, Z Kostrouch, M Kostrouchov\\xc3\\xa. Valproic acid, a molecular lead to multiple regulatory pathways. Folia biologica. vol 53. issue 2. 2007-05-23. PMID:17448293.' |
focused studies uncovered the potential of valproic acid to interfere with multiple regulatory mechanisms including histone deacetylases, gsk3 alpha and beta, akt, the erk pathway, the phosphoinositol pathway, the tricarboxylic acid cycle, gaba, and the oxphos system. |
2007-05-23 |
2023-08-12 |
Not clear |
| Franck Vandermoere, Ikram El Yazidi-Belkoura, Yohann Demont, Christian Slomianny, Johann Antol, Jérôme Lemoine, Hubert Hondermarc. Proteomics exploration reveals that actin is a signaling target of the kinase Akt. Molecular & cellular proteomics : MCP. vol 6. issue 1. 2007-02-22. PMID:17088265. |
mass spectrometry analysis (maldi-tof and ms-ms) of sds-page-separated akt co-immunoprecipitates allowed the identification of 10 proteins: alpha -actinin, valosin-containing protein, inhibitor kappab kinase, mortalin, tubulin beta, cytokeratin 8, actin, 14-3-3sigma, proliferating cell nuclear antigen, and heat shock protein hsp27. |
2007-02-22 |
2023-08-12 |
Not clear |
| Jin Hee Lee, Louis Ragoli. AKT phosphorylation is essential for insulin-induced relaxation of rat vascular smooth muscle cells. American journal of physiology. Cell physiology. vol 291. issue 6. 2007-02-15. PMID:16855220. |
siaktc treatment resulted in increased insulin and ang ii-stimulated phosphorylation of contractile apparatus, such as mbp substrate (mypt1) and myosin light chain (mlc20), accompanied by increased rho-associated kinase alpha (rokalpha) activity, demonstrating the requirement of akt for insulin-induced vasorelaxation. |
2007-02-15 |
2023-08-12 |
rat |
| Chaodong Wu, Salmaan A Khan, Li-Jen Peng, Alex J Lang. Roles for fructose-2,6-bisphosphate in the control of fuel metabolism: beyond its allosteric effects on glycolytic and gluconeogenic enzymes. Advances in enzyme regulation. vol 46. 2007-01-17. PMID:16860376. |
although some effects may be secondary to changes in metabolite levels, high levels of f26p2 have been shown to regulate protein amount and/or phosphorylation state of hepatic nuclear factor 1-alpha (hnf1alpha), carbohydrate response element binding protein (chrebp), peroxisome proliferators-activated receptor alpha (pparalpha), and peroxisome proliferators-activated receptor gamma co-activator 1beta (pgc1beta), as well as akt and amp-activated protein kinase (ampk). |
2007-01-17 |
2023-08-12 |
Not clear |
| Shehla Hashim, Yuan Li, Madhu B Anand-Srivastav. Small cytoplasmic domain peptides of natriuretic peptide receptor-C attenuate cell proliferation through Gialpha protein/MAP kinase/PI3-kinase/AKT pathways. American journal of physiology. Heart and circulatory physiology. vol 291. issue 6. 2007-01-16. PMID:16920814. |
in addition, peptide 1 also inhibited vasoactive peptide-induced phosphorylation of erk1/2 and akt and enhanced expression of g(i)alpha proteins. |
2007-01-16 |
2023-08-12 |
Not clear |
| Tomohiro Kawaguchi, Yoji Yamashita, Masayuki Kanamori, Raelene Endersby, Krystof S Bankiewicz, Suzanne J Baker, Gabriele Bergers, Russell O Piepe. The PTEN/Akt pathway dictates the direct alphaVbeta3-dependent growth-inhibitory action of an active fragment of tumstatin in glioma cells in vitro and in vivo. Cancer research. vol 66. issue 23. 2007-01-10. PMID:17145879. |
the collagen type iv cleavage fragment tumstatin and its active subfragments bind to integrin alpha(v)beta(3) and inhibit activation of focal adhesion kinase, phophoinositol-3 kinase, akt, and mammalian target of rapamycin (mtor) in what is thought to be an endothelial cell-specific manner. |
2007-01-10 |
2023-08-12 |
mouse |
| Tomohiro Kawaguchi, Yoji Yamashita, Masayuki Kanamori, Raelene Endersby, Krystof S Bankiewicz, Suzanne J Baker, Gabriele Bergers, Russell O Piepe. The PTEN/Akt pathway dictates the direct alphaVbeta3-dependent growth-inhibitory action of an active fragment of tumstatin in glioma cells in vitro and in vivo. Cancer research. vol 66. issue 23. 2007-01-10. PMID:17145879. |
consistent with this idea, several integrin alpha(v)beta(3)-expressing glioma cell lines with pten mutations and high levels of phospho-akt (pakt) were unaffected by exposure to an active fragment of tumstatin (t3), whereas alpha(v)beta(3)-expressing glioma cell lines with a functional pten/low levels of pakt exhibited t3-induced growth suppression that could be bypassed by small interfering rna-mediated suppression of pten, introduction of a constitutively expressed akt, or introduction of the akt and mtor target eukaryotic translation initiation factor 4e. |
2007-01-10 |
2023-08-12 |
mouse |
| Jianfen Guo, Abdelkarim Sabri, Hasnae Elouardighi, Vitalyi Rybin, Susan F Steinber. Alpha1-adrenergic receptors activate AKT via a Pyk2/PDK-1 pathway that is tonically inhibited by novel protein kinase C isoforms in cardiomyocytes. Circulation research. vol 99. issue 12. 2007-01-05. PMID:17110596. |
akt is a potent antiapoptotic kinase, but its role in the cardioprotective actions of alpha(1)-adrenergic receptors (ars) remains uncertain, because alpha(1)-ars typically induce little-to-no akt activation in most cardiomyocyte models. |
2007-01-05 |
2023-08-12 |
rat |
| Jianfen Guo, Abdelkarim Sabri, Hasnae Elouardighi, Vitalyi Rybin, Susan F Steinber. Alpha1-adrenergic receptors activate AKT via a Pyk2/PDK-1 pathway that is tonically inhibited by novel protein kinase C isoforms in cardiomyocytes. Circulation research. vol 99. issue 12. 2007-01-05. PMID:17110596. |
this study identifies a prominent alpha(1)-ar-dependent akt activation pathway that is under tonic inhibitory control by novel protein kinase cs (npkcs) in neonatal rat cardiomyocyte cultures. |
2007-01-05 |
2023-08-12 |
rat |
| Jianfen Guo, Abdelkarim Sabri, Hasnae Elouardighi, Vitalyi Rybin, Susan F Steinber. Alpha1-adrenergic receptors activate AKT via a Pyk2/PDK-1 pathway that is tonically inhibited by novel protein kinase C isoforms in cardiomyocytes. Circulation research. vol 99. issue 12. 2007-01-05. PMID:17110596. |
we also implicate pyk2, pyk2 complex formation with pdk-1 and paxillin, and increased pdk-1-y373/376 phosphorylation as the mechanism that links alpha(1)-ar activation to increased akt phosphorylation. |
2007-01-05 |
2023-08-12 |
rat |
| Jianfen Guo, Abdelkarim Sabri, Hasnae Elouardighi, Vitalyi Rybin, Susan F Steinber. Alpha1-adrenergic receptors activate AKT via a Pyk2/PDK-1 pathway that is tonically inhibited by novel protein kinase C isoforms in cardiomyocytes. Circulation research. vol 99. issue 12. 2007-01-05. PMID:17110596. |
npkcs (which are prominent alpha(1)-ar effectors) interfere with this alpha(1)-ar-dependent akt activation by blocking pyk2/pdk-1/paxillin complex formation and pdk-1-y373/376 phosphorylation. |
2007-01-05 |
2023-08-12 |
rat |
| Jianfen Guo, Abdelkarim Sabri, Hasnae Elouardighi, Vitalyi Rybin, Susan F Steinber. Alpha1-adrenergic receptors activate AKT via a Pyk2/PDK-1 pathway that is tonically inhibited by novel protein kinase C isoforms in cardiomyocytes. Circulation research. vol 99. issue 12. 2007-01-05. PMID:17110596. |
collectively, these studies identify jnk and akt as functionally distinct downstream components of the alpha(1)-ar/pyk2 signaling pathway. |
2007-01-05 |
2023-08-12 |
rat |
| Samarjit Das, Cesar G Fraga, Dipak K Da. Cardioprotective effect of resveratrol via HO-1 expression involves p38 map kinase and PI-3-kinase signaling, but does not involve NFkappaB. Free radical research. vol 40. issue 10. 2006-11-08. PMID:17015251. |
resveratrol induced the activation of nuclear factor kappa-beta(nfkappab), the phosphorylation of p38map kinase beta and akt, as well as the inhibition of p38 map kinase alpha; all these effects but the activation of nfkappab, were completely reversed by treatment with snpp. |
2006-11-08 |
2023-08-12 |
rat |
| François Saller, Laurent Burnier, Marc Schapira, Anne Angelillo-Scherre. Role of the growth arrest-specific gene 6 (gas6) product in thrombus stabilization. Blood cells, molecules & diseases. vol 36. issue 3. 2006-11-03. PMID:16564713. |
the early release of gas6 by agonists perpetuates platelet activation through its three receptors, reinforcing outside-in alpha(iib)beta(3) signaling by activation of pi3k and akt signaling and stimulation of tyrosine phosphorylation of the beta(3) integrin. |
2006-11-03 |
2023-08-12 |
mouse |
| Richard D Patten, Richard H Kara. Estrogen replacement and cardiomyocyte protection. Trends in cardiovascular medicine. vol 16. issue 3. 2006-09-29. PMID:16546686. |
in vitro, physiologic concentrations of e(2) rapidly activated akt via estrogen receptor alpha (eralpha) and phosphoinositide-3 (pi3)-kinase-dependent mechanisms. |
2006-09-29 |
2023-08-12 |
mouse |
| Eddy H T Wu, Becky H L Tam, Yung H Won. Constitutively active alpha subunits of G(q/11) and G(12/13) families inhibit activation of the pro-survival Akt signaling cascade. The FEBS journal. vol 273. issue 11. 2006-08-23. PMID:16704413. |
constitutively active alpha subunits of g(q/11) and g(12/13) families inhibit activation of the pro-survival akt signaling cascade. |
2006-08-23 |
2023-08-12 |
human |
| Eddy H T Wu, Becky H L Tam, Yung H Won. Constitutively active alpha subunits of G(q/11) and G(12/13) families inhibit activation of the pro-survival Akt signaling cascade. The FEBS journal. vol 273. issue 11. 2006-08-23. PMID:16704413. |
in contrast, basal akt phosphorylation was unaffected by the overexpression of a constitutively active g alpha(s) mutant (g alpha(s)ql). |
2006-08-23 |
2023-08-12 |
human |
| Anne-Maj Samuelsson, Entela Bollano, Reza Mobini, Britt-Mari Larsson, Elmir Omerovic, Michael Fu, Finn Waagstein, Agneta Holmän. Hyperinsulinemia: effect on cardiac mass/function, angiotensin II receptor expression, and insulin signaling pathways. American journal of physiology. Heart and circulatory physiology. vol 291. issue 2. 2006-08-18. PMID:16565309. |
we also characterized insulin signaling pathways believed to promote myocyte growth and interact with proliferative responses mediated by g protein-coupled receptors, and we assessed myocardial insulin receptor substrate-1 (irs-1) and p110 alpha catalytic and p85 regulatory subunits of phospatidylinositol 3 kinase (pi3k), akt, mek, erk1/2, and s6 kinase-1 (s6k1). |
2006-08-18 |
2023-08-12 |
rat |
| Anne-Maj Samuelsson, Entela Bollano, Reza Mobini, Britt-Mari Larsson, Elmir Omerovic, Michael Fu, Finn Waagstein, Agneta Holmän. Hyperinsulinemia: effect on cardiac mass/function, angiotensin II receptor expression, and insulin signaling pathways. American journal of physiology. Heart and circulatory physiology. vol 291. issue 2. 2006-08-18. PMID:16565309. |
insulin decreased at1a-r mrna expression but increased protein levels and increased at2-r mrna and protein levels and phosphorylation of irs-1 (ser374/tyr989), mek1/2 (ser218/ser222), erk1/2 (thr202/tyr204), s6k1 (thr421/ser424/thr389), akt (thr308/thr308), and pi3k p110 alpha but not of p85 (tyr508). |
2006-08-18 |
2023-08-12 |
rat |
| Meng-Ru Shen, Yueh-Mei Hsu, Keng-Fu Hsu, Yih-Fung Chen, Ming-Jer Tang, Cheng-Yang Cho. Insulin-like growth factor 1 is a potent stimulator of cervical cancer cell invasiveness and proliferation that is modulated by alphavbeta3 integrin signaling. Carcinogenesis. vol 27. issue 5. 2006-07-31. PMID:16400188. |
the modulation of alpha(v)beta3 occupancy also affected the activation of igf-1r downstream-signaling elements, including activation of akt and extracellular signal-regulated protein kinases 1/2 (erk1/2). |
2006-07-31 |
2023-08-12 |
mouse |