| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Laurent Loufrani, Kevin Retailleau, Arnaud Bocquet, Odile Dumont, Kerstin Danker, Huguette Louis, Patrick Lacolley, Daniel Henrio. Key role of alpha(1)beta(1)-integrin in the activation of PI3-kinase-Akt by flow (shear stress) in resistance arteries. American journal of physiology. Heart and circulatory physiology. vol 294. issue 4. 2008-05-29. PMID:18245559. |
in mra phosphorylated akt and phosphatidylinositol 3-kinase (pi3-kinase) were significantly lower in alpha(1)(-/-) mice than in alpha(1)(+/+) mice, although total akt and endothelial nitric oxide synthase (enos) were not affected. |
2008-05-29 |
2023-08-12 |
mouse |
| Laurent Loufrani, Kevin Retailleau, Arnaud Bocquet, Odile Dumont, Kerstin Danker, Huguette Louis, Patrick Lacolley, Daniel Henrio. Key role of alpha(1)beta(1)-integrin in the activation of PI3-kinase-Akt by flow (shear stress) in resistance arteries. American journal of physiology. Heart and circulatory physiology. vol 294. issue 4. 2008-05-29. PMID:18245559. |
thus alpha(1)-integrin has a key role in flow (shear stress)-dependent vasodilation in resistance arteries by transmitting the signal to enos through activation of pi3-kinase and akt. |
2008-05-29 |
2023-08-12 |
mouse |
| Martín A Rivas, Romina P Carnevale, Cecilia J Proietti, Cinthia Rosemblit, Wendy Beguelin, Mariana Salatino, Eduardo H Charreau, Isabel Frahm, Sandra Sapia, Peter Brouckaert, Patricia V Elizalde, Roxana Schillac. TNF alpha acting on TNFR1 promotes breast cancer growth via p42/P44 MAPK, JNK, Akt and NF-kappa B-dependent pathways. Experimental cell research. vol 314. issue 3. 2008-04-14. PMID:18061162. |
tnf alpha acting on tnfr1 promotes breast cancer growth via p42/p44 mapk, jnk, akt and nf-kappa b-dependent pathways. |
2008-04-14 |
2023-08-12 |
human |
| Minghua Wu, Qiong Chen, Dan Li, Xiaoling Li, Xiayu Li, Chen Huang, Yunlian Tang, Yanhong Zhou, Di Wang, Ke Tang, Li Cao, Shourong Shen, Guiyuan L. LRRC4 inhibits human glioblastoma cells proliferation, invasion, and proMMP-2 activation by reducing SDF-1 alpha/CXCR4-mediated ERK1/2 and Akt signaling pathways. Journal of cellular biochemistry. vol 103. issue 1. 2008-02-29. PMID:17549698. |
in the present study, we demonstrate that cxc chemokine receptor 4 (cxcr4) is expressed in human glioblastoma u251 cell line, and that sdf-1 alpha increases the proliferation, chemotaxis, and invasion in cxcr4+ glioblastoma u251 cells through the activation of erk1/2 and akt. |
2008-02-29 |
2023-08-12 |
human |
| Bénédicte Buffin-Meyer, Pierre-Antoine Crassous, Christine Delage, Colette Denis, Stéphane Schaak, Hervé Pari. EGF receptor transactivation and PI3-kinase mediate stimulation of ERK by alpha(2A)-adrenoreceptor in intestinal epithelial cells: a role in wound healing. European journal of pharmacology. vol 574. issue 2-3. 2008-01-17. PMID:17655843. |
treatment of caco2-3b with the alpha(2)-adrenoreceptor agonist 5-bromo-6-(2-imidazolin-2-ylamino) quinoxaline (uk14304) induces not only erk, but also akt phosphorylation. |
2008-01-17 |
2023-08-12 |
human |
| Bénédicte Buffin-Meyer, Pierre-Antoine Crassous, Christine Delage, Colette Denis, Stéphane Schaak, Hervé Pari. EGF receptor transactivation and PI3-kinase mediate stimulation of ERK by alpha(2A)-adrenoreceptor in intestinal epithelial cells: a role in wound healing. European journal of pharmacology. vol 574. issue 2-3. 2008-01-17. PMID:17655843. |
in conclusion, alpha(2a)-adrenoreceptor activates erk and akt in intestinal cells by a common pathway which depends on pi3-kinase activation and results from egf receptor transactivation, via an autocrine/paracrine pathway implying mmp activation and heparin-binding-egf shedding. |
2008-01-17 |
2023-08-12 |
human |
| Li Cong, Jessica Gasser, Jessica Zhao, Baofeng Yang, Fanghong Li, Allan Z Zha. Human adiponectin inhibits cell growth and induces apoptosis in human endometrial carcinoma cells, HEC-1-A and RL95 2. Endocrine-related cancer. vol 14. issue 3. 2008-01-15. PMID:17914101. |
although adiponectin treatment markedly increases the phosphorylation (thr172) of amp-activated protein kinase alpha in both hec-1-a and rl95-2 within 30 min, prolonged exposure (48 h) leads to inactivation of akt as well as reduction of cyclin d1 protein expression in hec-1-a cells. |
2008-01-15 |
2023-08-12 |
human |
| Tomohiro Okunaga, Yoshishige Urata, Shinji Goto, Takayuki Matsuo, Shingo Mizota, Keisuke Tsutsumi, Izumi Nagata, Takahito Kondo, Yoshito Ihar. Calreticulin, a molecular chaperone in the endoplasmic reticulum, modulates radiosensitivity of human glioblastoma U251MG cells. Cancer research. vol 66. issue 17. 2007-11-26. PMID:16951181. |
furthermore, the gene expression of protein phosphatase 2ac alpha (pp2ac alpha), which is responsible for the dephosphorylation and inactivation of akt, was up-regulated in crt-overexpressing cells, and the regulation was dependent on ca(2+). |
2007-11-26 |
2023-08-12 |
human |
| Tomohiro Okunaga, Yoshishige Urata, Shinji Goto, Takayuki Matsuo, Shingo Mizota, Keisuke Tsutsumi, Izumi Nagata, Takahito Kondo, Yoshito Ihar. Calreticulin, a molecular chaperone in the endoplasmic reticulum, modulates radiosensitivity of human glioblastoma U251MG cells. Cancer research. vol 66. issue 17. 2007-11-26. PMID:16951181. |
thus, overexpression of crt modulates radiation-induced apoptosis by suppressing akt signaling through the up-regulation of pp2ac alpha expression via altered ca(2+) homeostasis. |
2007-11-26 |
2023-08-12 |
human |
| John J Dube, Bankim A Bhatt, Nikolas Dedousis, Arend Bonen, Robert M O'Dohert. Leptin, skeletal muscle lipids, and lipid-induced insulin resistance. American journal of physiology. Regulatory, integrative and comparative physiology. vol 293. issue 2. 2007-10-10. PMID:17491114. |
compared with controls (cont), hl increased insulin sensitivity, as assessed by hyperinsulinemic-euglycemic clamp ( approximately 15%), and increased skm akt ( approximately 30%) and glycogen synthase kinase 3 alpha ( approximately 52%) phosphorylation. |
2007-10-10 |
2023-08-12 |
rat |
| Anwesha Dey, E T Wong, P Bist, V Tergaonkar, David P Lan. Nutlin-3 inhibits the NFkappaB pathway in a p53-dependent manner: implications in lung cancer therapy. Cell cycle (Georgetown, Tex.). vol 6. issue 17. 2007-10-04. PMID:17786042. |
nutlin-3 does not inhibit akt phosphorylation, ikappab alpha phosphorylation, ikappab alpha degradation, p65 modification or p65 dna binding in the cell lines tested. |
2007-10-04 |
2023-08-12 |
Not clear |
| Georgios Giamas, Heidrun Hirner, Levani Shoshiashvili, Arnhild Grothey, Susanne Gessert, Michael Kühl, Doris Henne-Bruns, Constantinos E Vorgias, Uwe Knippschil. Phosphorylation of CK1delta: identification of Ser370 as the major phosphorylation site targeted by PKA in vitro and in vivo. The Biochemical journal. vol 406. issue 3. 2007-10-02. PMID:17594292. |
in the present study, we show that pka (camp-dependent protein kinase), akt (protein kinase b), clk2 (cdc-like kinase 2) and pkc (protein kinase c) alpha all phosphorylate ck1delta. |
2007-10-02 |
2023-08-12 |
xenopus_laevis |
| Yoon-Jung Jang, Dong Seok Kim, Ok-Hee Jeon, Doo-Sik Ki. Saxatilin suppresses tumor-induced angiogenesis by regulating VEGF expression in NCI-H460 human lung cancer cells. Journal of biochemistry and molecular biology. vol 40. issue 3. 2007-09-25. PMID:17562297. |
further experimental evidence indicated that saxatilin inhibits vegf production in nci-h460 cells by affecting hypoxia induced factor-1 alpha (hif-1 alpha) expression via the akt pathway. |
2007-09-25 |
2023-08-12 |
human |
| Oona Delpuech, Beatrice Griffiths, Philip East, Abdelkader Essafi, Eric W-F Lam, Boudewijn Burgering, Julian Downward, Almut Schulz. Induction of Mxi1-SR alpha by FOXO3a contributes to repression of Myc-dependent gene expression. Molecular and cellular biology. vol 27. issue 13. 2007-08-09. PMID:17452451. |
activation of foxo3a in response to inhibition of akt also resulted in activation of mxi1-sr alpha expression. |
2007-08-09 |
2023-08-12 |
Not clear |
| Han C Dan, Mazhar Adli, Albert S Baldwi. Regulation of mammalian target of rapamycin activity in PTEN-inactive prostate cancer cells by I kappa B kinase alpha. Cancer research. vol 67. issue 13. 2007-07-27. PMID:17616684. |
the results indicate a novel role for ikk alpha in controlling mtor function in cancer cells with constitutive akt activity. |
2007-07-27 |
2023-08-12 |
Not clear |
| Mi-Sung Kim, Sang Min Lee, Won Dong Kim, Sung Hwan Ki, Aree Moon, Chang Ho Lee, Sang Geon Ki. G alpha 12/13 basally regulates p53 through Mdm4 expression. Molecular cancer research : MCR. vol 5. issue 5. 2007-06-29. PMID:17510313. |
erk1/2 or akt was not responsible for p53 repression due to g alpha(12) deficiency. |
2007-06-29 |
2023-08-12 |
Not clear |
| Yorihisha Imanishi, Bo Hu, Michael J Jarzynka, Ping Guo, Esther Elishaev, Ifat Bar-Joseph, Shi-Yuan Chen. Angiopoietin-2 stimulates breast cancer metastasis through the alpha(5)beta(1) integrin-mediated pathway. Cancer research. vol 67. issue 9. 2007-06-18. PMID:17483337. |
inhibition of ilk and the alpha(5)beta(1) integrin abrogates ang2 modulation of akt, gsk-3beta, snail, and e-cadherin and ang2-stimulated breast cancer cell migration and invasion. |
2007-06-18 |
2023-08-12 |
human |
| Chiaki Kitamura, Tatsuji Nishihara, Yoshiko Ueno, Ker-Kong Chen, Takahiko Morotomi, Junya Yano, Masato Nagayoshi, Masamichi Terashit. Effects of sequential exposure to lipopolysaccharide and heat stress on dental pulp cells. Journal of cellular biochemistry. vol 99. issue 3. 2007-06-11. PMID:16676349. |
these results suggest that lps has the unique effects on the cytoprotection and the cell death of pulp cells during heat stress through the modification and the activation of heat stress responsive molecules, hsf1 and hsp27, and cell survival molecules, akt and nf-kappab/ikappab alpha. |
2007-06-11 |
2023-08-12 |
Not clear |
| P Baril, R Gangeswaran, P C Mahon, K Caulee, H M Kocher, T Harada, M Zhu, H Kalthoff, T Crnogorac-Jurcevic, N R Lemoin. Periostin promotes invasiveness and resistance of pancreatic cancer cells to hypoxia-induced cell death: role of the beta4 integrin and the PI3k pathway. Oncogene. vol 26. issue 14. 2007-05-23. PMID:17043657. |
at the molecular level, we provide evidence that the alpha(6)beta(4) integrin complex acts as the cell receptor of periostin in pancreatic cancer cells and that interaction promotes phosphorylation of focal adhesion kinase (fak) and protein kinase b (akt) though activation of the pi3 kinase pathway, but not the ras/mek/erk pathway. |
2007-05-23 |
2023-08-12 |
Not clear |
| b' M Kostrouchov\\xc3\\xa1, Z Kostrouch, M Kostrouchov\\xc3\\xa. Valproic acid, a molecular lead to multiple regulatory pathways. Folia biologica. vol 53. issue 2. 2007-05-23. PMID:17448293.' |
focused studies uncovered the potential of valproic acid to interfere with multiple regulatory mechanisms including histone deacetylases, gsk3 alpha and beta, akt, the erk pathway, the phosphoinositol pathway, the tricarboxylic acid cycle, gaba, and the oxphos system. |
2007-05-23 |
2023-08-12 |
Not clear |