| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Long Chen, Baoshan Xu, Lei Liu, Yan Luo, Jun Yin, Hongyu Zhou, Wenxing Chen, Tao Shen, Xiuzhen Han, Shile Huan. Hydrogen peroxide inhibits mTOR signaling by activation of AMPKalpha leading to apoptosis of neuronal cells. Laboratory investigation; a journal of technical methods and pathology. vol 90. issue 5. 2010-06-07. PMID:20142804. |
furthermore, we identified that h(2)o(2) induction of ros inhibited the upstream kinases, akt and phosphoinositide-dependent kinase 1 (pdk1), but not the type i insulin-like growth factor receptor (igfr), and activated the negative regulator, amp-activated protein kinase alpha (ampkalpha), but not the phosphatase and tensin homolog (pten) in the cells. |
2010-06-07 |
2023-08-12 |
Not clear |
| Ruyue Ji, Chih-Ling Chou, Wei Xu, Xiao-Bo Chen, David F Woodward, John W Rega. EP1 prostanoid receptor coupling to G i/o up-regulates the expression of hypoxia-inducible factor-1 alpha through activation of a phosphoinositide-3 kinase signaling pathway. Molecular pharmacology. vol 77. issue 6. 2010-06-01. PMID:20335389. |
this up-regulation of hif-1 alpha occurs under normoxic conditions and could be inhibited with wortmannin, akt inhibitor, and rapamycin, consistent with the activation of a phosphoinositide-3 kinase/akt/mammalian target of rapamycin (mtor) signaling pathway, respectively. |
2010-06-01 |
2023-08-12 |
human |
| Mikel Garcia-Marcos, Pradipta Ghosh, Jason Ear, Marilyn G Farquha. A structural determinant that renders G alpha(i) sensitive to activation by GIV/girdin is required to promote cell migration. The Journal of biological chemistry. vol 285. issue 17. 2010-05-20. PMID:20157114. |
moreover, when mutant g alpha(i3) w258f was expressed in hela cells they failed to undergo cell migration and to enhance akt signaling after growth factor or g protein-coupled receptor stimulation. |
2010-05-20 |
2023-08-12 |
Not clear |
| Ji Yeon Lee, Yong Gyu Lee, Jaehwi Lee, Keum-Jin Yang, Ae Ra Kim, Joo Young Kim, Moo-Ho Won, Jongsun Park, Byong Chul Yoo, Sanghee Kim, Won-Jea Cho, Jae Youl Ch. Akt Cys-310-targeted inhibition by hydroxylated benzene derivatives is tightly linked to their immunosuppressive effects. The Journal of biological chemistry. vol 285. issue 13. 2010-04-26. PMID:20054000. |
hq inhibition was mediated by blocking nf-kappab activation via suppression of its translocation pathway, which is composed of akt, i kappab alpha kinase beta, and i kappab alpha. |
2010-04-26 |
2023-08-12 |
Not clear |
| Victor May, Eve Lutz, Christopher MacKenzie, Kristin C Schutz, Kate Dozark, Karen M Braa. Pituitary adenylate cyclase-activating polypeptide (PACAP)/PAC1HOP1 receptor activation coordinates multiple neurotrophic signaling pathways: Akt activation through phosphatidylinositol 3-kinase gamma and vesicle endocytosis for neuronal survival. The Journal of biological chemistry. vol 285. issue 13. 2010-04-26. PMID:20093365. |
from inhibitor and immunoprecipitation analyses, the pacap/pac(1)hop1 receptor-mediated akt responses did not represent transactivation mechanisms but appeared to depend on g alpha(q)/phosphatidylinositol 3-kinase gamma activity and vesicular internalization pathways. |
2010-04-26 |
2023-08-12 |
Not clear |
| Andrew Sunters, Victoria J Armstrong, Gul Zaman, Robert M Kypta, Yoshiaki Kawano, Lance E Lanyon, Joanna S Pric. Mechano-transduction in osteoblastic cells involves strain-regulated estrogen receptor alpha-mediated control of insulin-like growth factor (IGF) I receptor sensitivity to Ambient IGF, leading to phosphatidylinositol 3-kinase/AKT-dependent Wnt/LRP5 receptor-independent activation of beta-catenin signaling. The Journal of biological chemistry. vol 285. issue 12. 2010-04-12. PMID:20042609. |
strain-related igf-ir activation of akt requires estrogen receptor alpha (eralpha) with which igf-1r physically associates. |
2010-04-12 |
2023-08-12 |
mouse |
| Gali Umscheif, Gali Umschwief, Na'ama A Shein, Alexander G Alexandrovich, Victoria Trembovler, Michal Horowitz, Esther Shoham. Heat acclimation provides sustained improvement in functional recovery and attenuates apoptosis after traumatic brain injury. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 30. issue 3. 2010-04-02. PMID:19904288. |
taken together with our previous reports, indicating increased akt phosphorylation and antioxidative capacity, alongside with reduced tumor necrosis alpha levels after tbi in ha animals, the current results support the involvement of an antiapoptotic effect in ha-induced neuroprotection. |
2010-04-02 |
2023-08-12 |
mouse |
| Narayanan Krishnaswamy, Nicolas Lacroix-Pepin, Pierre Chapdelaine, Hiroaki Taniguchi, Gilles Kauffenstein, Arpita Chakravarti, Ghislain Danyod, Michel A Fortie. Epidermal growth factor receptor is an obligatory intermediate for oxytocin-induced cyclooxygenase 2 expression and prostaglandin F2 alpha production in bovine endometrial epithelial cells. Endocrinology. vol 151. issue 3. 2010-03-26. PMID:20080869. |
because of the importance of receptor and nonreceptor tyrosine kinases in g protein-coupled receptor signaling, we studied the role of epidermal growth factor receptor (egfr), c-src, and phosphoinositide 3-kinase (pi3k) on ot-induced pgf(2 alpha) production in association with cyclooxygenase 2 (cox2) expression and erk1/2 and akt phosphorylation. |
2010-03-26 |
2023-08-12 |
cattle |
| Narayanan Krishnaswamy, Nicolas Lacroix-Pepin, Pierre Chapdelaine, Hiroaki Taniguchi, Gilles Kauffenstein, Arpita Chakravarti, Ghislain Danyod, Michel A Fortie. Epidermal growth factor receptor is an obligatory intermediate for oxytocin-induced cyclooxygenase 2 expression and prostaglandin F2 alpha production in bovine endometrial epithelial cells. Endocrinology. vol 151. issue 3. 2010-03-26. PMID:20080869. |
because ly294002 did not affect erk1/2 phosphorylation, but inhibited pgf(2 alpha) production and down-regulated cox2 expression, it is likely that the akt pathway is also involved in pgf(2 alpha) production. |
2010-03-26 |
2023-08-12 |
cattle |
| Federica Perrone, Luca Da Riva, Marta Orsenigo, Marco Losa, Genny Jocollè, Clara Millefanti, Elisa Pastore, Alessandro Gronchi, Marco Alessandro Pierotti, Silvana Pilott. PDGFRA, PDGFRB, EGFR, and downstream signaling activation in malignant peripheral nerve sheath tumor. Neuro-oncology. vol 11. issue 6. 2010-02-23. PMID:19246520. |
the activation of the downstream receptor pathways was also studied by means of v-akt murine thymoma viral oncogene homolog (akt), extracellular signal-regulated kinase (erk), and mammalian target of rapamycin (mtor) western blotting experiments, as well as rat sarcoma viral oncogene homolog (ras), v-raf murine sarcoma viral oncogene homolog b1 (braf), phosphoinositide-3-kinase, catalytic, alpha polypeptide (pi3kca), and phosphatase and tensin homolog deleted on chromosome ten (pten) mutational analysis and fluorescence in situ hybridization. |
2010-02-23 |
2023-08-12 |
rat |
| Chad E N Reiter, Jeong-a Kim, Michael J Quo. Green tea polyphenol epigallocatechin gallate reduces endothelin-1 expression and secretion in vascular endothelial cells: roles for AMP-activated protein kinase, Akt, and FOXO1. Endocrinology. vol 151. issue 1. 2010-02-22. PMID:19887561. |
egcg stimulated time-dependent phosphorylation of akt (s(473)), foxo1 (at akt phosphorylation site t(24)), and amp-activated protein kinase alpha (ampk alpha) (t(172)). |
2010-02-22 |
2023-08-12 |
human |
| Simone M Schoenwaelder, Akiko Ono, Warwick S Nesbitt, Joanna Lim, Kate Jarman, Shaun P Jackso. Phosphoinositide 3-kinase p110 beta regulates integrin alpha IIb beta 3 avidity and the cellular transmission of contractile forces. The Journal of biological chemistry. vol 285. issue 4. 2010-02-22. PMID:19940148. |
pi3k regulation of integrin alpha(iib)beta(3) activation (affinity modulation) primarily occurs downstream of g(i)-coupled and tyrosine kinase-linked receptors linked to the activation of rap1b, akt, and phospholipase c. in the present study, we demonstrate an important role for pi3ks in regulating the avidity (strength of adhesion) of high affinity integrin alpha(iib)beta(3) bonds, necessary for the cellular transmission of contractile forces. |
2010-02-22 |
2023-08-12 |
mouse |
| Kyun Heo, Kyung-A Park, Yun-Hee Kim, Sun-Hee Kim, Yong-Seok Oh, In-Hoo Kim, Sung Ho Ryu, Pann-Ghill Su. Sphingosine 1-phosphate induces vascular endothelial growth factor expression in endothelial cells. BMB reports. vol 42. issue 10. 2010-02-05. PMID:19874715. |
furthermore, a pharmacological inhibitory study revealed that g(alpha i/o)-mediated phospholipase c, akt, erk, and p38 mapk signaling are involved in this s1p-induced expression of vegf. |
2010-02-05 |
2023-08-12 |
mouse |
| Yosuke Osawa, Ekihiro Seki, Masayuki Adachi, Atsushi Suetsugu, Hiroyasu Ito, Hisataka Moriwaki, Mitsuru Seishima, Masahito Nagak. Role of acid sphingomyelinase of Kupffer cells in cholestatic liver injury in mice. Hepatology (Baltimore, Md.). vol 51. issue 1. 2010-01-15. PMID:19821528. |
in cholestatic liver injury, the remaining viable cells represented tolerance for tumor necrosis factor alpha (tnf-alpha)-induced hepatocyte apoptosis and regenerative features along with akt activation. |
2010-01-15 |
2023-08-12 |
mouse |
| Yuhui Jiang, Xiaoduo Xie, Yixuan Zhang, Xiaolin Luo, Xiao Wang, Fengjuan Fan, Dawei Zheng, Zhenzhen Wang, Yan Che. Regulation of G-protein signaling by RKTG via sequestration of the G betagamma subunit to the Golgi apparatus. Molecular and cellular biology. vol 30. issue 1. 2010-01-14. PMID:19884349. |
while the g alpha subunit is imperative for downstream signaling, the g betagamma subunit, in its own right, mediates a variety of cellular responses such as gpcr desensitization via recruiting grk to the plasma membrane and akt stimulation. |
2010-01-14 |
2023-08-12 |
Not clear |
| Erika A F R Roman, Daniel Reis, Talita Romanatto, Denis Maimoni, Eduardo A Ferreira, Gustavo A Santos, Adriana S Torsoni, Licio A Velloso, Marcio A Torson. Central leptin action improves skeletal muscle AKT, AMPK, and PGC1 alpha activation by hypothalamic PI3K-dependent mechanism. Molecular and cellular endocrinology. vol 314. issue 1. 2010-01-11. PMID:19698760. |
central leptin action improves skeletal muscle akt, ampk, and pgc1 alpha activation by hypothalamic pi3k-dependent mechanism. |
2010-01-11 |
2023-08-12 |
rat |
| Erika A F R Roman, Daniel Reis, Talita Romanatto, Denis Maimoni, Eduardo A Ferreira, Gustavo A Santos, Adriana S Torsoni, Licio A Velloso, Marcio A Torson. Central leptin action improves skeletal muscle AKT, AMPK, and PGC1 alpha activation by hypothalamic PI3K-dependent mechanism. Molecular and cellular endocrinology. vol 314. issue 1. 2010-01-11. PMID:19698760. |
central leptin improved tolerance to glucose (gtt), increased pgc1 alpha expression, and akt, ampk, acc and jak2 phosphorylation in the soleus muscle. |
2010-01-11 |
2023-08-12 |
rat |
| Erika A F R Roman, Daniel Reis, Talita Romanatto, Denis Maimoni, Eduardo A Ferreira, Gustavo A Santos, Adriana S Torsoni, Licio A Velloso, Marcio A Torson. Central leptin action improves skeletal muscle AKT, AMPK, and PGC1 alpha activation by hypothalamic PI3K-dependent mechanism. Molecular and cellular endocrinology. vol 314. issue 1. 2010-01-11. PMID:19698760. |
we concluded that the activation of the hypothalamic pi3k pathway is important for leptin-induced akt phosphorylation, as well as for active catabolic pathway through ampk and pgc1 alpha in sm. |
2010-01-11 |
2023-08-12 |
rat |
| Feijun Luo, David G Brooks, Hongtao Ye, Rifat Hamoudi, George Poulogiannis, Charles E Patek, Douglas J Winton, Mark J Arend. Mutated K-ras(Asp12) promotes tumourigenesis in Apc(Min) mice more in the large than the small intestines, with synergistic effects between K-ras and Wnt pathways. International journal of experimental pathology. vol 90. issue 5. 2009-12-14. PMID:19765110. |
k-ras(asp12) increased activation of mapk and akt signalling pathway targets phospho-extracellular signal-regulated kinase (perk) and pakt, and increased relative expression levels of wnt pathway targets vascular endothelial growth factor (vegf), gastrin, cyclo-oxygenase 2 (cox2) and t-cell lymphoma invasion and metastasis 1 (tiam1) in k-ras(asp12)/cre/apc(min/+) adenomas compared with that of apc(min/+) adenomas, although other wnt signalling pathway target genes such as peroxisome proliferator-activated receptor delta (ppard), matrix metalloproteinase 7 (mmp7), protein phosphatase 1 alpha (pp1a) and c-myc remained unchanged. |
2009-12-14 |
2023-08-12 |
mouse |
| Jenell M Eckert, Stephanie J Byer, Buffie J Clodfelder-Miller, Steven L Carrol. Neuregulin-1 beta and neuregulin-1 alpha differentially affect the migration and invasion of malignant peripheral nerve sheath tumor cells. Glia. vol 57. issue 14. 2009-12-09. PMID:19306381. |
while nrg-1 beta potently and persistently activated erk 1/2, sapk/jnk, akt and src family kinases, nrg-1 alpha did not activate akt and activated these other kinases with kinetics distinct from those evident in nrg-1 beta-stimulated cells. |
2009-12-09 |
2023-08-12 |
human |