| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mayumi Iwatake, Kuniaki Okamoto, Takashi Tanaka, Takayuki Tsukub. Punicalagin attenuates osteoclast differentiation by impairing NFATc1 expression and blocking Akt- and JNK-dependent pathways. Molecular and cellular biochemistry. vol 407. issue 1-2. 2016-05-31. PMID:26048715. |
the effects of punicalagin on intracellular signaling during the ocl differentiation of bmms indicated that punicalagin-treated ocls displayed markedly reduced phosphorylation of jun n-terminal kinase and akt, and partially impaired phosphorylation of extracellular signal-regulated kinase, p38 mitogen-activated protein kinase, and inhibitor of nuclear factor kappa-b alpha compared with untreated ocls. |
2016-05-31 |
2023-08-13 |
Not clear |
| Kawinthra Khwanraj, Suriyat Madlah, Khwanthana Grataitong, Permphan Dharmasaroj. Comparative mRNA Expression of eEF1A Isoforms and a PI3K/Akt/mTOR Pathway in a Cellular Model of Parkinson's Disease. Parkinson's disease. vol 2016. 2016-03-16. PMID:26981313. |
previous studies in nonneuronal cells showed that akt regulation can be increased by eukaryotic protein elongation factor 1 alpha 2 (eef1a2). |
2016-03-16 |
2023-08-13 |
Not clear |
| Xue-mei Mo, Han-xiao Su. The Anti-inflammatory Effect of the CXCR4 Antagonist-N15P Peptide and Its Modulation on Inflammation-Associated Mediators in LPS-Induced PBMC. Inflammation. vol 38. issue 3. 2016-02-23. PMID:25676435. |
in this study, we evaluated the anti-inflammatory effects of n15p polypeptide by the lps-induced peripheral blood mononuclear cell (pbmc) model and measured the level of inflammatory factors (tumor necrosis factor alpha (tnf-α), il-6, il-8, nuclear factor kappab (nf-κb), cyclooxygenase-2 (cox-2), toll-like receptor 4 (tlr4), myd88, phosphoinositide 3-kinase (pi3k), and akt). |
2016-02-23 |
2023-08-13 |
Not clear |
| Hari Priya Vemana, Zubair A Karim, Christine Conlon, Fadi T Khasawne. A critical role for the transient receptor potential channel type 6 in human platelet activation. PloS one. vol 10. issue 4. 2016-02-04. PMID:25928636. |
this inhibitor also significantly inhibited human platelet secretion (dense and alpha granules), integrin iib-iiia, akt and erk phosphorylation, again, in a tpr-selective manner; no effects were observed in response to adp receptor stimulation. |
2016-02-04 |
2023-08-13 |
mouse |
| Hiroyuki Sako, Kazumasa Fukuda, Yoshiro Saikawa, Rieko Nakamura, Tsunehiro Takahashi, Norihito Wada, Hirohumi Kawakubo, Hiroya Takeuchi, Tai Ohmori, Yuko Kitagaw. Antitumor effect of the tyrosine kinase inhibitor nilotinib on gastrointestinal stromal tumor (GIST) and imatinib-resistant GIST cells. PloS one. vol 9. issue 9. 2015-12-15. PMID:25221952. |
the phosphorylation status of key cell signaling pathways, receptor tyrosine kinase kit (cd117), platelet-derived growth factor receptor alpha (pdgfra) and downstream signaling kinases: serine-threonine kinase akt (akt) and extracellular signal-regulated kinase 1/2 (erk1/2) or the non-receptor tyrosine kinase: proto-oncogene tyrosine-protein kinase src (src), was analyzed in established cell lines and erk1/2 phosphorylation was found to be increased compared to the parental cells. |
2015-12-15 |
2023-08-13 |
Not clear |
| Tung O Chan, Jin Zhang, Brian C Tiegs, Brian Blumhof, Linda Yan, Nikhil Keny, Morgan Penny, Xue Li, John M Pascal, Roger S Armen, Ulrich Rodeck, Raymond B Pen. Akt kinase C-terminal modifications control activation loop dephosphorylation and enhance insulin response. The Biochemical journal. vol 471. issue 1. 2015-12-15. PMID:26201515. |
recently, we described a mechanism to enhance akt phosphorylation that restricts access of cellular phosphatases to the akt activation loop (thr(308) in akt1 or protein kinase b isoform alpha) in an atp-dependent manner. |
2015-12-15 |
2023-08-13 |
Not clear |
| Sumegha Mitra, Michael S Wade, Xiaoguang Sun, Nurgul Moldobaeva, Carlos Flores, Shwu-Fan Ma, Wei Zhang, Joe G N Garcia, Jeffrey R Jacobso. GADD45a promoter regulation by a functional genetic variant associated with acute lung injury. PloS one. vol 9. issue 6. 2015-10-08. PMID:24940746. |
growth arrest dna damage inducible alpha (gadd45a) is a stress-induced gene we have shown to participate in the pathophysiology of ventilator-induced lung injury (vili) via regulation of mechanical stress-induced akt ubiquitination and phosphorylation. |
2015-10-08 |
2023-08-13 |
Not clear |
| Mayumi Iwatake, Kuniaki Okamoto, Takashi Tanaka, Takayuki Tsukub. Castalagin Exerts Inhibitory Effects on Osteoclastogenesis Through Blocking a Broad Range of Signaling Pathways with Low Cytotoxicity. Phytotherapy research : PTR. vol 29. issue 6. 2015-10-06. PMID:25809147. |
the effects of castalagin on intracellular signaling during ocl differentiation showed that castalagin suppresses rankl-stimulated phosphorylation of major signaling pathways including protein kinase b (akt), extracellular signal-regulated kinase, jun n-terminal kinase, p38 mitogen-activated protein kinases, and inhibitor of nuclear factor kappa b alpha. |
2015-10-06 |
2023-08-13 |
Not clear |
| Jin-Woo Jeong, Won Sup Lee, Sung Chul Shin, Gi-Young Kim, Byung Tae Choi, Yung Hyun Cho. Anthocyanins downregulate lipopolysaccharide-induced inflammatory responses in BV2 microglial cells by suppressing the NF-κB and Akt/MAPKs signaling pathways. International journal of molecular sciences. vol 14. issue 1. 2015-09-21. PMID:23344054. |
moreover, anthocyanins inhibited nuclear translocation of nuclear factor-kappa b (nf-κb) by reducing inhibitor of nf-κb alpha degradation as well as phosphorylating extracellular signal-regulated kinase, c-jun n-terminal kinase, p38 mitogen-activated protein kinase, and akt. |
2015-09-21 |
2023-08-12 |
Not clear |
| Nina C Weber, Isabelle Riedemann, Kirsten F Smit, Karina Zitta, Djai van de Vondervoort, Coert J Zuurbier, Markus W Hollmann, Benedikt Preckel, Martin Albrech. Plasma from human volunteers subjected to remote ischemic preconditioning protects human endothelial cells from hypoxia-induced cell damage. Basic research in cardiology. vol 110. issue 2. 2015-09-14. PMID:25716080. |
western blot experiments of hypoxia inducible factor 1 alpha (hif1alpha), phosphorylated signal transducer and activator of transcription 5 (stat5), protein kinase b (akt) and extracellular signal-related kinase 1/2 (erk-1/2) were performed. |
2015-09-14 |
2023-08-13 |
human |
| Xiaojun Yu, Bo'an Zheng, Rui Cha. Lentivirus-mediated knockdown of eukaryotic translation initiation factor 3 subunit D inhibits proliferation of HCT116 colon cancer cells. Bioscience reports. vol 34. issue 6. 2015-08-24. PMID:25370813. |
signalling pathways responsible for cell growth and apoptosis have also been found altered after eif3d silencing, such as ampkα (amp-activated protein kinase alpha), bad, pras40 [proline-rich akt (pkb) substrate of 40 kda], sapk (stress-activated protein kinase)/jnk (c-jun n-terminal kinase), gsk3β and parp [poly(adp-ribose) polymerase]. |
2015-08-24 |
2023-08-13 |
human |
| Iawen Hsu, Chiuan-Ren Yeh, Spencer Slavin, Hiroshi Miyamoto, George J Netto, Yu-Chieh Tsai, Mesut Muyan, Xue-Ru Wu, Edward M Messing, Elizabeth A Guancial, Shuyuan Ye. Estrogen receptor alpha prevents bladder cancer via INPP4B inhibited akt pathway in vitro and in vivo. Oncotarget. vol 5. issue 17. 2015-08-06. PMID:25277204. |
estrogen receptor alpha prevents bladder cancer via inpp4b inhibited akt pathway in vitro and in vivo. |
2015-08-06 |
2023-08-13 |
mouse |
| Y Wang, Y Li, Y He, Y Sun, W Sun, Q Xie, G Yin, Y Du, L Wang, G Sh. Expression of G protein αq Subunit is Decreased in Lymphocytes from Patients with Rheumatoid Arthritis and is Correlated with Disease Activity. Scandinavian journal of immunology. vol 75. issue 2. 2015-07-28. PMID:21923740. |
gαq, the alpha subunit of gq, a member of the gq/11 sub-family, was reported to inhibit phosphatidylinositol-3-kinase (pi3k) activation and prevent the activation of akt. |
2015-07-28 |
2023-08-12 |
mouse |
| Jackson Nteeba, Shanthi Ganesan, Aileen F Keatin. Impact of obesity on ovotoxicity induced by 7,12-dimethylbenz[a]anthracene in mice. Biology of reproduction. vol 90. issue 3. 2014-11-04. PMID:24501177. |
therefore, we investigated ovarian expression of xenobiotic metabolism genes-microsomal epoxide hydrolase (ephx1), glutathione s-transferase (gst) class pi (gstp1) and class mu 1 (gstm1), and pi3k-signaling members (protein kinase b [akt] alpha [akt1], beta [akt2], and the forkhead transcription factor subfamily 3 [foxo3])-in lean and obese female mice after dmba exposure (1 mg/kg; intraperitoneal injection for 14 days). |
2014-11-04 |
2023-08-12 |
mouse |
| Yu Yamaguchi, Eiko Sakai, Hiroshi Sakamoto, Reiko Fumimoto, Yutaka Fukuma, Kazuhisa Nishishita, Kuniaki Okamoto, Takayuki Tsukub. Inhibitory effects of tert-butylhydroquinone on osteoclast differentiation via up-regulation of heme oxygenase-1 and down-regulation of HMGB1 release and NFATc1 expression. Journal of applied toxicology : JAT. vol 34. issue 1. 2014-10-27. PMID:23112101. |
moreover, tbhq treatment decreased the expression of nuclear factor of activated t cells cytoplasmic-1 (nfatc1), a master regulator of ocl differentiation, and of ocl markers transcriptionally regulated by nfatc1, such as src and cathepsin k. in addition, tbhq impaired phosphorylation of extracellular signal-regulated kinase, p38 mitogen-activated protein kinase (mapk), jun n-terminal kinase, akt, and inhibitor of nuclear factor kappa b alpha (iκbα). |
2014-10-27 |
2023-08-12 |
Not clear |
| Jennifer A Chalmers, Janet J Jang, Denise D Belsha. Glucose sensing mechanisms in hypothalamic cell models: glucose inhibition of AgRP synthesis and secretion. Molecular and cellular endocrinology. vol 382. issue 1. 2014-08-26. PMID:24145125. |
increasing glucose concentrations elicited a rise in akt and neuronal nitric oxide synthase (nnos) phosphorylation, camkkβ levels, and a reduction of amp-kinase alpha phosphorylation. |
2014-08-26 |
2023-08-12 |
Not clear |
| Artemio Z Tulio, Claire Chang, Indika Edirisinghe, Kevin D White, Joseph E Jablonski, Katarzyna Banaszewski, Archana Kangath, Ravi K Tadapaneni, Britt Burton-Freeman, Lauren S Jackso. Berry fruits modulated endothelial cell migration and angiogenesis via phosphoinositide-3 kinase/protein kinase B pathway in vitro in endothelial cells. Journal of agricultural and food chemistry. vol 60. issue 23. 2014-07-18. PMID:22448669. |
anthocyanin profiles of the extracts were characterized using hplc-esi/ms, and akt activation was investigated using the alpha screen surefire assay. |
2014-07-18 |
2023-08-12 |
human |
| Thanyanan Reungwetwattana, Grace Kho D. Targeted therapies in development for non-small cell lung cancer. Journal of carcinogenesis. vol 12. 2014-06-24. PMID:24574860. |
in non-small cell lung cancer (nsclc), the erbb family of receptors (e.g., egfr [epidermal growth factor receptor], her2 [human epidermal growth factor receptor 2]), ras (rat sarcoma gene), braf (v-raf murine sarcoma viral oncogene homolog b1), mapk (mitogen-activated protein kinase) c-met (c-mesenchymal-epithelial transition), fgfr (fibroblast growth factor receptor), ddr2 (discoidin domain receptor 2), pik3ca (phosphatidylinositol-4,5-bisphosphate3-kinase, catalytic subunit alpha)), pten (phosphatase and tensin homolog), akt (protein kinase b), alk (anaplastic lym phoma kinase), ret (rearranged during transfection), ros1 (reactive oxygen species 1) and eph (erythropoietin-producing hepatoma) are key targets of various agents currently in clinical development. |
2014-06-24 |
2023-08-12 |
human |
| Elisa Barile, Surya K De, Yongmei Feng, Vida Chen, Li Yang, Ze'ev Ronai, Maurizio Pellecchi. Synthesis and SAR studies of dual AKT/NF-κB inhibitors against melanoma. Chemical biology & drug design. vol 82. issue 5. 2014-05-14. PMID:23790042. |
the protein kinase b alpha (akt) and nuclear factor kappa-light-chain-enhancer of activated b cells (nf-κb) pathways are central regulators of cellular signaling events at the basis of tumor development and progression. |
2014-05-14 |
2023-08-12 |
Not clear |
| Yung-Ho Hsu, Tso-Hsiao Chen, Yen-Cheng Chen, Chung-Yi Cheng, Yuh-Mou Sue, Jia-Rung Chen, Cheng-Hsien Che. Urotensin II exerts antiapoptotic effect on NRK-52E cells through prostacyclin-mediated peroxisome proliferator-activated receptor alpha and Akt activation. Molecular and cellular endocrinology. vol 381. issue 1-2. 2014-05-01. PMID:23933501. |
urotensin ii exerts antiapoptotic effect on nrk-52e cells through prostacyclin-mediated peroxisome proliferator-activated receptor alpha and akt activation. |
2014-05-01 |
2023-08-12 |
mouse |