| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alessandro Cannavo, Giuseppe Rengo, Daniela Liccardo, Gianluigi Pironti, Maria Cecilia Scimia, Laura Scudiero, Claudio De Lucia, Marco Ferrone, Dario Leosco, Nicola Zambrano, Walter J Koch, Bruno Trimarco, Giovanni Esposit. Prothymosin alpha protects cardiomyocytes against ischemia-induced apoptosis via preservation of Akt activation. Apoptosis : an international journal on programmed cell death. vol 18. issue 10. 2014-03-26. PMID:23857453. |
prothymosin alpha protects cardiomyocytes against ischemia-induced apoptosis via preservation of akt activation. |
2014-03-26 |
2023-08-12 |
mouse |
| F Ebara, S Inada, M Morikawa, S-H Asaoka, Y Isozaki, A Saito, T Etoh, Y Shiotsuka, S G Roh, J Wegner, T Goto. Effect of nutrient intake on intramuscular glucose metabolism during the early growth stage in cross-bred steers (Japanese Black male × Holstein female). Journal of animal physiology and animal nutrition. vol 97. issue 4. 2014-02-18. PMID:22698257. |
we analysed mrna expression levels using the quantitative real-time polymerase chain reaction (pcr) assay for glucose transporters (glut1 and glut4), insulin receptor, phosphatidylinositol 3-kinase (pi-3k), protein kinase b (pkb, also known as akt), hexokinase 1 (hk1) and tumour necrosis factor alpha (tnfα). |
2014-02-18 |
2023-08-12 |
cattle |
| Cheng-Hsing Kao, Chih-Zen Chang, Yu-Feng Su, Yee-Jean Tsai, Kao-Ping Chang, Tzu-Kang Lin, Shiuh-Lin Hwang, Chih-Lung Li. 17β-Estradiol attenuates secondary injury through activation of Akt signaling via estrogen receptor alpha in rat brain following subarachnoid hemorrhage. The Journal of surgical research. vol 183. issue 1. 2013-08-27. PMID:23465388. |
17β-estradiol attenuates secondary injury through activation of akt signaling via estrogen receptor alpha in rat brain following subarachnoid hemorrhage. |
2013-08-27 |
2023-08-12 |
rat |
| Michele Biscuola, Koen Van de Vijver, María Ángeles Castilla, Laura Romero-Pérez, María Ángeles López-García, Juan Díaz-Martín, Xavier Matias-Guiu, Esther Oliva, José Palacios Calv. Oncogene alterations in endometrial carcinosarcomas. Human pathology. vol 44. issue 5. 2013-06-20. PMID:23199529. |
eleven tumors (32.3%) had mutations affecting the pi3k (phosphoinositide-3-kinase)/akt (v-akt murine thymoma viral oncogene homolog 1) (6 mutations in pik3ca (pi3k catalytic alpha polypeptide) and 1 in akt) and/or ras/braf (serine/threonine-protein kinase b-raf) pathway (3 kras [kirsten ras oncogene homolog], 2 nras [neuroblastoma ras viral oncogene homolog], and 1 braf). |
2013-06-20 |
2023-08-12 |
human |
| Hiroshi Sakamoto, Eiko Sakai, Reiko Fumimoto, Yu Yamaguchi, Yutaka Fukuma, Kazuhisa Nishishita, Kuniaki Okamoto, Takayuki Tsukub. Deltamethrin inhibits osteoclast differentiation via regulation of heme oxygenase-1 and NFATc1. Toxicology in vitro : an international journal published in association with BIBRA. vol 26. issue 6. 2013-01-04. PMID:22634059. |
the effects of deltamethrin on intracellular signaling during the ocl differentiation of bmms indicated that deltamethrin-treated ocls displayed impaired phosphorylation of extracellular signal-regulated kinase, p38 mitogen-activated protein kinase, jun n-terminal kinase, and akt, and slightly delayed phosphorylation of inhibitor of nuclear factor kappa b alpha (iκbα) compared with untreated ocls. |
2013-01-04 |
2023-08-12 |
Not clear |
| Lucia A Seale, Ann C Hashimoto, Suguru Kurokawa, Christy L Gilman, Ali Seyedali, Frederick P Bellinger, Arjun V Raman, Marla J Berr. Disruption of the selenocysteine lyase-mediated selenium recycling pathway leads to metabolic syndrome in mice. Molecular and cellular biology. vol 32. issue 20. 2013-01-03. PMID:22890841. |
insulin challenge of scly ko mice results in attenuated akt phosphorylation but does not decrease phosphorylation levels of amp kinase alpha (ampkα). |
2013-01-03 |
2023-08-12 |
mouse |
| Nuria Juanpere, Laia Agell, Marta Lorenzo, Silvia de Muga, Laura López-Vilaró, Raquel Murillo, Sergi Mojal, Sergio Serrano, José A Lorente, Josep Lloreta, Silvia Hernánde. Mutations in FGFR3 and PIK3CA, singly or combined with RAS and AKT1, are associated with AKT but not with MAPK pathway activation in urothelial bladder cancer. Human pathology. vol 43. issue 10. 2012-11-29. PMID:22417847. |
we analyzed mutations in fgfr3, phosphoinositide 3 kinase catalytic alpha polypeptide (pik3ca), v-akt murine thymoma viral oncogene homolog 1 (akt1), v-ki-ras2 kirsten rat sarcoma viral oncogene homolog (kras), v-ha-ras harvey rat sarcoma viral oncogene homolog (hras), and v-raf murine sarcoma viral oncogene homolog b1 (braf) in 88 urothelial cell carcinomas and the immunohistochemical expression of phospho-v-akt murine thymoma viral oncogene homolog (akt) and mitogen-activated protein kinase 1 and 2 (perk1/2) in 80 and 77 urothelial cell carcinomas, respectively. |
2012-11-29 |
2023-08-12 |
rat |
| Alan L Ho, Shyamprasad Deraje Vasudeva, Marick Laé, Tsuyoshi Saito, Violetta Barbashina, Cristina R Antonescu, Marc Ladanyi, Gary K Schwart. PDGF receptor alpha is an alternative mediator of rapamycin-induced Akt activation: implications for combination targeted therapy of synovial sarcoma. Cancer research. vol 72. issue 17. 2012-11-19. PMID:22787122. |
pdgf receptor alpha is an alternative mediator of rapamycin-induced akt activation: implications for combination targeted therapy of synovial sarcoma. |
2012-11-19 |
2023-08-12 |
Not clear |
| John Koren, Yoshinari Miyata, Janine Kiray, John C O'Leary, Lana Nguyen, Jianping Guo, Laura J Blair, Xiaokai Li, Xiokai Li, Umesh K Jinwal, Jin Q Cheng, Jason E Gestwicki, Chad A Dicke. Rhodacyanine derivative selectively targets cancer cells and overcomes tamoxifen resistance. PloS one. vol 7. issue 4. 2012-09-17. PMID:22563386. |
this effect is potentially due to altered estrogen receptor alpha phosphorylation, an outcome precipitated by selective reductions in akt levels (akt/pkb). |
2012-09-17 |
2023-08-12 |
Not clear |
| R Marinho, E R Ropelle, D E Cintra, C T De Souza, A S R Da Silva, F C Bertoli, E Colantonio, V D'Almeida, J R Paul. Endurance exercise training increases APPL1 expression and improves insulin signaling in the hepatic tissue of diet-induced obese mice, independently of weight loss. Journal of cellular physiology. vol 227. issue 7. 2012-07-19. PMID:21938726. |
the protein kinase akt plays a central role in the suppression of gluconeogenesis involving forkhead box o1 (foxo1) and peroxisome proliferator-activated receptor gamma co-activator 1 alpha (pgc-1α), and in the control of glycogen synthesis involving the glycogen synthase kinase beta (gsk3β) in the liver. |
2012-07-19 |
2023-08-12 |
mouse |
| J L Spencer-Segal, M C Tsuda, L Mattei, E M Waters, R D Romeo, T A Milner, B S McEwen, S Ogaw. Estradiol acts via estrogen receptors alpha and beta on pathways important for synaptic plasticity in the mouse hippocampal formation. Neuroscience. vol 202. 2012-05-18. PMID:22133892. |
estradiol effects on phosphorylated akt and trkb immunoreactivities were abolished in er alpha and er beta knockout mice. |
2012-05-18 |
2023-08-12 |
mouse |
| Yuji Ogura, Motoyuki Iemitsu, Hisashi Naito, Ryo Kakigi, Chiaki Kakehashi, Seiji Maeda, Tatsuo Akem. Single bout of running exercise changes LC3-II expression in rat cardiac muscle. Biochemical and biophysical research communications. vol 414. issue 4. 2012-01-06. PMID:22005460. |
in these samples, we evaluated the level of lc3-ii and p62, and the phosphorylation level of mammalian target of rapamycin (mtor), akt and amp-activated protein kinase alpha (ampkα) by western blotting. |
2012-01-06 |
2023-08-12 |
rat |
| Eun-Sook Kim, Jong-Sook Kim, Sang Geon Kim, Sejin Hwang, Chang Ho Lee, Aree Moo. Sphingosine 1-phosphate regulates matrix metalloproteinase-9 expression and breast cell invasion through S1P3-Gαq coupling. Journal of cell science. vol 124. issue Pt 13. 2011-12-19. PMID:21652634. |
in addition, activation of extracellular-signal-regulated kinases 1 and 2 (erk1/2), p38 and alpha serine/threonine-protein kinase (akt) are involved in the process of s1p-mediated induction of mmp-9 expression and invasion. |
2011-12-19 |
2023-08-12 |
human |
| Ping Xie, Vinay K Kondeti, Sun Lin, Yoshisuke Haruna, Kirtee Raparia, Yashpal S Kanwa. Role of extracellular matrix renal tubulo-interstitial nephritis antigen (TINag) in cell survival utilizing integrin (alpha)vbeta3/focal adhesion kinase (FAK)/phosphatidylinositol 3-kinase (PI3K)/protein kinase B-serine/threonine kinase (AKT) signaling pathway. The Journal of biological chemistry. vol 286. issue 39. 2011-11-22. PMID:21795690. |
role of extracellular matrix renal tubulo-interstitial nephritis antigen (tinag) in cell survival utilizing integrin (alpha)vbeta3/focal adhesion kinase (fak)/phosphatidylinositol 3-kinase (pi3k)/protein kinase b-serine/threonine kinase (akt) signaling pathway. |
2011-11-22 |
2023-08-12 |
rat |
| Zhen-Ning Tang, Fan Zhang, Peng Tang, Xiao-Wei Qi, Jun Jian. Hypoxia induces RANK and RANKL expression by activating HIF-1α in breast cancer cells. Biochemical and biophysical research communications. vol 408. issue 3. 2011-07-26. PMID:21514280. |
in addition, we found that hypoxia induced hypoxia-inducible factor-1 alpha (hif-1α) and phosphorylation of akt, resulting in upregulation of rank and rankl expression; hif-1α-targeted sirna and pi3k-akt inhibitor abrogated this upregulation in mda-mb-231 cells. |
2011-07-26 |
2023-08-12 |
Not clear |
| Fabio Bozzi, Andrea Ferrari, Tiziana Negri, Elena Conca, Da Riva Luca, Marco Losa, Paola Casieri, Marta Orsenigo, Andrea Lampis, Cristina Meazza, Michela Casanova, Marco A Pierotti, Elena Tamborini, Silvana Pilott. Molecular characterization of synovial sarcoma in children and adolescents: evidence of akt activation. Translational oncology. vol 1. issue 2. 2011-07-14. PMID:18633459. |
seventeen cases of pediatric ss showing the syt-ssx fusion transcript were screened immunohistochemically, biochemically, molecularly, and cytogenetically (depending on the available material) to investigate any expression/activation of epidermal growth factor receptor, platelet-derived growth factor receptor alpha (pdgfralpha), pdgfrbeta, akt, and deregulated wnt pathway. |
2011-07-14 |
2023-08-12 |
Not clear |
| Yang Lu, Xinqun Li, Haiquan Lu, Zhen Fa. 1, 9-Pyrazoloanthrones downregulate HIF-1α and sensitize cancer cells to cetuximab-mediated anti-EGFR therapy. PloS one. vol 5. issue 12. 2011-07-05. PMID:21209911. |
we previously showed that cetuximab can inhibit hypoxia-inducible factor-1 alpha (hif-1α) protein synthesis by inhibiting the activation of egfr downstream signaling pathways including erk, akt, and mtor. |
2011-07-05 |
2023-08-12 |
Not clear |
| Hetian Lei, Gisela Velez, Andrius Kazlauska. Pathological signaling via platelet-derived growth factor receptor {alpha} involves chronic activation of Akt and suppression of p53. Molecular and cellular biology. vol 31. issue 9. 2011-06-16. PMID:21357737. |
pathological signaling via platelet-derived growth factor receptor {alpha} involves chronic activation of akt and suppression of p53. |
2011-06-16 |
2023-08-12 |
Not clear |
| Omar E Franco, Ming Jiang, Douglas W Strand, James Peacock, Suzanne Fernandez, Roger S Jackson, Monica P Revelo, Neil A Bhowmick, Simon W Haywar. Altered TGF-β signaling in a subpopulation of human stromal cells promotes prostatic carcinogenesis. Cancer research. vol 71. issue 4. 2011-04-27. PMID:21303979. |
mixing fibroblasts expressing the empty vector and dominant negative tgfβr2 increased the expression of markers of myofibroblast differentiation [coexpression of vimentin and alpha smooth muscle actin (αsma)] through elevation of tgf-β1 and activation of the akt pathway. |
2011-04-27 |
2023-08-12 |
human |
| Hsiao-Yun Lin, Chih-Hsin Tang, Yi-Hung Chen, I-Hua Wei, Jia-Hong Chen, Chih-Ho Lai, Dah-Yuu L. Peptidoglycan enhances proinflammatory cytokine expression through the TLR2 receptor, MyD88, phosphatidylinositol 3-kinase/AKT and NF-kappaB pathways in BV-2 microglia. International immunopharmacology. vol 10. issue 8. 2011-03-03. PMID:20451669. |
moreover, pgn-mediated increase of kappab-luciferase activity was also inhibited by pre-transfection with dominant-negative mutants of p85, akt, ikk alpha or ikk beta. |
2011-03-03 |
2023-08-12 |
Not clear |