| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Subrina Jesmin, Chishimba N Mowa, Sayeeda Nusrat Sultana, Nobutake Shimojo, Hiroko Togashi, Yoshio Iwashima, Norihiro Kato, Akira Sato, Ichiro Sakuma, Michiaki Hiroe, Yuichi Hattori, Naoto Yamaguchi, Hiroyuki Kobayash. VEGF signaling is disrupted in the hearts of mice lacking estrogen receptor alpha. European journal of pharmacology. vol 641. issue 2-3. 2011-01-31. PMID:20639141. |
here, we sought to: 1) elucidate estrogen's influence on levels of vascular endothelial growth factor (vegf), a key regulator of cardiovascular processes, and components of its basic signaling machinery (vegf receptors, akt, and enos) in the heart, and 2) delineate the specific estrogen receptor signaling pathway that mediates its beneficial effects using mice lacking either estrogen receptor alpha or estrogen receptor beta. |
2011-01-31 |
2023-08-12 |
mouse |
| Yumiko Urano-Tashiro, Hironobu Sasaki, Mioko Sugawara-Kawasaki, Takeyuki Yamada, Akinori Sugiyama, Hirotada Akiyama, Yasushi Kawasaki, Fumio Tashir. Implication of Akt-dependent Prp19 alpha/14-3-3beta/Cdc5L complex formation in neuronal differentiation. Journal of neuroscience research. vol 88. issue 13. 2010-12-06. PMID:20629186. |
analysis of prp19 alpha mutants revealed that the phosphorylation of prp19 alpha at thr 193 by akt was critical for its binding with 14-3-3beta to translocate into the nuclei and for prp19 alpha/14-3-3beta/cdc5l complex formation in neuronal differentiation. |
2010-12-06 |
2023-08-12 |
Not clear |
| Jodi A McKenzie, Tong Liu, Agnessa G Goodson, Douglas Grossma. Survivin enhances motility of melanoma cells by supporting Akt activation and {alpha}5 integrin upregulation. Cancer research. vol 70. issue 20. 2010-11-23. PMID:20807805. |
survivin enhances motility of melanoma cells by supporting akt activation and {alpha}5 integrin upregulation. |
2010-11-23 |
2023-08-12 |
mouse |
| Risheng Cao, Zhumei Xu Cronk, Weibin Zha, Lixin Sun, Xuan Wang, Youwen Fang, Elaine Studer, Huiping Zhou, William M Pandak, Paul Dent, Gregorio Gil, Phillip B Hylemo. Bile acids regulate hepatic gluconeogenic genes and farnesoid X receptor via G(alpha)i-protein-coupled receptors and the AKT pathway. Journal of lipid research. vol 51. issue 8. 2010-10-20. PMID:20305288. |
bile acids regulate hepatic gluconeogenic genes and farnesoid x receptor via g(alpha)i-protein-coupled receptors and the akt pathway. |
2010-10-20 |
2023-08-12 |
rat |
| Amanda A Melillo, Chandra Shekhar Bakshi, J Andrés Melende. Francisella tularensis antioxidants harness reactive oxygen species to restrict macrophage signaling and cytokine production. The Journal of biological chemistry. vol 285. issue 36. 2010-10-05. PMID:20558723. |
schus4 infection also blocked signals required for macrophage cytokine production, including akt phosphorylation, ikappab alpha degradation, and nf-kappab nuclear localization and activation. |
2010-10-05 |
2023-08-12 |
human |
| Salvatore Piro, Eugenia T Maniscalchi, Adelina Monello, Giuseppe Pandini, Loriana G Mascali, Agata M Rabuazzo, Francesco Purrell. Palmitate affects insulin receptor phosphorylation and intracellular insulin signal in a pancreatic alpha-cell line. Endocrinology. vol 151. issue 9. 2010-10-04. PMID:20573722. |
alpha-tc1-6 cells were cultured in the presence or absence of palmitate (0.5 mmol/liter) up to 48 h. glucagon secretion, insulin and igf-ir autophosphorylation, and insulin receptor substrate (irs)-1, irs-2, phosphatidylinositol kinase (pi3k) (p85 alpha), and serine-threonine protein kinase (akt) phosphorylated (active) forms were measured. |
2010-10-04 |
2023-08-12 |
Not clear |
| Hui-Yan Luo, Wei Wei, Yan-Xia Shi, Xiao-Qin Chen, Yu-Hong Li, Feng Wang, Miao-Zhen Qiu, Fang-Hua Li, Shu-Li Yan, Mu-Sheng Zeng, Peng Huang, Rui-Hua X. Cetuximab enhances the effect of oxaliplatin on hypoxic gastric cancer cell lines. Oncology reports. vol 23. issue 6. 2010-09-30. PMID:20428833. |
combination treatment resulted in a marked inhibition of hif-1 alpha expression levels in hypoxic cells and caused a significant reduction in the expression of activated phosphorylated akt, erk1/2, p-bad and vegf in both normoxia and hypoxia with greater levels of inhibition in hypoxia. |
2010-09-30 |
2023-08-12 |
Not clear |
| Koji Osuka, Yasuo Watanabe, Nobuteru Usuda, Kimie Atsuzawa, Jun Yoshida, Masakazu Takayas. Modification of endothelial nitric oxide synthase through AMPK after experimental subarachnoid hemorrhage. Journal of neurotrauma. vol 26. issue 7. 2010-09-22. PMID:19226196. |
western blot analysis was used to study the temporal profiles of enos, phosphorylated (p)-enos at ser(1177) or thr(495), inducible nos (inos), amp-activated protein kinase alpha (ampk alpha, p-ampk alpha at thr(172)akt, p-akt at ser(473), cyclic amp-dependent protein kinase (pka), and p-pka at thr(197) in basilar arteries. |
2010-09-22 |
2023-08-12 |
rat |
| Svetlana V Scherbik, Margo A Brinto. Virus-induced Ca2+ influx extends survival of west nile virus-infected cells. Journal of virology. vol 84. issue 17. 2010-09-16. PMID:20538858. |
caspase 3 cleavage and activation of several kinases, including focal adhesion kinase (fak), mitogen-activated extracellular signal-regulated protein kinase (erk1/2), and protein-serine kinase b alpha (akt), at early times after wnv infection were shown to be dependent on ca(2+) influx. |
2010-09-16 |
2023-08-12 |
Not clear |
| Bhagirath Chaurasia, Jan Mauer, Linda Koch, Julia Goldau, Anja-Sterner Kock, Jens C Brünin. Phosphoinositide-dependent kinase 1 provides negative feedback inhibition to Toll-like receptor-mediated NF-kappaB activation in macrophages. Molecular and cellular biology. vol 30. issue 17. 2010-09-16. PMID:20584979. |
furthermore, primary macrophages derived from pdk-1(deltamyel) mice lack lps- and pam3csk4-stimulated akt activity but exhibit increased mrna expression and release of tumor necrosis factor alpha (tnf-alpha) and interleukin 6 (il-6). |
2010-09-16 |
2023-08-12 |
mouse |
| Markus H Gräle. Targeting sphingosine 1-phosphate (S1P) levels and S1P receptor functions for therapeutic immune interventions. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 26. issue 1. 2010-09-01. PMID:20502007. |
s1p receptors couple to different heterotrimeric g proteins including g alpha i, q, and 12/13, and elicit cellular signalling events by activating the small gtpases rac and rho and protein kinases akt, erk, and jnk, and by inducing cellular calcium flux and inhibiting camp accumulation, amongst others. |
2010-09-01 |
2023-08-12 |
Not clear |
| S Raichur, R L Fitzsimmons, S A Myers, M A Pearen, P Lau, N Eriksson, S M Wang, G E O Musca. Identification and validation of the pathways and functions regulated by the orphan nuclear receptor, ROR alpha1, in skeletal muscle. Nucleic acids research. vol 38. issue 13. 2010-08-24. PMID:20338882. |
expression profiling and pathway analysis indicated that ror alpha influenced genes involved in: (i) lipid and carbohydrate metabolism, cardiovascular and metabolic disease; (ii) lxr nuclear receptor signaling and (iii) akt and ampk signaling. |
2010-08-24 |
2023-08-12 |
mouse |
| S Raichur, R L Fitzsimmons, S A Myers, M A Pearen, P Lau, N Eriksson, S M Wang, G E O Musca. Identification and validation of the pathways and functions regulated by the orphan nuclear receptor, ROR alpha1, in skeletal muscle. Nucleic acids research. vol 38. issue 13. 2010-08-24. PMID:20338882. |
moreover, westerns and metabolic profiling were utilized to validate the genes, proteins and pathways (lipogenic, akt, ampk and fatty acid oxidation) involved in the regulation of metabolism by ror alpha 1. |
2010-08-24 |
2023-08-12 |
mouse |
| S Raichur, R L Fitzsimmons, S A Myers, M A Pearen, P Lau, N Eriksson, S M Wang, G E O Musca. Identification and validation of the pathways and functions regulated by the orphan nuclear receptor, ROR alpha1, in skeletal muscle. Nucleic acids research. vol 38. issue 13. 2010-08-24. PMID:20338882. |
the identified genes and pathways were in concordance with the demonstration of hyperglycemia, glucose intolerance, attenuated insulin-stimulated phosphorylation of akt and impaired glucose uptake in the transgenic heterozygous tg-ror alpha 1 delta de animals. |
2010-08-24 |
2023-08-12 |
mouse |
| Sara Borniquel, Nieves García-Quintáns, Inmaculada Valle, Yolanda Olmos, Brigitte Wild, Francisco Martínez-Granero, Estrella Soria, Santiago Lamas, María Monsalv. Inactivation of Foxo3a and subsequent downregulation of PGC-1 alpha mediate nitric oxide-induced endothelial cell migration. Molecular and cellular biology. vol 30. issue 16. 2010-08-20. PMID:20547753. |
pgc-1 alpha negatively regulated no-dependent endothelial cell migration in vitro, and inactivation of the phosphatidylinositol 3-kinase (pi3k)/protein kinase b (akt) pathway, which is activated by no, reduced no-mediated downregulation of pgc-1 alpha. |
2010-08-20 |
2023-08-12 |
Not clear |
| Nuria Barbarroja, Rosario López-Pedrera, Maria Dolores Mayas, Eduardo García-Fuentes, Lourdes Garrido-Sánchez, M Macías-González, Rajaa El Bekay, Antonio Vidal-Puig, Francisco J Tinahone. The obese healthy paradox: is inflammation the answer? The Biochemical journal. vol 430. issue 1. 2010-08-13. PMID:20522023. |
ikappabalpha [inhibitor of nf-kappab (nuclear factor kappab) alpha], the activation of erk1/2 (extracellular-signal-regulated kinase 1/2) and nf-kappab were discriminative of the state of insulin resistance and correlated with differential changes in irs-1 (insulin receptor substrate 1) expression and akt activation between ir-mo and nir-mo individuals. |
2010-08-13 |
2023-08-12 |
Not clear |
| Moreshwar S Desai, Zainuer Shabier, Michael Taylor, Fong Lam, Sundararajah Thevananther, Astrid Kosters, Saul J Karpe. Hypertrophic cardiomyopathy and dysregulation of cardiac energetics in a mouse model of biliary fibrosis. Hepatology (Baltimore, Md.). vol 51. issue 6. 2010-06-17. PMID:20512997. |
hearts of ddc-fed mice showed hypertrophic signaling (activation of v-akt murine thymoma viral oncogene/protein kinase b [akt], inhibition of glycogen synthase kinase-3beta [gsk3beta], a 20-fold up-regulation of beta myosin heavy chain rna and elevated g(s)alpha/g(i)alpha ratio. |
2010-06-17 |
2023-08-12 |
mouse |
| R W Matheny, M L Adam. PI3K p110 alpha and p110 beta have differential effects on Akt activation and protection against oxidative stress-induced apoptosis in myoblasts. Cell death and differentiation. vol 17. issue 4. 2010-06-15. PMID:19834495. |
pi3k p110 alpha and p110 beta have differential effects on akt activation and protection against oxidative stress-induced apoptosis in myoblasts. |
2010-06-15 |
2023-08-12 |
Not clear |
| R W Matheny, M L Adam. PI3K p110 alpha and p110 beta have differential effects on Akt activation and protection against oxidative stress-induced apoptosis in myoblasts. Cell death and differentiation. vol 17. issue 4. 2010-06-15. PMID:19834495. |
inhibition of p110 alpha reduced insulin-like growth factor-i (igf-i)-stimulated akt activity and prevented igf-i-mediated survival in h(2)o(2)-treated cells; in contrast, sirna knockdown of p110 beta increased igf-i-stimulated akt activity. |
2010-06-15 |
2023-08-12 |
Not clear |
| Shweta Rane, Minzhen He, Danish Sayed, Lin Yan, Dorothy Vatner, Maha Abdellati. An antagonism between the AKT and beta-adrenergic signaling pathways mediated through their reciprocal effects on miR-199a-5p. Cellular signalling. vol 22. issue 7. 2010-06-10. PMID:20193759. |
our present study shows that overexpression of a constitutively active akt (caakt) induced 70% reduction in mir-199a-5p and was associated with a robust increase in hif-1 alpha (10+/-2 fold) and sirt1 (4+/-0.8 fold) that was reversed by overexpression of mir-199a-5p. |
2010-06-10 |
2023-08-12 |
Not clear |