| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Elaine Xu, Mohan Kumar, Yi Zhang, William Ju, Toshiyuki Obata, Nina Zhang, Shiying Liu, Anna Wendt, Shaoping Deng, Yousuke Ebina, Michael B Wheeler, Matthias Braun, Qinghua Wan. Intra-islet insulin suppresses glucagon release via GABA-GABAA receptor system. Cell metabolism. vol 3. issue 1. 2009-01-08. PMID:16399504. |
in this study, we show that insulin induces activation of gabaa receptors in the alpha cells by receptor translocation via an akt kinase-dependent pathway. |
2009-01-08 |
2023-08-12 |
Not clear |
| R K Singh, T S Lange, K K Kim, A P Singh, N Vorsa, L Brar. Isothiocyanate NB7M causes selective cytotoxicity, pro-apoptotic signalling and cell-cycle regression in ovarian cancer cells. British journal of cancer. vol 99. issue 11. 2008-12-30. PMID:19002174. |
nb7m downregulated phosphorylation of prosurvival kinases (pi-3k, akt, ikk alpha), transcription factor nf-kappab, and expression of dna-pk and axl receptor tyrosine kinase. |
2008-12-30 |
2023-08-12 |
Not clear |
| Shane A Perrine, Jonathon S Miller, Ellen M Unterwal. Cocaine regulates protein kinase B and glycogen synthase kinase-3 activity in selective regions of rat brain. Journal of neurochemistry. vol 107. issue 2. 2008-12-24. PMID:18717814. |
amygdala, nucleus accumbens, caudate putamen, and hippocampus tissues were dissected 30 min following the last injection and analyzed for phosphorylated and total akt and gsk3(alpha and beta) protein levels using western blot analysis. |
2008-12-24 |
2023-08-12 |
rat |
| Charles N Landen, Tae-Jin Kim, Yvonne G Lin, William M Merritt, Aparna A Kamat, Liz Y Han, Whitney A Spannuth, Alpa M Nick, Nicholas B Jennnings, Michael S Kinch, David Tice, Anil K Soo. Tumor-selective response to antibody-mediated targeting of alphavbeta3 integrin in ovarian cancer. Neoplasia (New York, N.Y.). vol 10. issue 11. 2008-12-19. PMID:18953435. |
in this study, expression of the alpha(v)beta(3) integrin on ovarian cancer cell lines and murine endothelial cells was tested, and the effect of a fully humanized monoclonal antibody against alpha(v)beta(3), abegrin (etaracizumab), on cell invasion, viability, tumor growth, and the akt pathway were examined in vitro and in vivo. |
2008-12-19 |
2023-08-12 |
mouse |
| Charles N Landen, Tae-Jin Kim, Yvonne G Lin, William M Merritt, Aparna A Kamat, Liz Y Han, Whitney A Spannuth, Alpa M Nick, Nicholas B Jennnings, Michael S Kinch, David Tice, Anil K Soo. Tumor-selective response to antibody-mediated targeting of alphavbeta3 integrin in ovarian cancer. Neoplasia (New York, N.Y.). vol 10. issue 11. 2008-12-19. PMID:18953435. |
this study identifies tumor cell alpha(v)beta(3) integrin as an attractive target and defines the akt pathway as a predictor of response to function-blocking antibody. |
2008-12-19 |
2023-08-12 |
mouse |
| Arturo Rodriguez-Hernandez, Ivan Rubio-Gayosso, Israel Ramirez, Israel Ita-Islas, Eduardo Meaney, Samuel Gaxiola, Alejandra Meaney, Juan Asbun, Lauro Figueroa-Valverde, Guillermo Ceballo. Intraluminal-restricted 17 beta-estradiol exerts the same myocardial protection against ischemia/reperfusion injury in vivo as free 17 beta-estradiol. Steroids. vol 73. issue 5. 2008-11-12. PMID:18314151. |
17 beta-estradiol-macromolecular conjugate decreases phosphorylation level of pkc alpha and akt, as part of the process to induce myocardial protection against coronary i/r. |
2008-11-12 |
2023-08-12 |
rat |
| Catherine M Cahill, Jack T Roger. Interleukin (IL) 1beta induction of IL-6 is mediated by a novel phosphatidylinositol 3-kinase-dependent AKT/IkappaB kinase alpha pathway targeting activator protein-1. The Journal of biological chemistry. vol 283. issue 38. 2008-10-27. PMID:18515365. |
overexpression of either dominant-negative akt or ikappab kinase alpha mutant, ikkalphat23a, containing a mutation in a functional akt phosphorylation site, shown previously to be important for nfkappab activation, completely abrogated il-6 promoter activation in response to il-1. |
2008-10-27 |
2023-08-12 |
Not clear |
| E M Yazlovitskaya, A G Linkous, D K Thotala, K C Cuneo, D E Hallaha. Cytosolic phospholipase A2 regulates viability of irradiated vascular endothelium. Cell death and differentiation. vol 15. issue 10. 2008-10-27. PMID:18566601. |
the role of cpla(2) in the regulation of radiation-induced activation of akt and erk1/2 and cell viability was confirmed using human umbilical vein endothelial cells transfected with shrna for cpla(2)alpha and cultured embryonic fibroblasts from cpla(2)alpha(-/-) mice. |
2008-10-27 |
2023-08-12 |
mouse |
| T L Yuan, L C Cantle. PI3K pathway alterations in cancer: variations on a theme. Oncogene. vol 27. issue 41. 2008-10-08. PMID:18794884. |
receptor tyrosine kinases upstream of pi3k, the p110 alpha catalytic subunit of pi3k, the downstream kinase, akt, and the negative regulator, pten, are all frequently altered in cancer. |
2008-10-08 |
2023-08-12 |
Not clear |
| Salida Mirzoeva, Nam Deuk Kim, Karen Chiu, Carrie A Franzen, Raymond C Bergan, Jill C Pellin. Inhibition of HIF-1 alpha and VEGF expression by the chemopreventive bioflavonoid apigenin is accompanied by Akt inhibition in human prostate carcinoma PC3-M cells. Molecular carcinogenesis. vol 47. issue 9. 2008-09-04. PMID:18240292. |
inhibition of hif-1 alpha and vegf expression by the chemopreventive bioflavonoid apigenin is accompanied by akt inhibition in human prostate carcinoma pc3-m cells. |
2008-09-04 |
2023-08-12 |
human |
| Sungwoo Park, Jieun Song, Cheol O Joe, Incheol Shi. Akt stabilizes estrogen receptor alpha with the concomitant reduction in its transcriptional activity. Cellular signalling. vol 20. issue 7. 2008-09-02. PMID:18450422. |
akt stabilizes estrogen receptor alpha with the concomitant reduction in its transcriptional activity. |
2008-09-02 |
2023-08-12 |
Not clear |
| Sungwoo Park, Jieun Song, Cheol O Joe, Incheol Shi. Akt stabilizes estrogen receptor alpha with the concomitant reduction in its transcriptional activity. Cellular signalling. vol 20. issue 7. 2008-09-02. PMID:18450422. |
we have investigated the effect of akt on estrogen receptor (er) alpha protein level and its transcriptional activity. |
2008-09-02 |
2023-08-12 |
Not clear |
| Han C Dan, Albert S Baldwi. Differential involvement of IkappaB kinases alpha and beta in cytokine- and insulin-induced mammalian target of rapamycin activation determined by Akt. Journal of immunology (Baltimore, Md. : 1950). vol 180. issue 11. 2008-07-18. PMID:18490760. |
differential involvement of ikappab kinases alpha and beta in cytokine- and insulin-induced mammalian target of rapamycin activation determined by akt. |
2008-07-18 |
2023-08-12 |
Not clear |
| Fi-Tjen Mu, Robert K Andrews, Jane F Arthur, Adam D Munday, Susan L Cranmer, Shaun P Jackson, Frank C Stomski, Angel F Lopez, Michael C Bernd. A functional 14-3-3zeta-independent association of PI3-kinase with glycoprotein Ib alpha, the major ligand-binding subunit of the platelet glycoprotein Ib-IX-V complex. Blood. vol 111. issue 9. 2008-07-16. PMID:18299448. |
deleting these, but not upstream sequences of gpib alpha expressed in cho cells, inhibited vwf/ristocetin-dependent akt phosphorylation, relative to wild-type receptor, confirming this region encompassed a functional pi3-kinase-binding site. |
2008-07-16 |
2023-08-12 |
Not clear |
| Jonathan J Abbott, David R Howlett, Paul T Francis, Robert J William. Abeta(1-42) modulation of Akt phosphorylation via alpha7 nAChR and NMDA receptors. Neurobiology of aging. vol 29. issue 7. 2008-06-20. PMID:17292512. |
we report for the first time that acute exposure of primary mouse neurons to 400nm abeta(1-42) increased akt phosphorylation in an alpha(7) nicotinic receptor and nmda receptor dependant manner. |
2008-06-20 |
2023-08-12 |
mouse |
| Zhiwei Liu, Xinyuan Yu, Zahir A Shaik. Rapid activation of ERK1/2 and AKT in human breast cancer cells by cadmium. Toxicology and applied pharmacology. vol 228. issue 3. 2008-06-10. PMID:18275979. |
while the estrogen receptor antagonist, ici 182,780, did not prevent the effect of cd on these signals, specific sirna against her alpha significantly reduced cd-induced activation of erk1/2 and completely blocked the activation of akt. |
2008-06-10 |
2023-08-12 |
human |
| Zhiwei Liu, Xinyuan Yu, Zahir A Shaik. Rapid activation of ERK1/2 and AKT in human breast cancer cells by cadmium. Toxicology and applied pharmacology. vol 228. issue 3. 2008-06-10. PMID:18275979. |
it is concluded that cd, like estradiol, can cause rapid activation of erk1/2 and akt and that these signaling events are mediated by possible interaction with membrane er alpha and gpr30, but not er beta. |
2008-06-10 |
2023-08-12 |
human |
| Quan-Sheng Zhu, Wenhong Ren, Borys Korchin, Guy Lahat, Adam Dicker, Yiling Lu, Gordon Mills, Raphael E Pollock, Dina Le. Soft tissue sarcoma cells are highly sensitive to AKT blockade: a role for p53-independent up-regulation of GADD45 alpha. Cancer research. vol 68. issue 8. 2008-06-10. PMID:18413758. |
soft tissue sarcoma cells are highly sensitive to akt blockade: a role for p53-independent up-regulation of gadd45 alpha. |
2008-06-10 |
2023-08-12 |
mouse |
| Quan-Sheng Zhu, Wenhong Ren, Borys Korchin, Guy Lahat, Adam Dicker, Yiling Lu, Gordon Mills, Raphael E Pollock, Dina Le. Soft tissue sarcoma cells are highly sensitive to AKT blockade: a role for p53-independent up-regulation of GADD45 alpha. Cancer research. vol 68. issue 8. 2008-06-10. PMID:18413758. |
akt inhibition induced gadd45 alpha mrna and protein expression in all sts cells treated independent of p53 mutational status. |
2008-06-10 |
2023-08-12 |
mouse |
| Quan-Sheng Zhu, Wenhong Ren, Borys Korchin, Guy Lahat, Adam Dicker, Yiling Lu, Gordon Mills, Raphael E Pollock, Dina Le. Soft tissue sarcoma cells are highly sensitive to AKT blockade: a role for p53-independent up-regulation of GADD45 alpha. Cancer research. vol 68. issue 8. 2008-06-10. PMID:18413758. |
gadd45 alpha knockdown attenuated the g(2) arrest induced by akt inhibition. |
2008-06-10 |
2023-08-12 |
mouse |