| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Maja Grabacka, Przemyslaw M Plonka, Krystyna Urbanska, Krzysztof Reis. Peroxisome proliferator-activated receptor alpha activation decreases metastatic potential of melanoma cells in vitro via down-regulation of Akt. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 12. issue 10. 2006-07-26. PMID:16707598. |
peroxisome proliferator-activated receptor alpha activation decreases metastatic potential of melanoma cells in vitro via down-regulation of akt. |
2006-07-26 |
2023-08-12 |
Not clear |
| Uma Kant Misra, Rohit Deedwania, Salvatore Vincent Pizz. Activation and cross-talk between Akt, NF-kappaB, and unfolded protein response signaling in 1-LN prostate cancer cells consequent to ligation of cell surface-associated GRP78. The Journal of biological chemistry. vol 281. issue 19. 2006-07-18. PMID:16543232. |
silencing of grp78 gene expression by rnai suppressed activation of akt(thr-308), akt(ser-473), and ikappab kinase alpha kinase. |
2006-07-18 |
2023-08-12 |
human |
| Kersten M Small, Mary Rose Schwarb, Clare Glinka, Cheryl T Theiss, Kari M Brown, Carrie A Seman, Stephen B Ligget. Alpha2A- and alpha2C-adrenergic receptors form homo- and heterodimers: the heterodimeric state impairs agonist-promoted GRK phosphorylation and beta-arrestin recruitment. Biochemistry. vol 45. issue 15. 2006-05-31. PMID:16605244. |
signaling of the alpha(2a)-alpha(2c) heterodimer to the beta-arrestin-dependent activation of akt was decreased compared to that of the alpha(2a)ar homodimer, while p44/p42 map kinase activation was unaffected. |
2006-05-31 |
2023-08-12 |
Not clear |
| Anna Vilgelm, Zenglin Lian, Hong Wang, Stephen L Beauparlant, Andres Klein-Szanto, Lora Hedrick Ellenson, Antonio Di Cristofan. Akt-mediated phosphorylation and activation of estrogen receptor alpha is required for endometrial neoplastic transformation in Pten+/- mice. Cancer research. vol 66. issue 7. 2006-05-22. PMID:16585156. |
here, we show that loss of pten in the mouse endometrium activates akt and results in increased phosphorylation of estrogen receptor alpha (eralpha) on ser(167). |
2006-05-22 |
2023-08-12 |
mouse |
| Harish Srinivas, Dianren Xia, Nicole L Moore, Ivan P Uray, Heetae Kim, Long Ma, Nancy L Weigel, Powel H Brown, Jonathan M Kuri. Akt phosphorylates and suppresses the transactivation of retinoic acid receptor alpha. The Biochemical journal. vol 395. issue 3. 2006-05-10. PMID:16417524. |
akt phosphorylates and suppresses the transactivation of retinoic acid receptor alpha. |
2006-05-10 |
2023-08-12 |
Not clear |
| Georgios Karkoulias, Orthodoxia Mastrogianni, Anastasios Lymperopoulos, Herve Paris, Christodoulos Flordelli. alpha(2)-Adrenergic receptors activate MAPK and Akt through a pathway involving arachidonic acid metabolism by cytochrome P450-dependent epoxygenase, matrix metalloproteinase activation and subtype-specific transactivation of EGFR. Cellular signalling. vol 18. issue 5. 2006-04-10. PMID:16098714. |
alpha(2)-adrenergic receptors activate mapk and akt through a pathway involving arachidonic acid metabolism by cytochrome p450-dependent epoxygenase, matrix metalloproteinase activation and subtype-specific transactivation of egfr. |
2006-04-10 |
2023-08-12 |
Not clear |
| Georgios Karkoulias, Orthodoxia Mastrogianni, Anastasios Lymperopoulos, Herve Paris, Christodoulos Flordelli. alpha(2)-Adrenergic receptors activate MAPK and Akt through a pathway involving arachidonic acid metabolism by cytochrome P450-dependent epoxygenase, matrix metalloproteinase activation and subtype-specific transactivation of EGFR. Cellular signalling. vol 18. issue 5. 2006-04-10. PMID:16098714. |
furthermore, whereas u73122 abolished the effects of epinephrine, quinacrine only prevented the effects of epinephrine, suggesting that aa release through plc and its metabolites are responsible for mapk and akt activation by alpha(2)-ars. |
2006-04-10 |
2023-08-12 |
Not clear |
| Georgios Karkoulias, Orthodoxia Mastrogianni, Anastasios Lymperopoulos, Herve Paris, Christodoulos Flordelli. alpha(2)-Adrenergic receptors activate MAPK and Akt through a pathway involving arachidonic acid metabolism by cytochrome P450-dependent epoxygenase, matrix metalloproteinase activation and subtype-specific transactivation of EGFR. Cellular signalling. vol 18. issue 5. 2006-04-10. PMID:16098714. |
our results provide evidence for a putative pathway by which alpha(2)-ars activate mapk and akt in pc12 cells, involving stimulation of plc, aa release, aa metabolism by cytochrome p450-dependent epoxygenase, stimulation of matrix metalloproteinases and subtype-specific transactivation of egfr through src activation and heparin-binding egf-like growth factor release. |
2006-04-10 |
2023-08-12 |
Not clear |
| Kiyofumi Nagira, Toshiyasu Sasaoka, Tsutomu Wada, Kazuhito Fukui, Mariko Ikubo, Satoko Hori, Hiroshi Tsuneki, Shigeru Saito, Masashi Kobayash. Altered subcellular distribution of estrogen receptor alpha is implicated in estradiol-induced dual regulation of insulin signaling in 3T3-L1 adipocytes. Endocrinology. vol 147. issue 2. 2006-03-10. PMID:16269459. |
membrane-impermeable e2, e2-bsa, did not affect the insulin-induced phosphorylation of akt at 10(-8) m, but inhibited it at 10(-5) m. furthermore, e2 decreased the amount of estrogen receptor alpha at the plasma membrane at 10(-8) m, but increased it at 10(-5) m. in contrast, the subcellular distribution of estrogen receptor beta was not altered by the treatment. |
2006-03-10 |
2023-08-12 |
Not clear |
| Robert J Southgate, Clinton R Bruce, Andrew L Carey, Gregory R Steinberg, Ken Walder, Robert Monks, Matthew J Watt, John A Hawley, Morris J Birnbaum, Mark A Febbrai. PGC-1alpha gene expression is down-regulated by Akt- mediated phosphorylation and nuclear exclusion of FoxO1 in insulin-stimulated skeletal muscle. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 19. issue 14. 2006-02-27. PMID:16203862. |
there are multiple binding domains on the promoter region of the peroxisome proliferator activator receptor gamma coactivator-1 alpha (pgc-1alpha) gene, including a trio of insulin responsive elements that are activated by the forkhead box class-o (foxo1) winged helix transcription factor, which is known to be regulated by acute transforming retrovirus thymoma (akt). |
2006-02-27 |
2023-08-12 |
mouse |
| Jingyu Diao, Zeenat Asghar, Catherine B Chan, Michael B Wheele. Glucose-regulated glucagon secretion requires insulin receptor expression in pancreatic alpha-cells. The Journal of biological chemistry. vol 280. issue 39. 2005-11-30. PMID:16027126. |
defects in sirna-ir-expressing alpha-cells were associated with an alteration in the activity of akt and p70s6k where insulin-induced phosphorylation of protein kinase b/akt was greatly reduced while p70s6k activation was enhanced, suggesting that the related pathways play important roles in alpha cell function. |
2005-11-30 |
2023-08-12 |
mouse |
| Amir Abdollahi, David W Griggs, Heike Zieher, Alexandra Roth, Kenneth E Lipson, Rainer Saffrich, Hermann-Josef Gröne, Dennis E Hallahan, Ralph A Reisfeld, Juergen Debus, Andreas G Niethammer, Peter E Hube. Inhibition of alpha(v)beta3 integrin survival signaling enhances antiangiogenic and antitumor effects of radiotherapy. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 11. issue 17. 2005-11-01. PMID:16144931. |
we found that radiation up-regulates alpha(v)beta3 expression in endothelial cells and consecutively phosphorylates akt, which may provide a tumor escape mechanism from radiation injury mediated by integrin survival signaling. |
2005-11-01 |
2023-08-12 |
mouse |
| Daniel G Sedding, Jennifer Hermsen, Ulrike Seay, Oliver Eickelberg, Wolfgang Kummer, Carsten Schwencke, Ruth H Strasser, Harald Tillmanns, Ruediger C Braun-Dullaeu. Caveolin-1 facilitates mechanosensitive protein kinase B (Akt) signaling in vitro and in vivo. Circulation research. vol 96. issue 6. 2005-09-22. PMID:15731459. |
alpha(v)beta3 integrins were identified to colocalize with pi3-k/caveolin-1 complexes, and blockade of alpha(v)beta3 integrins prevented akt activation. |
2005-09-22 |
2023-08-12 |
mouse |
| Wei-Chien Huang, Ching-Chow Che. Akt phosphorylation of p300 at Ser-1834 is essential for its histone acetyltransferase and transcriptional activity. Molecular and cellular biology. vol 25. issue 15. 2005-09-15. PMID:16024795. |
here, we show that akt is activated and translocated to the nucleus in response to tumor necrosis factor alpha. |
2005-09-15 |
2023-08-12 |
Not clear |
| Shiow-Lin Pan, Jih-Hwa Guh, Chieh-Yu Peng, Shih-Wei Wang, Ya-Ling Chang, Fong-Chi Cheng, Jau-Hsiang Chang, Sheng-Chu Kuo, Fang-Yu Lee, Che-Ming Ten. YC-1 [3-(5'-hydroxymethyl-2'-furyl)-1-benzyl indazole] inhibits endothelial cell functions induced by angiogenic factors in vitro and angiogenesis in vivo models. The Journal of pharmacology and experimental therapeutics. vol 314. issue 1. 2005-08-26. PMID:15784655. |
yc-1 inhibited vegf- and bfgf-induced p42/p44 mitogen-activated protein kinase and akt phosphorylation as well as protein kinase c alpha translocation using western blot analysis. |
2005-08-26 |
2023-08-12 |
mouse |
| Ratna Prasad, Shailendra Giri, Narender Nath, Inderjit Singh, Avtar K Sing. Inhibition of phosphoinositide 3 kinase-Akt (protein kinase B)-nuclear factor-kappa B pathway by lovastatin limits endothelial-monocyte cell interaction. Journal of neurochemistry. vol 94. issue 1. 2005-08-08. PMID:15953363. |
it inhibits tumor necrosis factor alpha (tnfalpha)-induced pi3-kinase, akt and nf-kappab activation in these cells. |
2005-08-08 |
2023-08-12 |
Not clear |
| Makoto Hamasaki, Teru Hideshima, Pierfrancesco Tassone, Paola Neri, Kenji Ishitsuka, Hiroshi Yasui, Norihiko Shiraishi, Noopur Raje, Shaji Kumar, Donald H Picker, Gary S Jacob, Paul G Richardson, Nikhil C Munshi, Kenneth C Anderso. Azaspirane (N-N-diethyl-8,8-dipropyl-2-azaspiro [4.5] decane-2-propanamine) inhibits human multiple myeloma cell growth in the bone marrow milieu in vitro and in vivo. Blood. vol 105. issue 11. 2005-07-12. PMID:15705788. |
azaspirane inhibits signal transducer activator of transcription 3 (stat3) and a pi3-k (phosphatidylinositol 3-kinase) target (akt), but not extracellular signal-regulated kinase 1 and 2 (erk1/2), inhibits phosphorylation triggered by il-6, and also inhibits inhibitorkappabalpha (ikappabalpha) and nuclear factor kappab (nfkappab) p65 phosphorylation triggered by tumor necrosis factor alpha (tnf-alpha). |
2005-07-12 |
2023-08-12 |
mouse |
| Edward A Medina, Robert R Afsari, Tommer Ravid, S Sianna Castillo, Kent L Erickson, Tzipora Goldkor. Tumor necrosis factor-{alpha} decreases Akt protein levels in 3T3-L1 adipocytes via the caspase-dependent ubiquitination of Akt. Endocrinology. vol 146. issue 6. 2005-06-28. PMID:15746249. |
tumor necrosis factor-{alpha} decreases akt protein levels in 3t3-l1 adipocytes via the caspase-dependent ubiquitination of akt. |
2005-06-28 |
2023-08-12 |
Not clear |
| Luciano Vellon, Javier A Menendez, Ruth Lup. AlphaVbeta3 integrin regulates heregulin (HRG)-induced cell proliferation and survival in breast cancer. Oncogene. vol 24. issue 23. 2005-06-09. PMID:15782133. |
mechanistically, functional blockade of alpha(v)beta(3) impaired hrg-promoted hyperactivation of erk1/erk2 mapk without altering the activation of akt. |
2005-06-09 |
2023-08-12 |
Not clear |
| Luciano Vellon, Javier A Menendez, Ruth Lup. AlphaVbeta3 integrin regulates heregulin (HRG)-induced cell proliferation and survival in breast cancer. Oncogene. vol 24. issue 23. 2005-06-09. PMID:15782133. |
moreover, blockade of cyr61 expression impaired the hrg-induced hyperactivation of erk1/erk2 mapk without altering the activation status of akt in mda-mb-231 cells, thus resembling the effects exerted by the downregulation of hrg expression as well as by functional blockade of alpha(v)beta(3). |
2005-06-09 |
2023-08-12 |
Not clear |