| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jun Chung, Robin E Bachelder, Elizabeth A Lipscomb, Leslie M Shaw, Arthur M Mercuri. Integrin (alpha 6 beta 4) regulation of eIF-4E activity and VEGF translation: a survival mechanism for carcinoma cells. The Journal of cell biology. vol 158. issue 1. 2002-08-08. PMID:12105188. |
importantly, we show that this alpha 6 beta 4-dependent regulation of vegf translation plays an important role in the survival of metastatic breast carcinoma cells by sustaining a vegf autocrine signaling pathway that involves activation of pi-3k and akt. |
2002-08-08 |
2023-08-12 |
Not clear |
| Younghee Lee, Akihiko Gotoh, Hyung-Joo Kwon, Minute You, Lisa Kohli, Charlie Mantel, Scott Cooper, Giao Hangoc, Keisuke Miyazawa, Kazuma Ohyashiki, Hal E Broxmeye. Enhancement of intracellular signaling associated with hematopoietic progenitor cell survival in response to SDF-1/CXCL12 in synergy with other cytokines. Blood. vol 99. issue 12. 2002-07-11. PMID:12036856. |
sdf-1 alpha induced transient activation of extracellular stress-regulated kinase (erk1/2), ribosomal s6 kinase (p90rsk) and akt, molecules implicated in cell survival. |
2002-07-11 |
2023-08-12 |
mouse |
| Younghee Lee, Akihiko Gotoh, Hyung-Joo Kwon, Minute You, Lisa Kohli, Charlie Mantel, Scott Cooper, Giao Hangoc, Keisuke Miyazawa, Kazuma Ohyashiki, Hal E Broxmeye. Enhancement of intracellular signaling associated with hematopoietic progenitor cell survival in response to SDF-1/CXCL12 in synergy with other cytokines. Blood. vol 99. issue 12. 2002-07-11. PMID:12036856. |
moreover, erk1/2, p90rsk, and akt were synergistically activated by sdf-1 alpha in combination with granulocyte-macrophage colony-stimulating factor (gm-csf), steel factor (slf), or thrombopoietin (tpo). |
2002-07-11 |
2023-08-12 |
mouse |
| Gieri Camenisch, Maria Teresa Pisabarro, Daniel Sherman, Joe Kowalski, Mark Nagel, Phil Hass, Ming-Hong Xie, Austin Gurney, Sarah Bodary, Xiao Huan Liang, Kevin Clark, Maureen Beresini, Napoleone Ferrara, Hans-Peter Gerbe. ANGPTL3 stimulates endothelial cell adhesion and migration via integrin alpha vbeta 3 and induces blood vessel formation in vivo. The Journal of biological chemistry. vol 277. issue 19. 2002-06-13. PMID:11877390. |
this hypothesis was experimentally confirmed by the finding that recombinant angptl3 bound to alpha(v)beta(3) and induced integrin alpha(v)beta(3)-dependent haptotactic endothelial cell adhesion and migration and stimulated signal transduction pathways characteristic for integrin activation, including phosphorylation of akt, mitogen-activated protein kinase, and focal adhesion kinase. |
2002-06-13 |
2023-08-12 |
rat |
| Andrew M Arsham, David R Plas, Craig B Thompson, M Celeste Simo. Phosphatidylinositol 3-kinase/Akt signaling is neither required for hypoxic stabilization of HIF-1 alpha nor sufficient for HIF-1-dependent target gene transcription. The Journal of biological chemistry. vol 277. issue 17. 2002-05-31. PMID:11859074. |
high levels of akt signaling can modestly increase hif-1 alpha protein, but this increase does not affect hif-1 target gene expression. |
2002-05-31 |
2023-08-12 |
Not clear |
| Diane M Klotz, Sylvia Curtis Hewitt, Paolo Ciana, Michele Raviscioni, Jonathan K Lindzey, Julie Foley, Adriana Maggi, Richard P DiAugustine, Kenneth S Korac. Requirement of estrogen receptor-alpha in insulin-like growth factor-1 (IGF-1)-induced uterine responses and in vivo evidence for IGF-1/estrogen receptor cross-talk. The Journal of biological chemistry. vol 277. issue 10. 2002-04-15. PMID:11751931. |
in addition, igf-1 stimulated phosphorylation of uterine akt and mapk in both wt and alpha erko mice. |
2002-04-15 |
2023-08-12 |
mouse |
| Motohiro Nishida, Shuichi Takagahara, Yoshiko Maruyama, Yoshiyuki Sugimoto, Taku Nagao, Hitoshi Kuros. G beta gamma counteracts G alpha(q) signaling upon alpha(1)-adrenergic receptor stimulation. Biochemical and biophysical research communications. vol 291. issue 4. 2002-04-15. PMID:11866464. |
these results suggest that g beta gamma released from g(q) upon alpha(1)-adrenergic receptor stimulation activates erk and akt. |
2002-04-15 |
2023-08-12 |
rat |
| Motohiro Nishida, Shuichi Takagahara, Yoshiko Maruyama, Yoshiyuki Sugimoto, Taku Nagao, Hitoshi Kuros. G beta gamma counteracts G alpha(q) signaling upon alpha(1)-adrenergic receptor stimulation. Biochemical and biophysical research communications. vol 291. issue 4. 2002-04-15. PMID:11866464. |
however, activation of akt but not erk plays an important role in the protection against the g alpha(q)-induced cellular injury and apoptosis. |
2002-04-15 |
2023-08-12 |
rat |
| Johanna Ivaska, Liisa Nissinen, Nina Immonen, John E Eriksson, Veli-Matti Kähäri, Jyrki Hein. Integrin alpha 2 beta 1 promotes activation of protein phosphatase 2A and dephosphorylation of Akt and glycogen synthase kinase 3 beta. Molecular and cellular biology. vol 22. issue 5. 2002-04-02. PMID:11839802. |
integrin alpha 2 beta 1 promotes activation of protein phosphatase 2a and dephosphorylation of akt and glycogen synthase kinase 3 beta. |
2002-04-02 |
2023-08-12 |
Not clear |
| Johanna Ivaska, Liisa Nissinen, Nina Immonen, John E Eriksson, Veli-Matti Kähäri, Jyrki Hein. Integrin alpha 2 beta 1 promotes activation of protein phosphatase 2A and dephosphorylation of Akt and glycogen synthase kinase 3 beta. Molecular and cellular biology. vol 22. issue 5. 2002-04-02. PMID:11839802. |
here, we found that, in contrast what was found for cells adherent to fibronectin, alpha 2 beta 1-mediated cell adhesion to collagen leads to dephosphorylation of akt and glycogen synthase kinase 3 beta (gsk3 beta) and concomitantly to the induction of protein serine/threonine phosphatase 2a (pp2a) activity. |
2002-04-02 |
2023-08-12 |
Not clear |
| Johanna Ivaska, Liisa Nissinen, Nina Immonen, John E Eriksson, Veli-Matti Kähäri, Jyrki Hein. Integrin alpha 2 beta 1 promotes activation of protein phosphatase 2A and dephosphorylation of Akt and glycogen synthase kinase 3 beta. Molecular and cellular biology. vol 22. issue 5. 2002-04-02. PMID:11839802. |
these results indicate that cell adhesion to collagen modulates akt activity via the alpha 2 beta 1-induced activation of pp2a. |
2002-04-02 |
2023-08-12 |
Not clear |
| Nywana Sizemore, Natalia Lerner, Nicole Dombrowski, Hiroaki Sakurai, George R Star. Distinct roles of the Ikappa B kinase alpha and beta subunits in liberating nuclear factor kappa B (NF-kappa B) from Ikappa B and in phosphorylating the p65 subunit of NF-kappa B. The Journal of biological chemistry. vol 277. issue 6. 2002-03-05. PMID:11733537. |
distinct roles of the ikappa b kinase alpha and beta subunits in liberating nuclear factor kappa b (nf-kappa b) from ikappa b and in phosphorylating the p65 subunit of nf-kappa b. phosphatidylinositol 3'-kinase (pi3k) and the serine/threonine kinase akt have critical roles in phosphorylating and transactivating the p65 subunit of nuclear factor kappab (nf-kappab) in response to the pro-inflammatory cytokines interleukin-1 (il-1) and tumor necrosis factor (tnf). |
2002-03-05 |
2023-08-12 |
mouse |
| K Hisamoto, M Ohmichi, Y Kanda, K Adachi, Y Nishio, J Hayakawa, S Mabuchi, K Takahashi, K Tasaka, Y Miyamoto, N Taniguchi, Y Murat. Induction of endothelial nitric-oxide synthase phosphorylation by the raloxifene analog LY117018 is differentially mediated by Akt and extracellular signal-regulated protein kinase in vascular endothelial cells. The Journal of biological chemistry. vol 276. issue 50. 2002-01-24. PMID:11595733. |
moreover, raloxifene stimulated the activation of akt, erk, and enos in chinese hamster ovary cells expressing estrogen receptor alpha but not chinese hamster ovary cells expressing estrogen receptor beta. |
2002-01-24 |
2023-08-12 |
human |
| H Nakayama, T Ikebe, M Beppu, K Shirasun. High expression levels of nuclear factor kappaB, IkappaB kinase alpha and Akt kinase in squamous cell carcinoma of the oral cavity. Cancer. vol 92. issue 12. 2002-01-17. PMID:11753981. |
high expression levels of nuclear factor kappab, ikappab kinase alpha and akt kinase in squamous cell carcinoma of the oral cavity. |
2002-01-17 |
2023-08-12 |
Not clear |
| P P Ruvol. Ceramide regulates cellular homeostasis via diverse stress signaling pathways. Leukemia. vol 15. issue 8. 2001-08-16. PMID:11480555. |
ceramide activation of protein phosphatases has been shown to promote inactivation of a number of pro-growth cellular regulators including the kinases pkc alpha and akt, bcl2 and the retinoblastoma protein. |
2001-08-16 |
2023-08-12 |
Not clear |
| K Hisamoto, M Ohmichi, H Kurachi, J Hayakawa, Y Kanda, Y Nishio, K Adachi, K Tasaka, E Miyoshi, N Fujiwara, N Taniguchi, Y Murat. Estrogen induces the Akt-dependent activation of endothelial nitric-oxide synthase in vascular endothelial cells. The Journal of biological chemistry. vol 276. issue 5. 2001-06-21. PMID:11044445. |
we further examined the 17beta-e2-induced akt activity in chinese hamster ovary (cho) cells transiently transfected with cdnas for estrogen receptor alpha (eralpha) or estrogen receptor beta (erbeta). |
2001-06-21 |
2023-08-12 |
human |
| C H Yang, A Murti, S R Pfeffer, J G Kim, D B Donner, L M Pfeffe. Interferon alpha /beta promotes cell survival by activating nuclear factor kappa B through phosphatidylinositol 3-kinase and Akt. The Journal of biological chemistry. vol 276. issue 17. 2001-06-14. PMID:11278812. |
interferon alpha /beta promotes cell survival by activating nuclear factor kappa b through phosphatidylinositol 3-kinase and akt. |
2001-06-14 |
2023-08-12 |
Not clear |
| R Diem, R Meyer, J H Weishaupt, M Bah. Reduction of potassium currents and phosphatidylinositol 3-kinase-dependent AKT phosphorylation by tumor necrosis factor-(alpha) rescues axotomized retinal ganglion cells from retrograde cell death in vivo. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 6. 2001-06-07. PMID:11245689. |
reduction of potassium currents and phosphatidylinositol 3-kinase-dependent akt phosphorylation by tumor necrosis factor-(alpha) rescues axotomized retinal ganglion cells from retrograde cell death in vivo. |
2001-06-07 |
2023-08-12 |
Not clear |
| K I Ishibashi, T Imamura, P M Sharma, J Huang, S Ugi, J M Olefsk. Chronic endothelin-1 treatment leads to heterologous desensitization of insulin signaling in 3T3-L1 adipocytes. The Journal of clinical investigation. vol 107. issue 9. 2001-06-07. PMID:11342583. |
chronic et-1 treatment inhibited insulin-stimulated tyrosine phosphorylation of g alpha q/11 and irs-1, as well as their association with pi3-kinase and blocked the activation of pi3-kinase activity and phosphorylation of akt: in addition, chronic et-1 treatment caused irs-1 degradation, which could be blocked by inhibitors of pi3-kinase or p70 s6-kinase. |
2001-06-07 |
2023-08-12 |
Not clear |
| R P Cherla, R K Ganj. Stromal cell-derived factor 1 alpha-induced chemotaxis in T cells is mediated by nitric oxide signaling pathways. Journal of immunology (Baltimore, Md. : 1950). vol 166. issue 5. 2001-04-26. PMID:11207257. |
akt, which has been shown to mediate no production, was also phosphorylated upon sdf1 alpha stimulation. |
2001-04-26 |
2023-08-12 |
Not clear |