| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Daniel G Sedding, Jennifer Hermsen, Ulrike Seay, Oliver Eickelberg, Wolfgang Kummer, Carsten Schwencke, Ruth H Strasser, Harald Tillmanns, Ruediger C Braun-Dullaeu. Caveolin-1 facilitates mechanosensitive protein kinase B (Akt) signaling in vitro and in vivo. Circulation research. vol 96. issue 6. 2005-09-22. PMID:15731459. |
alpha(v)beta3 integrins were identified to colocalize with pi3-k/caveolin-1 complexes, and blockade of alpha(v)beta3 integrins prevented akt activation. |
2005-09-22 |
2023-08-12 |
mouse |
| Wei-Chien Huang, Ching-Chow Che. Akt phosphorylation of p300 at Ser-1834 is essential for its histone acetyltransferase and transcriptional activity. Molecular and cellular biology. vol 25. issue 15. 2005-09-15. PMID:16024795. |
here, we show that akt is activated and translocated to the nucleus in response to tumor necrosis factor alpha. |
2005-09-15 |
2023-08-12 |
Not clear |
| Shiow-Lin Pan, Jih-Hwa Guh, Chieh-Yu Peng, Shih-Wei Wang, Ya-Ling Chang, Fong-Chi Cheng, Jau-Hsiang Chang, Sheng-Chu Kuo, Fang-Yu Lee, Che-Ming Ten. YC-1 [3-(5'-hydroxymethyl-2'-furyl)-1-benzyl indazole] inhibits endothelial cell functions induced by angiogenic factors in vitro and angiogenesis in vivo models. The Journal of pharmacology and experimental therapeutics. vol 314. issue 1. 2005-08-26. PMID:15784655. |
yc-1 inhibited vegf- and bfgf-induced p42/p44 mitogen-activated protein kinase and akt phosphorylation as well as protein kinase c alpha translocation using western blot analysis. |
2005-08-26 |
2023-08-12 |
mouse |
| Ratna Prasad, Shailendra Giri, Narender Nath, Inderjit Singh, Avtar K Sing. Inhibition of phosphoinositide 3 kinase-Akt (protein kinase B)-nuclear factor-kappa B pathway by lovastatin limits endothelial-monocyte cell interaction. Journal of neurochemistry. vol 94. issue 1. 2005-08-08. PMID:15953363. |
it inhibits tumor necrosis factor alpha (tnfalpha)-induced pi3-kinase, akt and nf-kappab activation in these cells. |
2005-08-08 |
2023-08-12 |
Not clear |
| Makoto Hamasaki, Teru Hideshima, Pierfrancesco Tassone, Paola Neri, Kenji Ishitsuka, Hiroshi Yasui, Norihiko Shiraishi, Noopur Raje, Shaji Kumar, Donald H Picker, Gary S Jacob, Paul G Richardson, Nikhil C Munshi, Kenneth C Anderso. Azaspirane (N-N-diethyl-8,8-dipropyl-2-azaspiro [4.5] decane-2-propanamine) inhibits human multiple myeloma cell growth in the bone marrow milieu in vitro and in vivo. Blood. vol 105. issue 11. 2005-07-12. PMID:15705788. |
azaspirane inhibits signal transducer activator of transcription 3 (stat3) and a pi3-k (phosphatidylinositol 3-kinase) target (akt), but not extracellular signal-regulated kinase 1 and 2 (erk1/2), inhibits phosphorylation triggered by il-6, and also inhibits inhibitorkappabalpha (ikappabalpha) and nuclear factor kappab (nfkappab) p65 phosphorylation triggered by tumor necrosis factor alpha (tnf-alpha). |
2005-07-12 |
2023-08-12 |
mouse |
| Edward A Medina, Robert R Afsari, Tommer Ravid, S Sianna Castillo, Kent L Erickson, Tzipora Goldkor. Tumor necrosis factor-{alpha} decreases Akt protein levels in 3T3-L1 adipocytes via the caspase-dependent ubiquitination of Akt. Endocrinology. vol 146. issue 6. 2005-06-28. PMID:15746249. |
tumor necrosis factor-{alpha} decreases akt protein levels in 3t3-l1 adipocytes via the caspase-dependent ubiquitination of akt. |
2005-06-28 |
2023-08-12 |
Not clear |
| Luciano Vellon, Javier A Menendez, Ruth Lup. AlphaVbeta3 integrin regulates heregulin (HRG)-induced cell proliferation and survival in breast cancer. Oncogene. vol 24. issue 23. 2005-06-09. PMID:15782133. |
mechanistically, functional blockade of alpha(v)beta(3) impaired hrg-promoted hyperactivation of erk1/erk2 mapk without altering the activation of akt. |
2005-06-09 |
2023-08-12 |
Not clear |
| Luciano Vellon, Javier A Menendez, Ruth Lup. AlphaVbeta3 integrin regulates heregulin (HRG)-induced cell proliferation and survival in breast cancer. Oncogene. vol 24. issue 23. 2005-06-09. PMID:15782133. |
moreover, blockade of cyr61 expression impaired the hrg-induced hyperactivation of erk1/erk2 mapk without altering the activation status of akt in mda-mb-231 cells, thus resembling the effects exerted by the downregulation of hrg expression as well as by functional blockade of alpha(v)beta(3). |
2005-06-09 |
2023-08-12 |
Not clear |
| Heike Hall, Valentin Djonov, Martin Ehrbar, Matthias Hoechli, Jeffrey A Hubbel. Heterophilic interactions between cell adhesion molecule L1 and alphavbeta3-integrin induce HUVEC process extension in vitro and angiogenesis in vivo. Angiogenesis. vol 7. issue 3. 2005-04-25. PMID:15609076. |
furthermore, l1ig6 stimulated huvecs showed increased tyrosine phosphorylation of alpha(v)beta3 and phosphorylation of map kinases (erk1 and erk2) but not akt indicating specific activation of alpha(v) and alpha(v)beta3 followed by activation of downstream kinases. |
2005-04-25 |
2023-08-12 |
human |
| Amanda Dutton, Gary M Reynolds, Christopher W Dawson, Lawrence S Young, Paul G Murra. Constitutive activation of phosphatidyl-inositide 3 kinase contributes to the survival of Hodgkin's lymphoma cells through a mechanism involving Akt kinase and mTOR. The Journal of pathology. vol 205. issue 4. 2005-04-21. PMID:15714459. |
several downstream effectors of akt signalling, including glycogen synthase kinase 3 (gsk-3) alpha and beta and mtor substrates 4e-bp1 and p70 s6 kinase, were also phosphorylated in hl cells. |
2005-04-21 |
2023-08-12 |
Not clear |
| P Algenstaedt, N Hennigs, N Telkamp, B Schwarzloh, C Kausch, S Matthaei, N Hansen-Algenstaedt, H Grete. Met326Ile aminoacid polymorphism in the human p85 alpha gene has no major impact on early insulin signaling in type 2 diabetes. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 36. issue 10. 2005-03-10. PMID:15523593. |
furthermore, irs-1, irs-2, p85 alpha and mapk protein contents were not significantly changed, and neither were mapk or akt phosphorylation. |
2005-03-10 |
2023-08-12 |
human |
| Anju Agarwal, Kingshuk Das, Natalia Lerner, Swati Sathe, Muzaffer Cicek, Graham Casey, Nywana Sizemor. The AKT/I kappa B kinase pathway promotes angiogenic/metastatic gene expression in colorectal cancer by activating nuclear factor-kappa B and beta-catenin. Oncogene. vol 24. issue 6. 2005-03-02. PMID:15592509. |
the constitutive activation of nf kappa b- and beta-catenin-dependent transcription is inhibited by transiently transfecting either kinase dead (kd) ikk alpha, which blocks ikk alpha kinase activity, kd akt, which blocks akt activity, or wildtype (wt) pten, which inhibits pi3k and akt activity. |
2005-03-02 |
2023-08-12 |
Not clear |
| Anju Agarwal, Kingshuk Das, Natalia Lerner, Swati Sathe, Muzaffer Cicek, Graham Casey, Nywana Sizemor. The AKT/I kappa B kinase pathway promotes angiogenic/metastatic gene expression in colorectal cancer by activating nuclear factor-kappa B and beta-catenin. Oncogene. vol 24. issue 6. 2005-03-02. PMID:15592509. |
the ability of kd ikk alpha, kd akt or wt pten to decrease beta-catenin-dependent transcription is independent of their effects on nf kappa b. inducible expression of either kd ikk alpha or wt pten strongly inhibits both the constitutive nf kappa b- and beta-catenin-dependent promoter and endogenous gene activation. |
2005-03-02 |
2023-08-12 |
Not clear |
| Ferdinand H Bahlmann, Rong Song, Sascha M Boehm, Michael Mengel, Reinhard von Wasielewski, Carsten Lindschau, Torsten Kirsch, Kirsten de Groot, Robert Laudeley, Eva Niemczyk, Faikah Güler, Jan Menne, Hermann Haller, Danilo Flise. Low-dose therapy with the long-acting erythropoietin analogue darbepoetin alpha persistently activates endothelial Akt and attenuates progressive organ failure. Circulation. vol 110. issue 8. 2005-02-28. PMID:15302785. |
low-dose therapy with the long-acting erythropoietin analogue darbepoetin alpha persistently activates endothelial akt and attenuates progressive organ failure. |
2005-02-28 |
2023-08-12 |
human |
| Noriko Kamata, Haruo Kutsuna, Fumihiko Hato, Takayuki Kato, Nobuhide Oshitani, Tetsuo Arakawa, Seiichi Kitagaw. Activation of human neutrophils by granulocyte colony-stimulating factor, granulocyte-macrophage colony-stimulating factor, and tumor necrosis factor alpha: role of phosphatidylinositol 3-kinase. International journal of hematology. vol 80. issue 5. 2005-02-03. PMID:15646653. |
stimulation of human neutrophils with granulocyte colony-stimulating factor (g-csf), granulocyte-macrophage csf (gm-csf), or tumor necrosis factor alpha (tnf) resulted in phosphorylation of akt, the potency being gm-csf > g-csf = tnf, which was inhibited by wortmannin. |
2005-02-03 |
2023-08-12 |
human |
| Zsuzsanna Vértes, Ferenc Lengyel, Angéla Oszter, József L Környei, Balázs Sumegi, Marietta Vérte. Effect of estradiol on expression and activation of Akt protein in rat hypothalamus exposed to chronic [D-Met2, Pro5]-enkephalinamide treatment. Steroids. vol 69. issue 4. 2005-01-12. PMID:15183692. |
expression and activation of akt proteins, nuclear [3h]estradiol binding, and the expression of estrogen receptor alpha (eralpha) and beta (erbeta) and of progesterone receptor (pr) were investigated. |
2005-01-12 |
2023-08-12 |
rat |
| Muriel Coulpier, Carlos F Ibáñe. Retrograde propagation of GDNF-mediated signals in sympathetic neurons. Molecular and cellular neurosciences. vol 27. issue 2. 2005-01-11. PMID:15485769. |
retrograde signaling was associated with retrograde transport of radiolabeled gdnf and gfr alpha 1, as well as activation of ret and akt, but not of erk1/2, in cell bodies. |
2005-01-11 |
2023-08-12 |
Not clear |
| Pierre P Massion, Peter M Taflan, Yu Shyr, S M Jamshedur Rahman, Pinar Yildiz, Bashar Shakthour, Mary E Edgerton, Matthew Ninan, Jeremiah J Andersen, Adriana L Gonzale. Early involvement of the phosphatidylinositol 3-kinase/Akt pathway in lung cancer progression. American journal of respiratory and critical care medicine. vol 170. issue 10. 2004-12-14. PMID:15317667. |
we examined the association between gene copy number of the pi3-kinase catalytic subunit alpha (pik3ca) and phosphorylated akt expression in invasive and preinvasive lung cancers. |
2004-12-14 |
2023-08-12 |
Not clear |
| Shishir Shishodia, Dimpy Koul, Bharat B Aggarwa. Cyclooxygenase (COX)-2 inhibitor celecoxib abrogates TNF-induced NF-kappa B activation through inhibition of activation of I kappa B alpha kinase and Akt in human non-small cell lung carcinoma: correlation with suppression of COX-2 synthesis. Journal of immunology (Baltimore, Md. : 1950). vol 173. issue 3. 2004-11-02. PMID:15265936. |
cyclooxygenase (cox)-2 inhibitor celecoxib abrogates tnf-induced nf-kappa b activation through inhibition of activation of i kappa b alpha kinase and akt in human non-small cell lung carcinoma: correlation with suppression of cox-2 synthesis. |
2004-11-02 |
2023-08-12 |
human |
| Shishir Shishodia, Dimpy Koul, Bharat B Aggarwa. Cyclooxygenase (COX)-2 inhibitor celecoxib abrogates TNF-induced NF-kappa B activation through inhibition of activation of I kappa B alpha kinase and Akt in human non-small cell lung carcinoma: correlation with suppression of COX-2 synthesis. Journal of immunology (Baltimore, Md. : 1950). vol 173. issue 3. 2004-11-02. PMID:15265936. |
celecoxib also inhibited the tnf-induced interaction of akt with i kappa b alpha kinase (ikk). |
2004-11-02 |
2023-08-12 |
human |