| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Heike Hall, Valentin Djonov, Martin Ehrbar, Matthias Hoechli, Jeffrey A Hubbel. Heterophilic interactions between cell adhesion molecule L1 and alphavbeta3-integrin induce HUVEC process extension in vitro and angiogenesis in vivo. Angiogenesis. vol 7. issue 3. 2005-04-25. PMID:15609076. |
furthermore, l1ig6 stimulated huvecs showed increased tyrosine phosphorylation of alpha(v)beta3 and phosphorylation of map kinases (erk1 and erk2) but not akt indicating specific activation of alpha(v) and alpha(v)beta3 followed by activation of downstream kinases. |
2005-04-25 |
2023-08-12 |
human |
| Amanda Dutton, Gary M Reynolds, Christopher W Dawson, Lawrence S Young, Paul G Murra. Constitutive activation of phosphatidyl-inositide 3 kinase contributes to the survival of Hodgkin's lymphoma cells through a mechanism involving Akt kinase and mTOR. The Journal of pathology. vol 205. issue 4. 2005-04-21. PMID:15714459. |
several downstream effectors of akt signalling, including glycogen synthase kinase 3 (gsk-3) alpha and beta and mtor substrates 4e-bp1 and p70 s6 kinase, were also phosphorylated in hl cells. |
2005-04-21 |
2023-08-12 |
Not clear |
| P Algenstaedt, N Hennigs, N Telkamp, B Schwarzloh, C Kausch, S Matthaei, N Hansen-Algenstaedt, H Grete. Met326Ile aminoacid polymorphism in the human p85 alpha gene has no major impact on early insulin signaling in type 2 diabetes. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 36. issue 10. 2005-03-10. PMID:15523593. |
furthermore, irs-1, irs-2, p85 alpha and mapk protein contents were not significantly changed, and neither were mapk or akt phosphorylation. |
2005-03-10 |
2023-08-12 |
human |
| Anju Agarwal, Kingshuk Das, Natalia Lerner, Swati Sathe, Muzaffer Cicek, Graham Casey, Nywana Sizemor. The AKT/I kappa B kinase pathway promotes angiogenic/metastatic gene expression in colorectal cancer by activating nuclear factor-kappa B and beta-catenin. Oncogene. vol 24. issue 6. 2005-03-02. PMID:15592509. |
the constitutive activation of nf kappa b- and beta-catenin-dependent transcription is inhibited by transiently transfecting either kinase dead (kd) ikk alpha, which blocks ikk alpha kinase activity, kd akt, which blocks akt activity, or wildtype (wt) pten, which inhibits pi3k and akt activity. |
2005-03-02 |
2023-08-12 |
Not clear |
| Anju Agarwal, Kingshuk Das, Natalia Lerner, Swati Sathe, Muzaffer Cicek, Graham Casey, Nywana Sizemor. The AKT/I kappa B kinase pathway promotes angiogenic/metastatic gene expression in colorectal cancer by activating nuclear factor-kappa B and beta-catenin. Oncogene. vol 24. issue 6. 2005-03-02. PMID:15592509. |
the ability of kd ikk alpha, kd akt or wt pten to decrease beta-catenin-dependent transcription is independent of their effects on nf kappa b. inducible expression of either kd ikk alpha or wt pten strongly inhibits both the constitutive nf kappa b- and beta-catenin-dependent promoter and endogenous gene activation. |
2005-03-02 |
2023-08-12 |
Not clear |
| Ferdinand H Bahlmann, Rong Song, Sascha M Boehm, Michael Mengel, Reinhard von Wasielewski, Carsten Lindschau, Torsten Kirsch, Kirsten de Groot, Robert Laudeley, Eva Niemczyk, Faikah Güler, Jan Menne, Hermann Haller, Danilo Flise. Low-dose therapy with the long-acting erythropoietin analogue darbepoetin alpha persistently activates endothelial Akt and attenuates progressive organ failure. Circulation. vol 110. issue 8. 2005-02-28. PMID:15302785. |
low-dose therapy with the long-acting erythropoietin analogue darbepoetin alpha persistently activates endothelial akt and attenuates progressive organ failure. |
2005-02-28 |
2023-08-12 |
human |
| Noriko Kamata, Haruo Kutsuna, Fumihiko Hato, Takayuki Kato, Nobuhide Oshitani, Tetsuo Arakawa, Seiichi Kitagaw. Activation of human neutrophils by granulocyte colony-stimulating factor, granulocyte-macrophage colony-stimulating factor, and tumor necrosis factor alpha: role of phosphatidylinositol 3-kinase. International journal of hematology. vol 80. issue 5. 2005-02-03. PMID:15646653. |
stimulation of human neutrophils with granulocyte colony-stimulating factor (g-csf), granulocyte-macrophage csf (gm-csf), or tumor necrosis factor alpha (tnf) resulted in phosphorylation of akt, the potency being gm-csf > g-csf = tnf, which was inhibited by wortmannin. |
2005-02-03 |
2023-08-12 |
human |
| Zsuzsanna Vértes, Ferenc Lengyel, Angéla Oszter, József L Környei, Balázs Sumegi, Marietta Vérte. Effect of estradiol on expression and activation of Akt protein in rat hypothalamus exposed to chronic [D-Met2, Pro5]-enkephalinamide treatment. Steroids. vol 69. issue 4. 2005-01-12. PMID:15183692. |
expression and activation of akt proteins, nuclear [3h]estradiol binding, and the expression of estrogen receptor alpha (eralpha) and beta (erbeta) and of progesterone receptor (pr) were investigated. |
2005-01-12 |
2023-08-12 |
rat |
| Muriel Coulpier, Carlos F Ibáñe. Retrograde propagation of GDNF-mediated signals in sympathetic neurons. Molecular and cellular neurosciences. vol 27. issue 2. 2005-01-11. PMID:15485769. |
retrograde signaling was associated with retrograde transport of radiolabeled gdnf and gfr alpha 1, as well as activation of ret and akt, but not of erk1/2, in cell bodies. |
2005-01-11 |
2023-08-12 |
Not clear |
| Pierre P Massion, Peter M Taflan, Yu Shyr, S M Jamshedur Rahman, Pinar Yildiz, Bashar Shakthour, Mary E Edgerton, Matthew Ninan, Jeremiah J Andersen, Adriana L Gonzale. Early involvement of the phosphatidylinositol 3-kinase/Akt pathway in lung cancer progression. American journal of respiratory and critical care medicine. vol 170. issue 10. 2004-12-14. PMID:15317667. |
we examined the association between gene copy number of the pi3-kinase catalytic subunit alpha (pik3ca) and phosphorylated akt expression in invasive and preinvasive lung cancers. |
2004-12-14 |
2023-08-12 |
Not clear |
| Shishir Shishodia, Dimpy Koul, Bharat B Aggarwa. Cyclooxygenase (COX)-2 inhibitor celecoxib abrogates TNF-induced NF-kappa B activation through inhibition of activation of I kappa B alpha kinase and Akt in human non-small cell lung carcinoma: correlation with suppression of COX-2 synthesis. Journal of immunology (Baltimore, Md. : 1950). vol 173. issue 3. 2004-11-02. PMID:15265936. |
cyclooxygenase (cox)-2 inhibitor celecoxib abrogates tnf-induced nf-kappa b activation through inhibition of activation of i kappa b alpha kinase and akt in human non-small cell lung carcinoma: correlation with suppression of cox-2 synthesis. |
2004-11-02 |
2023-08-12 |
human |
| Shishir Shishodia, Dimpy Koul, Bharat B Aggarwa. Cyclooxygenase (COX)-2 inhibitor celecoxib abrogates TNF-induced NF-kappa B activation through inhibition of activation of I kappa B alpha kinase and Akt in human non-small cell lung carcinoma: correlation with suppression of COX-2 synthesis. Journal of immunology (Baltimore, Md. : 1950). vol 173. issue 3. 2004-11-02. PMID:15265936. |
celecoxib also inhibited the tnf-induced interaction of akt with i kappa b alpha kinase (ikk). |
2004-11-02 |
2023-08-12 |
human |
| Nicola J Jordan, Julia M W Gee, Denise Barrow, Alan E Wakeling, Robert I Nicholso. Increased constitutive activity of PKB/Akt in tamoxifen resistant breast cancer MCF-7 cells. Breast cancer research and treatment. vol 87. issue 2. 2004-11-02. PMID:15377841. |
high levels of basal akt, gsk3 alpha / beta and p70s6 kinase phosphorylation are all inhibited by the pi3 kinase inhibitor, ly 294002. |
2004-11-02 |
2023-08-12 |
Not clear |
| Nicola J Jordan, Julia M W Gee, Denise Barrow, Alan E Wakeling, Robert I Nicholso. Increased constitutive activity of PKB/Akt in tamoxifen resistant breast cancer MCF-7 cells. Breast cancer research and treatment. vol 87. issue 2. 2004-11-02. PMID:15377841. |
the ligands for the egfr/erbb1 receptor, egf (epidermal growth factor) and tgf alpha (transforming growth factor- alpha ) demonstrate an increased ability to activate akt in tam-r compared with parental mcf-7 cells and it is proposed that the preferred autocrine or paracrine activation of akt occurs via the erbb heterodimer egfr/erbb2 in tam-r cells. |
2004-11-02 |
2023-08-12 |
Not clear |
| Daniela Matei, David D Chang, Meei-Huey Jen. Imatinib mesylate (Gleevec) inhibits ovarian cancer cell growth through a mechanism dependent on platelet-derived growth factor receptor alpha and Akt inactivation. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 10. issue 2. 2004-10-04. PMID:14760091. |
imatinib mesylate (gleevec) inhibits ovarian cancer cell growth through a mechanism dependent on platelet-derived growth factor receptor alpha and akt inactivation. |
2004-10-04 |
2023-08-12 |
Not clear |
| Pradip K Majumder, Phillip G Febbo, Rachel Bikoff, Raanan Berger, Qi Xue, Louis M McMahon, Judith Manola, James Brugarolas, Timothy J McDonnell, Todd R Golub, Massimo Loda, Heidi A Lane, William R Seller. mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways. Nature medicine. vol 10. issue 6. 2004-07-28. PMID:15156201. |
expression profiling showed that hif-1 alpha targets, including genes encoding most glycolytic enzymes, constituted the dominant transcriptional response to akt activation and mtor inhibition. |
2004-07-28 |
2023-08-12 |
mouse |
| Michael V G Latronico, Stefan Costinean, Maria Luisa Lavitrano, Cesare Peschle, Gianluigi Condorell. Regulation of cell size and contractile function by AKT in cardiomyocytes. Annals of the New York Academy of Sciences. vol 1015. 2004-07-28. PMID:15201165. |
in these cells, akt is activated by upstream molecules such as beta-adrenergic receptor, insulin-like growth factor-1 or insulin receptor, through pi3k alpha; whereas its activation is inhibited by the pten molecule. |
2004-07-28 |
2023-08-12 |
mouse |
| Koh Ono, Yoshitaka Iwanaga, Madoka Hirayama, Teruhisa Kawamura, Naoya Sowa, Koji Hasegaw. Contribution of caveolin-1 alpha and Akt to TNF-alpha-induced cell death. American journal of physiology. Lung cellular and molecular physiology. vol 287. issue 1. 2004-07-08. PMID:15020298. |
contribution of caveolin-1 alpha and akt to tnf-alpha-induced cell death. |
2004-07-08 |
2023-08-12 |
Not clear |
| Keishi Makino, Chi-Ping Day, Shao-Chun Wang, Yan M Li, Mien-Chie Hun. Upregulation of IKKalpha/IKKbeta by integrin-linked kinase is required for HER2/neu-induced NF-kappaB antiapoptotic pathway. Oncogene. vol 23. issue 21. 2004-05-20. PMID:15021910. |
stable expression of ilk-kd in her2/neu-transformed cells suppressed akt phosphorylation and the expression of ikappab kinase alpha and beta (ikkalpha and beta) at both the protein and mrna levels, preventing ikappab-alpha degradation and nf-kappab activation. |
2004-05-20 |
2023-08-12 |
Not clear |
| Edward B Arias, Junghoon Kim, Gregory D Carte. Prolonged incubation in PUGNAc results in increased protein O-Linked glycosylation and insulin resistance in rat skeletal muscle. Diabetes. vol 53. issue 4. 2004-05-20. PMID:15047606. |
pugnac did not significantly alter insulin-stimulated phosphorylation of akt (serine and threonine) or its substrates glycogen synthase kinase (gsk)3 alpha and gsk3 beta. |
2004-05-20 |
2023-08-12 |
rat |