| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sung Jin Kim, Mi-Gi Lee, Joohwan Lee, Myoung-Sook Shi. Silkworm ( Nutrients. vol 16. issue 13. 2024-07-13. PMID:38999911. |
molecular analyses demonstrated that swp significantly enhanced the phosphorylation of estrogen receptor alpha (erα), erk, and akt. |
2024-07-13 |
2024-07-15 |
mouse |
| Adedeji K Adebayo, Poornima Bhat-Nakshatri, Christopher Davis, Steven P Angus, Cihat Erdogan, Hongyu Gao, Nick Green, Brijesh Kumar, Yunlong Liu, Harikrishna Nakshatr. Oxygen tension-dependent variability in the cancer cell kinome impacts signaling pathways and response to targeted therapies. iScience. vol 27. issue 6. 2024-06-14. PMID:38872973. |
physioxia caused pdgfrβ-mediated activation of akt and extracellular regulated kinase (erk) that reduced sensitivity to egfr and phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (pik3ca) inhibition and maintained pdgfrβ+ epithelial-mesenchymal hybrid cells with potential cancer stem cell (csc) properties. |
2024-06-14 |
2024-06-16 |
Not clear |
| Lei Jiang, Zhibo Zhang, Zhaofeng Luo, Luan Li, Shengtao Yuan, Min Cui, Ke He, Jing Xia. Rupatadine inhibits colorectal cancer cell proliferation through the PIP5K1A/Akt/CDK2 pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 176. 2024-06-05. PMID:38838507. |
phosphatidylinositol-4-phosphate 5-kinase type 1 alpha (pip5k1a) acts upstream of the akt regulatory pathway and is abnormally expressed in many types of malignancies. |
2024-06-05 |
2024-06-08 |
Not clear |
| Y Feng, C Zhao, T Li, M Wang, B R Serrano, A R Barcenas, L Qu, W Zhao, M She. Quercetin ameliorates lipid deposition in primary hepatocytes of the chicken embryo. British poultry science. 2024-05-10. PMID:38727603. |
que mitigated lipid accumulation through the alpha serine/threonine protein kinase (akt) and extracellular signal-regulated kinase (erk) pathways. |
2024-05-10 |
2024-05-27 |
chicken |
| Tong Chen, Lin Zhang, Liangyu Yao, Jiaochen Luan, Xiang Zhou, Rong Cong, Xuejiang Guo, Chao Qin, Ninghong Son. Zinc oxide nanoparticles-induced testis damage at single-cell resolution: Depletion of spermatogonia reservoir and disorder of Sertoli cell homeostasis. Environment international. vol 181. 2023-11-02. PMID:37918063. |
mechanically, zno nps triggered fatty acid accumulation in gc-1 cells through protein kinase b (akt)/mammalian target of rapamycin (mtor) signaling and peroxisome proliferator-activated receptor alpha (pparα)/acyl-coa oxidase 1 (acox1) axis, contributing to cell apoptosis. |
2023-11-02 |
2023-11-08 |
rat |
| Jiangyi Wang, Xiaoyu Lin, Zongshan Shen, Guoqing Li, Lei Hu, Qiong Li, Yang Li, Jinsong Wang, Chunmei Zhang, Songlin Wang, Xiaoshan W. AKT from dental epithelium to papilla promotes odontoblast differentiation. Differentiation; research in biological diversity. vol 134. 2023-10-28. PMID:37898102. |
additionally, we found that de cells secreted collagen type iv alpha 6 chain (col4a6) downstream of epithelial akt signaling to positively regulate mesenchymal akt levels. |
2023-10-28 |
2023-11-08 |
Not clear |
| Ewa Mlyczyńska, Patrycja Kurowska, Dominika Wachowska, Małgorzata Grzesiak, Joelle Dupont, Agnieszka Ra. Phoenixin-14 as a novel direct regulator of porcine luteal cell functions. Biology of reproduction. 2023-10-10. PMID:37815939. |
also, pnx-14 increased the expression of gpr173 and the phosphorylation of extracellular signal-regulated kinase 1/2 (erk1/2), protein kinase b (akt), inhibited the phosphorylation of protein kinase a (pka), and had mixed effect on amp-activated protein kinase alpha (ampkα) and protein kinase c (pkc). |
2023-10-10 |
2023-10-15 |
Not clear |
| Mohamed S Abdel-Bakky, Anas S A Aldakhili, Hussein M Ali, Ali Y Babiker, Ahmad H Alhowail, Salman A A Mohamme. Evaluation of Cisplatin-Induced Acute Renal Failure Amelioration Using Fondaparinux and Alteplase. Pharmaceuticals (Basel, Switzerland). vol 16. issue 7. 2023-07-29. PMID:37513824. |
the fund + cis group showed significantly increased expression levels of platelet count, retinoid x receptor alpha (rxr-α) and phosphorylated akt (p-akt) in addition to decreased levels of urea, blood urea nitrogen (bun), uric acid, white blood cells (wbcs), red blood cells (rbcs), relative kidney body weight, kidney injury score, glucose, prothrombin (pt), a disintegrin and metalloproteinases-10 (adam10), extracellular matrix deposition, protease-activated receptor 2 (par-2), and fibrinogen expression when compared to the cis-only group. |
2023-07-29 |
2023-08-14 |
mouse |
| Zhuang-Zhi Wang, Hai-Chen Xu, Huan-Xia Zhou, Chen-Kai Zhang, Bo-Ming Li, Jia-Han He, Pin-Shi Ni, Xiao-Ming Yu, Yun-Qing Liu, Fang-Hui L. Long-term detraining reverses the improvement of lifelong exercise on skeletal muscle ferroptosis and inflammation in aging rats: fiber-type dependence of the Keap1/Nrf2 pathway. Biogerontology. 2023-06-08. PMID:37289374. |
compared with lat, det remarkably downregulated adiponectin and upregulated tumor necrosis factor alpha (tnf-α) expression, while phosphoinositide 3-kinase (pi3k), protein kinase b (akt), and 70-kda ribosomal protein s6 kinase (p70s6k) protein expression decreased, and that of foxo1 and muscle atrophy f-box (mafbx) proteins increased in the quadriceps femoris. |
2023-06-08 |
2023-08-14 |
rat |
| Seyeon Oh, Suk Bae Seo, Gunpoong Kim, Sosorburam Batsukh, Kuk Hui Son, Kyunghee Byu. Poly-D,L-Lactic Acid Stimulates Angiogenesis and Collagen Synthesis in Aged Animal Skin. International journal of molecular sciences. vol 24. issue 9. 2023-05-14. PMID:37175693. |
heat shock protein 90 (hsp90), hypoxia-inducible factor-1 alpha (hif-1α), and vascular endothelial growth factor (vegf) are proangiogenic factors that stimulate the activities of phosphoinositide 3-kinase (pi3k), protein kinase b (akt), and extracellular signal-regulated kinase 1/2 (erk1/2). |
2023-05-14 |
2023-08-14 |
Not clear |
| Y Ma, Y Du, J Yang, Q He, H Wang, X Li. Anti-inflammatory effect of Irisin on LPS-stimulated macrophages through inhibition of MAPK pathway. Physiological research. vol 72. issue 2. 2023-05-09. PMID:37159857. |
irisin pretreatment significantly inhibited the phosphorylation of erk and akt and increased the expression of ppar alpha and ppar gamma. |
2023-05-09 |
2023-08-14 |
Not clear |
| Carmen Amititeloaie, Liliana Chelaru, Gabriela Luminiţa Geleţu, Anca Sava, Alexandra Jităreanu, Andreea Mihaela Tibeică, Marcel Costulean. Apoptosis of pro-B lymphocytes induced by NR4A1 activation in the presence of gingival fibroblast exosomes and TNFα, caspase 8, STAT3, and Akt pathways modulators. Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie. vol 64. issue 1. 2023-05-02. PMID:37128789. |
in order to experimentally evaluate the apoptosis of pro-b type lymphocytes, induced as a result of the known activation of orphan nuclear receptor 4a1 (nr4a1), through cytosporone b (csn-b, 10 μm), in the presence or absence of exosomes derived from gingival fibroblasts, we administered as a treatment: 1 μm r-7050 [functional inhibitor of tumor necrosis factor alpha (tnfα)], 1 μm z-ietd-fmk (functional inhibitor of caspase 8), 1 μm gsk690693 (functional inhibitor of akt 1∕2∕3 pathways) and, last but not least, 1 μm scutellarin [functional inhibitor of receptor activator of nuclear factor-kappa b ligand (rankl)] and therefore of the signal transducer and activator of transcription 3 (stat3) pathway. |
2023-05-02 |
2023-08-14 |
Not clear |
| Naser-Aldin Lashgari, Nazanin Momeni Roudsari, Maryam Shayan, Sadaf Eshraghi, Saeideh Momtaz, Tannaz Jamialahmadi, Amir Hossein Abdolghaffari, Amirhossein Sahebka. Spinal Muscular Atrophy Treatment: The MTOR Regulatory Intervention. Current medicinal chemistry. 2023-02-15. PMID:36788689. |
mtor: mammalian/mechanistic target of rapamycin; sma: spinal muscular atrophy; igf-1r: insulin-like growth factor type 1 receptor; foxo3a: forkhead box class o 3a; eif4ebp1: eukaryotic translation initiation factor 4e-binding protein 1; atrogin-1 (fbox32): atrophy gene-1 (f-box only protein 32); traf2: tnf receptor-associated factor 2; p38 (mapk14): p38 (mitogen-activated protein kinase 14); rras2: ras related 2; erk (mapk1): extracellular signal-regulated kinase 1/2 (mitogen-activated protein kinase 1); sbma: spinal and bulbar muscular atrophy; smn: survival motor neuron; akt: protein kinase b; mafbx/atrogin-1: muscle atrophy f-box; murf-1: muscle ring-finger protein-1; wt: wild-type; gc-klf15-bcaa: circadian glucocorticoid-krüppel-like factor 15-branched-chain amino acid; sbma: spinal and bulbar muscular atrophy; pgc1α: proliferator-activated receptor γ coactivator 1 alpha ctrp3: c1q/tnf-related protein 3; smn: survival motor neuron; vegf: vascular endothelial growth factor; pten: phosphatase and tensin homolog. |
2023-02-15 |
2023-08-14 |
Not clear |
| Mei Zhang, Xinyu Cai, Jingyu Liu, Jidong Zhou, Qingqing Shi, Yue Jiang, Nannan Kang, Xin Zhen, Min Wu, Panpan Qiu, Guijun Yan, Haixiang Sun, Dong L. A novel lncRNA lncSAMD11-1:1 interacts with PIP4K2A to promote endometrial decidualization by stabilizing FoxO1 nuclear localization. The international journal of biochemistry & cell biology. 2022-08-20. PMID:35987479. |
mechanistically, lncsamd11-1:1 and phosphatidylinositol-5-phosphate 4-kinase type 2 alpha (pip4k2a) translocated out of nucleus and bound to each other during decidualization, thereby inhibiting the phosphorylation of akt and promoting foxo1 nuclear localization. |
2022-08-20 |
2023-08-14 |
human |
| Mai O Kadry, Rehab M Abdel Megee. Ubiquitous toxicity of Mercuric Chloride in target tissues and organs: Impact of Ubidecarenone and liposomal-Ubidecarenone STAT 5A/ PTEN /PI3K/AKT signaling pathways. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS). vol 74. 2022-08-11. PMID:35952450. |
nevertheless, liposomal drug delivery system is a promising era in the field of nano-medicine and have the advantageous of increasing drug bioavailability and retention phenomena in addition to targeting organ for all mentioned the present study was designed to investigate the hypothesis that messenger rna gene expression of signal transducer and activator of transcription- 5 a (stat-5a), phosphatase and tensin homolog (pten), phosphoinositol kinase (pi3k) and alpha serine/threonine-protein kinase (akt) can trigger hgcl3 induced nephrotoxicity post ubidecarenone and liposomal ubidecarenone therapy. |
2022-08-11 |
2023-08-14 |
Not clear |
| Chen-Yi Tang, He Wang, Yan Zhang, Zhongliang Wang, Guochun Zhu, Abigail McVicar, Yi-Ping Li, Wei Che. GPR125 positively regulates osteoclastogenesis potentially through AKT-NF-κB and MAPK signaling pathways. International journal of biological sciences. vol 18. issue 6. 2022-04-13. PMID:35414778. |
we also found that phosphorylated akt (p-akt) expression was downregulated, as well as nuclear factor kappa-b (nf-κb) signaling pathway protein phosphorylated-ikb alpha (p-ikbα). |
2022-04-13 |
2023-08-13 |
Not clear |
| Lucas Araújo Ferreira, Marcos Divino Ferreira-Junior, Keytiane de Jesus Viana Amaral, Keilah Valéria Naves Cavalcante, Carolina Nobre Ribeiro Pontes, Larissa Cristin, Dos Santos Ribeiro, Beatriz Gonçalves Dos Santos, Carlos Henrique Xavier, Paulo Cezar de Freitas Mathias, Monica Levy Andersen, Gustavo Rodrigues Pedrino, Carlos Henrique de Castro, Renata Mazaro-Costa, Rodrigo Mello Gome. Maternal postnatal early overfeeding induces sex-related cardiac dysfunction and alters sexually hormones levels in young offspring. The Journal of nutritional biochemistry. 2022-02-23. PMID:35196578. |
in addition, only male rats from slo group had decreased akt and type 2 ang-2 receptor, increased catalase and type alpha estrogenic receptor protein levels. |
2022-02-23 |
2023-08-13 |
rat |
| Qiu-Yuan Gong, Lin Cai, Yao Jing, Wei Wang, Dian-Xu Yang, Shi-Wen Chen, Heng-Li Tia. Urolithin A alleviates blood-brain barrier disruption and attenuates neuronal apoptosis following traumatic brain injury in mice. Neural regeneration research. vol 17. issue 9. 2022-02-10. PMID:35142690. |
we found that ua greatly reduced brain edema; increased the expression of tight junction proteins in injured cortex; increased the immunopositivity of two neuronal autophagy markers, microtubule-associated protein 1a/b light chain 3a/b (lc3) and p62; downregulated protein kinase b (akt) and mammalian target of rapamycin (mtor), two regulators of the phosphatidylinositol 3-kinase (pi3k)/akt/mtor signaling pathway; decreased the phosphorylation levels of inhibitor of nfκb (iκb) kinase alpha (ikkα) and nuclear factor kappa b (nfκb), two regulators of the neuroinflammation-related akt/ikk/nfκb signaling pathway; reduced blood-brain barrier permeability and neuronal apoptosis in injured cortex; and improved mouse neurological function. |
2022-02-10 |
2023-08-13 |
mouse |
| Cristina Quintavalle, Nathalie Meyer-Schaller, Stephanie Roessler, Diego Calabrese, Romina Marone, Tobias Riedl, Silvia Picco-Rey, Orestis A Panagiotou, Sarp Uzun, Salvatore Piscuoglio, Tuyana Boldanova, Chaoran B Bian, David Semela, Wolfram Jochum, Gieri Cathomas, Kirsten D Mertz, Joachim Diebold, Luca Mazzucchelli, Viktor H Koelzer, Achim Weber, Thomas Decaens, Luigi M Terracciano, Mathias Heikenwalder, Yujin Hoshida, Jesper B Andersen, Snorri S Thorgeirsson, Matthias S Matte. miR-579-3p Controls Hepatocellular Carcinoma Formation by Regulating the Phosphoinositide 3-Kinase-Protein Kinase B Pathway in Chronically Inflamed Liver. Hepatology communications. 2022-02-08. PMID:35132819. |
correlation with messenger rna expression profiles further revealed that mir-579-3p directly attenuated phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (pik3ca) expression and consequently protein kinase b (akt) and phosphorylated akt. |
2022-02-08 |
2023-08-13 |
Not clear |
| Sibi Raj, Kavindra Kumar Kesari, Arun Kumar, Brijesh Rathi, Ashok Sharma, Piyush Kumar Gupta, Saurabh Kumar Jha, Niraj Kumar Jha, Petr Slama, Shubhadeep Roychoudhury, Dhruv Kuma. Molecular mechanism(s) of regulation(s) of c-MET/HGF signaling in head and neck cancer. Molecular cancer. vol 21. issue 1. 2022-01-27. PMID:35081970. |
c-met pathway acts on several downstream effectors including phospholipase c gamma (plcγ), cellular src kinase (c-src), phosphotidylinsitol-3-oh kinase (pi3k), alpha serine/threonine-protein kinase (akt), mitogen-activated protein kinase (mapk), and wingless-related integration site (wnt) pathways. |
2022-01-27 |
2023-08-13 |
human |