| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tatsuro Egawa, Takeshi Ogawa, Takumi Yokokawa, Kohei Kido, Katsumasa Goto, Tatsuya Hayash. Methylglyoxal reduces molecular responsiveness to 4 weeks of endurance exercise in mouse plantaris muscle. Journal of applied physiology (Bethesda, Md. : 1985). 2022-01-13. PMID:35023763. |
mice in the voluntary exercise group were housed in a cage with a running wheel, while mice in the mg-treated groups received drinking water containing 1% mg. four weeks of voluntary exercise induced several molecular adaptations in the plantaris muscle, including increased expression of peroxisome proliferator-activated receptor gamma coactivator 1 alpha (pgc1α), mitochondria complex proteins, toll-like receptor 4 (tlr4), 72-kda heat shock protein (hsp72), hexokinase ii, and glyoxalase 1; this also enhanced insulin-stimulated akt ser |
2022-01-13 |
2023-08-13 |
mouse |
| Patrick Türck, Ashley Nemec-Bakk, Tanu Talwar, Zacharias Suntres, Adriane Belló-Klein, Alex Sander da Rosa Araujo, Neelam Khape. Blueberry extract attenuates norepinephrine-induced oxidative stress and apoptosis in H9c2 cardiac cells. Molecular and cellular biochemistry. 2022-01-06. PMID:34988854. |
ne led to increased activity of protein kinase b (akt), forkhead box o3a and amp-activated protein kinase alpha and decreased activity of signal transducer and activator of transcription 3. |
2022-01-06 |
2023-08-13 |
Not clear |
| Mei Yu, Mengyuan Wang, Shiyu Han, Long Han, Yue Kan, Juan Zhao, Xizhong Yu, Jing Yan, Yu Jin, Zhenwen Zhang, Wenbing Shang, Penghua Fan. Spexin ameliorates skeletal muscle insulin resistance through activation of GAL2 receptor. European journal of pharmacology. 2022-01-02. PMID:34973950. |
furthermore, spexin markedly augmented the peroxisome proliferator-activated receptor gamma coactivator 1 alpha (pgc-1α) expression and deacetylation, and further triggered glucose transporter 4 (glut4) expression and trafficking in myotubes through p38 mitogen-activated protein kinase (p38mapk) and protein kinase b (akt) activation. |
2022-01-02 |
2023-08-13 |
mouse |
| Huohuo Wang, Juanjuan Wang, Yihua Zhu, Huiping Yan, Yifan L. Effects of Different Intensity Exercise on Glucose Metabolism and Hepatic IRS/PI3K/AKT Pathway in SD Rats Exposed with TCDD. International journal of environmental research and public health. vol 18. issue 24. 2021-12-24. PMID:34948750. |
we measured the hepatic mrna expression levels of irs2, phosphatidylinositol-3-kinases catalytic subunit alpha (pik3ca), akt by real-time pcr. |
2021-12-24 |
2023-08-13 |
rat |
| Qian Zeng, Fangfang Jin, Husun Qian, Hongling Chen, Yange Wang, Dian Zhang, Yu Wei, Tingmei Chen, Bianqin Guo, Chengsen Cha. The miR-345-3p/PPP2CA signaling axis promotes proliferation and invasion of breast cancer cells. Carcinogenesis. 2021-12-18. PMID:34922339. |
further research identified protein phosphatase 2 catalytic subunit alpha (ppp2ca), a suppressor of akt phosphorylation, as a candidate target of mir-345-3p. |
2021-12-18 |
2023-08-13 |
mouse |
| Hsiao-Chi Tsai, Yan-You Lai, Hsuan-Chih Hsu, Yi-Chin Fong, Ming-Yu Lien, Chih-Hsin Tan. CCL4 Stimulates Cell Migration in Human Osteosarcoma via the mir-3927-3p/Integrin αvβ3 Axis. International journal of molecular sciences. vol 22. issue 23. 2021-12-10. PMID:34884541. |
analysis of osteosarcoma cell lines identified that ccl4 promotes integrin αvβ3 expression and cell migration by activating the focal adhesion kinase (fak), protein kinase b (akt), and hypoxia inducible factor 1 subunit alpha (hif-1α) signaling pathways, which can downregulate microrna-3927-3p expression. |
2021-12-10 |
2023-08-13 |
human |
| Ali Nasrollahzadeh, Majid Momeny, Hamidreza Fasehee, Marjan Yaghmaie, Davood Bashash, Saeed Hassani, Seyed A Mousavi, Seyed H Ghaffar. Anti-proliferative activity of disulfiram through regulation of the AKT-FOXO axis: A proteomic study of molecular targets. Biochimica et biophysica acta. Molecular cell research. vol 1868. issue 10. 2021-11-29. PMID:34182011. |
nine differentially expressed proteins were identified among which, three candidates including calmodulin (cam), peroxiredoxin 1 (prdx1) and collagen type i alpha 1 (col1a1) are involved in the regulation of the akt signaling pathway. |
2021-11-29 |
2023-08-13 |
Not clear |
| Yingchao Ye, Yaoyao Cai, Erjie Xia, Kejian Shi, Zhousheng Jin, Hongfei Chen, Fangfang Xia, Yun Xia, Thomas J Papadimos, Xuzhong Xu, Le Liu, Quanguang Wan. Apelin-13 Reverses Bupivacaine-Induced Cardiotoxicity via the Adenosine Monophosphate-Activated Protein Kinase Pathway. Anesthesia and analgesia. vol 133. issue 4. 2021-11-22. PMID:34524989. |
bupivacaine can inhibit protein kinase b (akt) phosphorylation and activated adenosine monophosphate-activated protein kinase alpha (ampkα). |
2021-11-22 |
2023-08-13 |
Not clear |
| Fake Liao, Xiunian Hu, Rijiang Che. The effects of Omarigliptin on promoting osteoblastic differentiation. Bioengineered. 2021-11-17. PMID:34787070. |
osteogenic medium was used to induce osteoblastic differentiation in mc3t3‑e1 cells, and was verified by the increased alkaline phosphatase (alp) activity, enhanced mineralization, and promoted expression level of osteoblastic differentiation-related factors, including bone morphogenetic protein-2 (bmp-2), alp, osteocalcin (ocn), collagen type i alpha 1 (col1a1), collagen type i alpha 2 (col1a2), runx2, osterix (sp7), fibroblast growth factor receptor 2 (fgfr2), and fibroblast growth factor receptor 3 (fgfr3), accompanied by the activation of the p38 and akt pathways. |
2021-11-17 |
2023-08-13 |
Not clear |
| Rong Zhang, Sifen Lu, Xudan Yang, Maojun Li, Hui Jia, Jing Liao, Qing Jing, Yanmei Wu, Haichuan Wang, Feng Xiao, Xiaohong Bai, Xiaoxue Na, Yulin Kang, Ling Wan, Jiyun Yan. miR-19a-3p downregulates tissue factor and functions as a potential therapeutic target for sepsis-induced disseminated intravascular coagulation. Biochemical pharmacology. vol 192. 2021-11-16. PMID:34246626. |
western blotting was used to detect the protein levels of tf, akt serine/threonine kinase (akt), extracellular regulated protein kinases (erk), nuclear factor kappa b (nf-κb) p65, nfkb inhibitor alpha (iκb-a) and their phosphorylated counterparts in cell experiments. |
2021-11-16 |
2023-08-13 |
human |
| Tian-Wen Ni, Xiao-Chuan Duan, Meng Wang, Mei-Qi Jia, Ying Chen, Yang Yu, Nan Qin, Hong-Quan Dua. Alkaloid derivative ION-31a inhibits breast cancer metastasis and angiogenesis by targeting HSP90α. Bioorganic chemistry. vol 115. 2021-11-09. PMID:34329994. |
ion-31a acts via inhibiting the hsp90/hypoxia inducible factor 1 alpha (hif-1α)/vascular endothelial growth factor (vegf)/vegf receptor 2 (vegfr2) pathway and downregulating downstream signal pathways, including protein kinase b (akt)/mammalian target of rapamycin (mtor), akt2/protein kinase c epsilon (pkcζ), extracellular regulated kinase 1/2 (erk1/2), focal adhesion kinase (fak), and mitogen-activated protein kinase 14 (p38mapk) pathways. |
2021-11-09 |
2023-08-13 |
Not clear |
| Jelena Stanisic, Tamara Ivkovic, Snjezana Romic, Manja Zec, Tijana Culafic, Mojca Stojiljkovic, Goran Koricana. Beneficial effect of walnuts on vascular tone is associated with Akt signalling, voltage-dependent calcium channel LTCC and ATP-sensitive potassium channel Kv1.2. International journal of food sciences and nutrition. vol 72. issue 3. 2021-10-14. PMID:32693647. |
in contrast with increased energy intake and body mass gain, aortic protein level of l-type calcium channel alpha subunit was decreased and the level of sur2b subunit of atp-sensitive k + channel was increased in healthy rats subjected to walnuts, together with improved akt phosphorylation. |
2021-10-14 |
2023-08-13 |
rat |
| Cihan Gur, Fatih Mehmet Kandemir, Ekrem Darendelioglu, Cuneyt Caglayan, Sefa Kucukler, Ozge Kandemir, Mustafa Ileritur. Morin protects against acrylamide-induced neurotoxicity in rats: an investigation into different signal pathways. Environmental science and pollution research international. vol 28. issue 36. 2021-09-20. PMID:33939091. |
biochemical and western blot analyses showed that acr increased malondialdehyde (mda), p38α mitogen-activated protein kinase (p38α mapk), nuclear factor kappa-b (nf-κb), tumor necrosis factor alpha (tnf-α), interleukin-1 beta (il-1β), interleukin-6 (il-6), cyclooxygenase-2 (cox-2), p53, caspase-3, bcl-2 associated x protein (bax), beclin-1, light chain 3a (lc3a), and light chain 3b (lc3b) levels and decreased those of superoxide dismutase (sod), catalase (cat), glutathione peroxidase (gpx), glutathione (gsh), b-cell lymphoma-2 (bcl-2), mammalian target of rapamycin (mtor), phosphoinositide 3-kinase (pi3k), and protein kinase b (akt) in brain tissue and therefore induced neurotoxicity by causing oxidative stress, inflammation, apoptosis, and autophagy. |
2021-09-20 |
2023-08-13 |
rat |
| Yasuto Kunii, Junya Matsumoto, Ryuta Izumi, Atsuko Nagaoka, Mizuki Hino, Risa Shishido, Makoto Sainouchi, Hiroyasu Akatsu, Yoshio Hashizume, Akiyoshi Kakita, Hirooki Yab. Evidence for Altered Phosphoinositide Signaling-Associated Molecules in the Postmortem Prefrontal Cortex of Patients with Schizophrenia. International journal of molecular sciences. vol 22. issue 15. 2021-09-08. PMID:34361045. |
protein expression levels of phosphatidylinositol 4-phosphate 5-kinase type-1 gamma (pip5k1c), phosphatidylinositol 4-kinase alpha (pik4ca, also known as pik4a), phosphatase and tensin homolog deleted from chromosome 10 (pten), protein kinase b (akt), and glycogen synthase kinase 3β (gsk3β) were measured using enzyme-linked immunosorbent assays and multiplex fluorescent bead-based immunoassays of the prefrontal cortex (pfc) of postmortem samples from 23 schizophrenia patients and 47 normal controls. |
2021-09-08 |
2023-08-13 |
Not clear |
| Tomozumi Takatani, Jun Shirakawa, Kimitaka Shibue, Manoj K Gupta, Hyunki Kim, Shusheng Lu, Jiang Hu, Morris F White, Robert T Kennedy, Rohit N Kulkarn. Insulin receptor substrate 1, but not IRS2, plays a dominant role in regulating pancreatic alpha cell function in mice. The Journal of biological chemistry. vol 296. 2021-08-23. PMID:33839150. |
alpha cell lines with stable irs1 knockdown could not repress glucagon mrna expression and exhibited a reduction in phosphorylation of akt ser/thr kinase (akt, at ser-473 and thr-308). |
2021-08-23 |
2023-08-13 |
mouse |
| Gelareh Daneshvar, Saghar Boostani, Mehdi Moghanibashi, Parisa Mohamadyneja. PHLPP2 gene L1016S (rs61733127) and PIK3R1 gene Met326Ile (rs3730089) polymorphisms are associated with the risk of colon and breast cancers. Nucleosides, nucleotides & nucleic acids. vol 40. issue 7. 2021-08-16. PMID:34193013. |
the pik3r1 and phlpp2 genes encode the p85 alpha subunit of pi3k and a phosphatase for akt, respectively, which play a direct role in regulating the pi3k-akt pathway that promotes cell survival, growth, and differentiation. |
2021-08-16 |
2023-08-13 |
Not clear |
| Mohammed A Mansou. SP3 is associated with migration, invasion, and Akt/PKB signalling in MDA-MB-231 breast cancer cells. Journal of biochemical and molecular toxicology. vol 35. issue 3. 2021-07-13. PMID:33113244. |
the gene expression analysis from the cancer genome atlas datasets indicated that sp3 is strongly correlated with akt signalling-related proteins, g protein subunit alpha 13, and rab33b (rab33b, member ras oncogene family). |
2021-07-13 |
2023-08-13 |
Not clear |
| Jian Wang, Xiean Ling, Min Zhou, Guanggui Ding, Bin Peng, Jun Wa. Thermal treatment decreases resistance to osimertinib in non-small cell lung cancer through the EGFR/PI3K/AKT pathway. Neoplasma. vol 68. issue 3. 2021-06-02. PMID:33724860. |
cell viability, apoptosis, sensitivity to osi, threonine-methionine amino acid substitution at position 790 (t790m) mutation levels, and protein expression of epidermal growth factor receptor (egfr), phosphatidylinositol 3-kinase (pi3k), protein kinase b (akt), hypoxia-inducible factor-1 alpha (hif-1a) were detected using different methods. |
2021-06-02 |
2023-08-13 |
mouse |
| Hamid Behrouj, Atefeh Seghatoleslam, Pooneh Mokarram, Saeid Ghavam. Effect of casein kinase 1α inhibition on autophagy flux and the AKT/phospho-β-catenin (S552) axis in HCT116, a RAS-mutated colorectal cancer cell line. Canadian journal of physiology and pharmacology. vol 99. issue 3. 2021-03-22. PMID:33635146. |
casein kinase 1 alpha (ck1α) is an enzyme that simultaneously regulates wnt/β-catenin and akt. |
2021-03-22 |
2023-08-13 |
Not clear |
| M Z Mohamed, Mf Abed El Baky, O A Hassan, H H Mohammed, A M Abdel-Azi. PTEN/PI3K/VEGF signaling pathway involved in the protective effect of xanthine oxidase inhibitor febuxostat against endometrial hyperplasia in rats. Human & experimental toxicology. vol 39. issue 9. 2021-03-16. PMID:32228192. |
gene expressions of phosphatidylinositol-3-kinase (pi3k), akt, and hypoxia-inducible factor 1 alpha were assessed by the quantitative real-time polymerase chain reaction. |
2021-03-16 |
2023-08-13 |
rat |