| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ji Young Kim, Chan Hyung Kim, Eun Young Lee, Je Hoon Se. Alpha B-Crystallin Overexpression Protects Oligodendrocyte Precursor Cells Against Oxidative Stress-Induced Apoptosis Through the Akt Pathway. Journal of molecular neuroscience : MN. vol 70. issue 5. 2021-01-04. PMID:31970633. |
alpha b-crystallin overexpression protects oligodendrocyte precursor cells against oxidative stress-induced apoptosis through the akt pathway. |
2021-01-04 |
2023-08-13 |
Not clear |
| Moustafa Al Hariri, Miran A Jaffa, Richard Saoud, Jingfu Zhao, Rui Zhu, Aneese A Jaffa, Ghewa A El-Achkar, Mayssam Moussa, Firas Kobeissy, Anwarul Hassan, Fuad N Ziyadeh, Yehia Mechref, Ayad A Jaff. Vascular Cells Proteome Associated with Bradykinin and Leptin Inflammation and Oxidative Stress Signals. Antioxidants (Basel, Switzerland). vol 9. issue 12. 2020-12-29. PMID:33316969. |
bk and leptin induced the expression of inflammatory cytokines such as tumor necrosis factor alpha (tnf-α) and interleukin-1β (il-1β) and pathway analysis revealed the activation of mitogen-activated protein kinases (mapks) and akt pathways. |
2020-12-29 |
2023-08-13 |
rat |
| Arianna Mazzoli, Maria Stefania Spagnuolo, Cristina Gatto, Martina Nazzaro, Rosa Cancelliere, Raffaella Crescenzo, Susanna Iossa, Luisa Ciglian. Adipose Tissue and Brain Metabolic Responses to Western Diet-Is There a Similarity between the Two? International journal of molecular sciences. vol 21. issue 3. 2020-11-05. PMID:31991770. |
specific cyto/adipokines (tumor necrosis factor alpha (tnf-α), adiponectin), critical obesity-inflammatory markers (haptoglobin, lipocalin), and insulin signaling or survival protein network (insulin receptor substrate 1 (irs), akt, erk) were quantified in epididymal white adipose tissue (e-wat), hippocampus, and frontal cortex. |
2020-11-05 |
2023-08-13 |
rat |
| Antoni Camins, Felix Junyent, Ester Verdaguer, Carlos Beas-Zarate, Argelia E Rojas-Mayorquín, Daniel Ortuño-Sahagún, Mercè Pallà. Resveratrol: An Antiaging Drug with Potential Therapeutic Applications in Treating Diseases. Pharmaceuticals (Basel, Switzerland). vol 2. issue 3. 2020-10-01. PMID:27713233. |
by activating sirtuin 1, resveratrol modulates the activity of numerous proteins, including peroxisome proliferator-activated receptor coactivator-1α (pgc-1 alpha), the foxo family, akt (protein kinase b) and nfκβ. |
2020-10-01 |
2023-08-13 |
Not clear |
| Levi Arnold, Jonathan Enders, Sufi Mary Thoma. Activated HGF-c-Met Axis in Head and Neck Cancer. Cancers. vol 9. issue 12. 2020-10-01. PMID:29231907. |
the receptor and its ligand act on several downstream effectors including phospholipase c gamma (plcγ), cellular src kinase (c-src), phosphotidylinsitol-3-oh kinase (pi3k) alpha serine/threonine-protein kinase (akt), mitogen activate protein kinase (mapk), and wingless-related integration site (wnt) pathways. |
2020-10-01 |
2023-08-13 |
Not clear |
| Kanako Hagihara, Kanako Kinoshita, Kouki Ishida, Shihomi Hojo, Yoshinori Kameoka, Ryosuke Satoh, Teruaki Takasaki, Reiko Sugiur. A genome-wide screen for FTY720-sensitive mutants reveals genes required for ROS homeostasis. Microbial cell (Graz, Austria). vol 4. issue 12. 2020-10-01. PMID:29234668. |
although the involvement of multiple signaling molecules, such as jnk (jun n-terminal kinase), akt (alpha serine/threonine-protein kinase) and sphk has been reported, the exact mechanisms how fty720 induces cell growth inhibition and the functional relationship between fty720 and these signaling pathways remain elusive. |
2020-10-01 |
2023-08-13 |
Not clear |
| Ying Cheng, Xin Dai, Ti Yang, Nan Zhang, Zhenzhong Liu, Yiguo Jian. Low Long Noncoding RNA Growth Arrest-Specific Transcript 5 Expression in the Exosomes of Lung Cancer Cells Promotes Tumor Angiogenesis. Journal of oncology. vol 2019. 2020-10-01. PMID:31186629. |
in addition, we found that gas5 competitively bound mirna-29-3p with phosphatase and tensin homolog (pten), upregulating pten mrna and protein expression, and inhibited level of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (pi3k) and serine/threonine kinase 1 (akt) phosphorylation in huvecs. |
2020-10-01 |
2023-08-13 |
mouse |
| Su Xu, Zhao-Xiu Xu, Shuai Yan, Jin Le, Hao Chen, Lan Ming, Shu-Guang Xu, Tao Li. Curcumin suppresses intestinal microvascular endothelial cells invasion and angiogenesis induced by activated platelets. Experimental and therapeutic medicine. vol 18. issue 2. 2020-10-01. PMID:31316605. |
the α-smooth muscle actin, collagen i, e-cadherin, phosphorylated (p-) phosphoinositide 3-kinase (pi3k), p-protein kinase b (akt), p-mammalian target of rapamycin (m-tor) and hypoxia inducible factor subunit alpha (hif-1α) protein expression levels of the curcumin-treated groups were significantly downregulated in a dose-dependent manner compared with the platelet group. |
2020-10-01 |
2023-08-13 |
rat |
| Bing Xu, Amy Krie, Pradip De, Casey Williams, Rachel Elsey, Jessica Klein, Brian Leyland-Jone. Utilizing Tumor and Plasma Liquid Biopsy in Treatment Decision Making for an Estrogen Receptor-Positive Advanced Breast Cancer Patient. Cureus. vol 9. issue 6. 2020-09-29. PMID:28856074. |
the drugs target the hormonal signaling pathway, phosphoinositide 3-kinase (pi3k)-rac-alpha serine/threonine-protein kinase (akt) pathway, and cyclin d1 (ccnd1)-cdk4/6 pathway, based on the patient's estrogen-receptor-positive (er+) disease and phosphatidylinositol -4,5-bisphosphate 3-kinase catalytic subunit alpha ( |
2020-09-29 |
2023-08-13 |
Not clear |
| Eylem Kulkoyluoglu-Cotul, Brandi Patrice Smith, Kinga Wrobel, Yiru Chen Zhao, Karen Lee Ann Chen, Kadriye Hieronymi, Ozan Berk Imir, Kevin Duong, Caitlin O'Callaghan, Aditi Mehta, Sunati Sahoo, Barbara Haley, Hua Chang, Yosef Landesman, Zeynep Madak-Erdoga. Combined Targeting of Estrogen Receptor Alpha and XPO1 Prevent Akt Activation, Remodel Metabolic Pathways and Induce Autophagy to Overcome Tamoxifen Resistance. Cancers. vol 11. issue 4. 2020-09-29. PMID:30987380. |
combined targeting of estrogen receptor alpha and xpo1 prevent akt activation, remodel metabolic pathways and induce autophagy to overcome tamoxifen resistance. |
2020-09-29 |
2023-08-13 |
Not clear |
| Youde Jiang, Li Liu, Hainan Li, Jie-Mei Wang, Jena J Steinl. Insulin Signal Transduction is Impaired in the Type 2 Diabetic Retina. Journal of diabetes and clinical research. vol 2. issue 1. 2020-09-28. PMID:32432228. |
retinal lysates from five month old male db/db and db/+ (control) mice were collected and processed for western blotting or elisa analyses for insulin receptor, insulin receptor substrate-1 (irs-1), akt, tumor necrosis factor alpha (tnfα) and caspase 3 levels. |
2020-09-28 |
2023-08-13 |
mouse |
| Chiao-Nan Chen, Yi-Hung Liao, Shiow-Chwen Tsai, LaDora V Thompso. Age-dependent effects of caloric restriction on mTOR and ubiquitin-proteasome pathways in skeletal muscles. GeroScience. vol 41. issue 6. 2020-07-09. PMID:31676964. |
total protein content and the phosphorylation level of akt, mtor, s6k, and 4ebp1 and protein content of key markers in the upp (foxo3a, atrogin, murf1, ubiquitinated proteins, proteasome subunits alpha 7 and beta 5) were determined. |
2020-07-09 |
2023-08-13 |
rat |
| N C Turner, E Alarcón, A C Armstrong, M Philco, Y A López Chuken, M-P Sablin, K Tamura, A Gómez Villanueva, J A Pérez-Fidalgo, S Y A Cheung, C Corcoran, M Cullberg, B R Davies, E C de Bruin, A Foxley, J P O Lindemann, R Maudsley, M Moschetta, E Outhwaite, M Pass, P Rugman, G Schiavon, M Oliveir. BEECH: a dose-finding run-in followed by a randomised phase II study assessing the efficacy of AKT inhibitor capivasertib (AZD5363) combined with paclitaxel in patients with estrogen receptor-positive advanced or metastatic breast cancer, and in a PIK3CA mutant sub-population. Annals of oncology : official journal of the European Society for Medical Oncology. vol 30. issue 5. 2020-06-12. PMID:30860570. |
beech investigated the efficacy of capivasertib (azd5363), an oral inhibitor of akt isoforms 1-3, in combination with the first-line weekly paclitaxel for advanced or metastatic estrogen receptor-positive (er+)/human epidermal growth factor receptor 2-negative (her2-) breast cancer, and in a phosphoinositide 3-kinase, catalytic, alpha polypeptide mutation sub-population (pik3ca+). |
2020-06-12 |
2023-08-13 |
Not clear |
| Deniz Gulfem Ozturk, Muhammed Kocak, Arzu Akcay, Kubilay Kinoglu, Erdogan Kara, Yalcin Buyuk, Hilal Kazan, Devrim Gozuaci. MITF-MIR211 axis is a novel autophagy amplifier system during cellular stress. Autophagy. vol 15. issue 3. 2020-05-13. PMID:30290719. |
abbreviations: actb: actin beta; akt: akt serine/threonine kinase; akt1s1/pras40: akt1 substrate 1; ampk: amp-activated protein kinase; atg: autophagy-related; becn1: beclin 1; deptor: dep domain containing mtor interacting protein; gabarap: gaba type a receptor-associated protein; hif1a: hypoxia inducible factor 1 subunit alpha; lamp1: lysosomal associated membrane protein 1; map1lc3b/lc3b: microtubule associated protein 1 light chain 3 beta; mapkap1/sin1: mitogen-activated protein kinase associated protein 1; mitf: melanogenesis associated transcription factor; mlst8: mtor associated protein, lst8 homolog; mre: mirna response element; mtor: mechanistic target of rapamycin kinase; mtorc1: mtor complex 1; mtorc2: mtor complex 2; prr5/protor 1: proline rich 5; prr5l/protor 2: proline rich 5 like; rack1: receptor for activated c kinase 1; rptor: regulatory associated protein of mtor complex 1; rictor: rptor independent companion of mtor complex 2; rps6kb/p70s6k: ribosomal protein s6 kinase; rt-qpcr: quantitative reverse transcription-polymerase chain reaction; sqstm1: sequestosome 1; stk11/lkb1: serine/threonine kinase 11; tfe3: transcription factor binding to ighm enhancer 3; tfeb: transcription factor eb; tsc1/2: tsc complex subunit 1/2; ulk1: unc-51 like autophagy activating kinase 1; uvrag: uv radiation resistance associated; vim: vimentin; vps11: vps11, corvet/hops core subunit; vps18: vps18, corvet/hops core subunit; wipi1: wd repeat domain, phosphoinositide interacting 1. |
2020-05-13 |
2023-08-13 |
human |
| Isabela Machado Barbosa David, Flávia de Souza Fernandes, Juliana Barreto Dos Santos Silva Ferreira, Daniela Dero Lüdtke, Daniel Fernandes Martins, Franciane Bobinski, Thiago Bezerra Gaspar Carvalho da Silva, Luiza Daux Buffon, Maria Biatriz Rodrigues Kopper, Gustavo Silveira da Silva, Rodrigo Costa Zeferino, Rozangela Curi Pedrosa, Maicon Roberto Kviecinsk. Dietary supplementation with procyanidin-rich Pinus pinaster extract is associated with attenuated Ehrlich tumor development in mice. Nutrition research (New York, N.Y.). vol 62. 2020-05-08. PMID:30803506. |
ascitic fluid from six mice/group was evaluated by determining total volume; tumor packed cell volume; cell viability; tumor cell death type; inflammatory infiltrate; and levels of tumor necrosis factor alpha (tnf-α), interleukin 1 beta (il-1β), carbonyl proteins, lipid peroxidation, cyclooxigenase-2 (cox-2) expression and akt phosphorylation (p-akt). |
2020-05-08 |
2023-08-13 |
mouse |
| Mohammad Harun-Or-Rashid, Finn Hallböö. Alpha 2-Adrenergic Receptor Agonist Brimonidine Stimulates ERK1/2 and AKT Signaling via Transactivation of EGF Receptors in the Human MIO-M1 Müller Cell Line. Current eye research. vol 44. issue 1. 2020-02-28. PMID:30198788. |
alpha 2-adrenergic receptor agonist brimonidine stimulates erk1/2 and akt signaling via transactivation of egf receptors in the human mio-m1 müller cell line. |
2020-02-28 |
2023-08-13 |
human |
| Bing Yang, Chun-Shui Pan, Quan Li, Zhu Yang, Feng-Xi Long, Jing-Yu Fan, Chuan-She Wang, Jing-Yan Han, Dong-Xin Tan. Inhibitory effects of Chanling Gao on the proliferation and liver metastasis of transplanted colorectal cancer in nude mice. PloS one. vol 14. issue 2. 2019-12-02. PMID:30789971. |
on the 28th day after the operation, crc growth and liver metastasis were assessed by morphology, the changes in the expression of hif-1α (hypoxia inducible factor-1α), stromal cell-derived factor-1 alpha (sdf-1α), cxcr4 (c-x-c chemokine receptor type 4), pi3k, and akt in the transplanted tumor and sdf-1α and cxcr4 in the liver were detected by western blot and immunohistochemistry. |
2019-12-02 |
2023-08-13 |
mouse |
| Rosa Mistica C Ignacio, Carla R Gibbs, Eun-Sook Lee, Deok-Soo So. The TGFα-EGFR-Akt signaling axis plays a role in enhancing proinflammatory chemokines in triple-negative breast cancer cells. Oncotarget. vol 9. issue 50. 2019-11-20. PMID:30034618. |
we found that transforming growth factor alpha (tgfα) could serve as a main ligand for egfr to drive egfr-mediated akt activation in tnbc cells. |
2019-11-20 |
2023-08-13 |
Not clear |
| Rumeng Tan, Hongzhe Tian, Bo Yang, Bo Zhang, Chen Dai, Zhenyi Han, Meixi Wang, Yakun Li, Lai Wei, Dong Chen, Guangyao Wang, Huifang Yang, Fan He, Zhishui Che. Autophagy and Akt in the protective effect of erythropoietin helix B surface peptide against hepatic ischaemia/reperfusion injury in mice. Scientific reports. vol 8. issue 1. 2019-11-13. PMID:30279567. |
we assessed alanine aminotransferase (alt), aspartate aminotransferase (ast) and lactate dehydrogenase (ldh) levels in mouse sera, and performed haematoxylin/eosin (he) staining, immunohistochemistry, electron microscopy, immunofluorescence microscopy, and western blotting on liver tissue to detect the degree of liver injury, liver apoptosis, autophagy, and the expression of microtubule associated protein 1 light chain 3 alpha (map1lc3, or lc3), beclin 1, phospho-mtor, mtor, phospho-akt (p-akt), and akt. |
2019-11-13 |
2023-08-13 |
mouse |
| Zuoqing Li, Juntao Xie, Yingchun Fei, Pengfei Gao, Qigen Xie, Wenzong Gao, Zhe X. GDNF family receptor alpha 2 promotes neuroblastoma cell proliferation by interacting with PTEN. Biochemical and biophysical research communications. vol 510. issue 3. 2019-11-04. PMID:30722993. |
in present study, we found that gdnf family receptor alpha 2 (gfra2) was upregulated in neuroblastoma cells and tissues, and its overexpression promoted neuroblastoma cell proliferation, as revealed using colony formation, soft agar growth, and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (mtt) assays tumor suppressor phosphatase and tensin homolog (pten) is an inhibitor of the phosphatidylinositol-4,5-bisphosphate 3-kinase (pi3k)/akt serine/threonine kinase (akt) pathway that interacts with gfra2. |
2019-11-04 |
2023-08-13 |
Not clear |