| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yilin Ren, Yan Geng, Yan Du, Wang Li, Zhen-Ming Lu, Hong-Yu Xu, Guo-Hua Xu, Jin-Song Shi, Zheng-Hong X. Polysaccharide of Hericium erinaceus attenuates colitis in C57BL/6 mice via regulation of oxidative stress, inflammation-related signaling pathways and modulating the composition of the gut microbiota. The Journal of nutritional biochemistry. vol 57. 2019-10-29. PMID:29677563. |
meanwhile, hecp blocked phosphorylation of nuclear factor-κb (nf-κb) p65, nf-κb inhibitor alpha (iκb-α), mitogen-activated protein kinases (mapk) and protein kinase b (akt) in dss-treated mice. |
2019-10-29 |
2023-08-13 |
mouse |
| Steven Lehrer, Sheryl Green, Francine R Dembitzer, Peter H Rheinstein, Kenneth E Rosenzwei. Increased RNA Expression of von Willebrand Factor Gene Is Associated With Infiltrating Lobular Breast Cancer and Normal PAM50 Subtype. Cancer genomics & proteomics. vol 16. issue 3. 2019-09-06. PMID:31018945. |
ilc shows a high frequency of cadherin 1 (cdh1) mutations, along with loss of phosphatase and tensin homolog (pten), activation of alpha serine/threonine kinase (akt), and mutations in t-box transcription factor (tbx3) and forkhead box protein a1 (foxa1). |
2019-09-06 |
2023-08-13 |
Not clear |
| Jing Liu, Pengfei Zhang, Yong Zhao, Hongfu Zhan. Low dose carbendazim disrupts mouse spermatogenesis might Be through estrogen receptor related histone and DNA methylation. Ecotoxicology and environmental safety. vol 176. 2019-06-07. PMID:30939404. |
furthermore, cbz exposure damaged estrogen receptor alpha (erα) pathway by decreased the protein levels of erα and its targets pi3k and akt. |
2019-06-07 |
2023-08-13 |
mouse |
| Gamal Badr, Nancy K Ramadan, Hanem S Abdel-Tawab, Samia F Ahmed, Mohamed H Mahmou. Camel whey protein protects lymphocytes from apoptosis via the PI3K-AKT, NF-κB, ATF-3, and HSP-70 signaling pathways in heat-stressed male mice. Biochemistry and cell biology = Biochimie et biologie cellulaire. vol 96. issue 4. 2018-12-11. PMID:29166568. |
exposure to hs resulted in impaired phosphorylation of akt and iκb-α (nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, alpha); increased expression of activating transcription factor 3 (atf-3) and 70 kda heat shock proteins (hsp70); and aberrant distribution of cd3+ t cells and cd20+ b cells in the thymus and spleen. |
2018-12-11 |
2023-08-13 |
mouse |
| Jongkyoo Kim, Kimberly B Wellmann, Zachary K Smith, Bradley J Johnso. All-trans retinoic acid increases the expression of oxidative myosin heavy chain through the PPARδ pathway in bovine muscle cells derived from satellite cells. Journal of animal science. vol 96. issue 7. 2018-11-26. PMID:29688535. |
after 96 h of incubation, cells were harvested and used to measure the gene expression of protein kinase b (akt), amp-activated protein kinase alpha (ampk), glucose transporter 4 (glut4), myogenin, lipoprotein lipase (lpl), myosin heavy chain (mhc) i, mhc iia, mhc iix, insulin like growth factor-1 (igf-1), peroxisome proliferator activated receptor gamma (pparγ), pparδ, and smad transcription factor 3 (smad3) mrna relative to ribosomal protein subunit 9 (rps9). |
2018-11-26 |
2023-08-13 |
cattle |
| Tao Xian, Yuyang Gan, Yi Lu, Mengxi Wang, Wanwan Yuan, Yumeng Zhou, Junye Chen, Kun Wang, Shaofeng Xiong, Qiren Huan. Ameliorative effects of indomethacin at different concentrations on endothelial insulin resistance through two distinct pathways. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 106. 2018-11-26. PMID:30119183. |
intriguingly, we further identified that 0.25 mm of idmt noticeably induced the expression levels of pparγ, akt and endothelial nitric oxide synthase (enos) but failed to notably reverse the increases in expression levels of cox-2, inhibitory κb kinase (ikk) and tumor necrosis factor alpha (tnfα) induced by hg/hf; whereas 1.0 mm of idmt exerted opposite effects compared with 0.25 mm of idmt. |
2018-11-26 |
2023-08-13 |
Not clear |
| S-H Kim, B-J Seung, S-H Cho, H-Y Lim, J-H Hwang, J-H Su. Expression of Oestrogen Receptor, Progesterone Receptor and Akt in Canine Circumanal Gland Tumours. Journal of comparative pathology. vol 162. 2018-10-29. PMID:30060844. |
we investigated the expression of oestrogen receptor alpha (or-α), progesterone receptor (pr) and akt in canine circumanal gland tumours. |
2018-10-29 |
2023-08-13 |
Not clear |
| Huiping Tan, Chunlin Wu, Lei Ji. A Possible Role for Long Interspersed Nuclear Elements-1 (LINE-1) in Huntington's Disease Progression. Medical science monitor : international medical journal of experimental and clinical research. vol 24. 2018-10-16. PMID:29851926. |
in addition, a significant decrease in the pro-survival proteins such as the phosphoproteins of akt target proteins, mtorc1 activity, and ampk alpha levels was observed with the increase in the expression l1-orf2. |
2018-10-16 |
2023-08-13 |
mouse |
| Yang Li, Tao Zhang, Yanhui Zhang, Xingkai Zhao, Wenbo Wan. Targeting the FOXM1-regulated long noncoding RNA TUG1 in osteosarcoma. Cancer science. vol 109. issue 10. 2018-10-12. PMID:30099814. |
tug1 accelerated osteosarcoma proliferation, migration, and invasion by competitively sponging mir-219a-5p, leading to upregulation of phosphatidylinositol-4, 5-bisphosphate 3-kinase catalytic subunit alpha and activation of the protein kinase b (akt) signaling pathway. |
2018-10-12 |
2023-08-13 |
Not clear |
| Simran Alexandria Polce, Cameron Burke, Lucas Martins França, Benjamin Kramer, Antonio Marcus de Andrade Paes, Maria Alicia Carrillo-Sepulved. Ellagic Acid Alleviates Hepatic Oxidative Stress and Insulin Resistance in Diabetic Female Rats. Nutrients. vol 10. issue 5. 2018-09-24. PMID:29693586. |
in conclusion, our results demonstrate that ea diminishes blood glucose levels and potently suppress nafld in diabetic rats via mechanisms that involve reductions in p47-phox and hif-α, upregulation of nrf2 and enhancement of the akt signaling pathway in the liver. |
2018-09-24 |
2023-08-13 |
rat |
| Rahmaniah Rahmaniah, Yuyuntia Yuyuntia, Vivian Soetikno, Wawaimuli Arozal, Radiana Dhewayani Antarianto, Melva Louis. Alpha mangostin Inhibits Hepatic Stellate Cells Activation Through TGF-β/Smad and Akt Signaling Pathways: An in vitro Study in LX2. Drug research. vol 68. issue 3. 2018-08-27. PMID:28992660. |
alpha mangostin inhibits hepatic stellate cells activation through tgf-β/smad and akt signaling pathways: an in vitro study in lx2. |
2018-08-27 |
2023-08-13 |
rat |
| Rahmaniah Rahmaniah, Yuyuntia Yuyuntia, Vivian Soetikno, Wawaimuli Arozal, Radiana Dhewayani Antarianto, Melva Louis. Alpha mangostin Inhibits Hepatic Stellate Cells Activation Through TGF-β/Smad and Akt Signaling Pathways: An in vitro Study in LX2. Drug research. vol 68. issue 3. 2018-08-27. PMID:28992660. |
this study was aimed to investigate the effect of alpha mangostin on hepatic stellate cells (hsc) activation and proliferation through tgf-β/smad and akt signaling pathways. |
2018-08-27 |
2023-08-13 |
rat |
| Jackson Nteeba, Shanthi Ganesan, Jill A Madden, Mackenzie J Dickson, Aileen F Keatin. Progressive obesity alters ovarian insulin, phosphatidylinositol-3 kinase, and chemical metabolism signaling pathways and potentiates ovotoxicity induced by phosphoramide mustard in mice. Biology of reproduction. vol 96. issue 2. 2018-06-27. PMID:28203716. |
the impact of progressive obesity on ovarian genes encoding mrna involved in insulin-mediated pi3k signaling and xenobiotic biotransformation [insulin receptor (insr), insulin receptor substrate 1 (irs1), 2 (irs2), and 3 (irs3); kit ligand (kitlg), stem cell growth factor receptor (kit), protein kinase b (akt) alpha (akt1), beta (akt2), forkhead transcription factor (foxo) subfamily 1 (foxo1), and subfamily 3 (foxo3a), microsomal epoxide hydrolase (ephx1), cytochrome p450 family 2, subfamily e, polypeptide 1 (cyp2e1), glutathione s-transferase (gst) class pi (gstp1) and class mu 1 (gstm1)] was determined in normal wild-type nonagouti (a/a; lean) and lethal yellow mice (kk.cg-ay/j; obese) at 6, 12, 18, or 24 weeks of age. |
2018-06-27 |
2023-08-13 |
mouse |
| Sau-Yeen Loke, Peter Tsun-Hon Wong, Wei-Yi On. Global gene expression changes in the prefrontal cortex of rabbits with hypercholesterolemia and/or hypertension. Neurochemistry international. vol 102. 2018-01-25. PMID:27890723. |
these include: proteasome, insulin, akt, erk1/2, histone, il12, interferon alpha and nfκb. |
2018-01-25 |
2023-08-13 |
Not clear |
| Elvira Valera, Brian Spencer, Jerel A Fields, Ivy Trinh, Anthony Adame, Michael Mante, Edward Rockenstein, Paula Desplats, Eliezer Maslia. Combination of alpha-synuclein immunotherapy with anti-inflammatory treatment in a transgenic mouse model of multiple system atrophy. Acta neuropathologica communications. vol 5. issue 1. 2017-12-19. PMID:28057080. |
these effects were associated with an activation of the akt signaling pathway, which may mediate cytoprotective effects downstream tumor necrosis factor alpha (tnfα). |
2017-12-19 |
2023-08-13 |
mouse |
| Ewa Jablonska, Patryk Gorniak, Maciej Szydlowski, Tomasz Sewastianik, Emilia Bialopiotrowicz, Anna Polak, Krzysztof Warzocha, Przemyslaw Juszczynsk. MiR-17-92 represses PTPROt and PP2A phosphatases and amplifies tonic BCR signaling in DLBCL cells. Experimental hematology. vol 46. 2017-06-06. PMID:27720936. |
introduction of mir-17-92 into dlbcl cells dampened the expression of the ptprot and pp2a regulatory subunits ppp2r2a (protein phosphatase 2, regulatory subunit b, alpha) and ppp2r5e (protein phosphatase 2, regulatory subunit b, epsilon isoform) and increased the magnitude of syk and akt phosphorylation upon bcr ligation. |
2017-06-06 |
2023-08-13 |
Not clear |
| Sonia I Vlaicu, Alexandru Tatomir, Dallas Boodhoo, Takahiro Ito, Matthew Fosbrink, Cornelia Cudrici, Armugam P Mekala, Jonathan Ciriello, Doiniţa Crişan, Emil Boţan, Violeta Rus, Horea Ru. RGC-32 is expressed in the human atherosclerotic arterial wall: Role in C5b-9-induced cell proliferation and migration. Experimental and molecular pathology. vol 101. issue 2. 2017-05-29. PMID:27619159. |
rgc-32 silencing caused a significant reduction in the expression of cyclin d1, cyclin d3, akt, rock1, rho gdp dissociation inhibitor alpha and profilin. |
2017-05-29 |
2023-08-13 |
human |
| Norbert Nass, Sebastian Streit, Christian Wybranski, Julian Jürgens, Jan Brauner, Nadine Schulz, Maciej Powerski, Jens Ricke, Thomas Kalinski, Oliver Dudeck, Max Seidensticke. Validation of VX2 as a Hepatocellular Carcinoma Model: Comparison of the Molecular Reaction of VX2 and HepG2 Tumor Cells to Sorafenib In Vitro. Anticancer research. vol 37. issue 1. 2017-01-30. PMID:28011478. |
phosphorylation of protein kinase b (akt) the mitogen-activated protein kinases (mapks) p38 and p42/44 (extracellular signal-regulated kinase, erk1/2) and inhibitor of kappa light chain gene enhancer alpha (iĸbα) was determined by western blotting as these events are associated with early signaling cascades. |
2017-01-30 |
2023-08-13 |
human |
| Nilanjana Das, Neerajana Datta, Uttara Chatterjee, Mrinal Kanti Ghos. Estrogen receptor alpha transcriptionally activates casein kinase 2 alpha: A pivotal regulator of promyelocytic leukaemia protein (PML) and AKT in oncogenesis. Cellular signalling. vol 28. issue 6. 2016-11-10. PMID:27012497. |
estrogen receptor alpha transcriptionally activates casein kinase 2 alpha: a pivotal regulator of promyelocytic leukaemia protein (pml) and akt in oncogenesis. |
2016-11-10 |
2023-08-13 |
mouse |
| Yaoyao Jia, Chunyan Wu, Jiyoung Kim, Bobae Kim, Sung-Joon Le. Astaxanthin reduces hepatic lipid accumulations in high-fat-fed C57BL/6J mice via activation of peroxisome proliferator-activated receptor (PPAR) alpha and inhibition of PPAR gamma and Akt. The Journal of nutritional biochemistry. vol 28. 2016-11-07. PMID:26878778. |
astaxanthin reduces hepatic lipid accumulations in high-fat-fed c57bl/6j mice via activation of peroxisome proliferator-activated receptor (ppar) alpha and inhibition of ppar gamma and akt. |
2016-11-07 |
2023-08-13 |
mouse |