| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Paulo L Pfitzinger, Laura Fangmann, Kun Wang, Elke Demir, Engin Gürlevik, Bettina Fleischmann-Mundt, Jennifer Brooks, Jan G D'Haese, Steffen Teller, Andreas Hecker, Moritz Jesinghaus, Carsten Jäger, Lei Ren, Rouzanna Istvanffy, Florian Kühnel, Helmut Friess, Güralp Onur Ceyhan, Ihsan Ekin Demi. Indirect cholinergic activation slows down pancreatic cancer growth and tumor-associated inflammation. Journal of experimental & clinical cancer research : CR. vol 39. issue 1. 2021-09-06. PMID:33357230. |
here, we investigated the role of indirect cholinergic activation on pca progression through inhibition of acetylcholinesterase (ache) via clinically available ache-inhibitors, i.e. |
2021-09-06 |
2023-08-13 |
Not clear |
| Dhanasak Dhanasobhon, Maria-Carmen Medrano, Léa J Becker, Yunuen Moreno-Lopez, Sehrazat Kavraal, Charlotte Bichara, Rémy Schlichter, Perrine Inquimbert, Ipek Yalcin, Matilde Cordero-Erausqui. Enhanced analgesic cholinergic tone in the spinal cord in a mouse model of neuropathic pain. Neurobiology of disease. vol 155. 2021-09-03. PMID:33845128. |
the alterations thus appear to be in the neurons receiving the cholinergic signaling, which is confirmed by the fact that subthreshold doses of acetylcholinesterase (ache) inhibitors in sham animals become anti-allodynic in cuff mice and by the altered expression of the β2 nicotinic receptor subunit. |
2021-09-03 |
2023-08-13 |
mouse |
| Nikolina Maček Hrvat, Zrinka Kovari. Counteracting poisoning with chemical warfare nerve agents. Arhiv za higijenu rada i toksikologiju. vol 71. issue 4. 2021-08-30. PMID:33410774. |
phosphylation of the pivotal enzyme acetylcholinesterase (ache) by nerve agents (nas) leads to irreversible inhibition of the enzyme and accumulation of neurotransmitter acetylcholine, which induces cholinergic crisis, that is, overstimulation of muscarinic and nicotinic membrane receptors in the central and peripheral nervous system. |
2021-08-30 |
2023-08-13 |
Not clear |
| Zohreh Zare, Sam Zarbakhsh, Shamim Mashhadban, Afshin Moradgholi, Moslem Mohammad. Apoptosis is involved in paraoxon-induced histological changes in rat cerebellum. Drug and chemical toxicology. 2021-08-20. PMID:34412520. |
acute toxicity of organophosphorus compounds is primarily caused by inhibition of acetylcholinesterase (ache) at cholinergic synapses. |
2021-08-20 |
2023-08-13 |
rat |
| Mark J Millan, Anne Dekeyne, Alain Gobert, Mauricette Brocco, Clotilde Mannoury la Cour, Jean-Claude Ortuno, David Watson, Kevin C F Fon. Dual-acting agents for improving cognition and real-world function in Alzheimer's disease: Focus on 5-HT6 and D3 receptors as hubs. Neuropharmacology. vol 177. 2021-08-12. PMID:32525060. |
moreover, a range of mechanistically-diverse agents (glutamatergic, histaminergic, monoaminergic, cholinergic) have disappointed in clinical trials, alone and/or in association with ache inhibitors. |
2021-08-12 |
2023-08-13 |
Not clear |
| James B Machamer, James P Apland, Brittany M Winner, Sarah E Wolfe, Kathleen T Pagarigan, Kevin M Bounader, Shane A Kasten, Michael Adler, Patrick M McNut. Functional basis for dose-dependent antagonism of rat and rabbit neuromuscular transmission by the bis-pyridinium oxime MMB4. Archives of toxicology. vol 94. issue 11. 2021-08-06. PMID:32691075. |
organophosphorus (op) compounds inhibit central and peripheral acetylcholinesterase (ache) activity, overstimulating cholinergic receptors and causing autonomic dysfunction (e.g., bronchoconstriction, excess secretions), respiratory impairment, seizure and death at high doses. |
2021-08-06 |
2023-08-13 |
rat |
| Chonny Herrera-Acevedo, Camilo Perdomo-Madrigal, Kenyi Herrera-Acevedo, Ericsson Coy-Barrera, Luciana Scotti, Marcus Tullius Scott. Machine learning models to select potential inhibitors of acetylcholinesterase activity from SistematX: a natural products database. Molecular diversity. vol 25. issue 3. 2021-08-06. PMID:34132933. |
the enzyme acetylcholinesterase (ache) cleaves the ester bonds in acetylcholine and plays an important role in the termination of acetylcholine activity at cholinergic synapses in various regions of the nervous system. |
2021-08-06 |
2023-08-13 |
Not clear |
| George Andrew Reid, Sultan Darves. Distribution of acetylcholinesterase in the hippocampal formation of the Atlantic white-sided dolphin (Lagenorhynchus acutus). The Journal of comparative neurology. vol 529. issue 5. 2021-08-02. PMID:32779183. |
there have been a number of studies detailing the distribution of acetylcholinesterase (ache) in the hippocampal formation of terrestrial mammals with the goal of gaining a greater understanding of some aspects of the cholinergic innervation to this region, as well as its parcellation. |
2021-08-02 |
2023-08-13 |
Not clear |
| Aaron J Polichnowski, Geoffrey A Williamson, Tesha E Blair, Donald B Hoove. Autonomic and cholinergic mechanisms mediating cardiovascular and temperature effects of donepezil in conscious mice. American journal of physiology. Regulatory, integrative and comparative physiology. vol 320. issue 6. 2021-07-28. PMID:33851543. |
donepezil is a centrally acting acetylcholinesterase (ache) inhibitor with therapeutic potential in inflammatory diseases; however, the underlying autonomic and cholinergic mechanisms remain unclear. |
2021-07-28 |
2023-08-13 |
mouse |
| Aaron J Polichnowski, Geoffrey A Williamson, Tesha E Blair, Donald B Hoove. Autonomic and cholinergic mechanisms mediating cardiovascular and temperature effects of donepezil in conscious mice. American journal of physiology. Regulatory, integrative and comparative physiology. vol 320. issue 6. 2021-07-28. PMID:33851543. |
central versus peripheral cholinergic effects of donepezil were assessed using pharmacological approaches including comparison with the peripherally acting ache inhibitor, neostigmine. |
2021-07-28 |
2023-08-13 |
mouse |
| Bhupesh Chandra Semwal, Debapriya Garabad. Amyloid beta (1-42) downregulates adenosine-2b receptors in addition to mitochondrial impairment and cholinergic dysfunction in memory-sensitive mouse brain regions. Journal of receptor and signal transduction research. vol 40. issue 6. 2021-07-13. PMID:32496898. |
in addition, aβ significantly increased cholinergic dysfunction in terms of decrease in the activity of chat and ach level and increase in the ache activity in the hippocampus, pre-frontal cortex and amygdala of ad-like animals. |
2021-07-13 |
2023-08-13 |
mouse |
| Miroslav Pohank. Pharmacological Influencing of The Cholinergic Anti-inflammatory Pathway in Infectious Diseases and Inflammatory Pathologies. Mini reviews in medicinal chemistry. vol 21. issue 6. 2021-07-12. PMID:33208075. |
the cholinergic anti-inflammatory pathway can be stimulated or suppressed by agonizing or antagonizing α7 nachr or by inhibition of ache. |
2021-07-12 |
2023-08-13 |
Not clear |
| Mikaela Peglow Pinz, Ane Gabriela Vogt, Karline da Costa Rodrigues, Angélica Schiavom Dos Reis, Luis Fernando Barbosa Duarte, Mariana Gallio Fronza, William Borges Domingues, Eduardo Bierhaus Blodorn, Diego Alves, Vinicius Farias Campos, Lucielli Savegnago, Ethel Antunes Wilhelm, Cristiane Luches. Effect of a purine derivative containing selenium to improve memory decline and anxiety through modulation of the cholinergic system and Na Metabolic brain disease. vol 36. issue 5. 2021-06-22. PMID:33651275. |
the cholinergic system was investigated based on by looking at expression and activity of ache and expression of choline acetyltransferase (chat). |
2021-06-22 |
2023-08-13 |
mouse |
| Monica A Silva, Alessandra S Kiametis, Werner Trepto. Donepezil Inhibits Acetylcholinesterase via Multiple Binding Modes at Room Temperature. Journal of chemical information and modeling. vol 60. issue 7. 2021-06-17. PMID:32096991. |
ache is important for neurotransmission at neuromuscular junctions and cholinergic brain synapses by hydrolyzing acetylcholine into acetate and choline. |
2021-06-17 |
2023-08-13 |
Not clear |
| Bashir Akhlaq Akhoon, Sushil Choudhary, Harshita Tiwari, Ajay Kumar, Manas Ranjan Barik, Laxmi Rathor, Rakesh Pandey, Amit Nargotr. Discovery of a New Donepezil-like Acetylcholinesterase Inhibitor for Targeting Alzheimer's Disease: Computational Studies with Biological Validation. Journal of chemical information and modeling. vol 60. issue 10. 2021-06-17. PMID:32955256. |
so far, donepezil is the only food and drug administration-approved dual-binding site inhibitor of acetylcholinesterase (ache) that can amplify the cholinergic activity and also decrease aβ aggregation in alzheimer patients. |
2021-06-17 |
2023-08-13 |
Not clear |
| Kevin G McGarry, Kevin E Schill, Tyson P Winters, Erin E Lemmon, Carol L Sabourin, Jill A Harvilchuck, Robert A Moye. Characterization of Cholinesterases From Multiple Large Animal Species for Medical Countermeasure Development Against Chemical Warfare Nerve Agents. Toxicological sciences : an official journal of the Society of Toxicology. vol 174. issue 1. 2021-06-09. PMID:31879781. |
disruption of cholinergic function through the inhibition of acetylcholinesterase (ache) leads to the accumulation of the neurotransmitter acetylcholine. |
2021-06-09 |
2023-08-13 |
Not clear |
| Shani Vaknine, Hermona Sore. Central and peripheral anti-inflammatory effects of acetylcholinesterase inhibitors. Neuropharmacology. vol 168. 2021-05-27. PMID:32143069. |
acetylcholinesterase (ache) inhibitors modulate acetylcholine hydrolysis and hence play a key role in determining the cholinergic tone and in implementing its impact on the cholinergic blockade of inflammatory processes. |
2021-05-27 |
2023-08-13 |
mouse |
| b' Martin Kr\\xc3\\xa1tk\\xc3\\xbd, Karol\\xc3\\xadna Jaklov\\xc3\\xa1, \\xc5\\xa0\\xc3\\xa1rka \\xc5\\xa0t\\xc4\\x9bp\\xc3\\xa1nkov\\xc3\\xa1, Katar\\xc3\\xadna Svr\\xc4\\x8dkov\\xc3\\xa1, V\\xc3\\xa1clav Pfl\\xc3\\xa9gr, Jarmila Vin\\xc5\\xa1ov\\xc3\\xa. N-[3,5-Bis(trifluoromethyl)phenyl]-5-bromo-2-hydroxybenzamide Analogues: Novel Acetyl- and Butyrylcholinesterase Inhibitors. Current topics in medicinal chemistry. vol 20. issue 23. 2021-05-17. PMID:32814530.' |
development of acetyl- (ache) and butyrylcholinesterase (buche) inhibitors belongs to viable strategies for the treatment of dementia and other diseases related to decrease in cholinergic neurotransmission. |
2021-05-17 |
2023-08-13 |
Not clear |
| G A Toledo-Ibarra, M I Girón-Pérez, C E Covantes-Rosales, G H Ventura-Ramón, G Pérez-Sánchez, A López-Torres, K J G Diaz-Resendiz, E Becerril-Villanueva, L Pavó. Alterations in the non-neuronal cholinergic system induced by in-vitro exposure to diazoxon in spleen mononuclear cells of Nile tilapia (O. niloticus). Fish & shellfish immunology. vol 108. 2021-05-17. PMID:33285167. |
since the target molecule of diazinon is typically the acetylcholinesterase enzyme (ache), the existence of a non-neuronal cholinergic system in leukocytes makes them susceptible to alterations by diazinon. |
2021-05-17 |
2023-08-13 |
Not clear |
| G A Toledo-Ibarra, M I Girón-Pérez, C E Covantes-Rosales, G H Ventura-Ramón, G Pérez-Sánchez, A López-Torres, K J G Diaz-Resendiz, E Becerril-Villanueva, L Pavó. Alterations in the non-neuronal cholinergic system induced by in-vitro exposure to diazoxon in spleen mononuclear cells of Nile tilapia (O. niloticus). Fish & shellfish immunology. vol 108. 2021-05-17. PMID:33285167. |
the data indicate that diazoxon directly alters elements in the cholinergic system of smnc by ache inhibition or indirectly through the interaction with achr, which is likely related to the immunotoxic properties of diazinon and its metabolites. |
2021-05-17 |
2023-08-13 |
Not clear |