| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Uğur Güller, Pınar Güller, Mehmet Çiftc. Radical Scavenging and Antiacetylcholinesterase Activities of Ethanolic Extracts of Carob, Clove, and Linden. Alternative therapies in health and medicine. vol 27. issue 5. 2021-10-12. PMID:32619207. |
when ache is inhibited, the ach levels increase in the cholinergic synapses. |
2021-10-12 |
2023-08-13 |
Not clear |
| Antonio Monroy-Noyola, Damianys Almenares-Lopez, Eugenio Vilanova Gisber. Hydrolysis of chiral organophosphorus compounds by phosphotriesterases and mammalian paraoxonase-1. Frontiers in bioscience (Landmark edition). vol 26. 2021-10-06. PMID:33049692. |
acute exposure of humans to these mixtures induces the covalent modification of acetylcholinesterase (ache) and neuropathy target esterase (nte) and causes a cholinergic syndrome or organophosphate-induced delayed polyneuropathy syndrome (opidp). |
2021-10-06 |
2023-08-13 |
Not clear |
| Muharrem Kalaycı, Cüneyt Türkeş, Mustafa Arslan, Yeliz Demir, Şükrü Beydemi. Novel benzoic acid derivatives: Synthesis and biological evaluation as multitarget acetylcholinesterase and carbonic anhydrase inhibitors. Archiv der Pharmazie. vol 354. issue 3. 2021-10-06. PMID:33155700. |
the utility of cholinergic replacement by acetylcholinesterase (ache) inhibitors in ad treatment has been well documented so far. |
2021-10-06 |
2023-08-13 |
human |
| Chetan Thingore, Viplav Kshirsagar, Archana Juveka. Amelioration of oxidative stress and neuroinflammation in lipopolysaccharide-induced memory impairment using Rosmarinic acid in mice. Metabolic brain disease. vol 36. issue 2. 2021-10-05. PMID:33068223. |
imbalance in the cholinergic system was analyzed by measuring the acetylcholinesterase (ache) activity. |
2021-10-05 |
2023-08-13 |
mouse |
| Eng Leng Saw, James T Pearson, Daryl O Schwenke, Pujika Emani Munasinghe, Hirotsugu Tsuchimochi, Shruti Rawal, Sean Coffey, Philip Davis, Richard Bunton, Isabelle Van Hout, Yuko Kai, Michael J A Williams, Yoshihiko Kakinuma, Martin Fronius, Rajesh Katar. Activation of the cardiac non-neuronal cholinergic system prevents the development of diabetes-associated cardiovascular complications. Cardiovascular diabetology. vol 20. issue 1. 2021-10-05. PMID:33618724. |
recent evidence suggests that cardiomyocytes possess a non-neuronal cholinergic system (nncs) that comprises of choline acetyltransferase (chat), choline transporter 1 (cht1), vesicular acetylcholine transporter (vacht), acetylcholinesterase (ache) and type-2 muscarinic ach receptors (m |
2021-10-05 |
2023-08-13 |
Not clear |
| Aijaz Ahmad Malik, Suvash Chandra Ojha, Nalini Schaduangrat, Chanin Nantasenama. ABCpred: a webserver for the discovery of acetyl- and butyryl-cholinesterase inhibitors. Molecular diversity. 2021-10-05. PMID:34609711. |
acetylcholinesterase (ache) hydrolyses ach and inhibits the cholinergic transmission. |
2021-10-05 |
2023-08-13 |
Not clear |
| Jayme Cannon, Shengzhuang Tang, Seok Ki Cho. Caged Oxime Reactivators Designed for the Light Control of Acetylcholinesterase Reactivation Photochemistry and photobiology. 2021-10-04. PMID:34558680. |
caged oxime reactivators designed for the light control of acetylcholinesterase reactivation despite its promising role in the active control of biological functions by light, photocaging remains untested in acetylcholinesterase (ache), a key enzyme in the cholinergic family. |
2021-10-04 |
2023-08-13 |
Not clear |
| Ahsaan Ahmed, Shamim Akhtar, Nousheen Mushtaq, Shazia Haider, Rabya Munawar, Hassaan Ahmed Siddique, Arifa Akram, Zafar Saeed Saify, Muhammad Ari. 1,3-di-4-piperidylpropane derivatives as potential acetyl cholinesterase antagonists: Molecular docking, synthesis, and biological evaluation. Pakistan journal of pharmaceutical sciences. vol 34. issue 3. 2021-10-04. PMID:34602406. |
acetylcholine esterase (ache) is a key biological target responsible for the management of cholinergic transmission, and its inhibitors are used for the therapy of alzheimer's disease. |
2021-10-04 |
2023-08-13 |
Not clear |
| Danish Iqbal, Md Tabish Rehman, Abdulaziz Bin Dukhyil, Syed Mohd Danish Rizvi, Mohamed F Al Ajmi, Bader Mohammed Alshehri, Saeed Banawas, M Salman Khan, Wael Alturaiki, Mohammed Alsawee. High-Throughput Screening and Molecular Dynamics Simulation of Natural Product-like Compounds against Alzheimer's Disease through Multitarget Approach. Pharmaceuticals (Basel, Switzerland). vol 14. issue 9. 2021-10-01. PMID:34577637. |
we have explored the library of 2029 natural product-like compounds for their multi-targeting potential against ad by inhibiting ache, bche (cholinergic pathway) mao-a, and moa-b (oxidative stress pathway) through in silico high-throughput screening and molecular dynamics simulation. |
2021-10-01 |
2023-08-13 |
Not clear |
| Ashwani Arya, Rubal Chahal, Rekha Rao, Md Habibur Rahman, Deepak Kaushik, Muhammad Furqan Akhtar, Ammara Saleem, Shaden M A Khalifa, Hesham R El-Seedi, Mohamed Kamel, Ghadeer M Albadrani, Mohamed M Abdel-Daim, Vineet Mitta. Acetylcholinesterase Inhibitory Potential of Various Sesquiterpene Analogues for Alzheimer's Disease Therapy. Biomolecules. vol 11. issue 3. 2021-09-28. PMID:33669097. |
a vast literature was evident in the last decade, which affirms the potential of various sesquiterpenes in the improvement of cholinergic transmission by inhibiting the ache. |
2021-09-28 |
2023-08-13 |
Not clear |
| João Vitor Ferreira Rodrigues, Anna Paula Perin Vidigal, Vítor Sampaio Minassa, Thatiany Jardim Batista, Randriely Merscher Sobreira de Lima, Vinícius Rafael Funck, Leandro S Antero, Leonardo Barbosa Moraes Resstel, Juliana Barbosa Coitinho, Leandro Jose Bertoglio, Karla Nívea Sampaio, Vanessa Beijamin. A single dose of the organophosphate triazophos induces fear extinction deficits accompanied by hippocampal acetylcholinesterase inhibition. Neurotoxicology and teratology. vol 82. 2021-09-23. PMID:33031921. |
hippocampal and amygdalar ache activity and plasma butyrylcholinesterase (bche) were measured at the end of the experiment to confirm the cholinergic overstimulation. |
2021-09-23 |
2023-08-13 |
rat |
| Oksana Gerlits, Matthew P Blakeley, David A Keen, Zoran Radić, Andrey Kovalevsk. Room temperature crystallography of human acetylcholinesterase bound to a substrate analogue 4K-TMA: Towards a neutron structure. Current research in structural biology. vol 3. 2021-09-21. PMID:34541552. |
acetylcholinesterase (ache) catalyzes hydrolysis of acetylcholine thereby terminating cholinergic nerve impulses for efficient neurotransmission. |
2021-09-21 |
2023-08-13 |
human |
| Jong Min Kim, Uk Lee, Jin Yong Kang, Seon Kyeong Park, Jong Cheol Kim, Ho Jin He. Matcha Improves Metabolic Imbalance-Induced Cognitive Dysfunction. Oxidative medicine and cellular longevity. vol 2020. 2021-09-07. PMID:33312340. |
em improved the cerebral cholinergic system by regulating ach contents and expression of ache and chat. |
2021-09-07 |
2023-08-13 |
mouse |
| Paulo L Pfitzinger, Laura Fangmann, Kun Wang, Elke Demir, Engin Gürlevik, Bettina Fleischmann-Mundt, Jennifer Brooks, Jan G D'Haese, Steffen Teller, Andreas Hecker, Moritz Jesinghaus, Carsten Jäger, Lei Ren, Rouzanna Istvanffy, Florian Kühnel, Helmut Friess, Güralp Onur Ceyhan, Ihsan Ekin Demi. Indirect cholinergic activation slows down pancreatic cancer growth and tumor-associated inflammation. Journal of experimental & clinical cancer research : CR. vol 39. issue 1. 2021-09-06. PMID:33357230. |
here, we investigated the role of indirect cholinergic activation on pca progression through inhibition of acetylcholinesterase (ache) via clinically available ache-inhibitors, i.e. |
2021-09-06 |
2023-08-13 |
Not clear |
| Dhanasak Dhanasobhon, Maria-Carmen Medrano, Léa J Becker, Yunuen Moreno-Lopez, Sehrazat Kavraal, Charlotte Bichara, Rémy Schlichter, Perrine Inquimbert, Ipek Yalcin, Matilde Cordero-Erausqui. Enhanced analgesic cholinergic tone in the spinal cord in a mouse model of neuropathic pain. Neurobiology of disease. vol 155. 2021-09-03. PMID:33845128. |
the alterations thus appear to be in the neurons receiving the cholinergic signaling, which is confirmed by the fact that subthreshold doses of acetylcholinesterase (ache) inhibitors in sham animals become anti-allodynic in cuff mice and by the altered expression of the β2 nicotinic receptor subunit. |
2021-09-03 |
2023-08-13 |
mouse |
| Nikolina Maček Hrvat, Zrinka Kovari. Counteracting poisoning with chemical warfare nerve agents. Arhiv za higijenu rada i toksikologiju. vol 71. issue 4. 2021-08-30. PMID:33410774. |
phosphylation of the pivotal enzyme acetylcholinesterase (ache) by nerve agents (nas) leads to irreversible inhibition of the enzyme and accumulation of neurotransmitter acetylcholine, which induces cholinergic crisis, that is, overstimulation of muscarinic and nicotinic membrane receptors in the central and peripheral nervous system. |
2021-08-30 |
2023-08-13 |
Not clear |
| Zohreh Zare, Sam Zarbakhsh, Shamim Mashhadban, Afshin Moradgholi, Moslem Mohammad. Apoptosis is involved in paraoxon-induced histological changes in rat cerebellum. Drug and chemical toxicology. 2021-08-20. PMID:34412520. |
acute toxicity of organophosphorus compounds is primarily caused by inhibition of acetylcholinesterase (ache) at cholinergic synapses. |
2021-08-20 |
2023-08-13 |
rat |
| Mark J Millan, Anne Dekeyne, Alain Gobert, Mauricette Brocco, Clotilde Mannoury la Cour, Jean-Claude Ortuno, David Watson, Kevin C F Fon. Dual-acting agents for improving cognition and real-world function in Alzheimer's disease: Focus on 5-HT6 and D3 receptors as hubs. Neuropharmacology. vol 177. 2021-08-12. PMID:32525060. |
moreover, a range of mechanistically-diverse agents (glutamatergic, histaminergic, monoaminergic, cholinergic) have disappointed in clinical trials, alone and/or in association with ache inhibitors. |
2021-08-12 |
2023-08-13 |
Not clear |
| James B Machamer, James P Apland, Brittany M Winner, Sarah E Wolfe, Kathleen T Pagarigan, Kevin M Bounader, Shane A Kasten, Michael Adler, Patrick M McNut. Functional basis for dose-dependent antagonism of rat and rabbit neuromuscular transmission by the bis-pyridinium oxime MMB4. Archives of toxicology. vol 94. issue 11. 2021-08-06. PMID:32691075. |
organophosphorus (op) compounds inhibit central and peripheral acetylcholinesterase (ache) activity, overstimulating cholinergic receptors and causing autonomic dysfunction (e.g., bronchoconstriction, excess secretions), respiratory impairment, seizure and death at high doses. |
2021-08-06 |
2023-08-13 |
rat |
| Chonny Herrera-Acevedo, Camilo Perdomo-Madrigal, Kenyi Herrera-Acevedo, Ericsson Coy-Barrera, Luciana Scotti, Marcus Tullius Scott. Machine learning models to select potential inhibitors of acetylcholinesterase activity from SistematX: a natural products database. Molecular diversity. vol 25. issue 3. 2021-08-06. PMID:34132933. |
the enzyme acetylcholinesterase (ache) cleaves the ester bonds in acetylcholine and plays an important role in the termination of acetylcholine activity at cholinergic synapses in various regions of the nervous system. |
2021-08-06 |
2023-08-13 |
Not clear |