| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mohammed Sakib Musa, Md Tahsinul Islam, Wasif Billah, Md Siam Hossain, Md Shirajuce Shalakin Rahat, Imren Bayil, Yeasmin Akter Munni, Sumon Gangul. Structure-based virtual screening of Trachyspermum ammi metabolites targeting acetylcholinesterase for Alzheimer's disease treatment. PloS one. vol 19. issue 12. 2024-12-17. PMID:39689077. |
the cholinergic hypothesis posits that the degradation of acetylcholine by acetylcholinesterase (ache) contributes to ad development. |
2024-12-17 |
2024-12-21 |
human |
| M M García-Pimentel, M Mezzelani, N J Valdés, M E Giuliani, S Gorbi, F Regoli, V M León, J A Campill. Integrative oxidative stress biomarkers in gills and digestive gland of the combined exposure to citalopram and bezafibrate with polyethylene microplastics on mussels Mytilus galloprovincialis. Environmental pollution (Barking, Essex : 1987). 2024-12-11. PMID:39662579. |
both phacs impaired the cholinergic pathway long-term, even after the depuration period, as indicated by decreased ache levels in the gills, suggesting potential neurotoxic effects after prolonged exposure. |
2024-12-11 |
2024-12-14 |
Not clear |
| Natalia Kurhaluk, Oleksandr Lukash, Piotr Kamiński, Halina Tkaczenk. L-Arginine and Intermittent Hypoxia Are Stress-Limiting Factors in Male Wistar Rat Models. International journal of molecular sciences. vol 25. issue 22. 2024-11-27. PMID:39596428. |
in addition, our study investigated how the modulatory effect of the no synthase mechanism on the concentration of catecholamines (ca), such as adrenaline and noradrenaline, and their biosynthetic precursors (dopa, dopamine) varies depending on the cholinergic (acetylcholine, ach-acetylcholinesterase, ache) status in rats. |
2024-11-27 |
2024-11-29 |
rat |
| Mohd Kashif, Karthikeyan Chandrabose, Ashok Kumar Panduranga. Plausible Action of N-(3,4-Dimethoxy-Phenyl)-6,7-Dimethoxyquinazoline-4-Amine (TKM01) as an Armor Against Alzheimer's Disease: In Silico and In Vivo Insights. Journal of biochemical and molecular toxicology. vol 38. issue 12. 2024-11-18. PMID:39552492. |
amyloid β (aβ), a disrupted cholinergic system with high acetylcholinesterase (ache), oxidative stress (os), reduced antioxidants, and neuroinflammation are key factors influencing ad progression. |
2024-11-18 |
2024-11-22 |
cat |
| Donald E Moss, Ruth G Pere. The phospho-tau cascade, basal forebrain neurodegeneration, and dementia in Alzheimer's disease: Anti-neurodegenerative benefits of acetylcholinesterase inhibitors. Journal of Alzheimer's disease : JAD. 2024-11-13. PMID:39533696. |
a conundrum in alzheimer's disease (ad) is why the long-term use of acetylcholinesterase (ache) inhibitors, intended for treatment of dementia, results in slowing neurodegeneration in the cholinergic basal forebrain, hippocampus, and cortex. |
2024-11-13 |
2024-11-17 |
Not clear |
| Weizhen An, Zhongxi Huang, Wei Jiang, Fangning Du, Chenfeng Xu, Qian Shen, Naidi Yang, Jia Zhou, Lin Li, Changmin Y. A highly specific two-photon fluorescent probe for real-time monitoring of acetylcholinesterase in neurogenic disorders in vivo. Analytica chimica acta. vol 1331. 2024-11-12. PMID:39532407. |
acetylcholinesterase (ache) hydrolyses choline into thiocholine, which is essential for cholinergic neurons to revert to their resting state following activation. |
2024-11-12 |
2024-11-17 |
mouse |
| Namrita Halder, Sourabh Yadav, Girdhari La. Neuroimmune communication of the cholinergic system in gut inflammation and autoimmunity. Autoimmunity reviews. 2024-11-05. PMID:39500481. |
it includes the neurotransmitter acetylcholine (ach), the enzyme required for the synthesis of ach (choline acetyltransferase, chat), the enzyme required for its degradation (acetylcholinesterase, ache), and cholinergic receptors (nicotinic acetylcholine receptors and muscarinic acetylcholine receptors). |
2024-11-05 |
2024-11-08 |
Not clear |
| Yingjie Xia, Xiaoyang Wang, Maggie Suisui Guo, Jiahui Wu, Jin Gao, Tina T X Dong, Karl W K Tsi. The activation of inflammatory responses in the brain is potentiated by over-expressing acetylcholinesterase in myeloid lineage of transgenic mice. Journal of neurochemistry. 2024-11-05. PMID:39497654. |
in an in vitro study, the expression of ache was up-regulated in lipopolysaccharide (lps)-induced microglia/macrophage and contrarily potentiated the inflammatory responses via disturbing the cholinergic anti-inflammatory pathway (cap). |
2024-11-05 |
2024-11-07 |
mouse |
| Dai-Xu Wei, Duanfang Cai, Youguo Tan, Kezhi Liu, Jin-Wei Dao, Xiang Li, Aikeremujiang Muheremu. Poly(3-hydroxybutyrate-co-3-hydroxyvalerate-co-3-hydroxyhexanoate)-based microspheres as a sustained platform for Huperzine A delivery for alzheimer's disease therapy. International journal of biological macromolecules. 2024-10-24. PMID:39447780. |
huperzine a (hupa) is used in alzheimer's disease (ad) therapy for its effective inhibition of acetylcholinesterase (ache) and enhancement of cholinergic neuronal function. |
2024-10-24 |
2024-10-28 |
mouse |
| Martha Cecilia Rosales Hernández, Marycruz Olvera-Valdez, Jazziel Velazquez Toledano, Jessica Elena Mendieta Wejebe, Leticia Guadalupe Fragoso Morales, Alejandro Cru. Exploring the Benzazoles Derivatives as Pharmacophores for AChE, BACE1, and as Anti-Aβ Aggregation to Find Multitarget Compounds against Alzheimer's Disease. Molecules (Basel, Switzerland). vol 29. issue 19. 2024-10-16. PMID:39407708. |
ad is a multifactorial disease in which several pharmacological targets have been identified-some are involved with amyloid beta (aβ) production, such as beta secretase (bace1) and beta amyloid aggregation, while others are involved with the cholinergic system as acetylcholinesterase (ache) and butirylcholinesterase (bche) and nicotinic and muscarinic receptors, as well as the hyperphosphorylation of microtubule-associated protein (tau). |
2024-10-16 |
2024-10-18 |
Not clear |
| Paula Belén Salazar, Fernando Gabriel Dupuy, Mariana C Fiori, Samantha M Stanfield, Jon McCord, Guillermo A Altenberg, Carlos Javier Minah. Nanodisc-associated acetylcholinesterase as a novel model system of physiological relevant membrane-bound cholinesterases. Inhibition by phenolic compounds. Biochimica et biophysica acta. Biomembranes. 2024-10-08. PMID:39378913. |
acetylcholinesterase (ache) plays a pivotal role in the cholinergic system, and its inhibition is sought after in a wide range of applications, from insect control to alzheimer's disease treatment. |
2024-10-08 |
2024-10-11 |
human |
| Ilona Mojzych, Anna Zawadzka, Kryspin Andrzejewski, Monika Jampolska, Zuzana Bednarikova, Miroslav Gancar, Zuzana Gazova, Maciej Mazur, Katarzyna Kaczyńsk. A Novel Tetrahydroacridine Derivative with Potent Acetylcholinesterase Inhibitory Properties and Dissociative Capability against Aβ42 Fibrils Confirmed by In Vitro Studies. International journal of molecular sciences. vol 25. issue 18. 2024-09-28. PMID:39337556. |
treatment is mainly based on acetylcholinesterase (ache) inhibitors such as donepezil, rivastigmine, and galantamine, which exhibit numerous adverse cardiovascular and gastrointestinal effects due to excessive stimulation of peripheral cholinergic activity involving muscarinic receptors. |
2024-09-28 |
2024-10-01 |
Not clear |
| Lijun Wang, Jian Liu, Wenqian Gui, Rong Zhang, Xinmei Li, Liancheng Fang, Hui Li, Dandan Pan, Wenling Y. Molecular interaction mechanisms on (-)-epigallocatechin-3-gallate improving activities of inhibited acetylcholinesterase by selected organophosphorus pesticides in vitro & vivo. Scientific reports. vol 14. issue 1. 2024-09-27. PMID:39333189. |
(-)-epigallocatechin-3-gallate (egcg) is reported to have benefits for the treatment of alzheimer's disease by binding with acetylcholinesterase (ache) to enhance the cholinergic neurotransmission. |
2024-09-27 |
2024-10-01 |
zebrafish |
| Chhatrapal Patel, Richa Patel, Anuradha Kesharwani, Laxmi Rao, Nishant Sudhir Jai. Central cholinergic transmission modulates endocannabinoid-induced marble-burying behavior in mice. Behavioural brain research. 2024-09-15. PMID:39278464. |
moreover, anandamide in all the tested doses inhibited the brain ache activity indicating an anti-compulsive-like effect probably via an enhanced central cholinergic transmission. |
2024-09-15 |
2024-09-18 |
mouse |
| Chhatrapal Patel, Richa Patel, Anuradha Kesharwani, Laxmi Rao, Nishant Sudhir Jai. Central cholinergic transmission modulates endocannabinoid-induced marble-burying behavior in mice. Behavioural brain research. 2024-09-15. PMID:39278464. |
thus, the present investigation delineates the modulatory role of an enhanced central cholinergic transmission in the anandamide-induced anti-compulsive-like behavior in mice by inhibition of brain ache or via muscarinic and nicotinic receptors mediated mechanism. |
2024-09-15 |
2024-09-18 |
mouse |
| Ivan Kong, Gary Ka-Wing Yuen, Qi-Yun Wu, Maggie Sui-Sui Guo, Jin Gao, Tina Ting-Xia Dong, Karl Wah-Keung Tsi. Acetylcholine regulates the melanogenesis of retinal pigment epithelia cells via a cAMP-dependent pathway: A non-neuronal function of cholinergic system in retina. Heliyon. vol 10. issue 16. 2024-09-10. PMID:39253121. |
the mrna and protein expressions of cholinergic molecules, e.g., acetylcholinesterase (ache), butyrylcholinesterase (bche), and melanogenic molecules i.e., tyrosinase (tyr), microphthalmia-associated transcription factor (mitf), and melanin pigment were measured during melanogenesis of cultured arpe-19 cells. |
2024-09-10 |
2024-09-13 |
human |
| Ivan Kong, Gary Ka-Wing Yuen, Qi-Yun Wu, Maggie Sui-Sui Guo, Jin Gao, Tina Ting-Xia Dong, Karl Wah-Keung Tsi. Acetylcholine regulates the melanogenesis of retinal pigment epithelia cells via a cAMP-dependent pathway: A non-neuronal function of cholinergic system in retina. Heliyon. vol 10. issue 16. 2024-09-10. PMID:39253121. |
during melanogenesis of arpe-19 cells, the mrna and protein expressions of cholinergic molecules, e.g., ache and bche, were increased along with melanogenic molecules, i.e., tyr, mitf and melanin pigment. |
2024-09-10 |
2024-09-13 |
human |
| Paula Moyano, Andrea Flores, Javier San Juan, Jimena García, María José Anadón, Jose Carlos Plaza, Maria Victoria Naval, María de la Cabeza Fernández, Lucía Guerra-Menéndez, Javier Del Pin. Imidacloprid unique and repeated treatment produces cholinergic transmission disruption and apoptotic cell death in SN56 cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2024-09-09. PMID:39251036. |
bf sn56 cholinergic wild-type or acetylcholinesterase (ache), β-amyloid-precursor-protein (βapp), tau, glycogen-synthase-kinase-3-beta (gsk3β), beta-site-amyloid-precursor-protein-cleaving enzyme 1 (bace1), and/or nuclear-factor-erythroid-2-related-factor-2 (nrf2) silenced cells were treated for 1 and 14 days with imi (1 μm to 800 μm) with or without recombinant heat-shock-protein-70 (rhsp70), recombinant proteasome 20s (rp20s) and with or without n-acetyl-cysteine (nac) to determine the possible mechanisms that mediate this effect. |
2024-09-09 |
2024-09-13 |
Not clear |
| Paula Moyano, Andrea Flores, Javier San Juan, Jimena García, María José Anadón, Jose Carlos Plaza, Maria Victoria Naval, María de la Cabeza Fernández, Lucía Guerra-Menéndez, Javier Del Pin. Imidacloprid unique and repeated treatment produces cholinergic transmission disruption and apoptotic cell death in SN56 cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2024-09-09. PMID:39251036. |
imi treatment for 1 and 14 days altered cholinergic transmission through ache inhibition, and triggered cell death partially through oxidative stress generation, ache-s overexpression, hsp70 downregulation, p20s inhibition, and aβ and tau peptides accumulation. |
2024-09-09 |
2024-09-13 |
Not clear |
| Gabriele Horn, Franziska Frielingsdorf, Tobias Demel, Simone Rothmiller, Franz Worek, Niko Amen. Concentration-dependent effects of the nerve agents cyclosarin and VX on cytochrome P450 in a HepaRG cell-based liver model. Journal of applied toxicology : JAT. 2024-09-04. PMID:39228234. |
op can induce the uncontrolled overstimulation of the cholinergic system through inhibition of the enzyme acetylcholinesterase (ache). |
2024-09-04 |
2024-09-06 |
Not clear |