| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Stergiani-Chrysovalanti Peitzika, Eleni Pontik. A Review on Recent Approaches on Molecular Docking Studies of Novel Compounds Targeting Acetylcholinesterase in Alzheimer Disease. Molecules (Basel, Switzerland). vol 28. issue 3. 2023-02-11. PMID:36770750. |
low levels of acetylcholine and abnormal levels of beta-amyloid, t protein aggregation, inflammation, and oxidative stress, have been associated with ad, and therefore, research has been oriented towards the cholinergic system and primarily on acetylcholinesterase (ache) inhibitors. |
2023-02-11 |
2023-08-14 |
Not clear |
| Kexin Li, Yulong Liu, Yanqin Liu, Qian Li, Lei Guo, Jianwei Xi. The kinetic and molecular docking analysis of interactions between three V-type nerve agents and four human cholinesterases. Chemico-biological interactions. 2023-01-28. PMID:36708975. |
their primary toxicity was the consequence of the covalent inhibition of the pivotal acetylcholinesterase (ache), which induces overstimulation of cholinergic receptors and overaccumulation of cholines, eventually leading to death by respiratory arrest. |
2023-01-28 |
2023-08-14 |
human |
| Ignazio Schino, Mariangela Cantore, Modesto de Candia, Cosimo D Altomare, Catarina Maria, João Barros, Vasco Cachatra, Patrícia Calado, Karina Shimizu, Adilson A Freitas, Maria C Oliveira, Maria J Ferreira, José N C Lopes, Nicola A Colabufo, Amélia P Raute. Exploring Mannosylpurines as Copper Chelators and Cholinesterase Inhibitors with Potential for Alzheimer's Disease. Pharmaceuticals (Basel, Switzerland). vol 16. issue 1. 2023-01-21. PMID:36678552. |
alzheimer's disease (ad) is characterized by a progressive cholinergic neurotransmission imbalance, with a decrease of acetylcholinesterase (ache) activity followed by a significant increase of butyrylcholinesterase (bche) in the later ad stages. |
2023-01-21 |
2023-08-14 |
Not clear |
| Raquel B M de Almeida, Deyse B Barbosa, Mayra R do Bomfim, Jéssika A O Amparo, Bruno S Andrade, Silvia L Costa, Joaquín M Campos, Jorddy N Cruz, Cleydson B R Santos, Franco H A Leite, Mariana B Botur. Identification of a Novel Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase: In Vitro and In Silico Studies. Pharmaceuticals (Basel, Switzerland). vol 16. issue 1. 2023-01-21. PMID:36678592. |
the enhancement of cholinergic functions via acetylcholinesterase (ache) and butyrylcholinesterase (buche) inhibition is considered a valuable therapeutic strategy for the treatment of alzheimer's disease. |
2023-01-21 |
2023-08-14 |
Not clear |
| Melvin Selim Atay, Suat Sari, Ebru Bodu. Molecular and Computational Analysis Identify Statins as Selective Inhibitors of Human Butyrylcholinesterase. The protein journal. 2023-01-17. PMID:36648628. |
cholinesterase enzyme family consists of acetylcholinesterase (ache, 3.1.1.7), the major enzyme responsible for hydrolysis of acetylcholine at cholinergic synapses, and butyrylcholinesterase (bche, 3.1.1.8) a detoxification enzyme of plasma. |
2023-01-17 |
2023-08-14 |
human |
| Zhuo Wang, Chao Gao, Lei Zhang, Rubo Su. Hesperidin methylchalcone (HMC) hinders amyloid-β induced Alzheimer's disease by attenuating cholinesterase activity, macromolecular damages, oxidative stress and apoptosis via regulating NF-κB and Nrf2/HO-1 pathways. International journal of biological macromolecules. 2023-01-09. PMID:36623626. |
hmc significantly enhanced the cholinergic effects by inhibiting ache, buche, β-secretase activity, caspase-3 activity, and attenuating macromolecular damages and apoptosis. |
2023-01-09 |
2023-08-14 |
rat |
| Vasudevan Mani, Syed Imam Rabbani, Ali Shariq, Palanisamy Amirthalingam, Minhajul Arfee. Piracetam as a Therapeutic Agent for Doxorubicin-Induced Cognitive Deficits by Enhancing Cholinergic Functions and Reducing Neuronal Inflammation, Apoptosis, and Oxidative Stress in Rats. Pharmaceuticals (Basel, Switzerland). vol 15. issue 12. 2022-12-23. PMID:36559014. |
pira administration offered significant protection against dox-induced cognitive deficits in all maze tests and restored cholinergic functions via a significant reduction in ache levels. |
2022-12-23 |
2023-08-14 |
rat |
| Farzaneh Motafeghi, Abouzar Bagheri, Mohammad Seyedabadi, Fatemeh Shaki, Mohammad Shokrzade. Antidepressant-Like Effects of Edaravone and Minocycline: Investigation of Oxidative Stress, Neuroinflammation, Neurotrophic, and Apoptotic Pathways. Neurotoxicity research. 2022-12-15. PMID:36522510. |
maternal separation increased serum corticosterone levels, caused dysfunction of the cholinergic system, and also increased ache activity. |
2022-12-15 |
2023-08-14 |
rat |
| Saritha S L Silva, Luciane V Tureck, Leonardo C Souza, João V M Hortega, Ana Luiza Piumbini, Mayza D Teixeira, Lupe Furtado-Alle Writing-Reviewing, Maria A B F Vital, Ricardo L R Souz. Animal model of Alzheimer's disease induced by streptozotocin: new insights about cholinergic pathway. Brain research. 2022-11-27. PMID:36436686. |
disorders of the cholinergic system are well known to be involved in the pathogenesis of ad, characterized by increased acetylcholinesterase (ache) and butyrylcholinesterase (bche) and decreased acetyltransferase (chat) enzymatic activities. |
2022-11-27 |
2023-08-14 |
human |
| Saritha S L Silva, Luciane V Tureck, Leonardo C Souza, João V M Hortega, Ana Luiza Piumbini, Mayza D Teixeira, Lupe Furtado-Alle Writing-Reviewing, Maria A B F Vital, Ricardo L R Souz. Animal model of Alzheimer's disease induced by streptozotocin: new insights about cholinergic pathway. Brain research. 2022-11-27. PMID:36436686. |
thus, this study aimed to assess the long-term effects of icv-stz on the cholinergic system, through the measuring of ache and bche enzymatic activities in hippocampus, prefrontal cortex and liver of animals euthanized 30 and 120-days after the icv-stz. |
2022-11-27 |
2023-08-14 |
human |
| Saritha S L Silva, Luciane V Tureck, Leonardo C Souza, João V M Hortega, Ana Luiza Piumbini, Mayza D Teixeira, Lupe Furtado-Alle Writing-Reviewing, Maria A B F Vital, Ricardo L R Souz. Animal model of Alzheimer's disease induced by streptozotocin: new insights about cholinergic pathway. Brain research. 2022-11-27. PMID:36436686. |
regarding the cholinergic response to icv-stz, the 30-days and 120-days stz-induced rats exhibit decreased ache and bche activities only in the hippocampus. |
2022-11-27 |
2023-08-14 |
human |
| Saritha S L Silva, Luciane V Tureck, Leonardo C Souza, João V M Hortega, Ana Luiza Piumbini, Mayza D Teixeira, Lupe Furtado-Alle Writing-Reviewing, Maria A B F Vital, Ricardo L R Souz. Animal model of Alzheimer's disease induced by streptozotocin: new insights about cholinergic pathway. Brain research. 2022-11-27. PMID:36436686. |
this is the first study to investigate the long-term effects (more than 60 days) of the icv-stz on ache and bche activities, and our results, as well as those of a recent study, suggest that the cholinergic system may not be compromised by icv-stz, at least in the long term, which means that this model may not be the best model for studying the cholinergic system in ad or that it is informative only for a short period. |
2022-11-27 |
2023-08-14 |
human |
| Mohan Kumar Dash, Md Saydur Rahma. Molecular and biochemical responses to tributyltin (TBT) exposure in the American oyster: Triggers of stress-induced oxidative DNA damage and prooxidant-antioxidant imbalance in tissues by TBT. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2022-11-25. PMID:36427667. |
in this study, we investigated the effects of tbt on 8'-hydroxy-2'-deoxyguanosine (8-ohdg, a biomarker of pro-mutagenic dna lesion), double-stranded dna (dsdna), dinitrophenyl protein (dnp, a biomarker on reactive oxygen species, ros), 3-nitrotyrosine protein (ntp, a biomarker of reactive nitrogen species, rns), catalase (cat, an antioxidant), and acetylcholinesterase (ache, a cholinergic enzyme) expressions in the gills and digestive glands of oysters. |
2022-11-25 |
2023-08-14 |
cat |
| Anna Głowacka, Benjun Ji, Andrzej Antoni Szczepankiewicz, Małgorzata Skup, Olga Gajewska-Woźnia. BDNF Spinal Overexpression after Spinal Cord Injury Partially Protects Soleus Neuromuscular Junction from Disintegration, Increasing VAChT and AChE Transcripts in Soleus but Not Tibialis Anterior Motoneurons. Biomedicines. vol 10. issue 11. 2022-11-11. PMID:36359371. |
the gene expression of cholinergic molecules (vacht, chat, ache, nachr, machr) was investigated in tracer-identified, microdissected mn perikarya, and in muscle fibers with the use of qpcr. |
2022-11-11 |
2023-08-14 |
rat |
| Fatima Javed Mirza, Saadia Zahid, Sanila Amber, Sumera, Hira Jabeen, Noreen Asim, Syed Adnan Ali Sha. Multitargeted Molecular Docking and Dynamic Simulation Studies of Bioactive Compounds from Molecules (Basel, Switzerland). vol 27. issue 21. 2022-11-11. PMID:36364071. |
multitargeted molecular docking and dynamic simulation studies of bioactive compounds from alzheimer's disease (ad) has been associated with the hallmark features of cholinergic dysfunction, amyloid beta (aβ) aggregation and impaired synaptic transmission, which makes the associated proteins, such as β-site amyloid precursor protein cleaving enzyme 1 (bace i), acetylcholine esterase (ache) and synapsin i, ii and iii, major targets for therapeutic intervention. |
2022-11-11 |
2023-08-14 |
Not clear |
| b' Irene \\xc3\\x81lvarez-Berbel, Alba Espargar\\xc3\\xb3, Antonio Viayna, Ana Bel\\xc3\\xa9n Caballero, Maria Ant\\xc3\\xb2nia Busquets, Patrick G\\xc3\\xa1mez, Francisco Javier Luque, Raimon Sabat\\xc3\\xa. Three to Tango: Inhibitory Effect of Quercetin and Apigenin on Acetylcholinesterase, Amyloid-\\xce\\xb2 Aggregation and Acetylcholinesterase-Amyloid Interaction. Pharmaceutics. vol 14. issue 11. 2022-11-11. PMID:36365159.' |
since acetylcholinesterase (ache) promotes the formation of such plaques, the inhibition of this enzyme could slow down the progression of amyloid-β aggregation, hence being complementary to the palliative treatment of cholinergic decline. |
2022-11-11 |
2023-08-14 |
Not clear |
| Tapan Behl, Ishnoor Kaur, Aayush Sehgal, Sukhbir Singh, Neelam Sharma, Sumeet Gupta, Mohammed Albratty, Asim Najmi, Hassan A Alhazmi, Simona Bunga. AChE as a Spark in the Alzheimer's Blaze - Antagonizing Effect of a Cyclized Variant. Ageing research reviews. 2022-11-11. PMID:36368649. |
a significant protein, acetylcholinesterase (ache) becomes dysfunctional as a result of cholinergic neuronal loss in ad pathology. |
2022-11-11 |
2023-08-14 |
Not clear |
| Faezeh Aliakbarzadeh, Mohammad Rafiee, Fariba Khodagholi, Mohammad Reza Khorramizadeh, Hamed Manouchehri, Akbar Eslami, Fatemeh Sayehmiri, Anoushiravan Mohseni-Bandpe. Adverse effects of polystyrene nanoplastic and its binary mixtures with nonylphenol on zebrafish nervous system: From oxidative stress to impaired neurotransmitter system. Environmental pollution (Barking, Essex : 1987). 2022-11-06. PMID:36336178. |
multiple biomarkers concerning with oxidative-stress [catalase (cat) activity and reduced glutathione (gsh) level], cholinergic system [acetylcholinesterase (ache) activity], glutamatergic system [glutamine synthetase (gs) and glutamate dehydrogenase (gdh) activities], energy metabolism [a-ketoglutarate dehydrogenase (a-kgdh) activity], and histological alterations were assessed. |
2022-11-06 |
2023-08-14 |
cat |
| Arwa A Al-Maswary, Molly O'Reilly, Andrew P Holmes, A Damien Walmsley, Paul R Cooper, Ben A Scheve. Exploring the neurogenic differentiation of human dental pulp stem cells. PloS one. vol 17. issue 11. 2022-11-04. PMID:36331951. |
in hdpscs, upregulation of acetylcholinesterase (ache), choline o-acetyltransferase (chat), sodium channel alpha subunit 9 (scn9a), pou class 4 homeobox 1 (pou4f1/brn3a) along with a downregulation of motor neuron and pancreas homeobox 1 (mnx1) indicated that differentiation was more guided toward a cholinergic sensory neuronal lineage. |
2022-11-04 |
2023-08-14 |
human |
| Thankhoe A Rants'o, Lizette L Koekemoer, Jenny-Lee Panayides, Robyn L van Zy. Potential of Essential Oil-Based Anticholinesterase Insecticides against Molecules (Basel, Switzerland). vol 27. issue 20. 2022-10-27. PMID:36296618. |
the cholinergic system, of which acetylcholinesterase (ache) is a key enzyme, is essential to the |
2022-10-27 |
2023-08-14 |
Not clear |