| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kritika Kumari, Laishram R Sing. Trimethylamine N-oxide might impair cholinergic system by affecting the structural integrity of Acetylcholinesterase. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35555536. |
the results indicate that tmao might induce decline in the cholinergic system by impairing the function of ache. |
2022-05-13 |
2023-08-13 |
human |
| Khadija Boukholda, Brahim Gargouri, Bakhta Aouey, Abdelraheim Attaai, Mohamed Abd Elkodous, Mohamed Najimi, Bernd L Fiebich, Michèle Bouchard, Hamadi Fetou. Subacute silica nanoparticle exposure induced oxidative stress and inflammation in rat hippocampus combined with disruption of cholinergic system and behavioral functions. NanoImpact. vol 24. 2022-05-13. PMID:35559817. |
sinps affected the cholinergic system as reflected by reduced acetylcholinesterase (ache) and butyrylcholinesterase (bche) activity. |
2022-05-13 |
2023-08-13 |
rat |
| Khadija Boukholda, Brahim Gargouri, Bakhta Aouey, Abdelraheim Attaai, Mohamed Abd Elkodous, Mohamed Najimi, Bernd L Fiebich, Michèle Bouchard, Hamadi Fetou. Subacute silica nanoparticle exposure induced oxidative stress and inflammation in rat hippocampus combined with disruption of cholinergic system and behavioral functions. NanoImpact. vol 24. 2022-05-13. PMID:35559817. |
in addition, sinps significantly increased mrna expression level of genes related to inflammation (tnf-α, il-1β, il-6, and cox-2) and decreased mrna expression level of genes related to cholinergic system including choline acetyltransferase (chat), vesicular acetylcholine transporter (vacht), ache, muscarinic acetylcholine receptor m1 (m1achr) and nicotinic acetylcholine receptors (nachr). |
2022-05-13 |
2023-08-13 |
rat |
| Eric Herrera, Timothy Barry, Aishwarya Sriraman, Karen Brecht, Sandra DeBus, Ki Ma, Hilary Mccarren, C L Cadieu. Developing a Prenatal Acute Exposure and Medical Countermeasure Evaluation Model for Organophosphate Compounds in a Genetically Modified Mouse. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35560758. |
organophosphate (ops) compounds make up the most common class of pesticides as well as chemical warfare nerve agents (cwna), all of which covalently inhibit the active site of acetylcholinesterase (ache), resulting in intoxication via a cholinergic crisis. |
2022-05-13 |
2023-08-13 |
mouse |
| Vasudevan Mani, Minhajul Arfeen, Sultan Sajid, Yasser Almogbe. Aqueous Ajwa dates seeds extract improves memory impairment in type-2 diabetes mellitus rats by reducing blood glucose levels and enhancing brain cholinergic transmission. Saudi journal of biological sciences. vol 29. issue 4. 2022-05-09. PMID:35531250. |
acetylcholine (ach) and acetylcholinesterase (ache) levels were estimated from brain homogenates to assess cholinergic transmission. |
2022-05-09 |
2023-08-13 |
rat |
| K V Dileep, Kentaro Ihara, Chiemi Mishima-Tsumagari, Mutsuko Kukimoto-Niino, Mayumi Yonemochi, Kazuharu Hanada, Mikako Shirouzu, Kam Y J Zhan. Crystal structure of human acetylcholinesterase in complex with tacrine: Implications for drug discovery. International journal of biological macromolecules. 2022-05-08. PMID:35526766. |
restoration of the cholinergic transmission through acetylcholinesterase (ache) inhibitors is a promising disease modifying therapy. |
2022-05-08 |
2023-08-13 |
human |
| b' Mehmet Koca, U\\xc4\\x9fur G\\xc3\\xbcller, P\\xc4\\xb1nar G\\xc3\\xbcller, Ziya Da\\xc4\\x9falan, Bilal Ni\\xc5\\x9fanc\\xc4\\xb. Design and Synthesis of Novel Dual Cholinesterase Inhibitors: In Vitro Inhibition Studies Supported with Molecular Docking. Chemistry & biodiversity. 2022-04-26. PMID:35470963.' |
the major cholinesterase enzymes, acetylcholinesterase (ache) and butyrylcholinesterase (bche), are important in the therapy of alzheimer's disease (ad) based on the cholinergic hypothesis. |
2022-04-26 |
2023-08-13 |
human |
| Suksan Changlek, Mohammad Nasiruddin Rana, Moe Pwint Phyu, Naymul Karim, Hideyuki J Majima, Jitbanjong Tangpon. Curcumin Suppresses Lead-Induced Inflammation and Memory Loss in Mouse Model and In Silico Molecular Docking. Foods (Basel, Switzerland). vol 11. issue 6. 2022-03-25. PMID:35327278. |
cur treatment also improved memory loss, learning deficit, and cholinergic dysfunction via elevating acetylcholinesterase (ache) enzymatic activity and protein expression. |
2022-03-25 |
2023-08-13 |
mouse |
| Dara Dastan, Reza Zhiyani, Kiana Fasihi, Ahmad Ebad. An arginine-rich peptide inhibits AChE: template-based design, molecular modeling, synthesis, and biological evaluation. Journal of molecular modeling. vol 28. issue 4. 2022-03-08. PMID:35258696. |
ache, as a well-known target in ad, decreases the acetylcholine (ach) in cholinergic synapse and, besides, increases the rate of amyloid-beta (aβ) aggregation. |
2022-03-08 |
2023-08-13 |
Not clear |
| Dara Dastan, Reza Zhiyani, Kiana Fasihi, Ahmad Ebad. An arginine-rich peptide inhibits AChE: template-based design, molecular modeling, synthesis, and biological evaluation. Journal of molecular modeling. vol 28. issue 4. 2022-03-08. PMID:35258696. |
to block the destructive effects of ache on cholinergic neurons in ad, we designed a peptidic inhibitor of the peripheral anionic site (pas). |
2022-03-08 |
2023-08-13 |
Not clear |
| Majid Rasool Kamli, Abeer Abdullah M Sharaf, Jamal S M Sabir, Irfan A Rathe. Phytochemical Screening of Plants (Basel, Switzerland). vol 11. issue 4. 2022-02-26. PMID:35214846. |
phytochemical screening of the inhibition of acetylcholinesterase (ache) by cholinergic agents has been promoted as a potent strategy for treating and managing cognitive decline disorders. |
2022-02-26 |
2023-08-13 |
Not clear |
| Marta Kopańska, Anna Łagowska, Barbara Kuduk, Agnieszka Banaś-Ząbczy. Acrylamide Neurotoxicity as a Possible Factor Responsible for Inflammation in the Cholinergic Nervous System. International journal of molecular sciences. vol 23. issue 4. 2022-02-26. PMID:35216144. |
the blood ache is able to terminate the stimulation of the cholinergic anti-inflammatory pathway due to splitting ach. |
2022-02-26 |
2023-08-13 |
Not clear |
| Yiwen Xiao, Weizhong Liang, De Liu, Zhibin Zhang, Jun Chang, Du Zh. Isolation and acetylcholinesterase inhibitory activity of asterric acid derivatives produced by 3 Biotech. vol 12. issue 3. 2022-02-21. PMID:35186657. |
acetylcholinesterase (ache) inhibitors, which are based on cholinergic damage, remain the mainstream drugs to alleviate ad-related symptoms. |
2022-02-21 |
2023-08-13 |
Not clear |
| Hatice Esra Dura. Pyrimidines: Molecular docking and inhibition studies on carbonic anhydrase and cholinesterases. Biotechnology and applied biochemistry. 2022-02-03. PMID:35112394. |
cholinesterases (ches; ache, acetylcholinesterase and bche, butyrylcholinesterase) inhibitors and their benefits of cholinergic replacement in the treatment of ad have been researched and documented by scientists in various ways to date. |
2022-02-03 |
2023-08-13 |
human |
| Xian-Tao L. Alzheimer's disease therapy based on acetylcholinesterase inhibitor/blocker effects on voltage-gated potassium channels. Metabolic brain disease. 2022-01-31. PMID:35098414. |
to enhance the declined level of acetylcholine (ach) resulting from loss of cholinergic neurons, acetylcholinesterase (ache) inhibitors are developed and successfully approved for ad treatment in the clinic, with a limited therapeutic effectiveness. |
2022-01-31 |
2023-08-13 |
Not clear |
| Horst Thiermann, Franz Wore. Oximes should be used routinely in organophosphate poisoning. British journal of clinical pharmacology. 2022-01-13. PMID:35023196. |
every measure that allows an increase of synaptic ache activity at the earliest is essential for timely termination of the cholinergic crisis. |
2022-01-13 |
2023-08-13 |
Not clear |
| Horst Thiermann, Franz Wore. Oximes should be used routinely in organophosphate poisoning. British journal of clinical pharmacology. 2022-01-13. PMID:35023196. |
there is no doubt that obidoxime and pralidoxime are able to reactivate op inhibited ache activity in poisoned patients thereby increasing ache activity and contributing substantially to terminate cholinergic crisis. |
2022-01-13 |
2023-08-13 |
Not clear |
| Camila Fabiani, Brunella Biscussi, Juan Pablo Munafo, Ana Paula Murray, Jeremias Corradi, Silvia Susana Antollin. Molecular pharmacology. 2021-12-31. PMID:34969831. |
since cholinergic deficit is a major factor in this disease, two molecular targets for its treatment are the acetylcholinesterase (ache) and the nicotinic acetylcholine receptors (nachrs). |
2021-12-31 |
2023-08-13 |
Not clear |
| Danish Iqbal, M Salman Khan, Mohd Waiz, Md Tabish Rehman, Mohammed Alaidarous, Azfar Jamal, Abdulaziz S Alothaim, Mohamed F AlAjmi, Bader Mohammed Alshehri, Saeed Banawas, Mohammed Alsaweed, Yahya Madkhali, Abdulrahman Algarni, Suliman A Alsagaby, Wael Alturaik. Exploring the Binding Pattern of Geraniol with Acetylcholinesterase through In Silico Docking, Molecular Dynamics Simulation, and In Vitro Enzyme Inhibition Kinetics Studies. Cells. vol 10. issue 12. 2021-12-24. PMID:34944045. |
acetylcholinesterase (ache) inhibition is a key element in enhancing cholinergic transmission and subsequently relieving major symptoms of several neurological and neuromuscular disorders. |
2021-12-24 |
2023-08-13 |
Not clear |
| Donald E Moss, Ruth G Pere. Anti-neurodegenerative benefits of acetylcholinesterase inhibitors in Alzheimer's disease: Nexus of cholinergic and nerve growth factor dysfunction. Current Alzheimer research. 2021-12-16. PMID:34911424. |
here we review the anti-neurodegenerative benefits of ache inhibitors and the expected parallel disease-accelerating impairments caused by anticholinergics, within a framework of the cholinergic hypothesis of ad and ad-associated loss of nerve growth factor (ngf). |
2021-12-16 |
2023-08-13 |
Not clear |