| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Donald E Moss, Ruth G Pere. Anti-neurodegenerative benefits of acetylcholinesterase inhibitors in Alzheimer's disease: Nexus of cholinergic and nerve growth factor dysfunction. Current Alzheimer research. 2021-12-16. PMID:34911424. |
consistent with the "loss of trophic factor hypothesis of ad," we propose that ache inhibitors enhance acetylcholine-dependent release and uptake of ngf, thereby sustaining cholinergic neuronal viability and thus lowing ad-associated degeneration of the cbf, to delay dementia progression ultimately. |
2021-12-16 |
2023-08-13 |
Not clear |
| The-Huan Tran, Thi-Thu-Hien Vo, Thi-Quynh-Nhi Vo, Thi-Cam-Nhung Cao, Thai-Son Tra. Synthesis and Evaluation of the Acetylcholinesterase Inhibitory Activities of Some Flavonoids Derived from Naringenin. TheScientificWorldJournal. vol 2021. 2021-12-11. PMID:34887704. |
a research approach in the finding new treatment for ad that has attracted much interest from scientists for a long time is the reestablishment of cholinergic transmission through inhibition of acetylcholinesterase (ache). |
2021-12-11 |
2023-08-13 |
Not clear |
| Stacey Herriage, Guangping Chen, Carey Pop. Concentration-dependent effects of chlorpyrifos oxon on peroxisome proliferator-activated receptor signaling in MCF-7 cells. Toxicology in vitro : an international journal published in association with BIBRA. vol 78. 2021-12-10. PMID:34756920. |
ache is critical in regulating cholinergic signaling while faah catalyzes the inactivation of fatty acid signaling lipids including the endocannabinoid (ecb) n-arachidonylethanolamine (anandamide, aea) and ecb-like metabolites (e.g., oleoylethanolamide, oea). |
2021-12-10 |
2023-08-13 |
human |
| Sumei Wang, Qian Zhao, Gaochun Li, Mengwei Wang, Hongliang Liu, Xingchen Yu, Jingwen Chen, Pei Li, Lixin Dong, Guoyu Zhou, Yushan Cui, Mengru Wang, Li Liu, Aiguo Wan. The cholinergic system, intelligence, and dental fluorosis in school-aged children with low-to-moderate fluoride exposure. Ecotoxicology and environmental safety. vol 228. 2021-12-07. PMID:34808511. |
cholinergic system was assessed by the detection of choline acetyltransferase (chat), acetylcholinesterase (ache) and acetylcholine (ach) levels in serum. |
2021-12-07 |
2023-08-13 |
Not clear |
| Shuaizhang Li, Andrew J Li, Jameson Travers, Tuan Xu, Srilatha Sakamuru, Carleen Klumpp-Thomas, Ruili Huang, Menghang Xi. Identification of Compounds for Butyrylcholinesterase Inhibition. SLAS discovery : advancing life sciences R & D. vol 26. issue 10. 2021-12-04. PMID:34269114. |
bche plays a critical role in maintaining normal cholinergic function like acetylcholinesterase (ache) through hydrolyzing acetylcholine (ach). |
2021-12-04 |
2023-08-13 |
Not clear |
| Constantin Kondak, Gernot Riedel, Charles R Harrington, Claude M Wischik, Jochen Klei. Hydromethylthionine enhancement of central cholinergic signalling is blocked by rivastigmine and memantine. Journal of neurochemistry. 2021-12-02. PMID:34855998. |
the interactions observed in this study demonstrate that hmt enhances cholinergic activity in mouse brain by a mechanism of action unrelated to ache inhibition. |
2021-12-02 |
2023-08-13 |
mouse |
| Ryohei Tanaka-Kanegae, Koichiro Hamad. A novel in vitro assay model developed to measure both extracellular and intracellular acetylcholine levels for screening cholinergic agents. PloS one. vol 16. issue 10. 2021-11-30. PMID:34637466. |
cholinergic neurons utilize choline (ch) to synthetize acetylcholine (ach) and contain a high-affinity ch transporter, ch acetyltransferase (chat), ach receptors, and acetylcholinesterase (ache). |
2021-11-30 |
2023-08-13 |
Not clear |
| Ryohei Tanaka-Kanegae, Koichiro Hamad. A novel in vitro assay model developed to measure both extracellular and intracellular acetylcholine levels for screening cholinergic agents. PloS one. vol 16. issue 10. 2021-11-30. PMID:34637466. |
the associated changes in the cholinergic components may be reflected by intra- or extra-cellular ach levels, with an increase in extracellular ach levels occurring following ache inhibition. |
2021-11-30 |
2023-08-13 |
Not clear |
| Ryohei Tanaka-Kanegae, Koichiro Hamad. A novel in vitro assay model developed to measure both extracellular and intracellular acetylcholine levels for screening cholinergic agents. PloS one. vol 16. issue 10. 2021-11-30. PMID:34637466. |
we hypothesized that increases in intracellular ach levels can be more sensitively detected than those in extracellular ach levels, thereby capturing subtle effects in the cholinergic components other than ache. |
2021-11-30 |
2023-08-13 |
Not clear |
| b' Milena Mlaki\\xc4\\x87, Tena \\xc4\\x8cade\\xc5\\xbe, Danijela Bari\\xc4\\x87, Ivana Pu\\xc4\\x8dek, Ana Ratkovi\\xc4\\x87, \\xc5\\xbdeljko Marini\\xc4\\x87, Kornelija Lasi\\xc4\\x87, Zrinka Kovarik, Irena \\xc5\\xa0kori\\xc4\\x8. New Uncharged 2-Thienostilbene Oximes as Reactivators of Organophosphate-Inhibited Cholinesterases. Pharmaceuticals (Basel, Switzerland). vol 14. issue 11. 2021-11-30. PMID:34832929.' |
the inhibition of acetylcholinesterase (ache) and butyrylcholinesterase (bche) by organophosphates (ops) as nerve agents and pesticides compromises normal cholinergic nerve signal transduction in the peripheral and central nervous systems (cns) leading to cholinergic crisis. |
2021-11-30 |
2023-08-13 |
Not clear |
| Bhuvaneswari Sivaraman, Vijaykumar R, Bala Aakash Velmurugan, Ramalakshmi Nataraja. Acetylcholinesterase Enzyme Inhibitor Molecules with Therapeutic Potential for Alzheimer's Disease. CNS & neurological disorders drug targets. 2021-11-23. PMID:34602041. |
ache is found majorly in the central nervous system at the site of cholinergic neurotransmission. |
2021-11-23 |
2023-08-13 |
Not clear |
| Fanny C F Ip, Guangmiao Fu, Fengzhi Yang, Fangyuan Kang, Peiran Sun, Choi Ying Ling, Kit Cheung, Fangzhou Xie, Yueqing Hu, Lei Fu, Nancy Y I. A tacrine-tetrahydroquinoline heterodimer potently inhibits acetylcholinesterase activity and enhances neurotransmission in mice. European journal of medicinal chemistry. vol 226. 2021-11-22. PMID:34530383. |
acetylcholinesterase (ache) inhibitors have been used to improve cholinergic transmission in the brain for two decades and have proven effective for alleviating symptoms in the early stages of alzheimer's disease. |
2021-11-22 |
2023-08-13 |
mouse |
| Heidi Qunhui Xie, Yongchao Ma, Hualing Fu, Tuan Xu, Yali Luo, Yiyun Liu, Yangsheng Chen, Li Xu, Yingjie Xia, Bin Zha. New perspective on the regulation of acetylcholinesterase via the aryl hydrocarbon receptor. Journal of neurochemistry. vol 158. issue 6. 2021-11-17. PMID:33278027. |
acetylcholinesterase (ache, ec 3.1.1.7) plays important roles in cholinergic neurotransmission and has been widely recognized as a biomarker for monitoring pollution by organophosphate (op) and carbamate pesticides. |
2021-11-17 |
2023-08-13 |
Not clear |
| Heidi Qunhui Xie, Yongchao Ma, Hualing Fu, Tuan Xu, Yali Luo, Yiyun Liu, Yangsheng Chen, Li Xu, Yingjie Xia, Bin Zha. New perspective on the regulation of acetylcholinesterase via the aryl hydrocarbon receptor. Journal of neurochemistry. vol 158. issue 6. 2021-11-17. PMID:33278027. |
growing evidence has shown that there is a significant link between dioxin exposure and neurodegenerative diseases and neurodevelopmental disorders, most of which involve ache and cholinergic dysfunctions. |
2021-11-17 |
2023-08-13 |
Not clear |
| Aisha Siddiqui, Zahoor Shah, Rao Nargis Jahan, Iekhsan Othman, Yatinesh Kumar. Mechanistic role of boswellic acids in Alzheimer's disease: Emphasis on anti-inflammatory properties. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 144. 2021-11-17. PMID:34607104. |
it is also involved in inhibiting the acetylcholinesterase (ache) activity in the cholinergic pathway and improve choline levels as well as its binding with nicotinic receptors to produce anti-inflammatory effects. |
2021-11-17 |
2023-08-13 |
Not clear |
| Hyoeun Yoo, Hyun-Sook Ki. Cacao powder supplementation attenuates oxidative stress, cholinergic impairment, and apoptosis in D-galactose-induced aging rat brain. Scientific reports. vol 11. issue 1. 2021-11-15. PMID:34504131. |
the levels of serum malondialdehyde (mda), advanced glycation end-products (ages), brain and liver mda, the indicators of the d-galactose induced oxidative stress were significantly decreased in lc and hc but increased in g. the acetylcholinesterase (ache) activity of brain showed that the cholinergic impairment was significantly lower in lc, and hc than g. furthermore, the expression levels of catalase (cat), phospho-akt/akt, and procaspase-3 were significantly increased in lc and hc. |
2021-11-15 |
2023-08-13 |
rat |
| Yuki Takada-Takator. [Donepezil Reduces Amyloid Precursor Protein Endocytosis by Resulting from Increase in the Expression of Sorting Nexin Protein 33]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. vol 141. issue 6. 2021-11-11. PMID:34078793. |
donepezil, the most widely used drug for the treatment of alzheimer's disease (ad), is an acetylcholinesterase (ache) inhibitor and is thought to improve cognition by stimulating cholinergic neurotransmission. |
2021-11-11 |
2023-08-13 |
rat |
| Samuel Adetunji Onasanwo, Vanessa O Adamaigbo, Olusegun G Adebayo, Spiff E Eleaze. Moringa oleifera-supplemented diet protect against cortico-hippocampal neuronal degeneration in scopolamine-induced spatial memory deficit in mice: role of oxido-inflammatory and cholinergic neurotransmission pathway. Metabolic brain disease. vol 36. issue 8. 2021-11-11. PMID:34669098. |
thereafter, markers of cholinergic system inhibition (acetylcholinesterase; ache) and oxido-inflammatory stress (malonaldehyde, mda; nitrite; superoxide dismutase, sod; tumor necrosis factor-alpha, tnf-α) and histo-morphology of the cortico-hippocampal neuron were measured. |
2021-11-11 |
2023-08-13 |
mouse |
| Yitzhak Brzezinski-Sinai, Ester Zwang, Elena Plotnikova, Ester Halizov, Itzhak Shapira, David Zeltser, Ori Rogowski, Shlomo Berliner, Idit Matot, Shani Shenhar-Tsarfat. Cholinesterase activity in serum during general anesthesia in patients with or without vascular disease. Scientific reports. vol 11. issue 1. 2021-11-10. PMID:34404888. |
both ache and total cholinergic status (cs) decreased significantly after ga induction at 15 min and even more so by the end of surgery. |
2021-11-10 |
2023-08-13 |
Not clear |
| Jiyeon Han, Zhi Du, Mi Hee Li. Mechanistic Insight into the Design of Chemical Tools to Control Multiple Pathogenic Features in Alzheimer's Disease. Accounts of chemical research. vol 54. issue 20. 2021-11-10. PMID:34606227. |
finally, the loss of cholinergic transmission mediated by the neurotransmitter acetylcholine (ach) contributes to cognitive deficits observed in ad.in this account, we illustrate the design principles for small-molecule-based chemical tools with reactivities against metal-free aβ, metal-bound aβ, ros, and ache. |
2021-11-10 |
2023-08-13 |
Not clear |