| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K V Dileep, Kentaro Ihara, Chiemi Mishima-Tsumagari, Mutsuko Kukimoto-Niino, Mayumi Yonemochi, Kazuharu Hanada, Mikako Shirouzu, Kam Y J Zhan. Crystal structure of human acetylcholinesterase in complex with tacrine: Implications for drug discovery. International journal of biological macromolecules. 2022-05-08. PMID:35526766. |
restoration of the cholinergic transmission through acetylcholinesterase (ache) inhibitors is a promising disease modifying therapy. |
2022-05-08 |
2023-08-13 |
human |
| b' Mehmet Koca, U\\xc4\\x9fur G\\xc3\\xbcller, P\\xc4\\xb1nar G\\xc3\\xbcller, Ziya Da\\xc4\\x9falan, Bilal Ni\\xc5\\x9fanc\\xc4\\xb. Design and Synthesis of Novel Dual Cholinesterase Inhibitors: In Vitro Inhibition Studies Supported with Molecular Docking. Chemistry & biodiversity. 2022-04-26. PMID:35470963.' |
the major cholinesterase enzymes, acetylcholinesterase (ache) and butyrylcholinesterase (bche), are important in the therapy of alzheimer's disease (ad) based on the cholinergic hypothesis. |
2022-04-26 |
2023-08-13 |
human |
| Suksan Changlek, Mohammad Nasiruddin Rana, Moe Pwint Phyu, Naymul Karim, Hideyuki J Majima, Jitbanjong Tangpon. Curcumin Suppresses Lead-Induced Inflammation and Memory Loss in Mouse Model and In Silico Molecular Docking. Foods (Basel, Switzerland). vol 11. issue 6. 2022-03-25. PMID:35327278. |
cur treatment also improved memory loss, learning deficit, and cholinergic dysfunction via elevating acetylcholinesterase (ache) enzymatic activity and protein expression. |
2022-03-25 |
2023-08-13 |
mouse |
| Dara Dastan, Reza Zhiyani, Kiana Fasihi, Ahmad Ebad. An arginine-rich peptide inhibits AChE: template-based design, molecular modeling, synthesis, and biological evaluation. Journal of molecular modeling. vol 28. issue 4. 2022-03-08. PMID:35258696. |
ache, as a well-known target in ad, decreases the acetylcholine (ach) in cholinergic synapse and, besides, increases the rate of amyloid-beta (aβ) aggregation. |
2022-03-08 |
2023-08-13 |
Not clear |
| Dara Dastan, Reza Zhiyani, Kiana Fasihi, Ahmad Ebad. An arginine-rich peptide inhibits AChE: template-based design, molecular modeling, synthesis, and biological evaluation. Journal of molecular modeling. vol 28. issue 4. 2022-03-08. PMID:35258696. |
to block the destructive effects of ache on cholinergic neurons in ad, we designed a peptidic inhibitor of the peripheral anionic site (pas). |
2022-03-08 |
2023-08-13 |
Not clear |
| Majid Rasool Kamli, Abeer Abdullah M Sharaf, Jamal S M Sabir, Irfan A Rathe. Phytochemical Screening of Plants (Basel, Switzerland). vol 11. issue 4. 2022-02-26. PMID:35214846. |
phytochemical screening of the inhibition of acetylcholinesterase (ache) by cholinergic agents has been promoted as a potent strategy for treating and managing cognitive decline disorders. |
2022-02-26 |
2023-08-13 |
Not clear |
| Marta Kopańska, Anna Łagowska, Barbara Kuduk, Agnieszka Banaś-Ząbczy. Acrylamide Neurotoxicity as a Possible Factor Responsible for Inflammation in the Cholinergic Nervous System. International journal of molecular sciences. vol 23. issue 4. 2022-02-26. PMID:35216144. |
the blood ache is able to terminate the stimulation of the cholinergic anti-inflammatory pathway due to splitting ach. |
2022-02-26 |
2023-08-13 |
Not clear |
| Yiwen Xiao, Weizhong Liang, De Liu, Zhibin Zhang, Jun Chang, Du Zh. Isolation and acetylcholinesterase inhibitory activity of asterric acid derivatives produced by 3 Biotech. vol 12. issue 3. 2022-02-21. PMID:35186657. |
acetylcholinesterase (ache) inhibitors, which are based on cholinergic damage, remain the mainstream drugs to alleviate ad-related symptoms. |
2022-02-21 |
2023-08-13 |
Not clear |
| Hatice Esra Dura. Pyrimidines: Molecular docking and inhibition studies on carbonic anhydrase and cholinesterases. Biotechnology and applied biochemistry. 2022-02-03. PMID:35112394. |
cholinesterases (ches; ache, acetylcholinesterase and bche, butyrylcholinesterase) inhibitors and their benefits of cholinergic replacement in the treatment of ad have been researched and documented by scientists in various ways to date. |
2022-02-03 |
2023-08-13 |
human |
| Xian-Tao L. Alzheimer's disease therapy based on acetylcholinesterase inhibitor/blocker effects on voltage-gated potassium channels. Metabolic brain disease. 2022-01-31. PMID:35098414. |
to enhance the declined level of acetylcholine (ach) resulting from loss of cholinergic neurons, acetylcholinesterase (ache) inhibitors are developed and successfully approved for ad treatment in the clinic, with a limited therapeutic effectiveness. |
2022-01-31 |
2023-08-13 |
Not clear |
| Horst Thiermann, Franz Wore. Oximes should be used routinely in organophosphate poisoning. British journal of clinical pharmacology. 2022-01-13. PMID:35023196. |
every measure that allows an increase of synaptic ache activity at the earliest is essential for timely termination of the cholinergic crisis. |
2022-01-13 |
2023-08-13 |
Not clear |
| Horst Thiermann, Franz Wore. Oximes should be used routinely in organophosphate poisoning. British journal of clinical pharmacology. 2022-01-13. PMID:35023196. |
there is no doubt that obidoxime and pralidoxime are able to reactivate op inhibited ache activity in poisoned patients thereby increasing ache activity and contributing substantially to terminate cholinergic crisis. |
2022-01-13 |
2023-08-13 |
Not clear |
| Camila Fabiani, Brunella Biscussi, Juan Pablo Munafo, Ana Paula Murray, Jeremias Corradi, Silvia Susana Antollin. Molecular pharmacology. 2021-12-31. PMID:34969831. |
since cholinergic deficit is a major factor in this disease, two molecular targets for its treatment are the acetylcholinesterase (ache) and the nicotinic acetylcholine receptors (nachrs). |
2021-12-31 |
2023-08-13 |
Not clear |
| Danish Iqbal, M Salman Khan, Mohd Waiz, Md Tabish Rehman, Mohammed Alaidarous, Azfar Jamal, Abdulaziz S Alothaim, Mohamed F AlAjmi, Bader Mohammed Alshehri, Saeed Banawas, Mohammed Alsaweed, Yahya Madkhali, Abdulrahman Algarni, Suliman A Alsagaby, Wael Alturaik. Exploring the Binding Pattern of Geraniol with Acetylcholinesterase through In Silico Docking, Molecular Dynamics Simulation, and In Vitro Enzyme Inhibition Kinetics Studies. Cells. vol 10. issue 12. 2021-12-24. PMID:34944045. |
acetylcholinesterase (ache) inhibition is a key element in enhancing cholinergic transmission and subsequently relieving major symptoms of several neurological and neuromuscular disorders. |
2021-12-24 |
2023-08-13 |
Not clear |
| Donald E Moss, Ruth G Pere. Anti-neurodegenerative benefits of acetylcholinesterase inhibitors in Alzheimer's disease: Nexus of cholinergic and nerve growth factor dysfunction. Current Alzheimer research. 2021-12-16. PMID:34911424. |
here we review the anti-neurodegenerative benefits of ache inhibitors and the expected parallel disease-accelerating impairments caused by anticholinergics, within a framework of the cholinergic hypothesis of ad and ad-associated loss of nerve growth factor (ngf). |
2021-12-16 |
2023-08-13 |
Not clear |
| Donald E Moss, Ruth G Pere. Anti-neurodegenerative benefits of acetylcholinesterase inhibitors in Alzheimer's disease: Nexus of cholinergic and nerve growth factor dysfunction. Current Alzheimer research. 2021-12-16. PMID:34911424. |
consistent with the "loss of trophic factor hypothesis of ad," we propose that ache inhibitors enhance acetylcholine-dependent release and uptake of ngf, thereby sustaining cholinergic neuronal viability and thus lowing ad-associated degeneration of the cbf, to delay dementia progression ultimately. |
2021-12-16 |
2023-08-13 |
Not clear |
| The-Huan Tran, Thi-Thu-Hien Vo, Thi-Quynh-Nhi Vo, Thi-Cam-Nhung Cao, Thai-Son Tra. Synthesis and Evaluation of the Acetylcholinesterase Inhibitory Activities of Some Flavonoids Derived from Naringenin. TheScientificWorldJournal. vol 2021. 2021-12-11. PMID:34887704. |
a research approach in the finding new treatment for ad that has attracted much interest from scientists for a long time is the reestablishment of cholinergic transmission through inhibition of acetylcholinesterase (ache). |
2021-12-11 |
2023-08-13 |
Not clear |
| Stacey Herriage, Guangping Chen, Carey Pop. Concentration-dependent effects of chlorpyrifos oxon on peroxisome proliferator-activated receptor signaling in MCF-7 cells. Toxicology in vitro : an international journal published in association with BIBRA. vol 78. 2021-12-10. PMID:34756920. |
ache is critical in regulating cholinergic signaling while faah catalyzes the inactivation of fatty acid signaling lipids including the endocannabinoid (ecb) n-arachidonylethanolamine (anandamide, aea) and ecb-like metabolites (e.g., oleoylethanolamide, oea). |
2021-12-10 |
2023-08-13 |
human |
| Sumei Wang, Qian Zhao, Gaochun Li, Mengwei Wang, Hongliang Liu, Xingchen Yu, Jingwen Chen, Pei Li, Lixin Dong, Guoyu Zhou, Yushan Cui, Mengru Wang, Li Liu, Aiguo Wan. The cholinergic system, intelligence, and dental fluorosis in school-aged children with low-to-moderate fluoride exposure. Ecotoxicology and environmental safety. vol 228. 2021-12-07. PMID:34808511. |
cholinergic system was assessed by the detection of choline acetyltransferase (chat), acetylcholinesterase (ache) and acetylcholine (ach) levels in serum. |
2021-12-07 |
2023-08-13 |
Not clear |
| Shuaizhang Li, Andrew J Li, Jameson Travers, Tuan Xu, Srilatha Sakamuru, Carleen Klumpp-Thomas, Ruili Huang, Menghang Xi. Identification of Compounds for Butyrylcholinesterase Inhibition. SLAS discovery : advancing life sciences R & D. vol 26. issue 10. 2021-12-04. PMID:34269114. |
bche plays a critical role in maintaining normal cholinergic function like acetylcholinesterase (ache) through hydrolyzing acetylcholine (ach). |
2021-12-04 |
2023-08-13 |
Not clear |