| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| George Andrew Reid, Sultan Darves. Distribution of acetylcholinesterase in the hippocampal formation of the Atlantic white-sided dolphin (Lagenorhynchus acutus). The Journal of comparative neurology. vol 529. issue 5. 2021-08-02. PMID:32779183. |
there have been a number of studies detailing the distribution of acetylcholinesterase (ache) in the hippocampal formation of terrestrial mammals with the goal of gaining a greater understanding of some aspects of the cholinergic innervation to this region, as well as its parcellation. |
2021-08-02 |
2023-08-13 |
Not clear |
| Aaron J Polichnowski, Geoffrey A Williamson, Tesha E Blair, Donald B Hoove. Autonomic and cholinergic mechanisms mediating cardiovascular and temperature effects of donepezil in conscious mice. American journal of physiology. Regulatory, integrative and comparative physiology. vol 320. issue 6. 2021-07-28. PMID:33851543. |
donepezil is a centrally acting acetylcholinesterase (ache) inhibitor with therapeutic potential in inflammatory diseases; however, the underlying autonomic and cholinergic mechanisms remain unclear. |
2021-07-28 |
2023-08-13 |
mouse |
| Aaron J Polichnowski, Geoffrey A Williamson, Tesha E Blair, Donald B Hoove. Autonomic and cholinergic mechanisms mediating cardiovascular and temperature effects of donepezil in conscious mice. American journal of physiology. Regulatory, integrative and comparative physiology. vol 320. issue 6. 2021-07-28. PMID:33851543. |
central versus peripheral cholinergic effects of donepezil were assessed using pharmacological approaches including comparison with the peripherally acting ache inhibitor, neostigmine. |
2021-07-28 |
2023-08-13 |
mouse |
| Bhupesh Chandra Semwal, Debapriya Garabad. Amyloid beta (1-42) downregulates adenosine-2b receptors in addition to mitochondrial impairment and cholinergic dysfunction in memory-sensitive mouse brain regions. Journal of receptor and signal transduction research. vol 40. issue 6. 2021-07-13. PMID:32496898. |
in addition, aβ significantly increased cholinergic dysfunction in terms of decrease in the activity of chat and ach level and increase in the ache activity in the hippocampus, pre-frontal cortex and amygdala of ad-like animals. |
2021-07-13 |
2023-08-13 |
mouse |
| Miroslav Pohank. Pharmacological Influencing of The Cholinergic Anti-inflammatory Pathway in Infectious Diseases and Inflammatory Pathologies. Mini reviews in medicinal chemistry. vol 21. issue 6. 2021-07-12. PMID:33208075. |
the cholinergic anti-inflammatory pathway can be stimulated or suppressed by agonizing or antagonizing α7 nachr or by inhibition of ache. |
2021-07-12 |
2023-08-13 |
Not clear |
| Mikaela Peglow Pinz, Ane Gabriela Vogt, Karline da Costa Rodrigues, Angélica Schiavom Dos Reis, Luis Fernando Barbosa Duarte, Mariana Gallio Fronza, William Borges Domingues, Eduardo Bierhaus Blodorn, Diego Alves, Vinicius Farias Campos, Lucielli Savegnago, Ethel Antunes Wilhelm, Cristiane Luches. Effect of a purine derivative containing selenium to improve memory decline and anxiety through modulation of the cholinergic system and Na Metabolic brain disease. vol 36. issue 5. 2021-06-22. PMID:33651275. |
the cholinergic system was investigated based on by looking at expression and activity of ache and expression of choline acetyltransferase (chat). |
2021-06-22 |
2023-08-13 |
mouse |
| Monica A Silva, Alessandra S Kiametis, Werner Trepto. Donepezil Inhibits Acetylcholinesterase via Multiple Binding Modes at Room Temperature. Journal of chemical information and modeling. vol 60. issue 7. 2021-06-17. PMID:32096991. |
ache is important for neurotransmission at neuromuscular junctions and cholinergic brain synapses by hydrolyzing acetylcholine into acetate and choline. |
2021-06-17 |
2023-08-13 |
Not clear |
| Bashir Akhlaq Akhoon, Sushil Choudhary, Harshita Tiwari, Ajay Kumar, Manas Ranjan Barik, Laxmi Rathor, Rakesh Pandey, Amit Nargotr. Discovery of a New Donepezil-like Acetylcholinesterase Inhibitor for Targeting Alzheimer's Disease: Computational Studies with Biological Validation. Journal of chemical information and modeling. vol 60. issue 10. 2021-06-17. PMID:32955256. |
so far, donepezil is the only food and drug administration-approved dual-binding site inhibitor of acetylcholinesterase (ache) that can amplify the cholinergic activity and also decrease aβ aggregation in alzheimer patients. |
2021-06-17 |
2023-08-13 |
Not clear |
| Kevin G McGarry, Kevin E Schill, Tyson P Winters, Erin E Lemmon, Carol L Sabourin, Jill A Harvilchuck, Robert A Moye. Characterization of Cholinesterases From Multiple Large Animal Species for Medical Countermeasure Development Against Chemical Warfare Nerve Agents. Toxicological sciences : an official journal of the Society of Toxicology. vol 174. issue 1. 2021-06-09. PMID:31879781. |
disruption of cholinergic function through the inhibition of acetylcholinesterase (ache) leads to the accumulation of the neurotransmitter acetylcholine. |
2021-06-09 |
2023-08-13 |
Not clear |
| Shani Vaknine, Hermona Sore. Central and peripheral anti-inflammatory effects of acetylcholinesterase inhibitors. Neuropharmacology. vol 168. 2021-05-27. PMID:32143069. |
acetylcholinesterase (ache) inhibitors modulate acetylcholine hydrolysis and hence play a key role in determining the cholinergic tone and in implementing its impact on the cholinergic blockade of inflammatory processes. |
2021-05-27 |
2023-08-13 |
mouse |
| b' Martin Kr\\xc3\\xa1tk\\xc3\\xbd, Karol\\xc3\\xadna Jaklov\\xc3\\xa1, \\xc5\\xa0\\xc3\\xa1rka \\xc5\\xa0t\\xc4\\x9bp\\xc3\\xa1nkov\\xc3\\xa1, Katar\\xc3\\xadna Svr\\xc4\\x8dkov\\xc3\\xa1, V\\xc3\\xa1clav Pfl\\xc3\\xa9gr, Jarmila Vin\\xc5\\xa1ov\\xc3\\xa. N-[3,5-Bis(trifluoromethyl)phenyl]-5-bromo-2-hydroxybenzamide Analogues: Novel Acetyl- and Butyrylcholinesterase Inhibitors. Current topics in medicinal chemistry. vol 20. issue 23. 2021-05-17. PMID:32814530.' |
development of acetyl- (ache) and butyrylcholinesterase (buche) inhibitors belongs to viable strategies for the treatment of dementia and other diseases related to decrease in cholinergic neurotransmission. |
2021-05-17 |
2023-08-13 |
Not clear |
| G A Toledo-Ibarra, M I Girón-Pérez, C E Covantes-Rosales, G H Ventura-Ramón, G Pérez-Sánchez, A López-Torres, K J G Diaz-Resendiz, E Becerril-Villanueva, L Pavó. Alterations in the non-neuronal cholinergic system induced by in-vitro exposure to diazoxon in spleen mononuclear cells of Nile tilapia (O. niloticus). Fish & shellfish immunology. vol 108. 2021-05-17. PMID:33285167. |
since the target molecule of diazinon is typically the acetylcholinesterase enzyme (ache), the existence of a non-neuronal cholinergic system in leukocytes makes them susceptible to alterations by diazinon. |
2021-05-17 |
2023-08-13 |
Not clear |
| G A Toledo-Ibarra, M I Girón-Pérez, C E Covantes-Rosales, G H Ventura-Ramón, G Pérez-Sánchez, A López-Torres, K J G Diaz-Resendiz, E Becerril-Villanueva, L Pavó. Alterations in the non-neuronal cholinergic system induced by in-vitro exposure to diazoxon in spleen mononuclear cells of Nile tilapia (O. niloticus). Fish & shellfish immunology. vol 108. 2021-05-17. PMID:33285167. |
the data indicate that diazoxon directly alters elements in the cholinergic system of smnc by ache inhibition or indirectly through the interaction with achr, which is likely related to the immunotoxic properties of diazinon and its metabolites. |
2021-05-17 |
2023-08-13 |
Not clear |
| Muhammed Khairujjaman Mazumder, Anupom Borah, Shuvasish Choudhur. Inhibitory potential of plant secondary metabolites on anti-Parkinsonian drug targets: Relevance to pathophysiology, and motor and non-motor behavioural abnormalities. Medical hypotheses. vol 137. 2021-05-14. PMID:31954292. |
further, pd is associated with non-motor behavioural abnormalities as well, including cognitive impairment and mood disorders, which are caused due to cholinergic neurodegeneration, and thus inhibition of acetylcholinesterase (ache) is suggested. |
2021-05-14 |
2023-08-13 |
Not clear |
| Chang Liu, Chunyu Huang, Ruixue Ma, Wanying Zhai, Jingjing Deng, Tianshu Zho. Cu The Analyst. vol 145. issue 24. 2021-05-14. PMID:33410430. |
cu this work demonstrates a new strategy for sensing cerebrospinal acetylcholinesterase (ache) as a cholinergic biomarker for brain dysfunction based on graphene quantum dot (gqd)-functionalized lanthanide infinite coordination polymer (ln-icp) nanoparticles. |
2021-05-14 |
2023-08-13 |
rat |
| Richard L Rotund. The NMJ as a model synapse: New perspectives on formation, synaptic transmission and maintenance: Acetylcholinesterase at the neuromuscular junction. Neuroscience letters. vol 735. 2021-05-13. PMID:32540360. |
acetylcholinesterase (ache) is an essential enzymatic component of the neuromuscular junction where it is responsible for terminating neurotransmission by the cholinergic motor neurons. |
2021-05-13 |
2023-08-13 |
Not clear |
| Royce H Nichols, Janice E Chamber. Reactivation of organophosphate-inhibited serum butyrylcholinesterase by novel substituted phenoxyalkyl pyridinium oximes and traditional oximes. Toxicology. vol 452. 2021-05-12. PMID:33592259. |
oximes are a critical piece to the therapeutic regimen which remove the op from the inhibited ache and restore normal cholinergic function. |
2021-05-12 |
2023-08-13 |
human |
| Georgi Stavrakov, Irena Philipova, Atanas Lukarski, Mariyana Atanasova, Borislav Georgiev, Teodora Atanasova, Spiro Konstantinov, Irini Doytchinov. Discovery of a Novel Acetylcholinesterase Inhibitor by Fragment-Based Design and Virtual Screening. Molecules (Basel, Switzerland). vol 26. issue 7. 2021-05-12. PMID:33916760. |
even more, the cholinergic hypothesis, somewhat forgotten in recent years due to the shift in focus on amyloid cascade, is back to life, and the search for new, more effective ache inhibitors continues. |
2021-05-12 |
2023-08-13 |
Not clear |
| Taruna Pandey, Shachi Shuchi Smita, Anjali Mishra, Shreesh Raj Sammi, Rakesh Pande. Swertiamarin, a secoiridoid glycoside modulates nAChR and AChE activity. Experimental gerontology. vol 138. 2021-04-27. PMID:32590127. |
the ailments related to a malfunction in cholinergic functioning currently employ the use of inhibitors for acetylcholinesterase (ache) and n-methyl-d-aspartate (nmda) receptors. |
2021-04-27 |
2023-08-13 |
human |
| Qin Wu, Guangyu Li, Tangbin Huo, Xue Du, Qing Yang, Tien-Chieh Hung, Wei Ya. Mechanisms of parental co-exposure to polystyrene nanoplastics and microcystin-LR aggravated hatching inhibition of zebrafish offspring. The Science of the total environment. vol 774. 2021-04-21. PMID:33610984. |
we examined the altered expression levels of the genes associated with the hatching enzyme (tox16, foxp1, ctslb, xpb1, klf4, cap1, bmp4, cd63, he1.2, zhe1, and prl), cholinergic system (ache and chrnα7), and muscle development (wnt, myod, myf5, myogenin, and mrf4). |
2021-04-21 |
2023-08-13 |
zebrafish |