| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Muhammed Khairujjaman Mazumder, Anupom Borah, Shuvasish Choudhur. Inhibitory potential of plant secondary metabolites on anti-Parkinsonian drug targets: Relevance to pathophysiology, and motor and non-motor behavioural abnormalities. Medical hypotheses. vol 137. 2021-05-14. PMID:31954292. |
further, pd is associated with non-motor behavioural abnormalities as well, including cognitive impairment and mood disorders, which are caused due to cholinergic neurodegeneration, and thus inhibition of acetylcholinesterase (ache) is suggested. |
2021-05-14 |
2023-08-13 |
Not clear |
| Chang Liu, Chunyu Huang, Ruixue Ma, Wanying Zhai, Jingjing Deng, Tianshu Zho. Cu The Analyst. vol 145. issue 24. 2021-05-14. PMID:33410430. |
cu this work demonstrates a new strategy for sensing cerebrospinal acetylcholinesterase (ache) as a cholinergic biomarker for brain dysfunction based on graphene quantum dot (gqd)-functionalized lanthanide infinite coordination polymer (ln-icp) nanoparticles. |
2021-05-14 |
2023-08-13 |
rat |
| Richard L Rotund. The NMJ as a model synapse: New perspectives on formation, synaptic transmission and maintenance: Acetylcholinesterase at the neuromuscular junction. Neuroscience letters. vol 735. 2021-05-13. PMID:32540360. |
acetylcholinesterase (ache) is an essential enzymatic component of the neuromuscular junction where it is responsible for terminating neurotransmission by the cholinergic motor neurons. |
2021-05-13 |
2023-08-13 |
Not clear |
| Royce H Nichols, Janice E Chamber. Reactivation of organophosphate-inhibited serum butyrylcholinesterase by novel substituted phenoxyalkyl pyridinium oximes and traditional oximes. Toxicology. vol 452. 2021-05-12. PMID:33592259. |
oximes are a critical piece to the therapeutic regimen which remove the op from the inhibited ache and restore normal cholinergic function. |
2021-05-12 |
2023-08-13 |
human |
| Georgi Stavrakov, Irena Philipova, Atanas Lukarski, Mariyana Atanasova, Borislav Georgiev, Teodora Atanasova, Spiro Konstantinov, Irini Doytchinov. Discovery of a Novel Acetylcholinesterase Inhibitor by Fragment-Based Design and Virtual Screening. Molecules (Basel, Switzerland). vol 26. issue 7. 2021-05-12. PMID:33916760. |
even more, the cholinergic hypothesis, somewhat forgotten in recent years due to the shift in focus on amyloid cascade, is back to life, and the search for new, more effective ache inhibitors continues. |
2021-05-12 |
2023-08-13 |
Not clear |
| Taruna Pandey, Shachi Shuchi Smita, Anjali Mishra, Shreesh Raj Sammi, Rakesh Pande. Swertiamarin, a secoiridoid glycoside modulates nAChR and AChE activity. Experimental gerontology. vol 138. 2021-04-27. PMID:32590127. |
the ailments related to a malfunction in cholinergic functioning currently employ the use of inhibitors for acetylcholinesterase (ache) and n-methyl-d-aspartate (nmda) receptors. |
2021-04-27 |
2023-08-13 |
human |
| Qin Wu, Guangyu Li, Tangbin Huo, Xue Du, Qing Yang, Tien-Chieh Hung, Wei Ya. Mechanisms of parental co-exposure to polystyrene nanoplastics and microcystin-LR aggravated hatching inhibition of zebrafish offspring. The Science of the total environment. vol 774. 2021-04-21. PMID:33610984. |
we examined the altered expression levels of the genes associated with the hatching enzyme (tox16, foxp1, ctslb, xpb1, klf4, cap1, bmp4, cd63, he1.2, zhe1, and prl), cholinergic system (ache and chrnα7), and muscle development (wnt, myod, myf5, myogenin, and mrf4). |
2021-04-21 |
2023-08-13 |
zebrafish |
| Tamara Zorbaz, Petra Mišetić, Nicolas Probst, Suzana Žunec, Antonio Zandona, Gordana Mendaš, Vedran Micek, Nikolina Maček Hrvat, Maja Katalinić, Anissa Braïki, Ludovic Jean, Pierre-Yves Renard, Vesna Gabelica Marković, Zrinka Kovari. Pharmacokinetic Evaluation of Brain Penetrating Morpholine-3-hydroxy-2-pyridine Oxime as an Antidote for Nerve Agent Poisoning. ACS chemical neuroscience. vol 11. issue 7. 2021-04-14. PMID:32105443. |
nerve agents, the deadliest chemical warfare agents, are potent inhibitors of acetylcholinesterase (ache) and cause rapid cholinergic crisis with serious symptoms of poisoning. |
2021-04-14 |
2023-08-13 |
Not clear |
| Amar Pal Singh, Sapna Balayan, Vinita Hooda, R K Sarin, Nidhi Chauha. Nano-interface driven electrochemical sensor for pesticides detection based on the acetylcholinesterase enzyme inhibition. International journal of biological macromolecules. vol 164. 2021-04-12. PMID:32882280. |
the toxicity of the op pesticides arises due to their ability to inhibit the activity of acetylcholinesterase (ache), a cholinergic enzyme that is essential for the proper functioning of the central nervous system. |
2021-04-12 |
2023-08-13 |
Not clear |
| Belgin Sever, Cüneyt Türkeş, Mehlika Dilek Altıntop, Yeliz Demir, Şükrü Beydemi. Thiazolyl-pyrazoline derivatives: In vitro and in silico evaluation as potential acetylcholinesterase and carbonic anhydrase inhibitors. International journal of biological macromolecules. vol 163. 2021-04-02. PMID:32931834. |
the utility of cholinergic replacement by acetylcholinesterase (ache) inhibitors in ad treatment has been well-documented so far. |
2021-04-02 |
2023-08-13 |
human |
| b' Antonio Zandona, Gabriela Lihtar, Nikola Marakovi\\xc4\\x87, Katarina Mi\\xc5\\xa1, Valentina Bu\\xc5\\xa1i\\xc4\\x87, Dajana Ga\\xc5\\xa1o-Soka\\xc4\\x8d, Sergej Pirkmajer, Maja Katalini\\xc4\\x8. Vitamin B3-Based Biologically Active Compounds as Inhibitors of Human Cholinesterases. International journal of molecular sciences. vol 21. issue 21. 2021-03-29. PMID:33138280.' |
we evaluated the potential of nine vitamin b3 scaffold-based derivatives as acetylcholinesterase (ache) and butyrylcholinesterase (bche) inhibitors, as a starting point for the development of novel drugs for treating disorders with cholinergic neurotransmission-linked pathology. |
2021-03-29 |
2023-08-13 |
human |
| Alexandre A de Castro, Letícia C Assis, Flávia V Soares, Kamil Kuca, Daniel A Polisel, Elaine F F da Cunha, Teodorico C Ramalh. Trends in the Recent Patent Literature on Cholinesterase Reactivators (2016-2019). Biomolecules. vol 10. issue 3. 2021-03-17. PMID:32178264. |
irreversible or prolonged inhibition of ache, therefore, elevates synaptic ach leading to serious central and peripheral adverse effects which fall under the cholinergic syndrome spectra. |
2021-03-17 |
2023-08-13 |
Not clear |
| Renata P Sakata, Giorgio Antoniolli, Marcelo Lancellotti, Daniel Fabio Kawano, Euzébio Guimarães Barbosa, Wanda P Almeid. Synthesis and biological evaluation of 2'-Aminochalcone: A multi-target approach to find drug candidates to treat Alzheimer's disease. Bioorganic chemistry. vol 103. 2021-03-09. PMID:32890999. |
the physiopathology of ad is multifactorial and is mainly supported by the cholinergic and amyloid hypotheses, which allows the identification the fundamental role of some markers, such as the enzymes acetylcholinesterase (ache) and β-secretase (bace-1), and the β-amyloid peptide (aβ). |
2021-03-09 |
2023-08-13 |
Not clear |
| Nor Atiqah Jusril, Ain Nur Najihah Muhamad Juhari, Syahrul Imran Abu Bakar, Wan Mazlina Md Saad, Mohd Ilham Adena. Combining In Silico and In Vitro Studies to Evaluate the Acetylcholinesterase Inhibitory Profile of Different Accessions and the Biomarker Triterpenes of Molecules (Basel, Switzerland). vol 25. issue 15. 2021-03-01. PMID:32721993. |
acetylcholinesterase (ache) is an important beneficial target for ad to control cholinergic signaling deficit. |
2021-03-01 |
2023-08-13 |
Not clear |
| Janine Spieker, Johannes L Frieß, Laura Sperling, Gopenath Thangaraj, Astrid Vogel-Höpker, Paul G Laye. Cholinergic control of bone development and beyond. International immunopharmacology. vol 83. 2021-02-19. PMID:32208165. |
in results, we briefly summarize our in vivo and in vitro studies on bone development of chick and mouse [1,2], including (i) expressions of cholinergic components (ache, bche, chat) in chick embryo, (ii) characterisation of defects during skeletogenesis in prenatal che knockout mice, (iii) loss-of-function experiments with beads soaked in cholinergic components and implanted into chicken limb buds, and finally (iv) we use an in vitro mesenchymal 3d-micromass model that mimics cartilage and bone formation, which also had revealed complex crosstalks between cholinergic, radiation and inflammatory mechanisms [3]. |
2021-02-19 |
2023-08-13 |
mouse |
| Xiaohe Luo, Marianne Lauwers, Paul G Layer, Chunyi We. Non-neuronal Role of Acetylcholinesterase in Bone Development and Degeneration. Frontiers in cell and developmental biology. vol 8. 2021-02-16. PMID:33585459. |
acetylcholinesterase (ache), an enzyme catalyzing the degradation of acetylcholine, plays an important suppressive role in the cholinergic regulation by terminating the action of acetylcholine. |
2021-02-16 |
2023-08-13 |
Not clear |
| Mohamad Rima, Yara Lattouf, Maroun Abi Younes, Erika Bullier, Pascal Legendre, Jean-Marie Mangin, Elim Hon. Dynamic regulation of the cholinergic system in the spinal central nervous system. Scientific reports. vol 10. issue 1. 2021-01-19. PMID:32948826. |
in 1-day-old embryos, we show that spinal motoneurons express presynaptic cholinergic genes including choline acetyltransferase (chata), vesicular acetylcholine transporters (vachta, vachtb), high-affinity choline transporter (hacta) and acetylcholinesterase (ache), while nicotinic acetylcholine receptor (nachr) subunits are mainly expressed in interneurons. |
2021-01-19 |
2023-08-13 |
zebrafish |
| Van Dung Pham, Tuan Anh To, Cynthia Gagné-Thivierge, Manon Couture, Patrick Lagüe, Deqiang Yao, Marie-Ève Picard, Louis-André Lortie, Sabrina A Attéré, Xiaojun Zhu, Roger C Levesque, Steve J Charette, Rong Sh. Structural insights into the putative bacterial acetylcholinesterase ChoE and its substrate inhibition mechanism. The Journal of biological chemistry. vol 295. issue 26. 2021-01-13. PMID:32371400. |
mammalian acetylcholinesterase (ache) is well-studied, being important in both cholinergic brain synapses and the peripheral nervous systems and also a key drug target for many diseases. |
2021-01-13 |
2023-08-13 |
Not clear |
| Mbah Ntepe Leonel Javeres, Rabia Habib, Ngondi Judith, Moaz Iqbal, Eugenie Nepovimova, Kamil Kuca, Sajida Batool, Syed Muhammad Nurulai. Analysis of PON1 gene polymorphisms (rs662 and rs854560) and inflammatory markers in organophosphate pesticides exposed cohorts from two distinct populations. Environmental research. vol 191. 2021-01-11. PMID:32949615. |
the study was aimed to assess the cholinergic enzymes (ache and bche), pon1, and inflammatory markers (il1β, il6, tnfα, crp, apo ai, apo b) and determine the toxicogenetics association of pon1 gene (rs 662 and rs 85456) to chronically ops exposed groups from pakistan and cameroon. |
2021-01-11 |
2023-08-13 |
Not clear |
| Seong-Jin Yu, Kuo-Jen Wu, Eunkyung Bae, Yu-Syuan Wang, Chia-Wen Chiang, Li-Wei Kuo, Brandon K Harvey, Nigel H Greig, Yun Wan. Post-treatment with Posiphen Reduces Endoplasmic Reticulum Stress and Neurodegeneration in Stroke Brain. iScience. vol 23. issue 2. 2021-01-10. PMID:32058974. |
the use of ache inhibitors in patients is limited by systemic cholinergic side effects. |
2021-01-10 |
2023-08-13 |
Not clear |