| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Aurélie Nervo, André-Guilhem Calas, Florian Nachon, Eric Krejc. Respiratory failure triggered by cholinesterase inhibitors may involve activation of a reflex sensory pathway by acetylcholine spillover. Toxicology. vol 424. 2020-05-14. PMID:31175885. |
indeed, the role of ache at the cholinergic synapses is not only to accurately control the synaptic transmission but also to prevent the spillover of ach. |
2020-05-14 |
2023-08-13 |
mouse |
| Zrinka Kovarik, Nikolina Maček Hrvat, Jarosław Kalisiak, Maja Katalinić, Rakesh K Sit, Tamara Zorbaz, Zoran Radić, Valery V Fokin, K Barry Sharpless, Palmer Taylo. Counteracting tabun inhibition by reactivation by pyridinium aldoximes that interact with active center gorge mutants of acetylcholinesterase. Toxicology and applied pharmacology. vol 372. 2020-04-06. PMID:30978400. |
currently used therapy in counteracting excessive cholinergic stimulation consists of a muscarinic antagonist (atropine) and an oxime reactivator of inhibited ache, but the classical oximes are particularly ineffective in counteracting tabun exposure. |
2020-04-06 |
2023-08-13 |
human |
| Fernanda D'Avila da Silva, Pablo Andrei Nogara, Estael Ochoa-Rodríguez, Yanier Nuñez-Figueredo, Maylin Wong-Guerra, Denis Broock Rosemberg, João Batista Teixeira da Roch. Molecular docking and in vitro evaluation of a new hybrid molecule (JM-20) on cholinesterase activity from different sources. Biochimie. vol 168. 2020-04-06. PMID:31770565. |
the main function of ache is the hydrolysis of the neurotransmitter acetylcholine (ach) at the neuromuscular and in cholinergic brain synapses. |
2020-04-06 |
2023-08-13 |
human |
| Leticia B Wessler, Hemelin R Farias, Julia F Ronsani, Gabriela Candiotto, Paulo C L Dos Santos, Jade de Oliveira, Eduardo P Rico, Emilio L Strec. Acute exposure to leucine modifies behavioral parameters and cholinergic activity in zebrafish. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 78. 2020-04-03. PMID:31589917. |
in addition, we evaluated the effects of high levels of leucine in the acetylcholinesterase (ache) and choline acetyltransferase (chat) activities, components of cholinergic neurotransmission system. |
2020-04-03 |
2023-08-13 |
zebrafish |
| Lilly Toker, Israel Silman, Tzviya Zeev-Ben-Mordehai, Joel L Sussman, Lawrence M Schopfer, Oksana Lockridg. Polyproline-rich peptides associated with Torpedo californica acetylcholinesterase tetramers. Chemico-biological interactions. vol 319. 2020-03-16. PMID:32087110. |
acetylcholinesterase (ache) terminates cholinergic neurotransmission by hydrolyzing acetylcholine. |
2020-03-16 |
2023-08-13 |
Not clear |
| Oksana Gerlits, Xiaotian Kong, Xiaolin Cheng, Troy Wymore, Donald K Blumenthal, Palmer Taylor, Zoran Radić, Andrey Kovalevsk. Productive reorientation of a bound oxime reactivator revealed in room temperature X-ray structures of native and VX-inhibited human acetylcholinesterase. The Journal of biological chemistry. vol 294. issue 27. 2020-03-10. PMID:31138650. |
inhibited ache cannot hydrolyze the neurotransmitter acetylcholine leading to its build-up at the cholinergic synapses and creating an acute cholinergic crisis. |
2020-03-10 |
2023-08-13 |
human |
| Sabrina G Müller, Ana Paula Pesarico, Suzan G Rosa, Franciele Martini, Cristina W Nogueir. Contribution of cholinergic system and Nrf2/HO-1 signaling to the anti-amnesic action of 7-fluoro-1,3-diphenylisoquinoline-1-amine in mice. Chemico-biological interactions. vol 317. 2020-03-04. PMID:32001261. |
scopolamine induced amnesia and cholinergic dysfunction by increasing the acetylcholinesterase (ache) activity and content, decreasing the muscarinic m1 receptor levels in the prefrontal cortex and hippocampus of mice. |
2020-03-04 |
2023-08-13 |
mouse |
| Sabrina G Müller, Ana Paula Pesarico, Suzan G Rosa, Franciele Martini, Cristina W Nogueir. Contribution of cholinergic system and Nrf2/HO-1 signaling to the anti-amnesic action of 7-fluoro-1,3-diphenylisoquinoline-1-amine in mice. Chemico-biological interactions. vol 317. 2020-03-04. PMID:32001261. |
considering fdpi effects on the hippocampus, it was effective against the cholinergic dysfunction, ache activity and content, and m1 receptor levels, which collectively could contribute to its anti-amnesic effect. |
2020-03-04 |
2023-08-13 |
mouse |
| Yu-Ting Hu, Xin-Lu Chen, Shu-Han Huang, Qiong-Bin Zhu, Si-Yang Yu, Yi Shen, Arja Sluiter, Joost Verhaagen, Juan Zhao, Dick Swaab, Ai-Min Ba. Early growth response-1 regulates acetylcholinesterase and its relation with the course of Alzheimer's disease. Brain pathology (Zurich, Switzerland). vol 29. issue 4. 2020-02-12. PMID:30511454. |
we conclude that the egr1 can upregulate ache expression by a direct effect on its gene promoter, which may contribute significantly to the changes in cholinergic function in the course of ad. |
2020-02-12 |
2023-08-13 |
mouse |
| Charlotte Whitmore, Christopher D Lindsay, Mike Bird, Samuel J Gore, Helen Rice, Rebecca L Williams, Christopher M Timperley, A Christopher Gree. Assessment of false transmitters as treatments for nerve agent poisoning. Toxicology letters. vol 321. 2020-01-27. PMID:31830555. |
nerve agents inhibit acetylcholinesterase (ache), leading to a build-up of acetylcholine (ach) and overstimulation at cholinergic synapses. |
2020-01-27 |
2023-08-13 |
human |
| Devashree N Patil, Sushama A Patil, Srinivas Sistla, Jyoti P Jadha. Comparative biophysical characterization: A screening tool for acetylcholinesterase inhibitors. PloS one. vol 14. issue 5. 2020-01-14. PMID:31150404. |
the oldest cholinergic hypothesis is used to elevate the level of cognitive impairment and acetylcholinesterase (ache) comprises the major targeted enzyme in ad. |
2020-01-14 |
2023-08-13 |
Not clear |
| Irina A Vladimirova, Igor B Philyppov, Ganna V Sotkis, Eugenia M Kulieva, Yelyzaveta Y Shuba, Kseniya L Gulak, Roman Skryma, Natalia Prevarskaya, Yaroslav M Shub. Impairment of cholinergic bladder contractility in rat model of type I diabetes complicated by cystitis: Contribution of neurotransmitter-degrading ectoenzymes. European journal of pharmacology. vol 860. 2020-01-08. PMID:31299187. |
we conclude that decreased ache activities associated with diabetes and likely cystitis provide complementary factor to the described in literature altered expression of mach receptor subtypes linked to diabetes as well as to cystitis to produce dramatic modification of cholinergic nmt. |
2020-01-08 |
2023-08-13 |
rat |
| Shani Shenhar-Tsarfaty, Shiri Sherf-Dagan, Galia Berman, Muriel Webb, Asnat Raziel, Andrei Keidar, David Goitein, Nasser Sakran, Eti Zwang, Itzhak Shapira, David Zeltser, Shlomo Berliner, Ori Rogowski, Oren Shibolet, Shira Zelber-Sag. Obesity-related acetylcholinesterase elevation is reversed following laparoscopic sleeve gastrectomy. International journal of obesity (2005). vol 43. issue 2. 2020-01-03. PMID:29491490. |
however, the association between morbid obesity and ache and the changes in cholinergic tone following bariatric laparoscopic sleeve gastrectomy (lsg) surgery-induced weight reduction were never analyzed. |
2020-01-03 |
2023-08-13 |
Not clear |
| Yaghoub Pourshojaei, Khalil Eskandari, Ali Asadipou. Highly Significant Scaffolds to Design and Synthesis Cholinesterase Inhibitors as Anti-Alzheimer Agents. Mini reviews in medicinal chemistry. vol 19. issue 19. 2019-12-26. PMID:31538893. |
based on the cholinergic hypothesis, and xray crystallographic determination of the structure of acetylcholinesterase (ache) enzyme, the level of acetylcholine (ach, an important neurotransmitter associated with memory) in the hippocampus and cortex area of the brain has a direct effect on alzheimer. |
2019-12-26 |
2023-08-13 |
Not clear |
| Sun-Ho Han, Jong-Chan Park, Min Soo Byun, Dahyun Yi, Jun Ho Lee, Dong Young Lee, Inhee Mook-Jun. Blood acetylcholinesterase level is a potential biomarker for the early detection of cerebral amyloid deposition in cognitively normal individuals. Neurobiology of aging. vol 73. 2019-12-19. PMID:30316049. |
acetylcholinesterase (ache) is one of the major cholinergic enzymes, and there is no report to show the relationship between caβ accumulation and peripheral ache alteration in early stage of ad pathogenesis. |
2019-12-19 |
2023-08-13 |
Not clear |
| Keisuke Obara, Ayano Fujii, Chiaki Arie, Natsuki Harada, Fumiko Yamaki, Kazuhiro Matsuo, Takashi Yoshio, Yoshio Tanak. Inhibition of Recombinant Human Acetylcholinesterase Activity by Antipsychotics. Pharmacology. vol 104. issue 1-2. 2019-12-09. PMID:31067549. |
eps could be also caused by direct augmentation of cholinergic effects, for example, by acetylcholinesterase (ache) inhibition. |
2019-12-09 |
2023-08-13 |
human |
| Ji Hyun Kim, Mei Tong He, Min Jo Kim, Chang Yeol Yang, Yu Su Shin, Takako Yokozawa, Chan Hum Park, Eun Ju Ch. Safflower (Carthamus tinctorius L.) seed attenuates memory impairment induced by scopolamine in mice via regulation of cholinergic dysfunction and oxidative stress. Food & function. vol 10. issue 6. 2019-12-06. PMID:31165850. |
in addition, the safflower seed extract-administered group showed inhibition of the ache activity and improved cholinergic dysfunction. |
2019-12-06 |
2023-08-13 |
mouse |
| Jan Korabecny, Katarina Spilovska, Eva Mezeiova, Ondrej Benek, Radomir Juza, Daniel Kaping, Ondrej Souku. A Systematic Review on Donepezil-based Derivatives as Potential Cholinesterase Inhibitors for Alzheimer's Disease. Current medicinal chemistry. vol 26. issue 30. 2019-11-25. PMID:29768996. |
this review presents the overview of donepezilrelated compounds as potential anti-ad drugs developed on the basis of cholinergic hypothesis to act as solely ache and butyrylcholinesterase (bche) inhibitors. |
2019-11-25 |
2023-08-13 |
Not clear |
| Burgin, Szczupa. Basal acetylcholine release in leech ganglia depolarizes neurons through receptors with a nicotinic binding site The Journal of experimental biology. vol 201 (Pt 12). 2019-11-20. PMID:9600872. |
other neurons in the ganglion showed distinctive responses to the ache inhibitors that were coincident with their responses to cholinergic agonists. |
2019-11-20 |
2023-08-12 |
Not clear |
| Shalini Jayant, Bhupesh Sharm. Selective modulator of cannabinoid receptor type 2 (CB2) against biochemical alterations and brain damage in chronic cerebral hypoperfusion induced vascular dementia. Current neurovascular research. 2019-11-20. PMID:27599483. |
these animals have shown a considerable reduction in brain oxidative stress (thiobarbituric reactive acid substance-tbars; glutathione-gsh; catalase-cat and superoxide dismutase-sod), mitochondrial complex activity (complexes i, ii, iv) with the enhancement in cholinergic activity- ache and brain infarct size (ttc staining). |
2019-11-20 |
2023-08-13 |
rat |