| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Janice E Chambers, Edward C Mee. Central neuroprotection demonstrated by novel oxime countermeasures to nerve agent surrogates. Annals of the New York Academy of Sciences. vol 1479. issue 1. 2020-12-30. PMID:32319115. |
oximes, such as the pyridinium oxime pralidoxime (2-pam) in the united states, can reactivate the inhibited ache and restore cholinergic function. |
2020-12-30 |
2023-08-13 |
human |
| Barbara Kaproń, Robert Czarnomysy, Mariusz Wysokiński, Rudolf Andrys, Kamil Musilek, Andrea Angeli, Claudiu T Supuran, Tomasz Plec. 1,2,4-Triazole-based anticonvulsant agents with additional ROS scavenging activity are effective in a model of pharmacoresistant epilepsy. Journal of enzyme inhibition and medicinal chemistry. vol 35. issue 1. 2020-12-21. PMID:32253957. |
based on the enzymatic studies on human carbonic anhydrases (cas), acetylcholinesterase (ache) and butyrylcholinesterase (bche), one can assume that the herein investigated drug candidates will not impair the cognitive processes mediated by cas and will have minimal off-target cholinergic effects. |
2020-12-21 |
2023-08-13 |
mouse |
| Sílvia Chaves, Simonetta Resta, Federica Rinaldo, Marina Costa, Romane Josselin, Karolina Gwizdala, Luca Piemontese, Vito Capriati, A Raquel Pereira-Santos, Sandra M Cardoso, M Amélia Santo. Design, Synthesis, and In Vitro Evaluation of Hydroxybenzimidazole-Donepezil Analogues as Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease. Molecules (Basel, Switzerland). vol 25. issue 4. 2020-12-04. PMID:32098407. |
among the dnp-bim hybrids studied herein, the structural isomerization did not significantly improve the biological properties, while some substitutions, namely fluorine atom in each moiety or the methoxy group in the benzyl ring, evidenced higher cholinergic ache activity. |
2020-12-04 |
2023-08-13 |
Not clear |
| Anderson Ribeiro-Carvalho, Carla S Lima, Ana C Dutra-Tavares, Fernanda Nunes, André L Nunes-Freitas, Cláudio C Filgueiras, Alex C Manhães, Armando Meyer, Yael Abreu-Villaç. Mood-related behavioral and neurochemical alterations in mice exposed to low chlorpyrifos levels during the brain growth spurt. PloS one. vol 15. issue 10. 2020-11-24. PMID:33007016. |
here, we investigated whether a regimen of early low level cpf exposure that did not result in a significant inhibition of acetylcholinesterase (ache) had deleterious effects on mood-related behaviors, as well as on cholinergic and serotonergic biomarkers in the mice brain. |
2020-11-24 |
2023-08-13 |
mouse |
| Donald E Mos. Is Combining an Anticholinergic with a Cholinesterase Inhibitor a Good Strategy for High-Level CNS Cholinesterase Inhibition? Journal of Alzheimer's disease : JAD. vol 71. issue 4. 2020-11-06. PMID:31476160. |
a recent strategy for producing high-level cns acetylcholinesterase (ache) inhibition (50% or higher) is to co-administer a muscarinic anticholinergic with the ache inhibitor to block the dose-limiting cholinergic overstimulation of the gastrointestinal system, allow more robust ache inhibition in the cns, and improve efficacy in the treatment of alzheimer's disease. |
2020-11-06 |
2023-08-13 |
Not clear |
| J B Greer, J T Magnuson, K Hester, M Giroux, C Pope, T Anderson, J Liu, V Dang, N D Denslow, D Schlen. Effects of Chlorpyrifos on Cholinesterase and Serine Lipase Activities and Lipid Metabolism in Brains of Rainbow Trout (Oncorhynchus mykiss). Toxicological sciences : an official journal of the Society of Toxicology. 2020-11-01. PMID:31359069. |
chlorpyrifos is an organophosphorus insecticide that elicits acute toxicity through inhibition of acetylcholinesterase (ache), leading to acetylcholine accumulation and prolonged stimulation of cholinergic receptors throughout the central and peripheral nervous systems. |
2020-11-01 |
2023-08-13 |
Not clear |
| Yeheng Zhou, Wei Sun, Jiale Peng, Hui Yan, Li Zhang, Xingyong Liu, Zhili Zu. Design, synthesis and biological evaluation of novel copper-chelating acetylcholinesterase inhibitors with pyridine and N-benzylpiperidine fragments. Bioorganic chemistry. vol 93. 2020-10-20. PMID:31585263. |
ache is a classical and key target of cholinergic disorders. |
2020-10-20 |
2023-08-13 |
Not clear |
| Maria-Letizia Campanari, María-Salud García-Ayllón, Sorana Ciura, Javier Sáez-Valero, Edor Kabash. Neuromuscular Junction Impairment in Amyotrophic Lateral Sclerosis: Reassessing the Role of Acetylcholinesterase. Frontiers in molecular neuroscience. vol 9. 2020-10-01. PMID:28082868. |
interestingly, in addition to their cholinergic role ache is thought to play several "non-classical" roles that do not require catalytic function, most prominent among these is the facilitation of neurite growth, nmj formation and survival. |
2020-10-01 |
2023-08-13 |
Not clear |
| Jaymie R Voorhees, Diane S Rohlman, Pamela J Lein, Andrew A Piepe. Neurotoxicity in Preclinical Models of Occupational Exposure to Organophosphorus Compounds. Frontiers in neuroscience. vol 10. 2020-10-01. PMID:28149268. |
these compounds potently inhibit acetylcholinesterase (ache), the enzyme that inactivates acetylcholine at neuronal synapses, and acute exposure to high op levels can cause cholinergic crisis in humans and animals. |
2020-10-01 |
2023-08-13 |
Not clear |
| Etta Y L Liu, Miranda L Xu, Yan Jin, Qiyun Wu, Tina T X Dong, Karl W K Tsi. Genistein, a Phytoestrogen in Soybean, Induces the Expression of Acetylcholinesterase via G Protein-Coupled Receptor 30 in PC12 Cells. Frontiers in molecular neuroscience. vol 11. 2020-10-01. PMID:29535608. |
in parallel, the expression of tetrameric form of proline-rich membrane anchor (prima)-linked acetyl-cholinesterase (g4 ache), a key enzyme to hydrolyze acetylcholine in cholinergic synapses, was induced in a dose-dependent manner: this induction included the associated protein prima. |
2020-10-01 |
2023-08-13 |
Not clear |
| Stephen Brimijoin, Yang Gao, Liyi Geng, Vicky P Che. Treating Cocaine Addiction, Obesity, and Emotional Disorders by Viral Gene Transfer of Butyrylcholinesterase. Frontiers in pharmacology. vol 9. 2020-10-01. PMID:29535625. |
ache is universally understood as essential to cholinergic neurotransmission, voluntary muscle performance, and cognition, among other roles, and its catalytic impact is essential for life. |
2020-10-01 |
2023-08-13 |
mouse |
| Cong Lu, Yan Wang, Teng Xu, Qi Li, Donghui Wang, Lijing Zhang, Bei Fan, Fengzhong Wang, Xinmin Li. Genistein Ameliorates Scopolamine-Induced Amnesia in Mice Through the Regulation of the Cholinergic Neurotransmission, Antioxidant System and the ERK/CREB/BDNF Signaling. Frontiers in pharmacology. vol 9. 2020-10-01. PMID:30369882. |
additionally, ge remarkably promoted the cholinergic neurotransmission and protected against the oxidative stress damage in the hippocampus of scop-treated mice, as indicated by decreasing ache activity, elevating chat activity and ach level, increasing sod activity, lowering the level of mda and increasing gsh content. |
2020-10-01 |
2023-08-13 |
mouse |
| Edna Blotnick-Rubin, Lili Angliste. Fine Localization of Acetylcholinesterase in the Synaptic Cleft of the Vertebrate Neuromuscular Junction. Frontiers in molecular neuroscience. vol 11. 2020-09-30. PMID:29725289. |
acetylcholinesterase (ache) is concentrated at cholinergic synapses, where it is a major factor in controlling the duration of transmitter action. |
2020-09-30 |
2023-08-13 |
mouse |
| Angela K Tiethof, Jason R Richardson, Ronald P Har. Knockdown of Butyrylcholinesterase but Not Inhibition by Chlorpyrifos Alters Early Differentiation Mechanisms in Human Neural Stem Cells. Toxics. vol 6. issue 3. 2020-09-30. PMID:30200437. |
the organophosphate pesticide chlorpyrifos (cpf) primarily exerts toxicity through the inhibition of ache, which results in excess cholinergic stimulation at the synapse. |
2020-09-30 |
2023-08-13 |
human |
| Huixin Chen, Xiang Wu, Xinmei Gu, Yiying Zhou, Luying Ye, Ke Zhang, Hanbo Pan, Jialing Wang, Hua Wei, Binbin Zhu, C Benjamin Naman, Shinghung Mak, Paul R Carlier, Wei Cui, Yifan Ha. Tacrine(10)-Hupyridone Prevents Post-operative Cognitive Dysfunction via the Activation of BDNF Pathway and the Inhibition of AChE in Aged Mice. Frontiers in cellular neuroscience. vol 12. 2020-09-30. PMID:30483056. |
furthermore, a10e substantially enhanced choline acetyltransferase (chat)-positive area and decreased ache activity, in the hippocampus regions of surgery-treated mice, indicating that a10e could prevent surgery-induced dysfunction of cholinergic system, possibly via increasing the synthesis of acetylcholine and the inhibition of ache. |
2020-09-30 |
2023-08-13 |
mouse |
| Woo Bin Yoon, Hyeon Jun Choi, Ji Eun Kim, Ji Won Park, Mi Ju Kang, Su Ji Bae, Young Ju Lee, You Sang Choi, Kil Soo Kim, Young-Suk Jung, Joon-Yong Cho, Dae Youn Hwang, Hyun Keun Son. Comparison of scopolamine-induced cognitive impairment responses in three different ICR stocks. Laboratory animal research. vol 34. issue 4. 2020-09-30. PMID:30671121. |
to determine cholinergic dysfunction induction by spl exposure, activity of acetylcholinesterase (ache) assessed in the three icr stocks revealed no difference of acetylcholinesterase activity. |
2020-09-30 |
2023-08-13 |
mouse |
| Sedigheh Bakhtiari, Nahid Beladi Moghadam, Marjan Ehsani, Hamed Mortazavi, Siamak Sabour, Mahin Bakhsh. Can Salivary Acetylcholinesterase be a Diagnostic Biomarker for Alzheimer? Journal of clinical and diagnostic research : JCDR. vol 11. issue 1. 2020-09-29. PMID:28274046. |
due to the specific biosynthesis of acetylcholinesterase (ache) of cholinergic neurons, the enzyme has been proposed as a potential biochemical marker of cholinergic activity. |
2020-09-29 |
2023-08-13 |
Not clear |
| Erik Andrade-Jorge, José Bribiesca-Carlos, Francisco J Martínez-Martínez, Marvin A Soriano-Ursúa, Itzia I Padilla-Martínez, José G Trujillo-Ferrar. Crystal structure, DFT calculations and evaluation of 2-(2-(3,4-dimethoxyphenyl)ethyl)isoindoline-1,3-dione as AChE inhibitor. Chemistry Central journal. vol 12. issue 1. 2020-09-29. PMID:29938351. |
various reports have shown that phthalimide derivatives are potent inhibitors of ache, a key enzyme involved in the deterioration of the cholinergic system during the development of alzheimer's disease. |
2020-09-29 |
2023-08-13 |
Not clear |
| Mark E Gurne. Genetic Association of Phosphodiesterases With Human Cognitive Performance. Frontiers in molecular neuroscience. vol 12. 2020-09-29. PMID:30800055. |
notably absent was genetic association in healthy subjects to targets of cns drug discovery designed to improve cognition in disease states by the modulation of cholinergic [acetylcholinesterase (ache), choline acetyltransferase (chat), nicotinic alpha 7 acetylcholine receptor (chrna7)], serotonergic (htr6), histaminergic (hrh3), or glutamatergic (grm5) pathways. |
2020-09-29 |
2023-08-13 |
human |
| Chanjuan Zhang, Likun Hu, Dong Liu, Jian Huang, Wenhan Li. Circumdatin D Exerts Neuroprotective Effects by Attenuating LPS-Induced Pro-Inflammatory Responses and Downregulating Acetylcholinesterase Activity Frontiers in pharmacology. vol 11. 2020-09-28. PMID:32523534. |
circumdatin d exerts neuroprotective effects by attenuating lps-induced pro-inflammatory responses and downregulating acetylcholinesterase activity alzheimer's disease (ad) is a prevalent neurodegenerative disorder with multifactorial causes, of which systemic inflammation may play a key role to promote neurodegeneration, and acetylcholinesterase (ache) is a target protein to induce cholinergic transmission. |
2020-09-28 |
2023-08-13 |
Not clear |