| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Constantin Kondak, Gernot Riedel, Charles R Harrington, Claude M Wischik, Jochen Klei. Hydromethylthionine enhancement of central cholinergic signalling is blocked by rivastigmine and memantine. Journal of neurochemistry. 2021-12-02. PMID:34855998. |
the interactions observed in this study demonstrate that hmt enhances cholinergic activity in mouse brain by a mechanism of action unrelated to ache inhibition. |
2021-12-02 |
2023-08-13 |
mouse |
| Ryohei Tanaka-Kanegae, Koichiro Hamad. A novel in vitro assay model developed to measure both extracellular and intracellular acetylcholine levels for screening cholinergic agents. PloS one. vol 16. issue 10. 2021-11-30. PMID:34637466. |
cholinergic neurons utilize choline (ch) to synthetize acetylcholine (ach) and contain a high-affinity ch transporter, ch acetyltransferase (chat), ach receptors, and acetylcholinesterase (ache). |
2021-11-30 |
2023-08-13 |
Not clear |
| Ryohei Tanaka-Kanegae, Koichiro Hamad. A novel in vitro assay model developed to measure both extracellular and intracellular acetylcholine levels for screening cholinergic agents. PloS one. vol 16. issue 10. 2021-11-30. PMID:34637466. |
the associated changes in the cholinergic components may be reflected by intra- or extra-cellular ach levels, with an increase in extracellular ach levels occurring following ache inhibition. |
2021-11-30 |
2023-08-13 |
Not clear |
| Ryohei Tanaka-Kanegae, Koichiro Hamad. A novel in vitro assay model developed to measure both extracellular and intracellular acetylcholine levels for screening cholinergic agents. PloS one. vol 16. issue 10. 2021-11-30. PMID:34637466. |
we hypothesized that increases in intracellular ach levels can be more sensitively detected than those in extracellular ach levels, thereby capturing subtle effects in the cholinergic components other than ache. |
2021-11-30 |
2023-08-13 |
Not clear |
| b' Milena Mlaki\\xc4\\x87, Tena \\xc4\\x8cade\\xc5\\xbe, Danijela Bari\\xc4\\x87, Ivana Pu\\xc4\\x8dek, Ana Ratkovi\\xc4\\x87, \\xc5\\xbdeljko Marini\\xc4\\x87, Kornelija Lasi\\xc4\\x87, Zrinka Kovarik, Irena \\xc5\\xa0kori\\xc4\\x8. New Uncharged 2-Thienostilbene Oximes as Reactivators of Organophosphate-Inhibited Cholinesterases. Pharmaceuticals (Basel, Switzerland). vol 14. issue 11. 2021-11-30. PMID:34832929.' |
the inhibition of acetylcholinesterase (ache) and butyrylcholinesterase (bche) by organophosphates (ops) as nerve agents and pesticides compromises normal cholinergic nerve signal transduction in the peripheral and central nervous systems (cns) leading to cholinergic crisis. |
2021-11-30 |
2023-08-13 |
Not clear |
| Bhuvaneswari Sivaraman, Vijaykumar R, Bala Aakash Velmurugan, Ramalakshmi Nataraja. Acetylcholinesterase Enzyme Inhibitor Molecules with Therapeutic Potential for Alzheimer's Disease. CNS & neurological disorders drug targets. 2021-11-23. PMID:34602041. |
ache is found majorly in the central nervous system at the site of cholinergic neurotransmission. |
2021-11-23 |
2023-08-13 |
Not clear |
| Fanny C F Ip, Guangmiao Fu, Fengzhi Yang, Fangyuan Kang, Peiran Sun, Choi Ying Ling, Kit Cheung, Fangzhou Xie, Yueqing Hu, Lei Fu, Nancy Y I. A tacrine-tetrahydroquinoline heterodimer potently inhibits acetylcholinesterase activity and enhances neurotransmission in mice. European journal of medicinal chemistry. vol 226. 2021-11-22. PMID:34530383. |
acetylcholinesterase (ache) inhibitors have been used to improve cholinergic transmission in the brain for two decades and have proven effective for alleviating symptoms in the early stages of alzheimer's disease. |
2021-11-22 |
2023-08-13 |
mouse |
| Heidi Qunhui Xie, Yongchao Ma, Hualing Fu, Tuan Xu, Yali Luo, Yiyun Liu, Yangsheng Chen, Li Xu, Yingjie Xia, Bin Zha. New perspective on the regulation of acetylcholinesterase via the aryl hydrocarbon receptor. Journal of neurochemistry. vol 158. issue 6. 2021-11-17. PMID:33278027. |
acetylcholinesterase (ache, ec 3.1.1.7) plays important roles in cholinergic neurotransmission and has been widely recognized as a biomarker for monitoring pollution by organophosphate (op) and carbamate pesticides. |
2021-11-17 |
2023-08-13 |
Not clear |
| Heidi Qunhui Xie, Yongchao Ma, Hualing Fu, Tuan Xu, Yali Luo, Yiyun Liu, Yangsheng Chen, Li Xu, Yingjie Xia, Bin Zha. New perspective on the regulation of acetylcholinesterase via the aryl hydrocarbon receptor. Journal of neurochemistry. vol 158. issue 6. 2021-11-17. PMID:33278027. |
growing evidence has shown that there is a significant link between dioxin exposure and neurodegenerative diseases and neurodevelopmental disorders, most of which involve ache and cholinergic dysfunctions. |
2021-11-17 |
2023-08-13 |
Not clear |
| Aisha Siddiqui, Zahoor Shah, Rao Nargis Jahan, Iekhsan Othman, Yatinesh Kumar. Mechanistic role of boswellic acids in Alzheimer's disease: Emphasis on anti-inflammatory properties. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 144. 2021-11-17. PMID:34607104. |
it is also involved in inhibiting the acetylcholinesterase (ache) activity in the cholinergic pathway and improve choline levels as well as its binding with nicotinic receptors to produce anti-inflammatory effects. |
2021-11-17 |
2023-08-13 |
Not clear |
| Hyoeun Yoo, Hyun-Sook Ki. Cacao powder supplementation attenuates oxidative stress, cholinergic impairment, and apoptosis in D-galactose-induced aging rat brain. Scientific reports. vol 11. issue 1. 2021-11-15. PMID:34504131. |
the levels of serum malondialdehyde (mda), advanced glycation end-products (ages), brain and liver mda, the indicators of the d-galactose induced oxidative stress were significantly decreased in lc and hc but increased in g. the acetylcholinesterase (ache) activity of brain showed that the cholinergic impairment was significantly lower in lc, and hc than g. furthermore, the expression levels of catalase (cat), phospho-akt/akt, and procaspase-3 were significantly increased in lc and hc. |
2021-11-15 |
2023-08-13 |
rat |
| Yuki Takada-Takator. [Donepezil Reduces Amyloid Precursor Protein Endocytosis by Resulting from Increase in the Expression of Sorting Nexin Protein 33]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. vol 141. issue 6. 2021-11-11. PMID:34078793. |
donepezil, the most widely used drug for the treatment of alzheimer's disease (ad), is an acetylcholinesterase (ache) inhibitor and is thought to improve cognition by stimulating cholinergic neurotransmission. |
2021-11-11 |
2023-08-13 |
rat |
| Samuel Adetunji Onasanwo, Vanessa O Adamaigbo, Olusegun G Adebayo, Spiff E Eleaze. Moringa oleifera-supplemented diet protect against cortico-hippocampal neuronal degeneration in scopolamine-induced spatial memory deficit in mice: role of oxido-inflammatory and cholinergic neurotransmission pathway. Metabolic brain disease. vol 36. issue 8. 2021-11-11. PMID:34669098. |
thereafter, markers of cholinergic system inhibition (acetylcholinesterase; ache) and oxido-inflammatory stress (malonaldehyde, mda; nitrite; superoxide dismutase, sod; tumor necrosis factor-alpha, tnf-α) and histo-morphology of the cortico-hippocampal neuron were measured. |
2021-11-11 |
2023-08-13 |
mouse |
| Yitzhak Brzezinski-Sinai, Ester Zwang, Elena Plotnikova, Ester Halizov, Itzhak Shapira, David Zeltser, Ori Rogowski, Shlomo Berliner, Idit Matot, Shani Shenhar-Tsarfat. Cholinesterase activity in serum during general anesthesia in patients with or without vascular disease. Scientific reports. vol 11. issue 1. 2021-11-10. PMID:34404888. |
both ache and total cholinergic status (cs) decreased significantly after ga induction at 15 min and even more so by the end of surgery. |
2021-11-10 |
2023-08-13 |
Not clear |
| Jiyeon Han, Zhi Du, Mi Hee Li. Mechanistic Insight into the Design of Chemical Tools to Control Multiple Pathogenic Features in Alzheimer's Disease. Accounts of chemical research. vol 54. issue 20. 2021-11-10. PMID:34606227. |
finally, the loss of cholinergic transmission mediated by the neurotransmitter acetylcholine (ach) contributes to cognitive deficits observed in ad.in this account, we illustrate the design principles for small-molecule-based chemical tools with reactivities against metal-free aβ, metal-bound aβ, ros, and ache. |
2021-11-10 |
2023-08-13 |
Not clear |
| Karen G João, Romeu A Videira, Fátima Paiva-Martins, Patrícia Valentão, David M Pereira, Paula B Andrad. Homarine Alkyl Ester Derivatives as Promising Acetylcholinesterase Inhibitors. ChemMedChem. vol 16. issue 21. 2021-11-05. PMID:34342141. |
reversible acetylcholinesterase (ache) inhibitors are key therapeutic tools to modulate the cholinergic connectivity compromised in several degenerative pathologies. |
2021-11-05 |
2023-08-13 |
rat |
| Sean M Mooney-Leber, Dana Zeid, Prescilla Garcia-Trevizo, Laurel R Seemiller, Molly A Bogue, Stephen C Grubb, Gary Peltz, Thomas J Goul. Genetic Differences in Dorsal Hippocampus Acetylcholinesterase Activity Predict Contextual Fear Learning Across Inbred Mouse Strains. Frontiers in psychiatry. vol 12. 2021-11-05. PMID:34733190. |
since cholinergic signaling is affected by genetic background, we examined the genetic relationship between activity levels of acetylcholinesterase (ache), the primary enzyme involved in the acetylcholine metabolism, and learning using a panel of 20 inbred mouse strains. |
2021-11-05 |
2023-08-13 |
mouse |
| Paula Moyano, Andrea Flores, Jimena García, José Manuel García, María José Anadon, María Teresa Frejo, Emma Sola, Adela Pelayo, Javier Del Pin. Bisphenol A single and repeated treatment increases HDAC2, leading to cholinergic neurotransmission dysfunction and SN56 cholinergic apoptotic cell death through AChE variants overexpression and NGF/TrkA/P75 Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 157. 2021-11-01. PMID:34655688. |
bisphenol a single and repeated treatment increases hdac2, leading to cholinergic neurotransmission dysfunction and sn56 cholinergic apoptotic cell death through ache variants overexpression and ngf/trka/p75 bisphenol-a (bpa), a widely used plasticizer, induces cognitive dysfunctions following single and repeated exposure. |
2021-11-01 |
2023-08-13 |
Not clear |
| Simone Phillips, Jose Suarez-Torres, Harvey Checkoway, Dolores Lopez-Paredes, Sheila Gahagan, Jose Ricardo Suarez-Lope. Acetylcholinesterase activity and thyroid hormone levels in Ecuadorian adolescents living in agricultural settings where organophosphate pesticides are used. International journal of hygiene and environmental health. vol 233. 2021-10-25. PMID:33581413. |
organophosphates are frequently applied insecticides that inhibit acetylcholinesterase (ache) activity resulting in cholinergic overstimulation. |
2021-10-25 |
2023-08-13 |
Not clear |
| Namrita Halder, Girdhari La. Cholinergic System and Its Therapeutic Importance in Inflammation and Autoimmunity. Frontiers in immunology. vol 12. 2021-10-14. PMID:33936095. |
the cholinergic system includes the neurotransmitter\ molecule, acetylcholine (ach), cholinergic receptors (achrs), choline acetyltransferase (chat) enzyme, and acetylcholinesterase (ache) enzyme. |
2021-10-14 |
2023-08-13 |
Not clear |