| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yitzhak Brzezinski-Sinai, Ester Zwang, Elena Plotnikova, Ester Halizov, Itzhak Shapira, David Zeltser, Ori Rogowski, Shlomo Berliner, Idit Matot, Shani Shenhar-Tsarfat. Cholinesterase activity in serum during general anesthesia in patients with or without vascular disease. Scientific reports. vol 11. issue 1. 2021-11-10. PMID:34404888. |
both ache and total cholinergic status (cs) decreased significantly after ga induction at 15 min and even more so by the end of surgery. |
2021-11-10 |
2023-08-13 |
Not clear |
| Jiyeon Han, Zhi Du, Mi Hee Li. Mechanistic Insight into the Design of Chemical Tools to Control Multiple Pathogenic Features in Alzheimer's Disease. Accounts of chemical research. vol 54. issue 20. 2021-11-10. PMID:34606227. |
finally, the loss of cholinergic transmission mediated by the neurotransmitter acetylcholine (ach) contributes to cognitive deficits observed in ad.in this account, we illustrate the design principles for small-molecule-based chemical tools with reactivities against metal-free aβ, metal-bound aβ, ros, and ache. |
2021-11-10 |
2023-08-13 |
Not clear |
| Karen G João, Romeu A Videira, Fátima Paiva-Martins, Patrícia Valentão, David M Pereira, Paula B Andrad. Homarine Alkyl Ester Derivatives as Promising Acetylcholinesterase Inhibitors. ChemMedChem. vol 16. issue 21. 2021-11-05. PMID:34342141. |
reversible acetylcholinesterase (ache) inhibitors are key therapeutic tools to modulate the cholinergic connectivity compromised in several degenerative pathologies. |
2021-11-05 |
2023-08-13 |
rat |
| Sean M Mooney-Leber, Dana Zeid, Prescilla Garcia-Trevizo, Laurel R Seemiller, Molly A Bogue, Stephen C Grubb, Gary Peltz, Thomas J Goul. Genetic Differences in Dorsal Hippocampus Acetylcholinesterase Activity Predict Contextual Fear Learning Across Inbred Mouse Strains. Frontiers in psychiatry. vol 12. 2021-11-05. PMID:34733190. |
since cholinergic signaling is affected by genetic background, we examined the genetic relationship between activity levels of acetylcholinesterase (ache), the primary enzyme involved in the acetylcholine metabolism, and learning using a panel of 20 inbred mouse strains. |
2021-11-05 |
2023-08-13 |
mouse |
| Paula Moyano, Andrea Flores, Jimena García, José Manuel García, María José Anadon, María Teresa Frejo, Emma Sola, Adela Pelayo, Javier Del Pin. Bisphenol A single and repeated treatment increases HDAC2, leading to cholinergic neurotransmission dysfunction and SN56 cholinergic apoptotic cell death through AChE variants overexpression and NGF/TrkA/P75 Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 157. 2021-11-01. PMID:34655688. |
bisphenol a single and repeated treatment increases hdac2, leading to cholinergic neurotransmission dysfunction and sn56 cholinergic apoptotic cell death through ache variants overexpression and ngf/trka/p75 bisphenol-a (bpa), a widely used plasticizer, induces cognitive dysfunctions following single and repeated exposure. |
2021-11-01 |
2023-08-13 |
Not clear |
| Simone Phillips, Jose Suarez-Torres, Harvey Checkoway, Dolores Lopez-Paredes, Sheila Gahagan, Jose Ricardo Suarez-Lope. Acetylcholinesterase activity and thyroid hormone levels in Ecuadorian adolescents living in agricultural settings where organophosphate pesticides are used. International journal of hygiene and environmental health. vol 233. 2021-10-25. PMID:33581413. |
organophosphates are frequently applied insecticides that inhibit acetylcholinesterase (ache) activity resulting in cholinergic overstimulation. |
2021-10-25 |
2023-08-13 |
Not clear |
| Namrita Halder, Girdhari La. Cholinergic System and Its Therapeutic Importance in Inflammation and Autoimmunity. Frontiers in immunology. vol 12. 2021-10-14. PMID:33936095. |
the cholinergic system includes the neurotransmitter\ molecule, acetylcholine (ach), cholinergic receptors (achrs), choline acetyltransferase (chat) enzyme, and acetylcholinesterase (ache) enzyme. |
2021-10-14 |
2023-08-13 |
Not clear |
| Uğur Güller, Pınar Güller, Mehmet Çiftc. Radical Scavenging and Antiacetylcholinesterase Activities of Ethanolic Extracts of Carob, Clove, and Linden. Alternative therapies in health and medicine. vol 27. issue 5. 2021-10-12. PMID:32619207. |
when ache is inhibited, the ach levels increase in the cholinergic synapses. |
2021-10-12 |
2023-08-13 |
Not clear |
| Antonio Monroy-Noyola, Damianys Almenares-Lopez, Eugenio Vilanova Gisber. Hydrolysis of chiral organophosphorus compounds by phosphotriesterases and mammalian paraoxonase-1. Frontiers in bioscience (Landmark edition). vol 26. 2021-10-06. PMID:33049692. |
acute exposure of humans to these mixtures induces the covalent modification of acetylcholinesterase (ache) and neuropathy target esterase (nte) and causes a cholinergic syndrome or organophosphate-induced delayed polyneuropathy syndrome (opidp). |
2021-10-06 |
2023-08-13 |
Not clear |
| Muharrem Kalaycı, Cüneyt Türkeş, Mustafa Arslan, Yeliz Demir, Şükrü Beydemi. Novel benzoic acid derivatives: Synthesis and biological evaluation as multitarget acetylcholinesterase and carbonic anhydrase inhibitors. Archiv der Pharmazie. vol 354. issue 3. 2021-10-06. PMID:33155700. |
the utility of cholinergic replacement by acetylcholinesterase (ache) inhibitors in ad treatment has been well documented so far. |
2021-10-06 |
2023-08-13 |
human |
| Chetan Thingore, Viplav Kshirsagar, Archana Juveka. Amelioration of oxidative stress and neuroinflammation in lipopolysaccharide-induced memory impairment using Rosmarinic acid in mice. Metabolic brain disease. vol 36. issue 2. 2021-10-05. PMID:33068223. |
imbalance in the cholinergic system was analyzed by measuring the acetylcholinesterase (ache) activity. |
2021-10-05 |
2023-08-13 |
mouse |
| Eng Leng Saw, James T Pearson, Daryl O Schwenke, Pujika Emani Munasinghe, Hirotsugu Tsuchimochi, Shruti Rawal, Sean Coffey, Philip Davis, Richard Bunton, Isabelle Van Hout, Yuko Kai, Michael J A Williams, Yoshihiko Kakinuma, Martin Fronius, Rajesh Katar. Activation of the cardiac non-neuronal cholinergic system prevents the development of diabetes-associated cardiovascular complications. Cardiovascular diabetology. vol 20. issue 1. 2021-10-05. PMID:33618724. |
recent evidence suggests that cardiomyocytes possess a non-neuronal cholinergic system (nncs) that comprises of choline acetyltransferase (chat), choline transporter 1 (cht1), vesicular acetylcholine transporter (vacht), acetylcholinesterase (ache) and type-2 muscarinic ach receptors (m |
2021-10-05 |
2023-08-13 |
Not clear |
| Aijaz Ahmad Malik, Suvash Chandra Ojha, Nalini Schaduangrat, Chanin Nantasenama. ABCpred: a webserver for the discovery of acetyl- and butyryl-cholinesterase inhibitors. Molecular diversity. 2021-10-05. PMID:34609711. |
acetylcholinesterase (ache) hydrolyses ach and inhibits the cholinergic transmission. |
2021-10-05 |
2023-08-13 |
Not clear |
| Jayme Cannon, Shengzhuang Tang, Seok Ki Cho. Caged Oxime Reactivators Designed for the Light Control of Acetylcholinesterase Reactivation Photochemistry and photobiology. 2021-10-04. PMID:34558680. |
caged oxime reactivators designed for the light control of acetylcholinesterase reactivation despite its promising role in the active control of biological functions by light, photocaging remains untested in acetylcholinesterase (ache), a key enzyme in the cholinergic family. |
2021-10-04 |
2023-08-13 |
Not clear |
| Ahsaan Ahmed, Shamim Akhtar, Nousheen Mushtaq, Shazia Haider, Rabya Munawar, Hassaan Ahmed Siddique, Arifa Akram, Zafar Saeed Saify, Muhammad Ari. 1,3-di-4-piperidylpropane derivatives as potential acetyl cholinesterase antagonists: Molecular docking, synthesis, and biological evaluation. Pakistan journal of pharmaceutical sciences. vol 34. issue 3. 2021-10-04. PMID:34602406. |
acetylcholine esterase (ache) is a key biological target responsible for the management of cholinergic transmission, and its inhibitors are used for the therapy of alzheimer's disease. |
2021-10-04 |
2023-08-13 |
Not clear |
| Danish Iqbal, Md Tabish Rehman, Abdulaziz Bin Dukhyil, Syed Mohd Danish Rizvi, Mohamed F Al Ajmi, Bader Mohammed Alshehri, Saeed Banawas, M Salman Khan, Wael Alturaiki, Mohammed Alsawee. High-Throughput Screening and Molecular Dynamics Simulation of Natural Product-like Compounds against Alzheimer's Disease through Multitarget Approach. Pharmaceuticals (Basel, Switzerland). vol 14. issue 9. 2021-10-01. PMID:34577637. |
we have explored the library of 2029 natural product-like compounds for their multi-targeting potential against ad by inhibiting ache, bche (cholinergic pathway) mao-a, and moa-b (oxidative stress pathway) through in silico high-throughput screening and molecular dynamics simulation. |
2021-10-01 |
2023-08-13 |
Not clear |
| Ashwani Arya, Rubal Chahal, Rekha Rao, Md Habibur Rahman, Deepak Kaushik, Muhammad Furqan Akhtar, Ammara Saleem, Shaden M A Khalifa, Hesham R El-Seedi, Mohamed Kamel, Ghadeer M Albadrani, Mohamed M Abdel-Daim, Vineet Mitta. Acetylcholinesterase Inhibitory Potential of Various Sesquiterpene Analogues for Alzheimer's Disease Therapy. Biomolecules. vol 11. issue 3. 2021-09-28. PMID:33669097. |
a vast literature was evident in the last decade, which affirms the potential of various sesquiterpenes in the improvement of cholinergic transmission by inhibiting the ache. |
2021-09-28 |
2023-08-13 |
Not clear |
| João Vitor Ferreira Rodrigues, Anna Paula Perin Vidigal, Vítor Sampaio Minassa, Thatiany Jardim Batista, Randriely Merscher Sobreira de Lima, Vinícius Rafael Funck, Leandro S Antero, Leonardo Barbosa Moraes Resstel, Juliana Barbosa Coitinho, Leandro Jose Bertoglio, Karla Nívea Sampaio, Vanessa Beijamin. A single dose of the organophosphate triazophos induces fear extinction deficits accompanied by hippocampal acetylcholinesterase inhibition. Neurotoxicology and teratology. vol 82. 2021-09-23. PMID:33031921. |
hippocampal and amygdalar ache activity and plasma butyrylcholinesterase (bche) were measured at the end of the experiment to confirm the cholinergic overstimulation. |
2021-09-23 |
2023-08-13 |
rat |
| Oksana Gerlits, Matthew P Blakeley, David A Keen, Zoran Radić, Andrey Kovalevsk. Room temperature crystallography of human acetylcholinesterase bound to a substrate analogue 4K-TMA: Towards a neutron structure. Current research in structural biology. vol 3. 2021-09-21. PMID:34541552. |
acetylcholinesterase (ache) catalyzes hydrolysis of acetylcholine thereby terminating cholinergic nerve impulses for efficient neurotransmission. |
2021-09-21 |
2023-08-13 |
human |
| Jong Min Kim, Uk Lee, Jin Yong Kang, Seon Kyeong Park, Jong Cheol Kim, Ho Jin He. Matcha Improves Metabolic Imbalance-Induced Cognitive Dysfunction. Oxidative medicine and cellular longevity. vol 2020. 2021-09-07. PMID:33312340. |
em improved the cerebral cholinergic system by regulating ach contents and expression of ache and chat. |
2021-09-07 |
2023-08-13 |
mouse |