| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tapan Behl, Ishnoor Kaur, Aayush Sehgal, Sukhbir Singh, Neelam Sharma, Sumeet Gupta, Mohammed Albratty, Asim Najmi, Hassan A Alhazmi, Simona Bunga. AChE as a Spark in the Alzheimer's Blaze - Antagonizing Effect of a Cyclized Variant. Ageing research reviews. 2022-11-11. PMID:36368649. |
a significant protein, acetylcholinesterase (ache) becomes dysfunctional as a result of cholinergic neuronal loss in ad pathology. |
2022-11-11 |
2023-08-14 |
Not clear |
| Faezeh Aliakbarzadeh, Mohammad Rafiee, Fariba Khodagholi, Mohammad Reza Khorramizadeh, Hamed Manouchehri, Akbar Eslami, Fatemeh Sayehmiri, Anoushiravan Mohseni-Bandpe. Adverse effects of polystyrene nanoplastic and its binary mixtures with nonylphenol on zebrafish nervous system: From oxidative stress to impaired neurotransmitter system. Environmental pollution (Barking, Essex : 1987). 2022-11-06. PMID:36336178. |
multiple biomarkers concerning with oxidative-stress [catalase (cat) activity and reduced glutathione (gsh) level], cholinergic system [acetylcholinesterase (ache) activity], glutamatergic system [glutamine synthetase (gs) and glutamate dehydrogenase (gdh) activities], energy metabolism [a-ketoglutarate dehydrogenase (a-kgdh) activity], and histological alterations were assessed. |
2022-11-06 |
2023-08-14 |
cat |
| Arwa A Al-Maswary, Molly O'Reilly, Andrew P Holmes, A Damien Walmsley, Paul R Cooper, Ben A Scheve. Exploring the neurogenic differentiation of human dental pulp stem cells. PloS one. vol 17. issue 11. 2022-11-04. PMID:36331951. |
in hdpscs, upregulation of acetylcholinesterase (ache), choline o-acetyltransferase (chat), sodium channel alpha subunit 9 (scn9a), pou class 4 homeobox 1 (pou4f1/brn3a) along with a downregulation of motor neuron and pancreas homeobox 1 (mnx1) indicated that differentiation was more guided toward a cholinergic sensory neuronal lineage. |
2022-11-04 |
2023-08-14 |
human |
| Thankhoe A Rants'o, Lizette L Koekemoer, Jenny-Lee Panayides, Robyn L van Zy. Potential of Essential Oil-Based Anticholinesterase Insecticides against Molecules (Basel, Switzerland). vol 27. issue 20. 2022-10-27. PMID:36296618. |
the cholinergic system, of which acetylcholinesterase (ache) is a key enzyme, is essential to the |
2022-10-27 |
2023-08-14 |
Not clear |
| Yu Chen, Wenfeng Zhao, Jincheng Si, Yinuo Zheng, Hui Tan, Funa Meng, Guohai Yang, Yingqiu Gu, Lulu Q. Highly selective SERS detection of acetylcholinesterase in human blood based on catalytic reaction. Analytica chimica acta. vol 1232. 2022-10-18. PMID:36257753. |
acetylcholinesterase (ache) is a key hydrolase in the cholinergic system, which directly determines the degradation of neurotransmitters. |
2022-10-18 |
2023-08-14 |
human |
| Duo Yun, Yajie Wang, Yuyu Zhang, Mengzhen Jia, Tianzhi Xie, Yihang Zhao, Cong Yang, Weixuan Chen, Rui Guo, Xuebo Liu, Xiaoshuang Dai, Zhigang Liu, Tian Yua. Sesamol Attenuates Scopolamine-Induced Cholinergic Disorders, Neuroinflammation, and Cognitive Deficits in Mice. Journal of agricultural and food chemistry. 2022-10-14. PMID:36239029. |
importantly, sesamol could balance the cholinergic system by suppressing the ache activity and increasing the chat activity and |
2022-10-14 |
2023-08-14 |
mouse |
| Teodorico C Ramalho, Alexandre A de Castro, Daniel H S Leal, Jessika P Teixeira, Elaine Fontes Ferreira de Cunha, Kamil Kuc. Assessing the therapeutic and toxicological profile of novel acetylcholinesterase reactivators: value of in silico and in vitro data. Current medicinal chemistry. 2022-10-14. PMID:36239718. |
these toxic substances act through the inhibition of the acetylcholinesterase (ache) enzyme, which results in elevated synaptic acetylcholine (ach) levels, leading to serious adverse effects under the cholinergic syndrome. |
2022-10-14 |
2023-08-14 |
Not clear |
| Mohammad Golam Sabbir, Robert C Speth, Benedict C Albens. Loss of Cholinergic Receptor Muscarinic 1 (CHRM1) Protein in the Hippocampus and Temporal Cortex of a Subset of Individuals with Alzheimer's Disease, Parkinson's Disease, or Frontotemporal Dementia: Implications for Patient Survival. Journal of Alzheimer's disease : JAD. 2022-09-26. PMID:36155524. |
dysfunction of cholinergic neurotransmission is a hallmark of alzheimer's disease (ad); forming the basis for using acetylcholine (ach) esterase (ache) inhibitors to mitigate symptoms of ach deficiency in ad. |
2022-09-26 |
2023-08-14 |
Not clear |
| Muslum Gok, Nimrod Madrer, Tamara Zorbaz, Estelle R Bennett, David Greenberg, David A Bennett, Hermona Sore. Altered levels of variant cholinesterase transcripts contribute to the imbalanced cholinergic signaling in Alzheimer's and Parkinson's disease. Frontiers in molecular neuroscience. vol 15. 2022-09-19. PMID:36117917. |
acetylcholinesterase and butyrylcholinesterase (ache and bche) are involved in modulating cholinergic signaling, but their roles in alzheimer's and parkinson's diseases (ad and pd) remain unclear. |
2022-09-19 |
2023-08-14 |
Not clear |
| Ombretta Paladino, Arianna Moranda, Carla Falug. Spatiotemporal role of muscarinic signaling in early chick development: exposure to cholinomimetic agents by a mathematical model. Cell biology and toxicology. 2022-09-13. PMID:36098822. |
cholinomimetic substances exert their toxic activity on organisms as they inhibit the functionality of the cholinergic system by completely or partially replacing the ach molecule both at the level of the ache active site and at the level of acetylcholine receptors. |
2022-09-13 |
2023-08-14 |
chicken |
| Katelyn N Sette, Navatha Alugabelly, Lauren B Glenn, Shirley X Guo-Ross, M Katherine Parkes, Juliet R Wilson, Caitlin N Seay, Russell L Car. The Mechanistic Basis for the Toxicity Difference Between Juvenile Rats and Mice following Exposure to the Agricultural Insecticide Chlorpyrifos. Toxicology. 2022-09-12. PMID:36096317. |
at high exposure levels, organophosphorus insecticides (ops) exert their toxicity in mammals through the inhibition of brain acetylcholinesterase (ache) leading to the accumulation of acetylcholine in cholinergic synapses and hyperactivity of the nervous system. |
2022-09-12 |
2023-08-14 |
mouse |
| Ilenia Severi, Silvia Abbatelli, Jessica Perugini, Eleonora Di Mercurio, Martina Senzacqua, Antonio Giordan. Butyrylcholinesterase distribution in the mouse gastrointestinal tract: An immunohistochemical study. Journal of anatomy. 2022-08-25. PMID:36004682. |
whereas ache has a well-established role in regulating cholinergic neurotransmission in central and peripheral synapses, the physiological role of bche remains elusive. |
2022-08-25 |
2023-08-14 |
mouse |
| Luana C Llanes, Isabelle Kuehlewein, Igor V de França, Luana Veiga da Silva, José W da Cru. Anticholinesterase agents for Alzheimer's Disease treatment: an updated overview. Current medicinal chemistry. 2022-08-05. PMID:35927804. |
the therapeutic strategy adopted herein is the cholinergic hypothesis, for which acetylcholinesterase enzyme (ache) inhibitors constitute the main treatment for the disease. |
2022-08-05 |
2023-08-14 |
Not clear |
| Julie Somkhit, Constantin Yanicostas, Nadia Soussi-Yanicosta. Microglia Remodelling and Neuroinflammation Parallel Neuronal Hyperactivation Following Acute Organophosphate Poisoning. International journal of molecular sciences. vol 23. issue 15. 2022-07-28. PMID:35897817. |
ops cause irreversible acetylcholinesterase (ache) inhibition, inducing the so-called cholinergic syndrome characterized by peripheral manifestations and seizures associated with permanent psychomotor deficits. |
2022-07-28 |
2023-08-14 |
zebrafish |
| Giuseppe De Marco, Sabrine Afsa, Mariachiara Galati, Giulia Guerriero, Angela Mauceri, Hedi Ben Mansour, Tiziana Cappell. Time- and dose-dependent biological effects of a sub-chronic exposure to realistic doses of salicylic acid in the gills of mussel Mytilus galloprovincialis. Environmental science and pollution research international. 2022-07-13. PMID:35829880. |
inhibition of the cholinergic system was also reported by reduced acetylcholinesterase (ache) activity, mainly at t12. |
2022-07-13 |
2023-08-14 |
cat |
| Grażyna Budryn, Iwona Majak, Joanna Grzelczyk, Dominik Szwajgier, Alejandro Rodríguez-Martínez, Horacio Pérez-Sánche. Hydroxybenzoic Acids as Acetylcholinesterase Inhibitors: Calorimetric and Docking Simulation Studies. Nutrients. vol 14. issue 12. 2022-06-24. PMID:35745206. |
for this reason, ache inhibitors are used in the treatment of ad, the prolonged use of which may cause a cholinergic crisis. |
2022-06-24 |
2023-08-14 |
Not clear |
| Tess Puopolo, Chang Liu, Hang Ma, Navindra P Seera. Inhibitory Effects of Cannabinoids on Acetylcholinesterase and Butyrylcholinesterase Enzyme Activities. Medical cannabis and cannabinoids. vol 5. issue 1. 2022-06-15. PMID:35702400. |
acetylcholinesterase (ache) and butyrylcholinesterase (bche) are two cholinergic enzymes catalyzing the reaction of cleaving acetylcholine into acetate and choline at the neuromuscular junction. |
2022-06-15 |
2023-08-14 |
Not clear |
| Tess Puopolo, Chang Liu, Hang Ma, Navindra P Seera. Inhibitory Effects of Cannabinoids on Acetylcholinesterase and Butyrylcholinesterase Enzyme Activities. Medical cannabis and cannabinoids. vol 5. issue 1. 2022-06-15. PMID:35702400. |
abnormal hyperactivity of ache and bche can lead to cholinergic deficiency, which is associated with several neurological disorders including cognitive decline and memory impairments. |
2022-06-15 |
2023-08-14 |
Not clear |
| Tess Puopolo, Chang Liu, Hang Ma, Navindra P Seera. Inhibitory Effects of Cannabinoids on Acetylcholinesterase and Butyrylcholinesterase Enzyme Activities. Medical cannabis and cannabinoids. vol 5. issue 1. 2022-06-15. PMID:35702400. |
preclinical studies support that some cannabinoids including cannabidiol (cbd) and tetrahydrocannabinol (thc) may exert pharmacological effects on the cholinergic system, but it remains unclear whether cannabinoids can inhibit ache and bche activities. |
2022-06-15 |
2023-08-14 |
Not clear |
| Masato Mashimo, Koichiro Kawashima, Takeshi Fuji. Non-neuronal Cholinergic Muscarinic Acetylcholine Receptors in the Regulation of Immune Function. Biological & pharmaceutical bulletin. vol 45. issue 6. 2022-06-01. PMID:35650095. |
immune cells such as t and b cells, monocytes and macrophages all express most of the cholinergic components of the nervous system, including acetylcholine (ach), choline acetyltransferase (chat), high affinity choline transporter, muscarinic and nicotinic ach receptors (machrs and nachrs, respectively), and acetylcholinesterase (ache). |
2022-06-01 |
2023-08-13 |
Not clear |