| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Elif Tugce Karoglu-Eravsar, Melek Umay Tuz-Sasik, Aysenur Karaduman, Ayse Gokce Keskus, Ayca Arslan-Ergul, Ozlen Konu, Hulusi Kafaligonul, Michelle M Adam. Long-term Acetylcholinesterase Depletion Alters the Levels of Key Synaptic Proteins while Maintaining Neuronal Markers in the Aging Zebrafish (Danio rerio) Brain. Gerontology. 2023-10-04. PMID:37793352. |
interventions targeting cholinergic neurotransmission like acetylcholinesterase (ache) inhibition distinguish potential mechanisms to delay age-related impairments and attenuate deficits related to neurodegenerative diseases. |
2023-10-04 |
2023-10-07 |
zebrafish |
| Min Ji Go, Jong Min Kim, Hyo Lim Lee, Tae Yoon Kim, Seung Gyum Joo, Ju Hui Kim, Han Su Lee, Dae-Ok Kim, Ho Jin He. Anti-Amnesia-like Effect of International journal of molecular sciences. vol 24. issue 18. 2023-09-28. PMID:37762386. |
in addition, it had a protective effect on cholinergic and synaptic systems by regulating ach levels, ache activity, and protein expression levels of chat, ache, syp, and psd-95. |
2023-09-28 |
2023-10-07 |
mouse |
| Yuan Li, Mengyao Wu, Mengmeng Kong, Shaomei Sui, Qi Wang, Yan He, Jinsong G. Impact of Donepezil Supplementation on Alzheimer's Disease-like Pathology and Gut Microbiome in APP/PS1 Mice. Microorganisms. vol 11. issue 9. 2023-09-28. PMID:37764150. |
donepezil hydrochloride (dh), which enhances cholinergic activity by blocking acetylcholinesterase (ache), is one of the first-line drugs for ad treatment approved by the food and drug administration (fda) of the usa. |
2023-09-28 |
2023-10-07 |
mouse |
| Yunting Wang, Xueling Wu, Wujiang Ren, Yanxia Liu, Xueling Dai, Shuo Wang, Qing Huo, Yaxuan Su. Protective effects of fisetin in an Aβ1-42-induced rat model of Alzheimer's disease. Folia neuropathologica. vol 61. issue 2. 2023-08-17. PMID:37587894. |
meanwhile, fisetin also significantly attenuated ab1-42-induced cholinergic dysfunction such as elevated the activity of choline acetyltransferase (chat) and reduced the activity of acetylcholine esterase (ache). |
2023-08-17 |
2023-09-07 |
rat |
| - Liu Xianchu, - Peng Huan, - Liu Min. Asiatic acid ameliorates life and health span in fruit fly. Pakistan journal of pharmaceutical sciences. vol 36. issue 3. 2023-08-15. PMID:37580921. |
moreover, asiatic acid inhibited acetylcholine (ache) activity to alter cholinergic system in aging process. |
2023-08-15 |
2023-09-07 |
cat |
| Yasco Aracava, Edson X Albuquerque, Edna F R Pereir. (R,S)-trihexyphenidyl, acting via a muscarinic receptor-independent mechanism, inhibits hippocampal glutamatergic and GABAergic synaptic transmissions: Potential relevance for treatment of organophosphorus intoxication. Neuropharmacology. 2023-08-07. PMID:37549771. |
preclinical studies have reported that, compared to the muscarinic receptor (machr) antagonist atropine, (r,s)-trihexyphenidyl (thp) more effectively counters the cholinergic crisis, seizures, and neuropathology triggered by organophosphorus (op)-induced acetylcholinesterase (ache) inhibition. |
2023-08-07 |
2023-08-14 |
Not clear |
| Somyeong Lee, Md Niamul Haque, Do-Hee Lee, Jae-Sung Rhe. Comparison of the effects of sublethal concentrations of biofoulants, copper pyrithione and zinc pyrithione on a marine mysid - A multigenerational study. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2023-07-02. PMID:37394131. |
based on the 1/10 noecs and noec values calculated from 96 h-toxicity test, survival and growth, intermolt duration, feeding, and the number of newborn juveniles were measured by evaluating enzymatic activity of detoxification parameter glutathione s-transferase (gst) and cholinergic biomarker acetylcholinesterase (ache) in the marine mysid exposed to 96 h-noecs of cupt and znpt for four weeks across three generations. |
2023-07-02 |
2023-08-14 |
Not clear |
| Ana Paula Murray, Brunella Biscussi, Valeria Cavallaro, Martina Donozo, Silvana A Rodrigue. Naturally Occurring Cholinesterase Inhibitors from Plants, Fungi, Algae, and Animals: A Review of the Most Effective Inhibitors Reported in 2012-2022. Current neuropharmacology. 2023-06-26. PMID:37357520. |
since the development of the "cholinergic hypothesis" as an important therapeutic approach in the treatment of alzheimer's disease (ad), the scientific community has made a remarkable effort to discover new and effective molecules with the ability to inhibit the enzyme acetylcholinesterase (ache). |
2023-06-26 |
2023-08-14 |
Not clear |
| Carla Alves, Wagner Antonio Tamagno, Ana Paula Vanin, Aline Pompermaier, Leonardo José Gil Barcello. Cannabis sativa-based oils against aluminum-induced neurotoxicity. Scientific reports. vol 13. issue 1. 2023-06-17. PMID:37330587. |
cbd- and thc-based oils were able to increase the ache activity helping the cholinergic nervous system actuate against al toxicity which was reflected by the behavioral biomarkers changes. |
2023-06-17 |
2023-08-14 |
zebrafish |
| Sara Bibi, Rabia Habib, Sania Shafiq, Syed Sayyam Abbas, Shaiza Khan, Syed Ali Musstjab Akber Shah Eqani, Eugenie Nepovimova, Mansoor Shaukat Khan, Kamil Kuca, Syed Muhammad Nurulai. Influence of the chronic groundwater fluoride consumption on cholinergic enzymes, ACHE and BCHE gene SNPs and pro-inflammatory cytokines: A study with Pakistani population groups. The Science of the total environment. 2023-04-08. PMID:37030382. |
influence of the chronic groundwater fluoride consumption on cholinergic enzymes, ache and bche gene snps and pro-inflammatory cytokines: a study with pakistani population groups. |
2023-04-08 |
2023-08-14 |
human |
| Sara Bibi, Rabia Habib, Sania Shafiq, Syed Sayyam Abbas, Shaiza Khan, Syed Ali Musstjab Akber Shah Eqani, Eugenie Nepovimova, Mansoor Shaukat Khan, Kamil Kuca, Syed Muhammad Nurulai. Influence of the chronic groundwater fluoride consumption on cholinergic enzymes, ACHE and BCHE gene SNPs and pro-inflammatory cytokines: A study with Pakistani population groups. The Science of the total environment. 2023-04-08. PMID:37030382. |
cholinergic enzymes (ache and bche) were significantly increased among different exposure groups. |
2023-04-08 |
2023-08-14 |
human |
| Mohammed Shaban, Franklin Sosa, Muhammad Yasir Anwar, Irhoboudu Dickson Atogwe, Misbahuddin Khaj. Small Bowel Enteritis and Myocardial Depression Complicating Organophosphorus Poison in a Patient With Sleeve Gastrectomy and Intestinal Bypass Surgeries: An Atypical Presentation. Cureus. vol 15. issue 2. 2023-04-03. PMID:37007328. |
acute op toxicity is caused by inhibiting the acetylcholinesterase (ache) enzyme, resulting in a cholinergic surge. |
2023-04-03 |
2023-08-14 |
Not clear |
| b' Rudolf Vrabec, Gerald Blunden, Lucie Cahl\\xc3\\xadkov\\xc3\\xa. Natural Alkaloids as Multi-Target Compounds towards Factors Implicated in Alzheimer\'s Disease. International journal of molecular sciences. vol 24. issue 5. 2023-03-11. PMID:36901826.' |
the current treatment, based on the cholinergic hypothesis, is only symptomatic and mainly involves the restoration of acetylcholine (ach) levels through the inhibition of acetylcholinesterase (ache). |
2023-03-11 |
2023-08-14 |
Not clear |
| Asma B Omer, Obaid Afzal, Abdulmalik S A Altamimi, Shaktipal Patil, Shareefa A AlGhamdi, Amira M Alghamdi, Sami I Alzarea, Waleed Hassan Almalki, Imran Kazm. Neuroprotective Effect of Barbaloin on Streptozotocin-Induced Cognitive Dysfunction in Rats via Inhibiting Cholinergic and Neuroinflammatory Cytokines Pathway-TNF-α/IL-1β/IL-6/NF-κB. ACS omega. vol 8. issue 8. 2023-03-06. PMID:36872976. |
superoxide dismutase (sod), malondialdehyde (mda), catalase (cat), and glutathione (gsh) as oxidative stress markers were regulated to reverse the cognitive deterioration, and choline-acetyltransferase (chat) and acetyl-cholinesterase (ache) as indicators of cholinergic dysfunction, nuclear factor kappa-b (nf-κb), il-1β (interleukin-1β), il-6, and tumor necrosis factor-α (tnf-α) contents were used. |
2023-03-06 |
2023-08-14 |
rat |
| Aleksandar R Zivkovic, Georgina M Paul, Stefan Hofer, Karsten Schmidt, Thorsten Brenner, Markus A Weigand, Sebastian O Decke. Increased Enzymatic Activity of Acetylcholinesterase Indicates the Severity of the Sterile Inflammation and Predicts Patient Outcome following Traumatic Injury. Biomolecules. vol 13. issue 2. 2023-02-25. PMID:36830636. |
acetylcholinesterase (ache), an enzyme responsible for the hydrolysis of acetylcholine, plays an essential role in controlling cholinergic activity. |
2023-02-25 |
2023-08-14 |
Not clear |
| Vasudevan Mani, Minhajul Arfeen, Devendra Kumar Dhaked, Hamdoon A Mohammed, Palanisamy Amirthalingam, Hossam A Elsis. Neuroprotective Effect of Methanolic Ajwa Seed Extract on Lipopolysaccharide-Induced Memory Dysfunction and Neuroinflammation: In Vivo, Molecular Docking and Dynamics Studies. Plants (Basel, Switzerland). vol 12. issue 4. 2023-02-25. PMID:36840284. |
molecular modeling results revealed that the compound's ellagic acid, epicatechin, catechin, kaempferol, quercetin, and apigenin have the potential to act as a dual inhibitor of acetylcholinesterase (ache) and cox-2 and can be responsible for the improvement of both cholinergic and inflammatory conditions, while the cinnamic acid, hesperidin, hesperetin, narengin, and rutin compounds are responsible only for the improvement of cholinergic transmission. |
2023-02-25 |
2023-08-14 |
rat |
| Aravinda Babu, Mathew John, M J Liji, E Maria, S J Bhaskar, B K Binukmar, Ayyiliath M Sajith, Eeda Koti Reddy, K V Dileep, K Suni. Sub-pocket-focused designing of tacrine derivatives as potential acetylcholinesterase inhibitors. Computers in biology and medicine. vol 155. 2023-02-25. PMID:36841058. |
human acetylcholinesterase (hache) has a potential role in the management of acetylcholine, one of the neurotransmitters that modulate the overall activity of cholinergic system, ache inhibitors have a greater impact in the therapeutics. |
2023-02-25 |
2023-08-14 |
human |
| Christina Rabeler, TaiXi Gong, Danielle Ireland, Olivier Cochet-Escartin, Eva-Maria S Collin. Acetylcholinesterase Activity Staining in Freshwater Planarians. Current protocols. vol 3. issue 2. 2023-02-17. PMID:36799654. |
thus, this simple method can be used to qualitatively evaluate ache inhibition due to chemical exposure or rna interference, providing a new tool for mechanistic studies of effects on the cholinergic system. |
2023-02-17 |
2023-08-14 |
Not clear |
| Yvonne J Rosenberg, Kelly Garcia, Justin Diener, Dennis Sullivan, Scott Donahue, Lingjun Mao, Jonathan Lees, Xiaoming Jiang, Lori A Urban, Jeremiah D Momper, Kwok-Yiu Ho, Palmer Taylo. A single post-exposure oxime RS194B treatment rapidly reactivates acetylcholinesterase and reverses acute symptoms in macaques exposed to diethylphosphorothioate parathion and chlorpyrifos insecticides. Journal of neurochemistry. 2023-02-14. PMID:36786545. |
similar to nerve agents, insecticides are neurotoxins which target and inhibit acetylcholinesterase (ache) in central and peripheral synapses in the cholinergic nervous system. |
2023-02-14 |
2023-08-14 |
mouse |
| Yvonne J Rosenberg, Kelly Garcia, Justin Diener, Dennis Sullivan, Scott Donahue, Lingjun Mao, Jonathan Lees, Xiaoming Jiang, Lori A Urban, Jeremiah D Momper, Kwok-Yiu Ho, Palmer Taylo. A single post-exposure oxime RS194B treatment rapidly reactivates acetylcholinesterase and reverses acute symptoms in macaques exposed to diethylphosphorothioate parathion and chlorpyrifos insecticides. Journal of neurochemistry. 2023-02-14. PMID:36786545. |
thus, a single im injection of rs194b has been shown to rapidly restore blood ache and butyrylcholinesterase (bche) activity, reverse cholinergic symptoms and prevent death in macaques following lethal inhaled sarin and paraoxon exposure. |
2023-02-14 |
2023-08-14 |
mouse |