| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Adeola Oluwatosin Adedara, Getúlio Nicola Bressan, Matheus Mulling Dos Santos, Roselei Fachinetto, Amos Olalekan Abolaji, Nilda Vargas Barbos. Antioxidant responses driven by Hesperetin and Hesperidin Counteract Parkinson's Disease-like Phenotypes in Drosophila melanogaster. Neurotoxicology. 2024-02-29. PMID:38423185. |
in addition to in vivo parameters, we assayed some markers of oxidative stress (lipid peroxidation, protein carbonylation, thiol content, hydrogen peroxide, and nitrate/nitrite levels, mrna expression of keap-1 (kelch-like ech associated protein 1)/nrf2 (nuclear factor erythroid 2 related factor 2), catalase (cat), glutathione-s-transferase (gst) activities), and cholinergic (acetyl cholinesterase activity (ache) and dopaminergic signaling (content and the mrna expression of tyrosine hydroxylase (th), monoamine oxidase (mao) activity). |
2024-02-29 |
2024-03-03 |
cat |
| Juan Pablo Munafó, Brunella Biscussi, Diego Obiol, Marcelo Costabel, Cecilia Bouzat, Ana Paula Murray, Silvia Antollin. New Multitarget Molecules Derived from Caffeine as Potentiators of the Cholinergic System. ACS chemical neuroscience. 2024-02-26. PMID:38407056. |
our results show that the new compounds can inhibit ache and activate nachr with greater potency than caffeine and provide further information on the modulation mechanisms of pharmacological targets for the design of novel therapeutic interventions in cholinergic deficit. |
2024-02-26 |
2024-02-28 |
Not clear |
| Ali Taghizadehghalehjoughi, Muhammet Emin Naldan, Yesim Yeni, Sidika Genc, Ahmet Hacimuftuoglu, Mesut Isik, Adem Necip, İsmail Bolat, Serkan Yildirim, Sukru Beydemir, Mahmut Bayka. Effect of fentanyl and remifentanil on neuron damage and oxidative stress during induction neurotoxicity. Journal of cellular and molecular medicine. vol 28. issue 4. 2024-02-09. PMID:38332529. |
mtt, pon1 activity and total thiol levels for its effect on oxidative stress, ache and bche activities for its effect on the cholinergic system, and tnf, il-8 and il-10 gene levels for its neuroinflammation effect were determined. |
2024-02-09 |
2024-02-11 |
Not clear |
| F Javier Luque, Diego Muñoz-Torrer. Acetylcholinesterase: A Versatile Template to Coin Potent Modulators of Multiple Therapeutic Targets. Accounts of chemical research. 2024-02-09. PMID:38333993. |
conspectusthe enzyme acetylcholinesterase (ache) hydrolyzes the neurotransmitter acetylcholine (ach) at cholinergic synapses of the peripheral and central nervous system. |
2024-02-09 |
2024-02-11 |
human |
| Lei Xing, Pinyi Ma, Fangfang Che. A novel turn-on near-infrared fluorescent probe for highly sensitive in vitro and in vivo detection of acetylcholinesterase activity. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. vol 310. 2024-01-30. PMID:38290281. |
acetylcholinesterase (ache) is a key enzyme in the cholinergic pathway of the nervous systems, with its aberrant expression linked to various diseases. |
2024-01-30 |
2024-02-02 |
mouse |
| Antonio D'Errico, Rosarita Nasso, Antimo Di Maro, Nicola Landi, Angela Chambery, Rosita Russo, Stefania D'Angelo, Mariorosario Masullo, Rosaria Arcon. Identification and Characterization of Neuroprotective Properties of Thaumatin-like Protein 1a from Nutrients. vol 16. issue 2. 2024-01-26. PMID:38276545. |
identification and characterization of neuroprotective properties of thaumatin-like protein 1a from alzheimer's disease (ad) and parkinson's disease (pd) are multifactorial neurodegenerative disorders that are mostly treated with drugs inhibiting key enzymes of cholinergic and aminergic neurotransmission, such as acetyl and butyryl cholinesterase (ache, buche) or monoamine oxidases (mao)-a/b, and of a |
2024-01-26 |
2024-01-28 |
Not clear |
| Ali Naderi, Akın Akıncıoğlu, Ahmet Çağan, Hilal Çelikkaleli, Hülya Akıncıoğlu, Süleyman Göks. Design, synthesis and anticholinergic properties of novel α-benzyl dopamine, tyramine, and phenethylamine derivatives. Bioorganic chemistry. vol 144. 2024-01-23. PMID:38262088. |
within the scope of this study, the inhibition effects of dopamine-derived carbamates and amine salts on the cholinergic enzymes ache and bche were examined. |
2024-01-23 |
2024-01-26 |
Not clear |
| b' Suzana \\xc5\\xbdunec, Donna Vadlja, Alma Rami\\xc4\\x87, Antonio Zandona, Nikola Marakovi\\xc4\\x87, Iva Brekalo, Ines Primo\\xc5\\xbei\\xc4\\x8d, Maja Katalini\\xc4\\x8. Profiling Novel Quinuclidine-Based Derivatives as Potential Anticholinesterase Drugs: Enzyme Inhibition and Effects on Cell Viability. International journal of molecular sciences. vol 25. issue 1. 2024-01-11. PMID:38203326.' |
the enzymes acetylcholinesterase, ache, and butyrylcholinesterase, bche, responsible for hydrolyzing ach, can fine-tune the cholinergic system's activity and are, therefore, excellent pharmacological targets to address a range of medical conditions. |
2024-01-11 |
2024-01-13 |
Not clear |
| Mikael Ham Sembiring, Okta Nursanti, Tesia Aisyah Rahmani. Molecular docking and toxicity studies of nerve agents against acetylcholinesterase (AChE). Journal of receptor and signal transduction research. 2024-01-08. PMID:38189350. |
acetylcholinesterase (ache) is a cholinergic enzyme that plays an essential role in the autonomic nervous system. |
2024-01-08 |
2024-01-10 |
Not clear |
| Ya-Nan Zhang, Xin-Lu Chen, Ling-Yu Guo, Pei-Ran Jiang, Hui Lu, Kai Pan, Lei Guo, Yu-Ting Hu, Ai-Min Ba. Downregulation of peripheral luteinizing hormone rescues ovariectomy-associated cognitive deficits in APP/PS1 mice. Neurobiology of aging. vol 135. 2024-01-07. PMID:38185053. |
we and others found that the transcription factor early growth response-1 (egr1) regulates cholinergic function including the expression of acetylcholinesterase (ache) and plays a significant role in cognitive decline of ad. |
2024-01-07 |
2024-01-10 |
mouse |
| Xia Mu, Shengwei Yuan, Dinglin Zhang, Rui Lai, Chenyi Liao, Guohui L. Selective modulation of alkali metal ions on acetylcholinesterase. Physical chemistry chemical physics : PCCP. 2023-11-07. PMID:37934509. |
acetylcholinesterase (ache) is an important hydrolase in cholinergic synapses and a candidate target in the treatment of alzheimer's disease. |
2023-11-07 |
2023-11-08 |
human |
| Nalinee Kongkaew, Kowit Hengphasatporn, Yuwanda Injongkol, Pitchayathida Mee-Udorn, Liyi Shi, Panupong Mahalapbutr, Phornphimon Maitarad, Ryuhei Harada, Yasuteru Shigeta, Thanyada Rungrotmongkol, Alisa S Vangna. Design of electron-donating group substituted 2-PAM analogs as antidotes for organophosphate insecticide poisoning. RSC advances. vol 13. issue 46. 2023-11-06. PMID:37928857. |
the inhibition of acetylcholinesterase (ache) by ops leads to the overstimulation of cholinergic receptors, ultimately resulting in respiratory arrest, seizures, and death. |
2023-11-06 |
2023-11-08 |
Not clear |
| Ritu, Prakash Chandra, Asmita Da. "Cholinergic side Effect-Free anticancer drugs: paving the way for safer and more effective cancer treatment". Journal of biomolecular structure & dynamics. 2023-10-27. PMID:37885319. |
irinotecan-treated patients have developed cholinergic syndrome due to acetylcholinesterase (ache) enzyme inhibition. |
2023-10-27 |
2023-11-08 |
human |
| Ritu, Prakash Chandra, Asmita Da. "Cholinergic side Effect-Free anticancer drugs: paving the way for safer and more effective cancer treatment". Journal of biomolecular structure & dynamics. 2023-10-27. PMID:37885319. |
it appears that irinotecan or its metabolites directly interact with ache and inhibit its role of converting acetylcholine to choline, leading to an accumulation of acetylcholine and subsequent symptoms of the cholinergic syndrome. |
2023-10-27 |
2023-11-08 |
human |
| Shuoqi Jiang, Qiuya Gu, Xiaobin Y. Detection of insecticides by Tetronarce californica acetylcholinesterase via expression and in silico analysis. Applied microbiology and biotechnology. 2023-10-13. PMID:37831186. |
the acetylcholinesterase (ache) is involved in termination of synaptic transmission at cholinergic synapses and plays a vital role in the insecticide detection and inhibitor screening. |
2023-10-13 |
2023-10-15 |
Not clear |
| Jiajia Sun, Zhi Zhang, Kexin Yang, Gang Wei, Yanxia Li, Shenglong Zhan. Ameliorative effects of pine nut peptide-zinc chelate (Korean pine) on a mouse model of Alzheimer's disease. Experimental gerontology. 2023-10-11. PMID:37821052. |
it may exert its effects by ameliorating decreased ache levels and increased chat levels in the central cholinergic system, endogenous thiol antioxidants (enzymes) in the cerebral cortex, and by controlling the bacterial flora in the gut. |
2023-10-11 |
2023-10-15 |
mouse |
| Masarra Joda, Karen A Waters, Rita Machaalan. Choline-acetyltransferase (ChAT) and acetylcholinesterase (AChE) in the human infant dorsal motor nucleus of the Vagus (DMNV), and alterations according to sudden infant death syndrome (SIDS) category. Neurobiology of disease. 2023-10-09. PMID:37813167. |
amongst other molecules, the cholinergic system consists of choline-acetyltransferase (chat, - synthesis enzyme), acetylcholinesterase (ache - primary hydrolysis enzyme), and butyrylcholinesterase (buche - secondary hydrolysis enzyme). |
2023-10-09 |
2023-10-15 |
human |
| Sumanpreet Kaur, Sheemona Chowdhary, Deepak Kumar, Rajasri Bhattacharyya, Dibyajyoti Banerje. Organophosphorus and carbamate pesticides: molecular toxicology and laboratory testing. Clinica chimica acta; international journal of clinical chemistry. 2023-10-07. PMID:37805177. |
both inhibit acetylcholinesterase (ache) and cholinergic symptoms are mainly used for the diagnosis of pesticide poisoning. |
2023-10-07 |
2023-10-15 |
Not clear |
| Raissa Alves da Conceição, Natalia von Ranke, Luciana Azevedo, Daiana Franco, Nathalia Fonseca Nadur, Arthur Eugen Kummerle, Maria Letícia de C Barbosa, Alessandra M T Souz. Structure-based design of new N-benzyl-piperidine derivatives as multitarget-directed AChE/BuChE inhibitors for Alzheimer's disease. Journal of cellular biochemistry. 2023-10-05. PMID:37796142. |
based on the cholinergic hypothesis and considering the well-established role of butyrylcholinesterase (buche) in advanced stages of ad, the chemical structure of the acetylcholinesterase (ache) inhibitor drug donepezil (1) was rationally modified for the design of new n-benzyl-piperidine derivatives (4a-d) as potential multitarget-direct ache and buche inhibitors. |
2023-10-05 |
2023-10-07 |
Not clear |
| Elif Tugce Karoglu-Eravsar, Melek Umay Tuz-Sasik, Aysenur Karaduman, Ayse Gokce Keskus, Ayca Arslan-Ergul, Ozlen Konu, Hulusi Kafaligonul, Michelle M Adam. Long-term Acetylcholinesterase Depletion Alters the Levels of Key Synaptic Proteins while Maintaining Neuronal Markers in the Aging Zebrafish (Danio rerio) Brain. Gerontology. 2023-10-04. PMID:37793352. |
interventions targeting cholinergic neurotransmission like acetylcholinesterase (ache) inhibition distinguish potential mechanisms to delay age-related impairments and attenuate deficits related to neurodegenerative diseases. |
2023-10-04 |
2023-10-07 |
zebrafish |