| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Etta Y L Liu, Miranda L Xu, Yingjie Xia, Xiangpeng Kong, Qiyun Wu, Tina T X Dong, Karl W K Tsi. Activation of G protein-coupled receptor 30 by flavonoids leads to expression of acetylcholinesterase in cultured PC12 cells. Chemico-biological interactions. vol 306. 2019-06-05. PMID:31034797. |
the role of flavonoids in induction of a cholinergic enzyme, acetylcholinesterase (ache), was being explored here. |
2019-06-05 |
2023-08-13 |
Not clear |
| Kanzal Iman, Muhammad Usman Mirza, Nauman Mazhar, Michiel Vanmeert, Imran Irshad, Mohammad A Kama. In silico Structure-based Identification of Novel Acetylcholinesterase Inhibitors Against Alzheimer's Disease. CNS & neurological disorders drug targets. vol 17. issue 1. 2019-05-31. PMID:29336270. |
therapeutic interventions in ad are largely focused upon ache inhibitors designed essentially to prevent the loss of cholinergic function. |
2019-05-31 |
2023-08-13 |
Not clear |
| Raj P Kapur, Philipp W Raess, Samuel Hwang, Conrad Winte. Choline Transporter Immunohistochemistry: An Effective Substitute for Acetylcholinesterase Histochemistry to Diagnose Hirschsprung Disease With Formalin-fixed Paraffin-embedded Rectal Biopsies. Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society. vol 20. issue 4. 2019-05-29. PMID:28649946. |
acetylcholinesterase enzymatic histochemistry (ache ehc), which highlights abnormal cholinergic nerves in the mucosa of aganglionic bowel, has been used for decades to evaluate rectal biopsies for hirschsprung disease (hscr). |
2019-05-29 |
2023-08-13 |
Not clear |
| Paula Moyano, José Manuel García, María José Anadon, Margarita Lobo, Jimena García, María Teresa Frejo, Emma Sola, Adela Pelayo, Javier Del Pin. Manganese induced ROS and AChE variants alteration leads to SN56 basal forebrain cholinergic neuronal loss after acute and long-term treatment. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 125. 2019-05-20. PMID:30738988. |
manganese induced ros and ache variants alteration leads to sn56 basal forebrain cholinergic neuronal loss after acute and long-term treatment. |
2019-05-20 |
2023-08-13 |
Not clear |
| Paula Moyano, José Manuel García, María José Anadon, Margarita Lobo, Jimena García, María Teresa Frejo, Emma Sola, Adela Pelayo, Javier Del Pin. Manganese induced ROS and AChE variants alteration leads to SN56 basal forebrain cholinergic neuronal loss after acute and long-term treatment. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 125. 2019-05-20. PMID:30738988. |
we hypothesized that mn could induce bf cholinergic neuronal loss through oxidative stress generation, cholinergic transmission and ache variants alteration that could explain mn cognitive disorders. |
2019-05-20 |
2023-08-13 |
Not clear |
| Paula Moyano, José Manuel García, María José Anadon, Margarita Lobo, Jimena García, María Teresa Frejo, Emma Sola, Adela Pelayo, Javier Del Pin. Manganese induced ROS and AChE variants alteration leads to SN56 basal forebrain cholinergic neuronal loss after acute and long-term treatment. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 125. 2019-05-20. PMID:30738988. |
this study shows that mn impaired cholinergic transmission in sn56 cholinergic neurons from bf through alteration of ache and chat activity and cht expression. |
2019-05-20 |
2023-08-13 |
Not clear |
| Paula Moyano, José Manuel García, María José Anadon, Margarita Lobo, Jimena García, María Teresa Frejo, Emma Sola, Adela Pelayo, Javier Del Pin. Manganese induced ROS and AChE variants alteration leads to SN56 basal forebrain cholinergic neuronal loss after acute and long-term treatment. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 125. 2019-05-20. PMID:30738988. |
finally, mn induces cell death on sn56 cholinergic neurons and this effect is independent of cholinergic transmission alteration, but was mediated partially by oxidative stress generation and ache variants alteration. |
2019-05-20 |
2023-08-13 |
Not clear |
| Abdul Mannan Baig, Zohaib Rana, Sumayya Tariq, Salima Lalani, H R Ahma. Traced on the Timeline: Discovery of Acetylcholine and the Components of the Human Cholinergic System in a Primitive Unicellular Eukaryote Acanthamoeba spp. ACS chemical neuroscience. vol 9. issue 3. 2019-05-07. PMID:29058403. |
we show the evidence for the presence of homology of evolutionary conserved key enzymes of the cholinergic system like choline acetyltransferase (chat) and acetylcholinesterase (ache) in a. castellanii spp., which were found to be near identical to their human counterparts. |
2019-05-07 |
2023-08-13 |
human |
| Bruno Nune. Acute ecotoxicological effects of salicylic acid on the Polychaeta species Hediste diversicolor: evidences of low to moderate pro-oxidative effects. Environmental science and pollution research international. vol 26. issue 8. 2019-05-06. PMID:30684172. |
in order to determine the potential ecotoxicological effects caused by sa, individuals of the marine polychaeta species hediste diversicolor were exposed for 96 h to ecologically relevant concentrations of this compound, and several biochemical endpoints were evaluated, namely the activity of the antioxidant enzymes glutathione peroxidase (gpx) and catalase (cat), the phase ii biotransformation isoenzymes glutathione s-transferases (gsts), the cholinergic enzyme acetylcholinesterase (ache), and the determination of lipoperoxidative damage (thiobarbituric acid-reactive substances (tbars) assay). |
2019-05-06 |
2023-08-13 |
human |
| A M da Rocha, L W Kist, E A Almeida, D G H Silva, C D Bonan, S Altenhofen, C G Kaufmann, M R Bogo, D M Barros, S Oliveira, V Geraldo, R G Lacerda, A S Ferlauto, Luiz Orlando Ladeira, J M Monserra. Neurotoxicity in zebrafish exposed to carbon nanotubes: Effects on neurotransmitters levels and antioxidant system. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. vol 218. 2019-04-01. PMID:30543862. |
cholinergic, serotonergic, and dopaminergic systems, through ache activity and serotonin and dopamine levels, respectively were affected by swcnt in the zebrafish brain. |
2019-04-01 |
2023-08-13 |
zebrafish |
| Chanika Alahakoon, Tharaka L Dassanayake, Indika B Gawarammana, E Michael Sedgwick, Vajira S Weerasinghe, Ahmed Abdalla, Michael S Roberts, Nicholas A Buckle. Prediction of organophosphorus insecticide-induced intermediate syndrome with stimulated concentric needle single fibre electromyography. PloS one. vol 13. issue 9. 2019-02-25. PMID:30261032. |
ops inhibit acetylcholine esterase (ache), leading to over-activity of muscarinic and nicotinic cholinergic circuits. |
2019-02-25 |
2023-08-13 |
Not clear |
| Amrita A Chowdhury, Nitin B Gawali, Renuka Munshi, Archana R Juveka. Trigonelline insulates against oxidative stress, proinflammatory cytokines and restores BDNF levels in lipopolysaccharide induced cognitive impairment in adult mice. Metabolic brain disease. vol 33. issue 3. 2019-02-05. PMID:29277879. |
cholinergic involvement during neuroinflammation was evaluated by measuring levels of acetylcholinesterase (ache) enzyme. |
2019-02-05 |
2023-08-13 |
mouse |
| Tim Anderson, Jing Liu, Scott McMurry, Carey Pop. Comparative in vitro and in vivo effects of chlorpyrifos oxon in the outbred CD-1 mouse (Mus musculus) and great plains toad (Anaxyrus cognatus). Environmental toxicology and chemistry. vol 37. issue 7. 2019-02-04. PMID:29573455. |
these data suggest that the relatively low sensitivity of toads to cholinergic toxicity is based on the low sensitivity of brain ache, which in turn may be attributable to more effective target-site detoxification. |
2019-02-04 |
2023-08-13 |
mouse |
| Jonathan R de Almeida, Micheli Figueiro, Wanda Pereira Almeida, Carlos Henrique Tomich de Paula da Silv. Discovery of novel dual acetylcholinesterase inhibitors with antifibrillogenic activity related to Alzheimer's disease. Future medicinal chemistry. vol 10. issue 9. 2019-02-04. PMID:29676170. |
the current pharmacological approach is based on the improvement of cholinergic neurotransmission by inhibiting acetylcholinesterase (ache) with ache inhibitors. |
2019-02-04 |
2023-08-13 |
Not clear |
| Caio R D Assis, Amanda G Linhares, Mariana P Cabrera, Vagne M Oliveira, Kaline C C Silva, Marina Marcuschi, Elba V M Maciel Carvalho, Ranilson S Bezerra, Luiz B Carvalh. Erythrocyte acetylcholinesterase as biomarker of pesticide exposure: new and forgotten insights. Environmental science and pollution research international. vol 25. issue 19. 2018-12-20. PMID:29797194. |
acetylcholinesterase (ache) acts on the hydrolysis of acetylcholine, rapidly removing this neurotransmitter at cholinergic synapses and neuromuscular junctions as well as in neuronal growth and differentiation, modulation of cell adhesion ("electrotactins") and aryl-acylamidase activity (aaa). |
2018-12-20 |
2023-08-13 |
Not clear |
| Marlyete Chagas Araújo, Caio Rodrigo Dias Assis, Kaline Catiely Campos Silva, Kelma Sirleide Souza, Rafael Souto Azevedo, Maria Helena Menezes Estevam Alves, Luciano Clemente Silva, Valdir Luna Silva, Mônica Lúcia Adam, Luiz Bezerra Carvalho Junior, Ranilson Souza Bezerra, Maria Betânia Melo Oliveir. Characterization of brain acetylcholinesterase of bentonic fish Hoplosternum littorale: Perspectives of application in pesticides and metal ions biomonitoring. Aquatic toxicology (Amsterdam, Netherlands). vol 205. 2018-12-12. PMID:30408655. |
acetylcholinesterase (ache; ec 3.1.1.7) is a serine hydrolase, whose main function is to modulate neurotransmission at cholinergic synapses. |
2018-12-12 |
2023-08-13 |
Not clear |
| Zuzana Gazova, Ondrej Soukup, Vendula Sepsova, Katarina Siposova, Lucie Drtinova, Petr Jost, Katarina Spilovska, Jan Korabecny, Eugenie Nepovimova, Diana Fedunova, Martin Horak, Martina Kaniakova, Ze-Jun Wang, Ayman K Hamouda, Kamil Kuc. Multi-target-directed therapeutic potential of 7-methoxytacrine-adamantylamine heterodimers in the Alzheimer's disease treatment. Biochimica et biophysica acta. Molecular basis of disease. vol 1863. issue 2. 2018-12-11. PMID:27865910. |
moreover, they have ache inhibitory potency but they could not potentiate cholinergic transmission via direct interaction with cholinergic receptors. |
2018-12-11 |
2023-08-13 |
Not clear |
| Vivitri Prasasty, Muhammad Radifar, Enade Istyaston. Natural Peptides in Drug Discovery Targeting Acetylcholinesterase. Molecules (Basel, Switzerland). vol 23. issue 9. 2018-12-11. PMID:30217053. |
acetylcholinesterase-inhibitory peptide has gained much importance since it can inhibit acetylcholinesterase (ache) and increase the availability of acetylcholine in cholinergic synapses, enhancing cholinergic transmission in pharmacological treatment of alzheimer's disease (ad). |
2018-12-11 |
2023-08-13 |
Not clear |
| Marcella Reale, Erica Costantini, Marta Di Nicola, Chiara D'Angelo, Sara Franchi, Marco D'Aurora, Maria Di Bari, Viviana Orlando, Sabrina Galizia, Serena Ruggieri, Liborio Stuppia, Claudio Gasperini, Ada Maria Tata, Valentina Gatt. Butyrylcholinesterase and Acetylcholinesterase polymorphisms in Multiple Sclerosis patients: implication in peripheral inflammation. Scientific reports. vol 8. issue 1. 2018-11-21. PMID:29358722. |
the aim of the present research was to assess the associations between bche and ache genetic variations and serum cholinergic and inflammatory profiles in 102 relapsing remitting-ms patients and 117 healthy controls. |
2018-11-21 |
2023-08-13 |
Not clear |
| Marcella Reale, Erica Costantini, Marta Di Nicola, Chiara D'Angelo, Sara Franchi, Marco D'Aurora, Maria Di Bari, Viviana Orlando, Sabrina Galizia, Serena Ruggieri, Liborio Stuppia, Claudio Gasperini, Ada Maria Tata, Valentina Gatt. Butyrylcholinesterase and Acetylcholinesterase polymorphisms in Multiple Sclerosis patients: implication in peripheral inflammation. Scientific reports. vol 8. issue 1. 2018-11-21. PMID:29358722. |
we propose that serum bche and ache activity may be used as a secondary markers to assess the role of non-neuronal cholinergic system in regulating peripheral inflammation via ach regulation. |
2018-11-21 |
2023-08-13 |
Not clear |