| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Md Junaid, Nazrul Islam, Md Kamal Hossain, M Obayed Ullah, Mohammad A Hali. Metal based donepezil analogues designed to inhibit human acetylcholinesterase for Alzheimer's disease. PloS one. vol 14. issue 2. 2019-11-04. PMID:30785927. |
targeting acetylcholinesterase (ache) is one of the major strategies for ad therapeutics, as cholinergic pathways in the cerebral cortex and basal forebrain are compromised. |
2019-11-04 |
2023-08-13 |
human |
| Yulong Lin, Yalin Wang, Jie Lv, Nannan Wang, Jing Wang, Meng L. Targeted acetylcholinesterase-responsive drug carriers with long duration of drug action and reduced hepatotoxicity. International journal of nanomedicine. vol 14. 2019-11-01. PMID:31440049. |
acetylcholinesterase (ache) plays a critical role in the transmission of nerve impulse at the cholinergic synapses. |
2019-11-01 |
2023-08-13 |
Not clear |
| Yulong Lin, Yalin Wang, Jie Lv, Nannan Wang, Jing Wang, Meng L. Targeted acetylcholinesterase-responsive drug carriers with long duration of drug action and reduced hepatotoxicity. International journal of nanomedicine. vol 14. 2019-11-01. PMID:31440049. |
design and synthesis of ache inhibitors that increase the cholinergic transmission by blocking the degradation of acetylcholine can serve as a strategy for the treatment of ache-associated disease. |
2019-11-01 |
2023-08-13 |
Not clear |
| Eng Leng Saw, Yoshihiko Kakinuma, Martin Fronius, Rajesh Katar. The non-neuronal cholinergic system in the heart: A comprehensive review. Journal of molecular and cellular cardiology. vol 125. 2019-10-28. PMID:30343172. |
the existence of cardiac nncs has been confirmed by the presence of cholinergic markers in the cardiomyocytes, which are crucial for synthesis (choline acetyltransferase, chat), storage (vesicular acetylcholine transporter, vacht), reuptake of choline for synthesis (high-affinity choline transporter, cht1) and degradation (acetylcholinesterase, ache) of acetylcholine (ach). |
2019-10-28 |
2023-08-13 |
Not clear |
| Julie V Miller, Ryan F LeBouf, Kimberly A Kelly, Lindsay T Michalovicz, Anand Ranpara, Alicia R Locker, Diane B Miller, James P O'Callagha. The Neuroinflammatory Phenotype in a Mouse Model of Gulf War Illness is Unrelated to Brain Regional Levels of Acetylcholine as Measured by Quantitative HILIC-UPLC-MS/MS. Toxicological sciences : an official journal of the Society of Toxicology. vol 165. issue 2. 2019-09-25. PMID:29846716. |
although inhibition of ache leading to accumulation of acetylcholine (ach) will activate the cholinergic anti-inflammatory pathway, the signature symptomatology of gwi has been shown to be associated with neuroinflammation. |
2019-09-25 |
2023-08-13 |
mouse |
| Muhammed Khairujjaman Mazumder, Shuvasish Choudhur. Tea polyphenols as multi-target therapeutics for Alzheimer's disease: An in silico study. Medical hypotheses. vol 125. 2019-08-27. PMID:30902161. |
with neurodegeneration, the level of the neurotransmitter acetylcholine (ach), as well as acetylcholinesterase (ache), decreases in the synaptic cleft, called cholinergic deficiency. |
2019-08-27 |
2023-08-13 |
Not clear |
| Rui Sha, Yangsheng Chen, Yali Luo, Yiyun Liu, Li Xu, Heidi Qunhui Xie, Bin Zha. Effects of astrocyte conditioned medium on neuronal AChE expression upon 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure. Chemico-biological interactions. vol 309. 2019-08-19. PMID:31152735. |
acetylcholinesterase (ec3.1.1.7; ache) is a key enzyme in the cholinergic system. |
2019-08-19 |
2023-08-13 |
human |
| b' Maja D Vitorovi\\xc4\\x87-Todorovi\\xc4\\x87, Franz Worek, Andrej Perdih, Sonja \\xc4\\x90 Bauk, Tamara B Vujatovi\\xc4\\x87, Ilija N Cvijeti\\xc4\\x8. The in vitro protective effects of the three novel nanomolar reversible inhibitors of human cholinesterases against irreversible inhibition by organophosphorous chemical warfare agents. Chemico-biological interactions. vol 309. 2019-08-19. PMID:31228470.' |
acetylcholinesterase (ache) is an enzyme which terminates the cholinergic neurotransmission, by hydrolyzing acetylcholine at the nerve and nerve-muscle junctions. |
2019-08-19 |
2023-08-13 |
human |
| Lucieli K F Müller, Aleksandro S DA Silva, Nathieli B Bottari, Janio M Santurio, Vera M Morsch, Manoela M Piva, Ricardo E Mendes, Eduardo M Gloria, Diovani Paian. Effects of fed mycotoxin contaminated diets supplemented with spray-dried porcine plasma on cholinergic response and behavior in piglets. Anais da Academia Brasileira de Ciencias. vol 91. issue 2. 2019-07-26. PMID:31269106. |
taken together, the data suggest changes in ache and bche activities may indicate alterations in cholinergic neurotransmission and consequently in the behavior of piglets. |
2019-07-26 |
2023-08-13 |
Not clear |
| Yali Luo, Heidi Qunhui Xie, Yangsheng Chen, Yingjie Xia, Rui Sha, Yiyun Liu, Yongchao Ma, Tong Xu, Li Xu, Karl Wah-Keung Tsim, Bin Zha. Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure on acetylcholinesterase during myogenic differentiation of contractile rat primary skeletal muscle cells. Chemico-biological interactions. vol 308. 2019-07-22. PMID:31100272. |
acetylcholinesterase (ec3.1.1.7; ache), an enzyme critical for cholinergic neurotransmission, is abundantly expressed in neurons and mature myotubes, and we recently found that muscle ache expression was suppressed in parallel with the inhibition of myogenic differentiation upon tcdd treatment in mouse c2c12 cells. |
2019-07-22 |
2023-08-13 |
mouse |
| Tahira Javed, Rabia Habib, Sania Ghafoor, Baseerat Rumman, Sliha Awan, Leonel J M Ntepe, Sajida Batool, Syed M Nurulai. Association of status of acetylcholinesterase and ACHE gene 3' UTR variants (rs17228602, rs17228616) with drug addiction vulnerability in pakistani population. Chemico-biological interactions. vol 308. 2019-07-22. PMID:31129131. |
acetylecholine (ach), a cholinergic neurotransmitter hydrolyzed by acetylcholinesterase (ache), is an essential neurotransmitter and neuromodulator in central and peripheral nervous system and has regulatory influence on numerous neuronal functions including addiction. |
2019-07-22 |
2023-08-13 |
human |
| Tahira Javed, Rabia Habib, Sania Ghafoor, Baseerat Rumman, Sliha Awan, Leonel J M Ntepe, Sajida Batool, Syed M Nurulai. Association of status of acetylcholinesterase and ACHE gene 3' UTR variants (rs17228602, rs17228616) with drug addiction vulnerability in pakistani population. Chemico-biological interactions. vol 308. 2019-07-22. PMID:31129131. |
further studies with larger sample size and other variants of ache are recommended to identify novel therapeutic approaches for cholinergic based treatment of addiction. |
2019-07-22 |
2023-08-13 |
human |
| Miranda L Xu, Wilson K W Luk, Etta Y L Liu, Xiang P Kong, Qi Y Wu, Ying J Xia, Tina T X Dong, Karl W K Tsi. Differentiation of erythroblast requires the dimeric form of acetylcholinesterase: Interference with erythropoietin receptor. Chemico-biological interactions. vol 308. 2019-07-22. PMID:31170385. |
acetylcholinesterase (ache) hydrolyzes acetylcholine at cholinergic synapses, and which has various isoforms of ache, i.e. |
2019-07-22 |
2023-08-13 |
Not clear |
| Miranda L Xu, Wilson K W Luk, Cathy W C Bi, Etta Y L Liu, Kevin Q Y Wu, Ping Yao, Tina T X Dong, Karl W K Tsi. Erythropoietin regulates the expression of dimeric form of acetylcholinesterase during differentiation of erythroblast. Journal of neurochemistry. vol 146. issue 4. 2019-06-26. PMID:29675901. |
acetylcholinesterase (ache; ec 3.1.1.7) is known to hydrolyze acetylcholine at cholinergic synapses. |
2019-06-26 |
2023-08-13 |
Not clear |
| Etta Y L Liu, Miranda L Xu, Yingjie Xia, Xiangpeng Kong, Qiyun Wu, Tina T X Dong, Karl W K Tsi. Activation of G protein-coupled receptor 30 by flavonoids leads to expression of acetylcholinesterase in cultured PC12 cells. Chemico-biological interactions. vol 306. 2019-06-05. PMID:31034797. |
the role of flavonoids in induction of a cholinergic enzyme, acetylcholinesterase (ache), was being explored here. |
2019-06-05 |
2023-08-13 |
Not clear |
| Kanzal Iman, Muhammad Usman Mirza, Nauman Mazhar, Michiel Vanmeert, Imran Irshad, Mohammad A Kama. In silico Structure-based Identification of Novel Acetylcholinesterase Inhibitors Against Alzheimer's Disease. CNS & neurological disorders drug targets. vol 17. issue 1. 2019-05-31. PMID:29336270. |
therapeutic interventions in ad are largely focused upon ache inhibitors designed essentially to prevent the loss of cholinergic function. |
2019-05-31 |
2023-08-13 |
Not clear |
| Raj P Kapur, Philipp W Raess, Samuel Hwang, Conrad Winte. Choline Transporter Immunohistochemistry: An Effective Substitute for Acetylcholinesterase Histochemistry to Diagnose Hirschsprung Disease With Formalin-fixed Paraffin-embedded Rectal Biopsies. Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society. vol 20. issue 4. 2019-05-29. PMID:28649946. |
acetylcholinesterase enzymatic histochemistry (ache ehc), which highlights abnormal cholinergic nerves in the mucosa of aganglionic bowel, has been used for decades to evaluate rectal biopsies for hirschsprung disease (hscr). |
2019-05-29 |
2023-08-13 |
Not clear |
| Paula Moyano, José Manuel García, María José Anadon, Margarita Lobo, Jimena García, María Teresa Frejo, Emma Sola, Adela Pelayo, Javier Del Pin. Manganese induced ROS and AChE variants alteration leads to SN56 basal forebrain cholinergic neuronal loss after acute and long-term treatment. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 125. 2019-05-20. PMID:30738988. |
manganese induced ros and ache variants alteration leads to sn56 basal forebrain cholinergic neuronal loss after acute and long-term treatment. |
2019-05-20 |
2023-08-13 |
Not clear |
| Paula Moyano, José Manuel García, María José Anadon, Margarita Lobo, Jimena García, María Teresa Frejo, Emma Sola, Adela Pelayo, Javier Del Pin. Manganese induced ROS and AChE variants alteration leads to SN56 basal forebrain cholinergic neuronal loss after acute and long-term treatment. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 125. 2019-05-20. PMID:30738988. |
we hypothesized that mn could induce bf cholinergic neuronal loss through oxidative stress generation, cholinergic transmission and ache variants alteration that could explain mn cognitive disorders. |
2019-05-20 |
2023-08-13 |
Not clear |
| Paula Moyano, José Manuel García, María José Anadon, Margarita Lobo, Jimena García, María Teresa Frejo, Emma Sola, Adela Pelayo, Javier Del Pin. Manganese induced ROS and AChE variants alteration leads to SN56 basal forebrain cholinergic neuronal loss after acute and long-term treatment. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 125. 2019-05-20. PMID:30738988. |
this study shows that mn impaired cholinergic transmission in sn56 cholinergic neurons from bf through alteration of ache and chat activity and cht expression. |
2019-05-20 |
2023-08-13 |
Not clear |