| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Javier Del Pino, Paula Moyano, Gloria Gómez Díaz, María José Anadon, Maria Jesus Diaz, José Manuel García, Margarita Lobo, Adela Pelayo, Emma Sola, María Teresa Frej. Primary hippocampal neuronal cell death induction after acute and repeated paraquat exposures mediated by AChE variants alteration and cholinergic and glutamatergic transmission disruption. Toxicology. vol 390. 2017-10-23. PMID:28916328. |
primary hippocampal neuronal cell death induction after acute and repeated paraquat exposures mediated by ache variants alteration and cholinergic and glutamatergic transmission disruption. |
2017-10-23 |
2023-08-13 |
Not clear |
| Javier Del Pino, Paula Moyano, Gloria Gómez Díaz, María José Anadon, Maria Jesus Diaz, José Manuel García, Margarita Lobo, Adela Pelayo, Emma Sola, María Teresa Frej. Primary hippocampal neuronal cell death induction after acute and repeated paraquat exposures mediated by AChE variants alteration and cholinergic and glutamatergic transmission disruption. Toxicology. vol 390. 2017-10-23. PMID:28916328. |
in addition, pq induced, after 24h and 14days exposure, cell death on hippocampal neurons that was partially mediated by ache variants alteration and cholinergic and gultamatergic transmissions disruption. |
2017-10-23 |
2023-08-13 |
Not clear |
| Shalini Jayant, Bhupesh Sharm. Selective Modulator of Cannabinoid Receptor Type 2 Reduces Memory Impairment and Infarct Size During Cerebral Hypoperfusion and Vascular Dementia. Current neurovascular research. vol 13. issue 4. 2017-10-19. PMID:27586843. |
these animals have shown a considerable reduction in brain oxidative stress (thiobarbituric reactive acid substance-tbars; glutathione-gsh; catalase-cat and superoxide dismutase-sod), mitochondrial dysfunction (complexes i, ii, iv) with a significant enhancement in cholinergic activity- ache and brain infarct size2,3,5-triphenylterazolium chloride staining (ttc staining). |
2017-10-19 |
2023-08-13 |
rat |
| Talita P C Chierrito, Susimaire Pedersoli-Mantoani, Carlos Roca, Carlos Requena, Victor Sebastian-Perez, Willian O Castillo, Natalia C S Moreira, Concepción Pérez, Elza T Sakamoto-Hojo, Catarina S Takahashi, Jesús Jiménez-Barbero, F Javier Cañada, Nuria E Campillo, Ana Martinez, Ivone Carvalh. From dual binding site acetylcholinesterase inhibitors to allosteric modulators: A new avenue for disease-modifying drugs in Alzheimer's disease. European journal of medicinal chemistry. vol 139. 2017-10-16. PMID:28863358. |
unexpectely, we have found a potent allosteric modulator of ache able to target cholinergic and non-cholinergic functions by fixing a specific ache conformation, confirmed by std-nmr and molecular modeling studies. |
2017-10-16 |
2023-08-13 |
human |
| Babar Ali, Qazi M S Jamal, Saiba Shams, Naser A Al-Wabel, Mughees U Siddiqui, Mohammad A Alzohairy, Mohammed A Al Karaawi, Kavindra Kumar Kesari, Gohar Mushtaq, Mohammad A Kama. In Silico Analysis of Green Tea Polyphenols as Inhibitors of AChE and BChE Enzymes in Alzheimer's Disease Treatment. CNS & neurological disorders drug targets. vol 15. issue 5. 2017-10-04. PMID:26996169. |
the present docking study suggests that tea polyphenols inhibit ache as well as bche and enhance the cholinergic neurotransmission by prolonging the time. |
2017-10-04 |
2023-08-13 |
Not clear |
| Melissa A Pickett, Michael K Dush, Nanette M Nascone-Yode. Acetylcholinesterase plays a non-neuronal, non-esterase role in organogenesis. Development (Cambridge, England). vol 144. issue 15. 2017-10-02. PMID:28684626. |
acetylcholinesterase (ache) is crucial for degrading acetylcholine at cholinergic synapses. |
2017-10-02 |
2023-08-13 |
Not clear |
| Miranda L Xu, Cathy W C Bi, Etta Y L Liu, Tina T X Dong, Karl W K Tsi. Wnt3a induces the expression of acetylcholinesterase during osteoblast differentiation via the Runx2 transcription factor. The Journal of biological chemistry. vol 292. issue 30. 2017-09-26. PMID:28607150. |
acetylcholinesterase (ache) hydrolyzes acetylcholine to terminate cholinergic transmission in neurons. |
2017-09-26 |
2023-08-13 |
human |
| Thomas Driant, Florian Nachon, Cyril Ollivier, Pierre-Yves Renard, Etienne Dera. On the Influence of the Protonation States of Active Site Residues on AChE Reactivation: A QM/MM Approach. Chembiochem : a European journal of chemical biology. vol 18. issue 7. 2017-09-19. PMID:28106328. |
acetylcholinesterase (ache), an enzyme of the serine hydrolase superfamily, is a mediator of signal transmission at cholinergic synapses by catalyzing acetylcholine cleavage into acetate and choline. |
2017-09-19 |
2023-08-13 |
Not clear |
| Alon Simchovitz, Michael T Heneka, Hermona Sore. Personalized genetics of the cholinergic blockade of neuroinflammation. Journal of neurochemistry. vol 142 Suppl 2. 2017-09-07. PMID:28326544. |
cholinomirs coordinate the cognitive and inflammatory aspects of cholinergic signaling by targeting major cholinergic transcripts including the acetylcholine hydrolyzing enzyme acetylcholinesterase (ache). |
2017-09-07 |
2023-08-13 |
Not clear |
| Alon Simchovitz, Michael T Heneka, Hermona Sore. Personalized genetics of the cholinergic blockade of neuroinflammation. Journal of neurochemistry. vol 142 Suppl 2. 2017-09-07. PMID:28326544. |
since cholinergic signaling blocks neuroinflammation which is inherent to alzheimer's disease, genomic changes modifying ache's properties and its susceptibility to inhibitors and/or to cholinomirs regulation may affect the levels and properties of inflammasome components such as nlrp3. |
2017-09-07 |
2023-08-13 |
Not clear |
| Alon Simchovitz, Michael T Heneka, Hermona Sore. Personalized genetics of the cholinergic blockade of neuroinflammation. Journal of neurochemistry. vol 142 Suppl 2. 2017-09-07. PMID:28326544. |
several additional snps in the ache and other cholinergic genes await further studies, and might likewise involve different cholinomirs and pathways including those modulating the initiation and progression of neurodegenerative diseases. |
2017-09-07 |
2023-08-13 |
Not clear |
| Patrick Masson, Florian Nacho. Cholinesterase reactivators and bioscavengers for pre- and post-exposure treatments of organophosphorus poisoning. Journal of neurochemistry. vol 142 Suppl 2. 2017-09-07. PMID:28542985. |
organophosphorus agents (ops) irreversibly inhibit acetylcholinesterase (ache) causing a major cholinergic syndrome. |
2017-09-07 |
2023-08-13 |
Not clear |
| Richard D Burke, Spencer W Todd, Eric Lumsden, Roger J Mullins, Jacek Mamczarz, William P Fawcett, Rao P Gullapalli, William R Randall, Edna F R Pereira, Edson X Albuquerqu. Developmental neurotoxicity of the organophosphorus insecticide chlorpyrifos: from clinical findings to preclinical models and potential mechanisms. Journal of neurochemistry. vol 142 Suppl 2. 2017-09-07. PMID:28791702. |
clinical manifestations of an acute exposure of humans to op insecticides include a well-defined cholinergic crisis that develops as a result of the irreversible inhibition of acetylcholinesterase (ache), the enzyme that hydrolyzes the neurotransmitter acetylcholine (ach). |
2017-09-07 |
2023-08-13 |
Not clear |
| Yvonne J Rosenberg, Lingjun Mao, Xiaoming Jiang, Jonathan Lees, Limin Zhang, Zoran Radic, Palmer Taylo. Post-exposure treatment with the oxime RS194B rapidly reverses early and advanced symptoms in macaques exposed to sarin vapor. Chemico-biological interactions. vol 274. 2017-09-05. PMID:28693885. |
organophosphate (op) nerve agents and pesticides trigger a common mechanism of neurotoxicity resulting from critical targeting and inhibition of acetylcholinesterases (ache) in central and peripheral synapses in the cholinergic nervous system. |
2017-09-05 |
2023-08-13 |
human |
| Yong-Tao Xiao, Jun Wang, Wei Lu, Yi Cao, Wei Ca. Downregulated expression of microRNA-124 in pediatric intestinal failure patients modulates macrophages activation by inhibiting STAT3 and AChE. Cell death & disease. vol 7. issue 12. 2017-08-28. PMID:27977009. |
the ache potentially negates the cholinergic anti-inflammatory signal by hydrolyzing the acetylcholine. |
2017-08-28 |
2023-08-13 |
Not clear |
| Janine Spieker, Anica Ackermann, Anika Salfelder, Astrid Vogel-Höpker, Paul G Laye. Acetylcholinesterase Regulates Skeletal In Ovo Development of Chicken Limbs by ACh-Dependent and -Independent Mechanisms. PloS one. vol 11. issue 8. 2017-08-21. PMID:27574787. |
in conclusion, skeletogenesis in chick is regulated by an ach-dependent cholinergic system, but to some extent also by an ach-independent aspect of the ache protein. |
2017-08-21 |
2023-08-13 |
chicken |
| Deniz Yilmazer-Hanke, Marina Eliava, Joachim Hanke, Herbert Schwegler, Esther Asa. Density of acetylcholine esterase (AchE) and tyrosine hydroxylase (TH) containing fibers in the amygdala of roman high- and low-avoidance rats. Neuroscience letters. vol 632. 2017-08-08. PMID:27585749. |
in the present study, the density of acetylcholine esterase (ache)-positive cholinergic fibers and tyrosine hydroxylase immunoreactive (th-ir) fibers were analyzed in various amygdala nuclei. |
2017-08-08 |
2023-08-13 |
rat |
| Janine Spieker, Thomas Mudersbach, Astrid Vogel-Höpker, Paul G Laye. Endochondral Ossification Is Accelerated in Cholinesterase-Deficient Mice and in Avian Mesenchymal Micromass Cultures. PloS one. vol 12. issue 1. 2017-08-07. PMID:28118357. |
here, we analyzed endochondral ossification in mutant murine fetuses, in which genes of the rate-limiting cholinergic enzymes acetyl- (ache), or butyrylcholinesterase (bche), or both were deleted (called here a-b+, a+b-, a-b-, respectively). |
2017-08-07 |
2023-08-13 |
mouse |
| Janine Spieker, Thomas Mudersbach, Astrid Vogel-Höpker, Paul G Laye. Endochondral Ossification Is Accelerated in Cholinesterase-Deficient Mice and in Avian Mesenchymal Micromass Cultures. PloS one. vol 12. issue 1. 2017-08-07. PMID:28118357. |
we conclude that due to absence of either one or both cholinesterases in ko mice, or inhibition of ache in chicken micromass cultures, there is increase in cholinergic signalling, which leads to increased chondroblast production and premature mineralization, at the expense of incomplete chondrogenic differentiation. |
2017-08-07 |
2023-08-13 |
mouse |
| Stefani Altenhofen, Débora Dreher Nabinger, Melissa Talita Wiprich, Talita Carneiro Brandão Pereira, Maurício Reis Bogo, Carla Denise Bona. Tebuconazole alters morphological, behavioral and neurochemical parameters in larvae and adult zebrafish (Danio rerio). Chemosphere. vol 180. 2017-07-24. PMID:28431386. |
these findings demonstrated that tebuconazole could modulate the cholinergic system by altering ache activity and that this change may be associated with the reduced locomotion of these animals. |
2017-07-24 |
2023-08-13 |
zebrafish |