| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Natalia N Nalivaeva, Anthony J Turne. AChE and the amyloid precursor protein (APP) - Cross-talk in Alzheimer's disease. Chemico-biological interactions. vol 259. issue Pt B. 2017-01-30. PMID:27062894. |
both can be released from the cell membrane and we have shown that ache shedding involves a metalloproteinase-mediated mechanism which, like the α-secretase dependent cleavage of app, is stimulated by cholinergic agonists. |
2017-01-30 |
2023-08-13 |
Not clear |
| Natalia N Nalivaeva, Anthony J Turne. AChE and the amyloid precursor protein (APP) - Cross-talk in Alzheimer's disease. Chemico-biological interactions. vol 259. issue Pt B. 2017-01-30. PMID:27062894. |
on the contrary, sirna knock-down of app in cholinergic sn56 cells resulted in a significant upregulation of ache mrna levels. |
2017-01-30 |
2023-08-13 |
Not clear |
| Heidi Q Xie, Tuan Xu, Yangsheng Chen, Yunping Li, Yingjie Xia, Sherry L Xu, Lingyun Wang, Karl W K Tsim, Bin Zha. New perspectives for multi-level regulations of neuronal acetylcholinesterase by dioxins. Chemico-biological interactions. vol 259. issue Pt B. 2017-01-30. PMID:27374124. |
acetylcholinesterase (ache; ec 3.1.1.7) is a vital functional enzyme in cholinergic neurotransmission which can rapidly hydrolyze neurotransmitter, acetylcholine, in the central and peripheral nervous systems. |
2017-01-30 |
2023-08-13 |
mouse |
| Javier Del Pino, Gabriela Zeballos, María José Anadón, Paula Moyano, María Jesús Díaz, José Manuel García, María Teresa Frej. Cadmium-induced cell death of basal forebrain cholinergic neurons mediated by muscarinic M1 receptor blockade, increase in GSK-3β enzyme, β-amyloid and tau protein levels. Archives of toxicology. vol 90. issue 5. 2017-01-24. PMID:26026611. |
in this regard, we described in a previous work that cadmium blocks cholinergic transmission and induces a more pronounced cell death on cholinergic neurons from basal forebrain which is partially mediated by ache overexpression. |
2017-01-24 |
2023-08-13 |
Not clear |
| Javier Del Pino, Gabriela Zeballos, María José Anadón, Paula Moyano, María Jesús Díaz, José Manuel García, María Teresa Frej. Cadmium-induced cell death of basal forebrain cholinergic neurons mediated by muscarinic M1 receptor blockade, increase in GSK-3β enzyme, β-amyloid and tau protein levels. Archives of toxicology. vol 90. issue 5. 2017-01-24. PMID:26026611. |
for this purpose, we evaluated, in sn56 cholinergic mourine septal cell line from basal forebrain region, the cadmium toxic effects on neuronal viability through muscarinic m1 receptor, ache splice variants, gsk-3β enzyme, aβ and tau proteins. |
2017-01-24 |
2023-08-13 |
Not clear |
| Javier Del Pino, Gabriela Zeballos, María José Anadón, Paula Moyano, María Jesús Díaz, José Manuel García, María Teresa Frej. Cadmium-induced cell death of basal forebrain cholinergic neurons mediated by muscarinic M1 receptor blockade, increase in GSK-3β enzyme, β-amyloid and tau protein levels. Archives of toxicology. vol 90. issue 5. 2017-01-24. PMID:26026611. |
our present results provide new understanding of the mechanisms contributing to the harmful effects of cadmium on cholinergic neurons and suggest that cadmium could mediate these mechanisms by m1r blockade through ache splices altered expression. |
2017-01-24 |
2023-08-13 |
Not clear |
| Fen Li, Yun-Bin Zhao, Ding-Kun Wang, Xin Zou, Ke Fang, Kai-Fu Wan. Berberine relieves insulin resistance via the cholinergic anti-inflammatory pathway in HepG2 cells. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 36. issue 1. 2016-12-30. PMID:26838742. |
the mechanism may be related to the cholinergic anti-inflammatory pathway and the inhibition of ache activity. |
2016-12-30 |
2023-08-13 |
Not clear |
| Samanta Oliveira Loureiro, Daniele Susana Volkart Sidegum, Helena Biasibetti, Mery Stefani Leivas Pereira, Diogo Losch de Oliveira, Regina Pessoa-Pureur, Angela T S Wys. Crosstalk Among Disrupted Glutamatergic and Cholinergic Homeostasis and Inflammatory Response in Mechanisms Elicited by Proline in Astrocytes. Molecular neurobiology. vol 53. issue 2. 2016-12-13. PMID:25579384. |
we also evidenced misregulation of cholinergic anti-inflammatory system with increased acetylcholinesterase (ache) activity and decreased acetylcholine (ach) levels, contributing to the inflammatory status in pro-treated astrocytes. |
2016-12-13 |
2023-08-13 |
rat |
| Samanta Oliveira Loureiro, Daniele Susana Volkart Sidegum, Helena Biasibetti, Mery Stefani Leivas Pereira, Diogo Losch de Oliveira, Regina Pessoa-Pureur, Angela T S Wys. Crosstalk Among Disrupted Glutamatergic and Cholinergic Homeostasis and Inflammatory Response in Mechanisms Elicited by Proline in Astrocytes. Molecular neurobiology. vol 53. issue 2. 2016-12-13. PMID:25579384. |
our findings highlighted a crosstalk among disrupted glutamate homeostasis, cholinergic mechanisms, and inflammatory cytokines, since ionotropic (dl-ap5 and cnqx) and metabotropic (mcpg and mpep) glutamate antagonists were able to restore the extracellular glutamate and glutamine levels; downregulate tnfα and il6 production/release, modulate gs and ache activities; and restore ach levels. |
2016-12-13 |
2023-08-13 |
rat |
| Sriranjini Venkat Rao, Muralidhara, Sarat Chandra Yenisetti, Padmanabhan S Rajin. Evidence of neuroprotective effects of saffron and crocin in a Drosophila model of parkinsonism. Neurotoxicology. vol 52. 2016-12-13. PMID:26705857. |
while rot elevated the activity of acetylcholinesterase (ache) in head/body regions, both the treatments caused marked diminution of ache activity and restored the dopamine levels suggesting their effectiveness to mitigate cholinergic function. |
2016-12-13 |
2023-08-13 |
drosophila_melanogaster |
| Rabindranath Lo, Nellore Bhanu Chandar, Shibaji Ghosh, Bishwajit Gangul. The reactivation of tabun-inhibited mutant AChE with Ortho-7: steered molecular dynamics and quantum chemical studies. Molecular bioSystems. vol 12. issue 4. 2016-12-13. PMID:26879641. |
a highly toxic nerve agent, tabun, can inhibit acetylcholinesterase (ache) at cholinergic sites, which leads to serious cardiovascular complications, respiratory compromise and death. |
2016-12-13 |
2023-08-13 |
Not clear |
| Anders Allgardsson, Lotta Berg, Christine Akfur, Andreas Hörnberg, Franz Worek, Anna Linusson, Fredrik J Ekströ. Structure of a prereaction complex between the nerve agent sarin, its biological target acetylcholinesterase, and the antidote HI-6. Proceedings of the National Academy of Sciences of the United States of America. vol 113. issue 20. 2016-12-13. PMID:27140636. |
organophosphorus nerve agents interfere with cholinergic signaling by covalently binding to the active site of the enzyme acetylcholinesterase (ache). |
2016-12-13 |
2023-08-13 |
mouse |
| Alessandra Antunes dos Santos, Aline Aita Naime, Jade de Oliveira, Dirleise Colle, Danúbia Bonfanti dos Santos, Mariana Appel Hort, Eduardo Luiz Gasnhar Moreira, Cristina Suñol, Andreza Fabro de Bem, Marcelo Farin. Long-term and low-dose malathion exposure causes cognitive impairment in adult mice: evidence of hippocampal mitochondrial dysfunction, astrogliosis and apoptotic events. Archives of toxicology. vol 90. issue 3. 2016-11-14. PMID:25618550. |
the organophosphorus (op) pesticide malathion is a neurotoxic compound whose acute toxicity is primarily caused by the inhibition of acetylcholinesterase (ache), leading to cholinergic syndrome-related symptoms. |
2016-11-14 |
2023-08-13 |
mouse |
| Alessandra Antunes dos Santos, Aline Aita Naime, Jade de Oliveira, Dirleise Colle, Danúbia Bonfanti dos Santos, Mariana Appel Hort, Eduardo Luiz Gasnhar Moreira, Cristina Suñol, Andreza Fabro de Bem, Marcelo Farin. Long-term and low-dose malathion exposure causes cognitive impairment in adult mice: evidence of hippocampal mitochondrial dysfunction, astrogliosis and apoptotic events. Archives of toxicology. vol 90. issue 3. 2016-11-14. PMID:25618550. |
this study evaluated the effects of a repeated (15-day period) and low-dose malathion exposure on spatial memory and discrimination (object location task), as well as on biochemical parameters in the hippocampus of mice [ache and mitochondrial chain complexes activities; levels of proapoptotic proteins (bax and bak) and cholinergic neuronal and astroglial markers (chat and gfap, respectively)]. |
2016-11-14 |
2023-08-13 |
mouse |
| Alessandra Antunes dos Santos, Aline Aita Naime, Jade de Oliveira, Dirleise Colle, Danúbia Bonfanti dos Santos, Mariana Appel Hort, Eduardo Luiz Gasnhar Moreira, Cristina Suñol, Andreza Fabro de Bem, Marcelo Farin. Long-term and low-dose malathion exposure causes cognitive impairment in adult mice: evidence of hippocampal mitochondrial dysfunction, astrogliosis and apoptotic events. Archives of toxicology. vol 90. issue 3. 2016-11-14. PMID:25618550. |
malathion treatments (30 and 100 mg/kg, s.c.) did not affect the body weight of animals and caused no evident signs of cholinergic toxicity throughout the treatment, although the highest dose (100 mg/kg) was associated with inhibition of ache activity. |
2016-11-14 |
2023-08-13 |
mouse |
| A Patricio-Martínez, L Mendieta, I Martínez, J Aguilera, I D Limó. The recombinant C-terminal fragment of tetanus toxin protects against cholinotoxicity by intraseptal injection of β-amyloid peptide (25-35) in rats. Neuroscience. vol 315. 2016-10-19. PMID:26687435. |
the brains were removed to assess cholinergic markers, such as choline acetyltransferase (chat) and acetylcholinesterase (ache), and to explore neurodegeneration in the ms and hippocampus, using amino-cupric silver and h&e staining. |
2016-10-19 |
2023-08-13 |
rat |
| A Patricio-Martínez, L Mendieta, I Martínez, J Aguilera, I D Limó. The recombinant C-terminal fragment of tetanus toxin protects against cholinotoxicity by intraseptal injection of β-amyloid peptide (25-35) in rats. Neuroscience. vol 315. 2016-10-19. PMID:26687435. |
finally, capase-3, a marker of apoptosis, was examined in the ms. our results clearly demonstrate that the application of hc-tetx prevents the loss of cholinergic markers (chat and ache), the activation of capase-3, and neurodegeneration in the ms and the ca1 and ca3 subfields of the hippocampus. |
2016-10-19 |
2023-08-13 |
rat |
| Jana Zdarova Karasova, Milos Hroch, Kamil Musilek, Kamil Kuc. Small Quaternary Inhibitors K298 and K524: Cholinesterases Inhibition, Absorption, Brain Distribution, and Toxicity. Neurotoxicity research. vol 29. issue 2. 2016-10-14. PMID:26646154. |
inhibitors of acetylcholinesterase (ache) may be used in the treatment of various cholinergic deficits, among them being myasthenia gravis (mg). |
2016-10-14 |
2023-08-13 |
Not clear |
| Wen Luo, Ying Chen, Ting Wang, Chen Hong, Li-Ping Chang, Cong-Cong Chang, Ya-Cheng Yang, Song-Qiang Xie, Chao-Jie Wan. Design, synthesis and evaluation of novel 7-aminoalkyl-substituted flavonoid derivatives with improved cholinesterase inhibitory activities. Bioorganic & medicinal chemistry. vol 24. issue 4. 2016-10-14. PMID:26752094. |
compound 2-(naphthalen-1-yl)-7-(8-(pyrrolidin-1-yl)octyloxy)-4h-chromen-4-one (5q) showed the best inhibitory activity (ic50, 0.64μm for ache and 0.42μm for bche) which were better than our previously reported compounds and the commercially available cholinergic agent rivastigmine. |
2016-10-14 |
2023-08-13 |
Not clear |
| Saw Simeon, Nuttapat Anuwongcharoen, Watshara Shoombuatong, Aijaz Ahmad Malik, Virapong Prachayasittikul, Jarl E S Wikberg, Chanin Nantasenama. Probing the origins of human acetylcholinesterase inhibition via QSAR modeling and molecular docking. PeerJ. vol 4. 2016-09-07. PMID:27602288. |
as per the cholinergic hypothesis, the deficiency of choline is responsible for ad; therefore, the inhibition of ache is a lucrative therapeutic strategy for the treatment of ad. |
2016-09-07 |
2023-08-13 |
human |