| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jucimara Baldissarelli, Adriana Santi, Roberta Schmatz, Fátima Husein Abdalla, Andréia Machado Cardoso, Caroline Curry Martins, Glaecir R Mundstock Dias, Nicéia Spanholi Calgaroto, Luana Paula Pelinson, Karine Paula Reichert, Vania Lucia Loro, Vera Maria Melchiors Morsch, Maria Rosa Chitolina Schetinge. Hypothyroidism Enhanced Ectonucleotidases and Acetylcholinesterase Activities in Rat Synaptosomes can be Prevented by the Naturally Occurring Polyphenol Quercetin. Cellular and molecular neurobiology. vol 37. issue 1. 2017-02-13. PMID:26879755. |
this study demonstrated changes in the 5'-nucleotidase and ache activities indicating that purinergic and cholinergic neurotransmission are altered in this condition. |
2017-02-13 |
2023-08-13 |
rat |
| b' Valentina Bu\\xc5\\xa1i\\xc4\\x87, Maja Katalini\\xc4\\x87, Goran \\xc5\\xa0inko, Zrinka Kovarik, Dajana Ga\\xc5\\xa1o-Soka\\xc4\\x8. Pyridoxal oxime derivative potency to reactivate cholinesterases inhibited by organophosphorus compounds. Toxicology letters. vol 262. 2017-02-06. PMID:27693733.' |
organophosphorus (op) nerve agents (sarin, tabun vx and soman) inhibit the enzyme acetylcholinesterase (ache, ec 3.1.1.7) by binding to its active site while preventing neurotransmission in the cholinergic synapses. |
2017-02-06 |
2023-08-13 |
human |
| Nikolina Maček Hrvat, Suzana Žunec, Palmer Taylor, Zoran Radić, Zrinka Kovari. HI-6 assisted catalytic scavenging of VX by acetylcholinesterase choline binding site mutants. Chemico-biological interactions. vol 259. issue Pt B. 2017-02-01. PMID:27083141. |
the high toxicity of organophosphorus compounds originates from covalent inhibition of acetylcholinesterase (ache), an essential enzyme in cholinergic neurotransmission. |
2017-02-01 |
2023-08-13 |
mouse |
| Franz Worek, Horst Thiermann, Timo Will. Oximes in organophosphate poisoning: 60 years of hope and despair. Chemico-biological interactions. vol 259. issue Pt B. 2017-02-01. PMID:27125761. |
multiple in vitro and in vivo studies investigated the potential of oximes to reactivate op-inhibited ache and to reverse op-induced cholinergic signs. |
2017-02-01 |
2023-08-13 |
Not clear |
| Gopenath Thangaraj, Vadim Manakov, Aljona Cucu, Claudia Fournier, Paul G Laye. Inflammatory effects of TNFα are counteracted by X-ray irradiation and AChE inhibition in mouse micromass cultures. Chemico-biological interactions. vol 259. issue Pt B. 2017-01-30. PMID:27019294. |
after irradiation, both ache and alkaline phosphatase (alp) activities, a marker for bone mineralization, were raised, suggesting that x-rays stimulated cholinergic mechanisms during calcification. |
2017-01-30 |
2023-08-13 |
mouse |
| Miranda L Xu, Cathy W C Bi, Ava Y Y Kong, Tina T X Dong, Yung H Wong, Karl W K Tsi. Flavonoids induce the expression of acetylcholinesterase in cultured osteoblasts. Chemico-biological interactions. vol 259. issue Pt B. 2017-01-30. PMID:27019979. |
here, we aimed to test if flavonoid could induce a cholinergic enzyme, acetylcholinesterase (ache), as well as bone differentiation. |
2017-01-30 |
2023-08-13 |
rat |
| Natalia N Nalivaeva, Anthony J Turne. AChE and the amyloid precursor protein (APP) - Cross-talk in Alzheimer's disease. Chemico-biological interactions. vol 259. issue Pt B. 2017-01-30. PMID:27062894. |
app is the precursor of the aβ peptide, the pathological agent in ad, while ache is linked to its pathogenesis either by increasing cholinergic deficit or exacerbating aβ fibril formation and toxicity. |
2017-01-30 |
2023-08-13 |
Not clear |
| Natalia N Nalivaeva, Anthony J Turne. AChE and the amyloid precursor protein (APP) - Cross-talk in Alzheimer's disease. Chemico-biological interactions. vol 259. issue Pt B. 2017-01-30. PMID:27062894. |
both can be released from the cell membrane and we have shown that ache shedding involves a metalloproteinase-mediated mechanism which, like the α-secretase dependent cleavage of app, is stimulated by cholinergic agonists. |
2017-01-30 |
2023-08-13 |
Not clear |
| Natalia N Nalivaeva, Anthony J Turne. AChE and the amyloid precursor protein (APP) - Cross-talk in Alzheimer's disease. Chemico-biological interactions. vol 259. issue Pt B. 2017-01-30. PMID:27062894. |
on the contrary, sirna knock-down of app in cholinergic sn56 cells resulted in a significant upregulation of ache mrna levels. |
2017-01-30 |
2023-08-13 |
Not clear |
| Heidi Q Xie, Tuan Xu, Yangsheng Chen, Yunping Li, Yingjie Xia, Sherry L Xu, Lingyun Wang, Karl W K Tsim, Bin Zha. New perspectives for multi-level regulations of neuronal acetylcholinesterase by dioxins. Chemico-biological interactions. vol 259. issue Pt B. 2017-01-30. PMID:27374124. |
acetylcholinesterase (ache; ec 3.1.1.7) is a vital functional enzyme in cholinergic neurotransmission which can rapidly hydrolyze neurotransmitter, acetylcholine, in the central and peripheral nervous systems. |
2017-01-30 |
2023-08-13 |
mouse |
| Javier Del Pino, Gabriela Zeballos, María José Anadón, Paula Moyano, María Jesús Díaz, José Manuel García, María Teresa Frej. Cadmium-induced cell death of basal forebrain cholinergic neurons mediated by muscarinic M1 receptor blockade, increase in GSK-3β enzyme, β-amyloid and tau protein levels. Archives of toxicology. vol 90. issue 5. 2017-01-24. PMID:26026611. |
in this regard, we described in a previous work that cadmium blocks cholinergic transmission and induces a more pronounced cell death on cholinergic neurons from basal forebrain which is partially mediated by ache overexpression. |
2017-01-24 |
2023-08-13 |
Not clear |
| Javier Del Pino, Gabriela Zeballos, María José Anadón, Paula Moyano, María Jesús Díaz, José Manuel García, María Teresa Frej. Cadmium-induced cell death of basal forebrain cholinergic neurons mediated by muscarinic M1 receptor blockade, increase in GSK-3β enzyme, β-amyloid and tau protein levels. Archives of toxicology. vol 90. issue 5. 2017-01-24. PMID:26026611. |
for this purpose, we evaluated, in sn56 cholinergic mourine septal cell line from basal forebrain region, the cadmium toxic effects on neuronal viability through muscarinic m1 receptor, ache splice variants, gsk-3β enzyme, aβ and tau proteins. |
2017-01-24 |
2023-08-13 |
Not clear |
| Javier Del Pino, Gabriela Zeballos, María José Anadón, Paula Moyano, María Jesús Díaz, José Manuel García, María Teresa Frej. Cadmium-induced cell death of basal forebrain cholinergic neurons mediated by muscarinic M1 receptor blockade, increase in GSK-3β enzyme, β-amyloid and tau protein levels. Archives of toxicology. vol 90. issue 5. 2017-01-24. PMID:26026611. |
our present results provide new understanding of the mechanisms contributing to the harmful effects of cadmium on cholinergic neurons and suggest that cadmium could mediate these mechanisms by m1r blockade through ache splices altered expression. |
2017-01-24 |
2023-08-13 |
Not clear |
| Fen Li, Yun-Bin Zhao, Ding-Kun Wang, Xin Zou, Ke Fang, Kai-Fu Wan. Berberine relieves insulin resistance via the cholinergic anti-inflammatory pathway in HepG2 cells. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 36. issue 1. 2016-12-30. PMID:26838742. |
the mechanism may be related to the cholinergic anti-inflammatory pathway and the inhibition of ache activity. |
2016-12-30 |
2023-08-13 |
Not clear |
| Samanta Oliveira Loureiro, Daniele Susana Volkart Sidegum, Helena Biasibetti, Mery Stefani Leivas Pereira, Diogo Losch de Oliveira, Regina Pessoa-Pureur, Angela T S Wys. Crosstalk Among Disrupted Glutamatergic and Cholinergic Homeostasis and Inflammatory Response in Mechanisms Elicited by Proline in Astrocytes. Molecular neurobiology. vol 53. issue 2. 2016-12-13. PMID:25579384. |
we also evidenced misregulation of cholinergic anti-inflammatory system with increased acetylcholinesterase (ache) activity and decreased acetylcholine (ach) levels, contributing to the inflammatory status in pro-treated astrocytes. |
2016-12-13 |
2023-08-13 |
rat |
| Samanta Oliveira Loureiro, Daniele Susana Volkart Sidegum, Helena Biasibetti, Mery Stefani Leivas Pereira, Diogo Losch de Oliveira, Regina Pessoa-Pureur, Angela T S Wys. Crosstalk Among Disrupted Glutamatergic and Cholinergic Homeostasis and Inflammatory Response in Mechanisms Elicited by Proline in Astrocytes. Molecular neurobiology. vol 53. issue 2. 2016-12-13. PMID:25579384. |
our findings highlighted a crosstalk among disrupted glutamate homeostasis, cholinergic mechanisms, and inflammatory cytokines, since ionotropic (dl-ap5 and cnqx) and metabotropic (mcpg and mpep) glutamate antagonists were able to restore the extracellular glutamate and glutamine levels; downregulate tnfα and il6 production/release, modulate gs and ache activities; and restore ach levels. |
2016-12-13 |
2023-08-13 |
rat |
| Sriranjini Venkat Rao, Muralidhara, Sarat Chandra Yenisetti, Padmanabhan S Rajin. Evidence of neuroprotective effects of saffron and crocin in a Drosophila model of parkinsonism. Neurotoxicology. vol 52. 2016-12-13. PMID:26705857. |
while rot elevated the activity of acetylcholinesterase (ache) in head/body regions, both the treatments caused marked diminution of ache activity and restored the dopamine levels suggesting their effectiveness to mitigate cholinergic function. |
2016-12-13 |
2023-08-13 |
drosophila_melanogaster |
| Rabindranath Lo, Nellore Bhanu Chandar, Shibaji Ghosh, Bishwajit Gangul. The reactivation of tabun-inhibited mutant AChE with Ortho-7: steered molecular dynamics and quantum chemical studies. Molecular bioSystems. vol 12. issue 4. 2016-12-13. PMID:26879641. |
a highly toxic nerve agent, tabun, can inhibit acetylcholinesterase (ache) at cholinergic sites, which leads to serious cardiovascular complications, respiratory compromise and death. |
2016-12-13 |
2023-08-13 |
Not clear |
| Anders Allgardsson, Lotta Berg, Christine Akfur, Andreas Hörnberg, Franz Worek, Anna Linusson, Fredrik J Ekströ. Structure of a prereaction complex between the nerve agent sarin, its biological target acetylcholinesterase, and the antidote HI-6. Proceedings of the National Academy of Sciences of the United States of America. vol 113. issue 20. 2016-12-13. PMID:27140636. |
organophosphorus nerve agents interfere with cholinergic signaling by covalently binding to the active site of the enzyme acetylcholinesterase (ache). |
2016-12-13 |
2023-08-13 |
mouse |
| Alessandra Antunes dos Santos, Aline Aita Naime, Jade de Oliveira, Dirleise Colle, Danúbia Bonfanti dos Santos, Mariana Appel Hort, Eduardo Luiz Gasnhar Moreira, Cristina Suñol, Andreza Fabro de Bem, Marcelo Farin. Long-term and low-dose malathion exposure causes cognitive impairment in adult mice: evidence of hippocampal mitochondrial dysfunction, astrogliosis and apoptotic events. Archives of toxicology. vol 90. issue 3. 2016-11-14. PMID:25618550. |
the organophosphorus (op) pesticide malathion is a neurotoxic compound whose acute toxicity is primarily caused by the inhibition of acetylcholinesterase (ache), leading to cholinergic syndrome-related symptoms. |
2016-11-14 |
2023-08-13 |
mouse |