| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Javier Del Pino, Gabriela Zeballos, María José Anadon, María Jesús Díaz, Paula Moyano, Gloria Gómez Díaz, Jimena García, Margarita Lobo, María Teresa Frej. Muscarinic M1 receptor partially modulates higher sensitivity to cadmium-induced cell death in primary basal forebrain cholinergic neurons: A cholinesterase variants dependent mechanism. Toxicology. vol 361-362. 2017-05-01. PMID:27377441. |
it also induces cell death in sn56 cholinergic neurons from the basal forebrain through m1r blockage, alterations in the expression of ache variants and gsk-3β, and an increase in aβ and total and phosphorylated tau protein levels. |
2017-05-01 |
2023-08-13 |
Not clear |
| Javier Del Pino, Gabriela Zeballos, María José Anadon, María Jesús Díaz, Paula Moyano, Gloria Gómez Díaz, Jimena García, Margarita Lobo, María Teresa Frej. Muscarinic M1 receptor partially modulates higher sensitivity to cadmium-induced cell death in primary basal forebrain cholinergic neurons: A cholinesterase variants dependent mechanism. Toxicology. vol 361-362. 2017-05-01. PMID:27377441. |
accordingly, we hypothesized that cholinergic transmission blockage and higher sensitivity to cadmium-induced cell death of primary basal forebrain cholinergic neurons is mediated by m1r blockage, which triggers this effect through alteration of the expression of ache variants. |
2017-05-01 |
2023-08-13 |
Not clear |
| Javier Del Pino, Gabriela Zeballos, María José Anadon, María Jesús Díaz, Paula Moyano, Gloria Gómez Díaz, Jimena García, Margarita Lobo, María Teresa Frej. Muscarinic M1 receptor partially modulates higher sensitivity to cadmium-induced cell death in primary basal forebrain cholinergic neurons: A cholinesterase variants dependent mechanism. Toxicology. vol 361-362. 2017-05-01. PMID:27377441. |
to prove this hypothesis, we evaluated, in primary culture from the basal forebrain region, whether m1r silencing induces greater cell death in cholinergic neurons than cadmium does, and whether in sn56 cells m1r mediates the mechanisms described so as to play a part in the cadmium induction of cholinergic transmission blockage and cell death in this cell line through alteration of the expression of ache variants. |
2017-05-01 |
2023-08-13 |
Not clear |
| Javier Del Pino, Gabriela Zeballos, María José Anadon, María Jesús Díaz, Paula Moyano, Gloria Gómez Díaz, Jimena García, Margarita Lobo, María Teresa Frej. Muscarinic M1 receptor partially modulates higher sensitivity to cadmium-induced cell death in primary basal forebrain cholinergic neurons: A cholinesterase variants dependent mechanism. Toxicology. vol 361-362. 2017-05-01. PMID:27377441. |
moreover, all previously described mechanisms for blocking cholinergic transmission and inducing cell death on sn56 cells after cadmium exposure are partially mediated by m1r through the alteration of ache expression. |
2017-05-01 |
2023-08-13 |
Not clear |
| G A Toledo-Ibarra, K J G Díaz-Resendiz, L Pavón-Romero, A E Rojas-García, I M Medina-Díaz, M I Girón-Pére. Effects of diazinon on the lymphocytic cholinergic system of Nile tilapia fish (Oreochromis niloticus). Veterinary immunology and immunopathology. vol 176. 2017-04-07. PMID:27260186. |
the obtained results indicate that acute exposure to diazinon induces an increase in ach concentration and a decrease in nachr and machr concentrations and ache activity in fish immune cells, this suggests that the non-neuronal lymphocytic cholinergic system may be the main target in the mechanism of op immunotoxicity. |
2017-04-07 |
2023-08-13 |
Not clear |
| Ganiyu Oboh, Omodesola O Ogunruku, Sunday I Oyeleye, Tosin A Olasehinde, Ayokunle O Ademosun, Aline Augusti Boligo. Phenolic Extracts from Clerodendrum volubile Leaves Inhibit Cholinergic and Monoaminergic Enzymes Relevant to the Management of Some Neurodegenerative Diseases. Journal of dietary supplements. vol 14. issue 3. 2017-04-03. PMID:27753518. |
this study investigated the inhibitory effects of phenolic-rich extracts from clerodendrum volubile leaves on cholinergic [acetylcholinesterase (ache) and butyrylcholinesterase (bche)] and monoaminergic [monoamine oxidase (mao)] enzymes' activities and pro-oxidants [fe |
2017-04-03 |
2023-08-13 |
Not clear |
| Matheus D Baldissera, Carine F Souza, Pedro Henrique Doleski, Guerino B Júnior, Agueda C de Vargas, Bernardo Baldisserott. Involvement of cholinergic and purinergic systems during the inflammatory response caused by Aeromonas hydrophila in Rhamdia quelen. Microbial pathogenesis. vol 99. 2017-03-27. PMID:27521226. |
the aim of this study was to evaluate the cholinergic (acetylcholinesterase (ache) and butyrylcholinesterase (bche)) and purinergic (adenosine deaminase (ada)) systems in head kidney, spleen, total blood and serum samples in experimentally infected fish with a. hydrophila, and the involvement of these systems during the inflammatory process. |
2017-03-27 |
2023-08-13 |
Not clear |
| Matheus D Baldissera, Carine F Souza, Thirssa H Grando, Aleksandro S da Silva, Silvia G Monteir. Involvement of oxidative stress, cholinergic and adenosinergic systems on renal damage caused by Trypanosoma evansi infection: Relationship with lipid peroxidation. Microbial pathogenesis. vol 99. 2017-03-27. PMID:27565091. |
the aim of this study was to evaluate the oxidative stress variables, and enzymes of cholinergic (acetylcholinesterase (ache) and butyrylcholinesterase (bche)) and adenosinergic (adenosine deaminase (ada)) systems in renal tissue, as well as the relationship between these systems and lipid peroxidation. |
2017-03-27 |
2023-08-13 |
cat |
| Willyan Franco Hilario, Alice Laschuk Herlinger, Lorena Bianchine Areal, Lívia Silveira de Moraes, Tamara Andrea Alarcon Ferreira, Tassiane Emanuelle Servane Andrade, Cristina Martins-Silva, Rita Gomes Wanderley Pire. Cholinergic and Dopaminergic Alterations in Nigrostriatal Neurons Are Involved in Environmental Enrichment Motor Protection in a Mouse Model of Parkinson's Disease. Journal of molecular neuroscience : MN. vol 60. issue 4. 2017-03-23. PMID:27660217. |
as for the cholinergic system, mptp led to a decrease in the chat gene expression while increasing the expression of both ache and m1r. |
2017-03-23 |
2023-08-13 |
mouse |
| Stanton F McHardy, Hua-Yu Leo Wang, Shelby V McCowen, Matthew C Valde. Recent advances in acetylcholinesterase Inhibitors and Reactivators: an update on the patent literature (2012-2015). Expert opinion on therapeutic patents. vol 27. issue 4. 2017-03-22. PMID:27967267. |
in contrast, strong inhibition of ache can lead to cholinergic poisoning. |
2017-03-22 |
2023-08-13 |
Not clear |
| Jintanaporn Wattanathorn, Chatchada Sutalangk. Novel Food Supplement "CP1" Improves Motor Deficit, Cognitive Function, and Neurodegeneration in Animal Model of Parkinson's Disease. Rejuvenation research. vol 19. issue 4. 2017-03-21. PMID:26414358. |
based on pivotal roles of oxidative stress, dopaminergic and cholinergic systems on the pathophysiology of parkinson's disease (pd), the searching for functional food for patients attacked with pd from cyperus rotundus and zingiber officinale, the substances possessing antioxidant activity, and the suppression effects on monoamine oxidase b (mao-b) and acetylcholinesterase (ache) have been considered. |
2017-03-21 |
2023-08-13 |
rat |
| Hyolanda M Grosskopf, Rhayana K Grosskopf, Angelisa H Biazus, Marta L R Leal, Nathieli B Bottari, Mariana S Alves, Maria Rosa C Schetinger, Vera M Morsch, Gustavo Machado, Matheus D Baldissera, Aleksandro S Da Silv. Supplementation with copper edetate in control of Haemonchus contortus of sheep, and its effect on cholinesterase's and superoxide dismutase activities. Experimental parasitology. vol 173. 2017-03-13. PMID:28007539. |
cholinergic system was evaluated to determine the acetylcholinesterase (ache) activity in total blood and butyrylcholinesterase (bche) activity in serum. |
2017-03-13 |
2023-08-13 |
cat |
| Daniela Galimberti, Elio Scarpin. Old and new acetylcholinesterase inhibitors for Alzheimer's disease. Expert opinion on investigational drugs. vol 25. issue 10. 2017-03-10. PMID:27459153. |
acheis reversibly inhibit acetylcholinesterase (ache), thus increasing the availability of acetylcholine in cholinergic synapses, enhancing cholinergic transmission. |
2017-03-10 |
2023-08-13 |
Not clear |
| Roman Roy, Flavia Niccolini, Gennaro Pagano, Marios Politi. Cholinergic imaging in dementia spectrum disorders. European journal of nuclear medicine and molecular imaging. vol 43. issue 7. 2017-02-24. PMID:26984612. |
spect and pet studies using selective radioligands for cholinergic markers, such as [(11)c]mp4a and [(11)c]pmp pet for acetylcholinesterase (ache), [(123)i]5ia spect for the α4β2 nicotinic acetylcholine receptor and [(123)i]ibvm spect for the vesicular acetylcholine transporter, have been developed in an attempt to clarify those aspects of the diseases that remain unclear. |
2017-02-24 |
2023-08-13 |
Not clear |
| İlhami Gülçin, Andrea Scozzafava, Claudiu T Supuran, Hulya Akıncıoğlu, Zeynep Koksal, Fikret Turkan, Saleh Alwase. The effect of caffeic acid phenethyl ester (CAPE) on metabolic enzymes including acetylcholinesterase, butyrylcholinesterase, glutathione S-transferase, lactoperoxidase, and carbonic anhydrase isoenzymes I, II, IX, and XII. Journal of enzyme inhibition and medicinal chemistry. vol 31. issue 6. 2017-02-21. PMID:26453427. |
acetylcholinesterase (ache) is responsible for acetyl choline (ach) hydrolysis and plays a fundamental role in nerve impulse transmission by terminating the action of the ach neurotransmitter at cholinergic synapses and neuromuscular junctions. |
2017-02-21 |
2023-08-13 |
human |
| Jucimara Baldissarelli, Adriana Santi, Roberta Schmatz, Fátima Husein Abdalla, Andréia Machado Cardoso, Caroline Curry Martins, Glaecir R Mundstock Dias, Nicéia Spanholi Calgaroto, Luana Paula Pelinson, Karine Paula Reichert, Vania Lucia Loro, Vera Maria Melchiors Morsch, Maria Rosa Chitolina Schetinge. Hypothyroidism Enhanced Ectonucleotidases and Acetylcholinesterase Activities in Rat Synaptosomes can be Prevented by the Naturally Occurring Polyphenol Quercetin. Cellular and molecular neurobiology. vol 37. issue 1. 2017-02-13. PMID:26879755. |
this study demonstrated changes in the 5'-nucleotidase and ache activities indicating that purinergic and cholinergic neurotransmission are altered in this condition. |
2017-02-13 |
2023-08-13 |
rat |
| b' Valentina Bu\\xc5\\xa1i\\xc4\\x87, Maja Katalini\\xc4\\x87, Goran \\xc5\\xa0inko, Zrinka Kovarik, Dajana Ga\\xc5\\xa1o-Soka\\xc4\\x8. Pyridoxal oxime derivative potency to reactivate cholinesterases inhibited by organophosphorus compounds. Toxicology letters. vol 262. 2017-02-06. PMID:27693733.' |
organophosphorus (op) nerve agents (sarin, tabun vx and soman) inhibit the enzyme acetylcholinesterase (ache, ec 3.1.1.7) by binding to its active site while preventing neurotransmission in the cholinergic synapses. |
2017-02-06 |
2023-08-13 |
human |
| Nikolina Maček Hrvat, Suzana Žunec, Palmer Taylor, Zoran Radić, Zrinka Kovari. HI-6 assisted catalytic scavenging of VX by acetylcholinesterase choline binding site mutants. Chemico-biological interactions. vol 259. issue Pt B. 2017-02-01. PMID:27083141. |
the high toxicity of organophosphorus compounds originates from covalent inhibition of acetylcholinesterase (ache), an essential enzyme in cholinergic neurotransmission. |
2017-02-01 |
2023-08-13 |
mouse |
| Franz Worek, Horst Thiermann, Timo Will. Oximes in organophosphate poisoning: 60 years of hope and despair. Chemico-biological interactions. vol 259. issue Pt B. 2017-02-01. PMID:27125761. |
multiple in vitro and in vivo studies investigated the potential of oximes to reactivate op-inhibited ache and to reverse op-induced cholinergic signs. |
2017-02-01 |
2023-08-13 |
Not clear |
| Gopenath Thangaraj, Vadim Manakov, Aljona Cucu, Claudia Fournier, Paul G Laye. Inflammatory effects of TNFα are counteracted by X-ray irradiation and AChE inhibition in mouse micromass cultures. Chemico-biological interactions. vol 259. issue Pt B. 2017-01-30. PMID:27019294. |
after irradiation, both ache and alkaline phosphatase (alp) activities, a marker for bone mineralization, were raised, suggesting that x-rays stimulated cholinergic mechanisms during calcification. |
2017-01-30 |
2023-08-13 |
mouse |