| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Stanton F McHardy, Hua-Yu Leo Wang, Shelby V McCowen, Matthew C Valde. Recent advances in acetylcholinesterase Inhibitors and Reactivators: an update on the patent literature (2012-2015). Expert opinion on therapeutic patents. vol 27. issue 4. 2017-03-22. PMID:27967267. |
in contrast, strong inhibition of ache can lead to cholinergic poisoning. |
2017-03-22 |
2023-08-13 |
Not clear |
| Jintanaporn Wattanathorn, Chatchada Sutalangk. Novel Food Supplement "CP1" Improves Motor Deficit, Cognitive Function, and Neurodegeneration in Animal Model of Parkinson's Disease. Rejuvenation research. vol 19. issue 4. 2017-03-21. PMID:26414358. |
based on pivotal roles of oxidative stress, dopaminergic and cholinergic systems on the pathophysiology of parkinson's disease (pd), the searching for functional food for patients attacked with pd from cyperus rotundus and zingiber officinale, the substances possessing antioxidant activity, and the suppression effects on monoamine oxidase b (mao-b) and acetylcholinesterase (ache) have been considered. |
2017-03-21 |
2023-08-13 |
rat |
| Hyolanda M Grosskopf, Rhayana K Grosskopf, Angelisa H Biazus, Marta L R Leal, Nathieli B Bottari, Mariana S Alves, Maria Rosa C Schetinger, Vera M Morsch, Gustavo Machado, Matheus D Baldissera, Aleksandro S Da Silv. Supplementation with copper edetate in control of Haemonchus contortus of sheep, and its effect on cholinesterase's and superoxide dismutase activities. Experimental parasitology. vol 173. 2017-03-13. PMID:28007539. |
cholinergic system was evaluated to determine the acetylcholinesterase (ache) activity in total blood and butyrylcholinesterase (bche) activity in serum. |
2017-03-13 |
2023-08-13 |
cat |
| Daniela Galimberti, Elio Scarpin. Old and new acetylcholinesterase inhibitors for Alzheimer's disease. Expert opinion on investigational drugs. vol 25. issue 10. 2017-03-10. PMID:27459153. |
acheis reversibly inhibit acetylcholinesterase (ache), thus increasing the availability of acetylcholine in cholinergic synapses, enhancing cholinergic transmission. |
2017-03-10 |
2023-08-13 |
Not clear |
| Roman Roy, Flavia Niccolini, Gennaro Pagano, Marios Politi. Cholinergic imaging in dementia spectrum disorders. European journal of nuclear medicine and molecular imaging. vol 43. issue 7. 2017-02-24. PMID:26984612. |
spect and pet studies using selective radioligands for cholinergic markers, such as [(11)c]mp4a and [(11)c]pmp pet for acetylcholinesterase (ache), [(123)i]5ia spect for the α4β2 nicotinic acetylcholine receptor and [(123)i]ibvm spect for the vesicular acetylcholine transporter, have been developed in an attempt to clarify those aspects of the diseases that remain unclear. |
2017-02-24 |
2023-08-13 |
Not clear |
| İlhami Gülçin, Andrea Scozzafava, Claudiu T Supuran, Hulya Akıncıoğlu, Zeynep Koksal, Fikret Turkan, Saleh Alwase. The effect of caffeic acid phenethyl ester (CAPE) on metabolic enzymes including acetylcholinesterase, butyrylcholinesterase, glutathione S-transferase, lactoperoxidase, and carbonic anhydrase isoenzymes I, II, IX, and XII. Journal of enzyme inhibition and medicinal chemistry. vol 31. issue 6. 2017-02-21. PMID:26453427. |
acetylcholinesterase (ache) is responsible for acetyl choline (ach) hydrolysis and plays a fundamental role in nerve impulse transmission by terminating the action of the ach neurotransmitter at cholinergic synapses and neuromuscular junctions. |
2017-02-21 |
2023-08-13 |
human |
| Jucimara Baldissarelli, Adriana Santi, Roberta Schmatz, Fátima Husein Abdalla, Andréia Machado Cardoso, Caroline Curry Martins, Glaecir R Mundstock Dias, Nicéia Spanholi Calgaroto, Luana Paula Pelinson, Karine Paula Reichert, Vania Lucia Loro, Vera Maria Melchiors Morsch, Maria Rosa Chitolina Schetinge. Hypothyroidism Enhanced Ectonucleotidases and Acetylcholinesterase Activities in Rat Synaptosomes can be Prevented by the Naturally Occurring Polyphenol Quercetin. Cellular and molecular neurobiology. vol 37. issue 1. 2017-02-13. PMID:26879755. |
this study demonstrated changes in the 5'-nucleotidase and ache activities indicating that purinergic and cholinergic neurotransmission are altered in this condition. |
2017-02-13 |
2023-08-13 |
rat |
| b' Valentina Bu\\xc5\\xa1i\\xc4\\x87, Maja Katalini\\xc4\\x87, Goran \\xc5\\xa0inko, Zrinka Kovarik, Dajana Ga\\xc5\\xa1o-Soka\\xc4\\x8. Pyridoxal oxime derivative potency to reactivate cholinesterases inhibited by organophosphorus compounds. Toxicology letters. vol 262. 2017-02-06. PMID:27693733.' |
organophosphorus (op) nerve agents (sarin, tabun vx and soman) inhibit the enzyme acetylcholinesterase (ache, ec 3.1.1.7) by binding to its active site while preventing neurotransmission in the cholinergic synapses. |
2017-02-06 |
2023-08-13 |
human |
| Nikolina Maček Hrvat, Suzana Žunec, Palmer Taylor, Zoran Radić, Zrinka Kovari. HI-6 assisted catalytic scavenging of VX by acetylcholinesterase choline binding site mutants. Chemico-biological interactions. vol 259. issue Pt B. 2017-02-01. PMID:27083141. |
the high toxicity of organophosphorus compounds originates from covalent inhibition of acetylcholinesterase (ache), an essential enzyme in cholinergic neurotransmission. |
2017-02-01 |
2023-08-13 |
mouse |
| Franz Worek, Horst Thiermann, Timo Will. Oximes in organophosphate poisoning: 60 years of hope and despair. Chemico-biological interactions. vol 259. issue Pt B. 2017-02-01. PMID:27125761. |
multiple in vitro and in vivo studies investigated the potential of oximes to reactivate op-inhibited ache and to reverse op-induced cholinergic signs. |
2017-02-01 |
2023-08-13 |
Not clear |
| Gopenath Thangaraj, Vadim Manakov, Aljona Cucu, Claudia Fournier, Paul G Laye. Inflammatory effects of TNFα are counteracted by X-ray irradiation and AChE inhibition in mouse micromass cultures. Chemico-biological interactions. vol 259. issue Pt B. 2017-01-30. PMID:27019294. |
after irradiation, both ache and alkaline phosphatase (alp) activities, a marker for bone mineralization, were raised, suggesting that x-rays stimulated cholinergic mechanisms during calcification. |
2017-01-30 |
2023-08-13 |
mouse |
| Miranda L Xu, Cathy W C Bi, Ava Y Y Kong, Tina T X Dong, Yung H Wong, Karl W K Tsi. Flavonoids induce the expression of acetylcholinesterase in cultured osteoblasts. Chemico-biological interactions. vol 259. issue Pt B. 2017-01-30. PMID:27019979. |
here, we aimed to test if flavonoid could induce a cholinergic enzyme, acetylcholinesterase (ache), as well as bone differentiation. |
2017-01-30 |
2023-08-13 |
rat |
| Natalia N Nalivaeva, Anthony J Turne. AChE and the amyloid precursor protein (APP) - Cross-talk in Alzheimer's disease. Chemico-biological interactions. vol 259. issue Pt B. 2017-01-30. PMID:27062894. |
app is the precursor of the aβ peptide, the pathological agent in ad, while ache is linked to its pathogenesis either by increasing cholinergic deficit or exacerbating aβ fibril formation and toxicity. |
2017-01-30 |
2023-08-13 |
Not clear |
| Natalia N Nalivaeva, Anthony J Turne. AChE and the amyloid precursor protein (APP) - Cross-talk in Alzheimer's disease. Chemico-biological interactions. vol 259. issue Pt B. 2017-01-30. PMID:27062894. |
both can be released from the cell membrane and we have shown that ache shedding involves a metalloproteinase-mediated mechanism which, like the α-secretase dependent cleavage of app, is stimulated by cholinergic agonists. |
2017-01-30 |
2023-08-13 |
Not clear |
| Natalia N Nalivaeva, Anthony J Turne. AChE and the amyloid precursor protein (APP) - Cross-talk in Alzheimer's disease. Chemico-biological interactions. vol 259. issue Pt B. 2017-01-30. PMID:27062894. |
on the contrary, sirna knock-down of app in cholinergic sn56 cells resulted in a significant upregulation of ache mrna levels. |
2017-01-30 |
2023-08-13 |
Not clear |
| Heidi Q Xie, Tuan Xu, Yangsheng Chen, Yunping Li, Yingjie Xia, Sherry L Xu, Lingyun Wang, Karl W K Tsim, Bin Zha. New perspectives for multi-level regulations of neuronal acetylcholinesterase by dioxins. Chemico-biological interactions. vol 259. issue Pt B. 2017-01-30. PMID:27374124. |
acetylcholinesterase (ache; ec 3.1.1.7) is a vital functional enzyme in cholinergic neurotransmission which can rapidly hydrolyze neurotransmitter, acetylcholine, in the central and peripheral nervous systems. |
2017-01-30 |
2023-08-13 |
mouse |
| Javier Del Pino, Gabriela Zeballos, María José Anadón, Paula Moyano, María Jesús Díaz, José Manuel García, María Teresa Frej. Cadmium-induced cell death of basal forebrain cholinergic neurons mediated by muscarinic M1 receptor blockade, increase in GSK-3β enzyme, β-amyloid and tau protein levels. Archives of toxicology. vol 90. issue 5. 2017-01-24. PMID:26026611. |
in this regard, we described in a previous work that cadmium blocks cholinergic transmission and induces a more pronounced cell death on cholinergic neurons from basal forebrain which is partially mediated by ache overexpression. |
2017-01-24 |
2023-08-13 |
Not clear |
| Javier Del Pino, Gabriela Zeballos, María José Anadón, Paula Moyano, María Jesús Díaz, José Manuel García, María Teresa Frej. Cadmium-induced cell death of basal forebrain cholinergic neurons mediated by muscarinic M1 receptor blockade, increase in GSK-3β enzyme, β-amyloid and tau protein levels. Archives of toxicology. vol 90. issue 5. 2017-01-24. PMID:26026611. |
for this purpose, we evaluated, in sn56 cholinergic mourine septal cell line from basal forebrain region, the cadmium toxic effects on neuronal viability through muscarinic m1 receptor, ache splice variants, gsk-3β enzyme, aβ and tau proteins. |
2017-01-24 |
2023-08-13 |
Not clear |
| Javier Del Pino, Gabriela Zeballos, María José Anadón, Paula Moyano, María Jesús Díaz, José Manuel García, María Teresa Frej. Cadmium-induced cell death of basal forebrain cholinergic neurons mediated by muscarinic M1 receptor blockade, increase in GSK-3β enzyme, β-amyloid and tau protein levels. Archives of toxicology. vol 90. issue 5. 2017-01-24. PMID:26026611. |
our present results provide new understanding of the mechanisms contributing to the harmful effects of cadmium on cholinergic neurons and suggest that cadmium could mediate these mechanisms by m1r blockade through ache splices altered expression. |
2017-01-24 |
2023-08-13 |
Not clear |
| Fen Li, Yun-Bin Zhao, Ding-Kun Wang, Xin Zou, Ke Fang, Kai-Fu Wan. Berberine relieves insulin resistance via the cholinergic anti-inflammatory pathway in HepG2 cells. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 36. issue 1. 2016-12-30. PMID:26838742. |
the mechanism may be related to the cholinergic anti-inflammatory pathway and the inhibition of ache activity. |
2016-12-30 |
2023-08-13 |
Not clear |