| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alessandra Antunes dos Santos, Aline Aita Naime, Jade de Oliveira, Dirleise Colle, Danúbia Bonfanti dos Santos, Mariana Appel Hort, Eduardo Luiz Gasnhar Moreira, Cristina Suñol, Andreza Fabro de Bem, Marcelo Farin. Long-term and low-dose malathion exposure causes cognitive impairment in adult mice: evidence of hippocampal mitochondrial dysfunction, astrogliosis and apoptotic events. Archives of toxicology. vol 90. issue 3. 2016-11-14. PMID:25618550. |
this study evaluated the effects of a repeated (15-day period) and low-dose malathion exposure on spatial memory and discrimination (object location task), as well as on biochemical parameters in the hippocampus of mice [ache and mitochondrial chain complexes activities; levels of proapoptotic proteins (bax and bak) and cholinergic neuronal and astroglial markers (chat and gfap, respectively)]. |
2016-11-14 |
2023-08-13 |
mouse |
| Alessandra Antunes dos Santos, Aline Aita Naime, Jade de Oliveira, Dirleise Colle, Danúbia Bonfanti dos Santos, Mariana Appel Hort, Eduardo Luiz Gasnhar Moreira, Cristina Suñol, Andreza Fabro de Bem, Marcelo Farin. Long-term and low-dose malathion exposure causes cognitive impairment in adult mice: evidence of hippocampal mitochondrial dysfunction, astrogliosis and apoptotic events. Archives of toxicology. vol 90. issue 3. 2016-11-14. PMID:25618550. |
malathion treatments (30 and 100 mg/kg, s.c.) did not affect the body weight of animals and caused no evident signs of cholinergic toxicity throughout the treatment, although the highest dose (100 mg/kg) was associated with inhibition of ache activity. |
2016-11-14 |
2023-08-13 |
mouse |
| A Patricio-Martínez, L Mendieta, I Martínez, J Aguilera, I D Limó. The recombinant C-terminal fragment of tetanus toxin protects against cholinotoxicity by intraseptal injection of β-amyloid peptide (25-35) in rats. Neuroscience. vol 315. 2016-10-19. PMID:26687435. |
the brains were removed to assess cholinergic markers, such as choline acetyltransferase (chat) and acetylcholinesterase (ache), and to explore neurodegeneration in the ms and hippocampus, using amino-cupric silver and h&e staining. |
2016-10-19 |
2023-08-13 |
rat |
| A Patricio-Martínez, L Mendieta, I Martínez, J Aguilera, I D Limó. The recombinant C-terminal fragment of tetanus toxin protects against cholinotoxicity by intraseptal injection of β-amyloid peptide (25-35) in rats. Neuroscience. vol 315. 2016-10-19. PMID:26687435. |
finally, capase-3, a marker of apoptosis, was examined in the ms. our results clearly demonstrate that the application of hc-tetx prevents the loss of cholinergic markers (chat and ache), the activation of capase-3, and neurodegeneration in the ms and the ca1 and ca3 subfields of the hippocampus. |
2016-10-19 |
2023-08-13 |
rat |
| Jana Zdarova Karasova, Milos Hroch, Kamil Musilek, Kamil Kuc. Small Quaternary Inhibitors K298 and K524: Cholinesterases Inhibition, Absorption, Brain Distribution, and Toxicity. Neurotoxicity research. vol 29. issue 2. 2016-10-14. PMID:26646154. |
inhibitors of acetylcholinesterase (ache) may be used in the treatment of various cholinergic deficits, among them being myasthenia gravis (mg). |
2016-10-14 |
2023-08-13 |
Not clear |
| Wen Luo, Ying Chen, Ting Wang, Chen Hong, Li-Ping Chang, Cong-Cong Chang, Ya-Cheng Yang, Song-Qiang Xie, Chao-Jie Wan. Design, synthesis and evaluation of novel 7-aminoalkyl-substituted flavonoid derivatives with improved cholinesterase inhibitory activities. Bioorganic & medicinal chemistry. vol 24. issue 4. 2016-10-14. PMID:26752094. |
compound 2-(naphthalen-1-yl)-7-(8-(pyrrolidin-1-yl)octyloxy)-4h-chromen-4-one (5q) showed the best inhibitory activity (ic50, 0.64μm for ache and 0.42μm for bche) which were better than our previously reported compounds and the commercially available cholinergic agent rivastigmine. |
2016-10-14 |
2023-08-13 |
Not clear |
| Saw Simeon, Nuttapat Anuwongcharoen, Watshara Shoombuatong, Aijaz Ahmad Malik, Virapong Prachayasittikul, Jarl E S Wikberg, Chanin Nantasenama. Probing the origins of human acetylcholinesterase inhibition via QSAR modeling and molecular docking. PeerJ. vol 4. 2016-09-07. PMID:27602288. |
as per the cholinergic hypothesis, the deficiency of choline is responsible for ad; therefore, the inhibition of ache is a lucrative therapeutic strategy for the treatment of ad. |
2016-09-07 |
2023-08-13 |
human |
| Tetsade Piermartiri, Hongna Pan, Taiza H Figueiredo, Ann M Marin. α-Linolenic Acid, A Nutraceutical with Pleiotropic Properties That Targets Endogenous Neuroprotective Pathways to Protect against Organophosphate Nerve Agent-Induced Neuropathology. Molecules (Basel, Switzerland). vol 20. issue 11. 2016-08-19. PMID:26569216. |
op nerve agents inhibit the critical enzyme acetylcholinesterase (ache) that rapidly leads to a cholinergic crisis involving multiple organs. |
2016-08-19 |
2023-08-13 |
Not clear |
| Franz Worek, Martina Schilha, Katharina Neumaier, Nadine Aurbek, Timo Wille, Horst Thiermann, Kai Keh. On-site analysis of acetylcholinesterase and butyrylcholinesterase activity with the ChE check mobile test kit-Determination of reference values and their relevance for diagnosis of exposure to organophosphorus compounds. Toxicology letters. vol 249. 2016-08-16. PMID:27033775. |
however, in case of unspecific signs and of delayed onset of cholinergic crisis a rapid, reliable and on-site analysis of acetylcholinesterase (ache) and butyrylcholinesterase (bche) activity would be of great value. |
2016-08-16 |
2023-08-13 |
human |
| Jacek Kuchinka, Elżbieta Nowak, Tadeusz Kuder, Aleksander Szczurkowsk. Morphology and Topography of the Celiac Plexus in Degu (Octodon Degus). Anatomical record (Hoboken, N.J. : 2007). vol 298. issue 11. 2016-08-09. PMID:25926344. |
the classical h&e technique was used for analysis of the cytoarchitectonic of the ganglion, and the ache (karnovsky and roots, 1964) and spg (de la torre, 1980) techniques to observe cholinergic and adrenergic activity. |
2016-08-09 |
2023-08-13 |
Not clear |
| Linh My Thi Lam, Mai Thanh Thi Nguyen, Hai Xuan Nguyen, Phu Hoang Dang, Nhan Trung Nguyen, Hung Manh Tran, Hoa Thi Nguyen, Nui Minh Nguyen, Byung Sun Min, Jeong Ah Kim, Jae Sue Choi, Mao Van Ca. Anti-cholinesterases and memory improving effects of Vietnamese Xylia xylocarpa. Chemistry Central journal. vol 10. 2016-08-05. PMID:27493681. |
an increase in ache (a key enzyme in the cholinergic nervous system) levels around β-amyloid plaques and neurofibrillary tangles is a common feature of ad neuropathology. |
2016-08-05 |
2023-08-13 |
Not clear |
| Abdul Hameed, Syeda T Zehra, Syed J A Shah, Khalid M Khan, Rima D Alharthy, Norbert Furtmann, Jürgen Bajorath, Muhammad N Tahir, Jamshed Iqba. Syntheses, cholinesterases inhibition, and molecular docking studies of pyrido[2,3-b]pyrazine derivatives. Chemical biology & drug design. vol 86. issue 5. 2016-08-01. PMID:25951978. |
cholinesterases, acetylcholinesterase (ache) and butyrylcholinesterase (bche), have a role in cholinergic deficit which evidently leads to alzheimer's disease (ad). |
2016-08-01 |
2023-08-13 |
Not clear |
| Mullah Muhaiminul Islam, Arun Bahadur Gurung, Atanu Bhattacharjee, Kripamoy Aguan, Sivaprasad Mitr. Human serum albumin reduces the potency of acetylcholinesterase inhibitor based drugs for Alzheimer's disease. Chemico-biological interactions. vol 249. 2016-08-01. PMID:26902639. |
human serum albumin (hsa) induced modulation of acetylcholinesterase (ache) inhibition activity of four well-known cholinergic inhibitors like tacrine hydrochloride (tac), donepezil hydrochloride monohydrate (don), (-) huperzine a (hupa), eserine (ese) was monitored quantitatively by ellman's method. |
2016-08-01 |
2023-08-13 |
human |
| Hyeon-Joong Kim, Eun-Joo Shin, Byung-Hwan Lee, Sun-Hye Choi, Seok-Won Jung, Ik-Hyun Cho, Sung-Hee Hwang, Joon Yong Kim, Jung-Soo Han, ChiHye Chung, Choon-Gon Jang, Hyewon Rhim, Hyoung-Chun Kim, Seung-Yeol Na. Oral Administration of Gintonin Attenuates Cholinergic Impairments by Scopolamine, Amyloid-β Protein, and Mouse Model of Alzheimer's Disease. Molecules and cells. vol 38. issue 9. 2016-07-19. PMID:26255830. |
oral administration of gintonin (25 or 50 mg/kg, 2 weeks) also significantly attenuated amyloid-β protein (aβ)-induced cholinergic dysfunctions, such as decreased acetylcholine concentration, decreased choline acetyltransferase (chat) activity and immunoreactivity, and increased acetylcholine esterase (ache) activity. |
2016-07-19 |
2023-08-13 |
mouse |
| Peng Wu, Yuandai Luo, Lifang Zhen, Xianda Hu, Ying Shang, Yinuo Liao, Huiyuan Xue, Fukai Huang, Wei Xia. Rannasangpei Is a Therapeutic Agent in the Treatment of Vascular Dementia. Evidence-based complementary and alternative medicine : eCAM. vol 2016. 2016-06-13. PMID:27293454. |
elisa revealed that the treatments with both doses of rsnp could reinstate the cholinergic activity in the vd animals by elevating the production of choline acetyltransferase (chat) and reducing the acetylcholinesterase (ache); the treatment of rsnp could also reboot the level of superoxide dismutase (sod) and decrease malondialdehyde (mda). |
2016-06-13 |
2023-08-13 |
rat |
| Piotr Draczkowski, Anna Tomaszuk, Pawel Halczuk, Maciej Strzemski, Dariusz Matosiuk, Krzysztof Jozwia. Determination of affinity and efficacy of acetylcholinesterase inhibitors using isothermal titration calorimetry. Biochimica et biophysica acta. vol 1860. issue 5. 2016-06-09. PMID:26586471. |
acetylcholinesterase (ache), an enzyme rapidly terminating nerve signals at synapses of cholinergic neurons is an important drug target in treatment of alzheimer's disease and related memory loss conditions. |
2016-06-09 |
2023-08-13 |
Not clear |
| Cecilia Engdahl, Sofie Knutsson, Sten-Åke Fredriksson, Anna Linusson, Göran Bucht, Fredrik Ekströ. Acetylcholinesterases from the Disease Vectors Aedes aegypti and Anopheles gambiae: Functional Characterization and Comparisons with Vertebrate Orthologues. PloS one. vol 10. issue 10. 2016-06-06. PMID:26447952. |
a potential target for the development of insecticides with reduced off-target toxicity is the cholinergic enzyme acetylcholinesterase (ache). |
2016-06-06 |
2023-08-13 |
mouse |
| Miroslav Pohanka, Petr Dobe. Caffeine inhibits acetylcholinesterase, but not butyrylcholinesterase. International journal of molecular sciences. vol 14. issue 5. 2016-05-26. PMID:23698772. |
in the present work, we focused on the question whether caffeine can inhibit acetylcholinesterase (ache) and/or, butyrylcholinesterase (bche), the two enzymes participating in cholinergic neurotransmission. |
2016-05-26 |
2023-08-12 |
human |
| Tetsade C B Piermartiri, Hongna Pan, Jun Chen, John McDonough, Neil Grunberg, James P Apland, Ann M Marin. Alpha-Linolenic Acid-Induced Increase in Neurogenesis is a Key Factor in the Improvement in the Passive Avoidance Task After Soman Exposure. Neuromolecular medicine. vol 17. issue 3. 2016-05-20. PMID:25920465. |
exposure to organophosphorous (op) nerve agents such as soman inhibits the critical enzyme acetylcholinesterase (ache) leading to excessive acetylcholine accumulation in synapses, resulting in cholinergic crisis, status epilepticus and brain damage in survivors. |
2016-05-20 |
2023-08-13 |
Not clear |
| Sara Maria Fossati, Simona Candiani, Marie-Therese Nödl, Luca Maragliano, Maria Pennuto, Pedro Domingues, Fabio Benfenati, Mario Pestarino, Letizia Zull. Identification and Expression of Acetylcholinesterase in Octopus vulgaris Arm Development and Regeneration: a Conserved Role for ACHE? Molecular neurobiology. vol 52. issue 1. 2016-05-17. PMID:25112677. |
acetylcholinesterase (ache) is a glycoprotein with a key role in terminating synaptic transmission in cholinergic neurons of both vertebrates and invertebrates. |
2016-05-17 |
2023-08-13 |
Not clear |