| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ramu Venkatesan, Lalita Subedi, Eui-Ju Yeo, Sun Yeou Ki. Lactucopicrin ameliorates oxidative stress mediated by scopolamine-induced neurotoxicity through activation of the NRF2 pathway. Neurochemistry international. vol 99. 2018-01-03. PMID:27346436. |
the current study aimed to investigate the molecular mechanisms underlying scopolamine-induced cholinergic neuronal dysfunction and the neuroprotective effect of lactucopicrin, an inhibitor of acetylcholine esterase (ache). |
2018-01-03 |
2023-08-13 |
Not clear |
| Cong Lu, Liming Dong, Jingwei Lv, Yan Wang, Bei Fan, Fengzhong Wang, Xinmin Li. 20(S)-protopanaxadiol (PPD) alleviates scopolamine-induced memory impairment via regulation of cholinergic and antioxidant systems, and expression of Egr-1, c-Fos and c-Jun in mice. Chemico-biological interactions. vol 279. 2018-01-03. PMID:29133030. |
ppd regulated cholinergic function by inhibiting scop-induced elevation of acetylcholinesterase (ache) activity, decline of choline acetyltransferase (chat) activity and decrease of acetylcholine (ach) level. |
2018-01-03 |
2023-08-13 |
mouse |
| Umit M Kocyigit, Parham Taslimi, Hayreddin Gezegen, İlhami Gulçin, Mustafa Ceyla. Evaluation of acetylcholinesterase and carbonic anhydrase inhibition profiles of 1,2,3,4,6-pentasubstituted-4-hydroxy-cyclohexanes. Journal of biochemical and molecular toxicology. vol 31. issue 9. 2018-01-02. PMID:28613396. |
prevalent drugs for the symptomatic therapy of dementia are significant in increasing the associated cholinergic deficiency by inhibiting acetylcholinesterase (ache). |
2018-01-02 |
2023-08-13 |
human |
| Jong Min Kim, Seon Kyeong Park, Tian Jiao Guo, Jin Yong Kang, Jeong Su Ha, Du Sang Lee, Uk Lee, Ho Jin He. Anti-amnesic effect of Dendropanax morbifera via JNK signaling pathway on cognitive dysfunction in high-fat diet-induced diabetic mice. Behavioural brain research. vol 312. 2017-12-19. PMID:27288590. |
in animal experiments using y-maze, passive avoidance and morris water maze tests, the cognitive and behavioral disorders in hfd-induced diabetic mice were considerably recovered by regulating cholinergic systems, including acetylcholine (ach) levels and acetylcholinesterase (ache) inhibition, and antioxidant systems, including superoxide dismutase (sod), glutathione (gsh), oxidized gsh, and malondialdehyde (mda) levels. |
2017-12-19 |
2023-08-13 |
mouse |
| Bo Feng, Xiao-Yang Zhao, Yi-Zhou Song, Wen-Na Liang, Ji-Liang Li. Sarsasapogenin reverses depressive-like behaviors and nicotinic acetylcholine receptors induced by olfactory bulbectomy. Neuroscience letters. vol 639. 2017-12-19. PMID:27988349. |
we examined ob-induced changes in cholinergic signalling, as well as ache, α4-nachr, and α7-nachr expression in the hippocampus. |
2017-12-19 |
2023-08-13 |
rat |
| Guozhen Qiu, Shengqiang Chen, Jialing Guo, Jie Wu, Yong-Hong Y. Alpha-asarone improves striatal cholinergic function and locomotor hyperactivity in Fmr1 knockout mice. Behavioural brain research. vol 312. 2017-12-13. PMID:27316341. |
to elucidate the mechanism underlying this improvement, we evaluated the expressions of various cholinergic markers, as well as acetylcholinesterase (ache) activity and acetylcholine (ach) levels, in the striatum of fmr1 ko mice. |
2017-12-13 |
2023-08-13 |
mouse |
| Madhavan Nampoothiri, Grandhi Venkata Ramalingayya, Nampurath Gopalan Kutty, Nandakumar Krishnadas, Chamallamudi Mallikarjuna Ra. Insulin Combined with Glucose Improves Spatial Learning and Memory in Aluminum Chloride-Induced Dementia in Rats. Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer. vol 36. issue 2. 2017-12-07. PMID:29199596. |
behavioral parameters (morris water maze test) along with biochemical parameters (hippocampus and frontal cortex) such as acetylcholinesterase (ache), catalase, and glutathione (gsh) levels were assessed to correlate cognitive function with cholinergic transmission and oxidative stress. |
2017-12-07 |
2023-08-13 |
rat |
| Tamara Lazarevic-Pasti, Andreja Leskovac, Tatjana Momic, Sandra Petrovic, Vesna Vasi. Modulators of Acetylcholinesterase Activity: From Alzheimer's Disease to Anti-Cancer Drugs. Current medicinal chemistry. vol 24. issue 30. 2017-11-29. PMID:28685687. |
acetylcholinesterase (ache) is involved in the termination of impulse transmission by rapid hydrolysis of the neurotransmitter acetylcholine in numerous cholinergic pathways in the central and peripheral nervous systems. |
2017-11-29 |
2023-08-13 |
Not clear |
| D K Rieger, A A Dos Santos, C Suñol, M Farin. Involvement of superoxide in malaoxon-induced toxicity in primary cultures of cortical neurons. Journal of toxicology and environmental health. Part A. vol 80. issue 19-21. 2017-11-16. PMID:28849997. |
the neurotoxic effects are attributed mainly to acetylcholinesterase (ache) enzyme inhibition, which is responsible for cholinergic manifestations in individuals acutely exposed to op. |
2017-11-16 |
2023-08-13 |
mouse |
| Javier Del Pino, Paula Moyano, Gloria Gómez Díaz, María José Anadon, Maria Jesus Diaz, José Manuel García, Margarita Lobo, Adela Pelayo, Emma Sola, María Teresa Frej. Primary hippocampal neuronal cell death induction after acute and repeated paraquat exposures mediated by AChE variants alteration and cholinergic and glutamatergic transmission disruption. Toxicology. vol 390. 2017-10-23. PMID:28916328. |
primary hippocampal neuronal cell death induction after acute and repeated paraquat exposures mediated by ache variants alteration and cholinergic and glutamatergic transmission disruption. |
2017-10-23 |
2023-08-13 |
Not clear |
| Javier Del Pino, Paula Moyano, Gloria Gómez Díaz, María José Anadon, Maria Jesus Diaz, José Manuel García, Margarita Lobo, Adela Pelayo, Emma Sola, María Teresa Frej. Primary hippocampal neuronal cell death induction after acute and repeated paraquat exposures mediated by AChE variants alteration and cholinergic and glutamatergic transmission disruption. Toxicology. vol 390. 2017-10-23. PMID:28916328. |
in addition, pq induced, after 24h and 14days exposure, cell death on hippocampal neurons that was partially mediated by ache variants alteration and cholinergic and gultamatergic transmissions disruption. |
2017-10-23 |
2023-08-13 |
Not clear |
| Shalini Jayant, Bhupesh Sharm. Selective Modulator of Cannabinoid Receptor Type 2 Reduces Memory Impairment and Infarct Size During Cerebral Hypoperfusion and Vascular Dementia. Current neurovascular research. vol 13. issue 4. 2017-10-19. PMID:27586843. |
these animals have shown a considerable reduction in brain oxidative stress (thiobarbituric reactive acid substance-tbars; glutathione-gsh; catalase-cat and superoxide dismutase-sod), mitochondrial dysfunction (complexes i, ii, iv) with a significant enhancement in cholinergic activity- ache and brain infarct size2,3,5-triphenylterazolium chloride staining (ttc staining). |
2017-10-19 |
2023-08-13 |
rat |
| Talita P C Chierrito, Susimaire Pedersoli-Mantoani, Carlos Roca, Carlos Requena, Victor Sebastian-Perez, Willian O Castillo, Natalia C S Moreira, Concepción Pérez, Elza T Sakamoto-Hojo, Catarina S Takahashi, Jesús Jiménez-Barbero, F Javier Cañada, Nuria E Campillo, Ana Martinez, Ivone Carvalh. From dual binding site acetylcholinesterase inhibitors to allosteric modulators: A new avenue for disease-modifying drugs in Alzheimer's disease. European journal of medicinal chemistry. vol 139. 2017-10-16. PMID:28863358. |
unexpectely, we have found a potent allosteric modulator of ache able to target cholinergic and non-cholinergic functions by fixing a specific ache conformation, confirmed by std-nmr and molecular modeling studies. |
2017-10-16 |
2023-08-13 |
human |
| Babar Ali, Qazi M S Jamal, Saiba Shams, Naser A Al-Wabel, Mughees U Siddiqui, Mohammad A Alzohairy, Mohammed A Al Karaawi, Kavindra Kumar Kesari, Gohar Mushtaq, Mohammad A Kama. In Silico Analysis of Green Tea Polyphenols as Inhibitors of AChE and BChE Enzymes in Alzheimer's Disease Treatment. CNS & neurological disorders drug targets. vol 15. issue 5. 2017-10-04. PMID:26996169. |
the present docking study suggests that tea polyphenols inhibit ache as well as bche and enhance the cholinergic neurotransmission by prolonging the time. |
2017-10-04 |
2023-08-13 |
Not clear |
| Melissa A Pickett, Michael K Dush, Nanette M Nascone-Yode. Acetylcholinesterase plays a non-neuronal, non-esterase role in organogenesis. Development (Cambridge, England). vol 144. issue 15. 2017-10-02. PMID:28684626. |
acetylcholinesterase (ache) is crucial for degrading acetylcholine at cholinergic synapses. |
2017-10-02 |
2023-08-13 |
Not clear |
| Miranda L Xu, Cathy W C Bi, Etta Y L Liu, Tina T X Dong, Karl W K Tsi. Wnt3a induces the expression of acetylcholinesterase during osteoblast differentiation via the Runx2 transcription factor. The Journal of biological chemistry. vol 292. issue 30. 2017-09-26. PMID:28607150. |
acetylcholinesterase (ache) hydrolyzes acetylcholine to terminate cholinergic transmission in neurons. |
2017-09-26 |
2023-08-13 |
human |
| Thomas Driant, Florian Nachon, Cyril Ollivier, Pierre-Yves Renard, Etienne Dera. On the Influence of the Protonation States of Active Site Residues on AChE Reactivation: A QM/MM Approach. Chembiochem : a European journal of chemical biology. vol 18. issue 7. 2017-09-19. PMID:28106328. |
acetylcholinesterase (ache), an enzyme of the serine hydrolase superfamily, is a mediator of signal transmission at cholinergic synapses by catalyzing acetylcholine cleavage into acetate and choline. |
2017-09-19 |
2023-08-13 |
Not clear |
| Alon Simchovitz, Michael T Heneka, Hermona Sore. Personalized genetics of the cholinergic blockade of neuroinflammation. Journal of neurochemistry. vol 142 Suppl 2. 2017-09-07. PMID:28326544. |
cholinomirs coordinate the cognitive and inflammatory aspects of cholinergic signaling by targeting major cholinergic transcripts including the acetylcholine hydrolyzing enzyme acetylcholinesterase (ache). |
2017-09-07 |
2023-08-13 |
Not clear |
| Alon Simchovitz, Michael T Heneka, Hermona Sore. Personalized genetics of the cholinergic blockade of neuroinflammation. Journal of neurochemistry. vol 142 Suppl 2. 2017-09-07. PMID:28326544. |
since cholinergic signaling blocks neuroinflammation which is inherent to alzheimer's disease, genomic changes modifying ache's properties and its susceptibility to inhibitors and/or to cholinomirs regulation may affect the levels and properties of inflammasome components such as nlrp3. |
2017-09-07 |
2023-08-13 |
Not clear |
| Alon Simchovitz, Michael T Heneka, Hermona Sore. Personalized genetics of the cholinergic blockade of neuroinflammation. Journal of neurochemistry. vol 142 Suppl 2. 2017-09-07. PMID:28326544. |
several additional snps in the ache and other cholinergic genes await further studies, and might likewise involve different cholinomirs and pathways including those modulating the initiation and progression of neurodegenerative diseases. |
2017-09-07 |
2023-08-13 |
Not clear |