| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| b' Andrey Kovalevsky, Donald K Blumenthal, Xiaolin Cheng, Palmer Taylor, Zoran Radi\\xc4\\x8. Limitations in current acetylcholinesterase structure-based design of oxime antidotes for organophosphate poisoning. Annals of the New York Academy of Sciences. vol 1378. issue 1. 2017-07-19. PMID:27371941.' |
acetylcholinesterase (ache; ec 3.1.1.7), an essential enzyme of cholinergic neurotransmission in vertebrates, is a primary target in acute nerve agent and organophosphate (op) pesticide intoxication. |
2017-07-19 |
2023-08-13 |
Not clear |
| Takeshi Fujii, Masato Mashimo, Yasuhiro Moriwaki, Hidemi Misawa, Shiro Ono, Kazuhide Horiguchi, Koichiro Kawashim. Physiological functions of the cholinergic system in immune cells. Journal of pharmacological sciences. vol 134. issue 1. 2017-07-13. PMID:28552584. |
immunological activation of t cells up-regulates cholinergic activity, including chat and ache expression. |
2017-07-13 |
2023-08-13 |
Not clear |
| Galina F Makhaeva, Elena V Rudakova, Larisa V Sigolaeva, Ilya N Kurochkin, Rudy J Richardso. Neuropathy target esterase in mouse whole blood as a biomarker of exposure to neuropathic organophosphorus compounds. Journal of applied toxicology : JAT. vol 36. issue 11. 2017-07-10. PMID:26970094. |
because brain nte and ache inhibition are biomarkers of opidn and acute cholinergic toxicity, respectively, we compared nte and ache 20-min ic50 values as well as ed50 values 1 h after single intraperitoneal (i.p.) |
2017-07-10 |
2023-08-13 |
mouse |
| Galina F Makhaeva, Elena V Rudakova, Larisa V Sigolaeva, Ilya N Kurochkin, Rudy J Richardso. Neuropathy target esterase in mouse whole blood as a biomarker of exposure to neuropathic organophosphorus compounds. Journal of applied toxicology : JAT. vol 36. issue 11. 2017-07-10. PMID:26970094. |
moreover, the data suggest that relative inhibition of blood nte and ache provide a way to assess the likelihood that op compound exposure in a susceptible species would produce cholinergic and/or delayed neuropathic effects. |
2017-07-10 |
2023-08-13 |
mouse |
| Xu Rui, Li Wenfang, Cheng Jing, Chen Meng, Ding Chengcheng, Xu Jiqu, Rong Shuan. Neuroprotective effects of phytosterol esters against high cholesterol-induced cognitive deficits in aged rat. Food & function. vol 8. issue 3. 2017-07-07. PMID:28256666. |
furthermore, pse improved cholinergic activities by restoring the acetylcholine (ach) content and decreasing acetylcholinesterase (ache) activity in the cerebral cortex, as well as by elevating choline acetyl transferase (chat) activity in the hippocampus and the cerebral cortex. |
2017-07-07 |
2023-08-13 |
rat |
| Ali Haider, Wali Inam, Shahab Ali Khan, Hifza, Wajahat Mahmood, Ghulam Abba. β-glucan attenuated scopolamine induced cognitive impairment via hippocampal acetylcholinesterase inhibition in rats. Brain research. vol 1644. 2017-06-29. PMID:27180103. |
hence, it can be deduced that β-glucan possesses potential to enhance central cholinergic tone via inhibiting ache enzyme. |
2017-06-29 |
2023-08-13 |
rat |
| Maja Katalinić, Nikolina Maček Hrvat, Krešimir Baumann, Sara Morasi Piperčić, Sandro Makarić, Srđanka Tomić, Ozren Jović, Tomica Hrenar, Ante Miličević, Dubravko Jelić, Suzana Žunec, Ines Primožič, Zrinka Kovari. A comprehensive evaluation of novel oximes in creation of butyrylcholinesterase-based nerve agent bioscavengers. Toxicology and applied pharmacology. vol 310. 2017-05-31. PMID:27654152. |
a well-considered treatment of acute nerve agents poisoning involves the exogenous administration of butyrylcholinesterase (bche, ec 3.1.1.8) as a stoichiometric bioscavenger efficient in preventing cholinergic crises caused by acetylcholinesterase (ache, ec 3.1.1.7) inhibition. |
2017-05-31 |
2023-08-13 |
mouse |
| Wenwen Lian, Jiansong Fang, Lvjie Xu, Wei Zhou, De Kang, Wandi Xiong, Hao Jia, Ai-Lin Liu, Guan-Hua D. DL0410 Ameliorates Memory and Cognitive Impairments Induced by Scopolamine via Increasing Cholinergic Neurotransmission in Mice. Molecules (Basel, Switzerland). vol 22. issue 3. 2017-05-18. PMID:28272324. |
dl0410 was discovered as a dual inhibitor of acetylcholinesterase (ache) and butyrylcholinestease (buche), with potent efficiency in in-vitro experiments, but its in vivo effect on the cholinergic model has not been evaluated, and its action mechanism has also not been illustrated. |
2017-05-18 |
2023-08-13 |
mouse |
| Wenwen Lian, Jiansong Fang, Lvjie Xu, Wei Zhou, De Kang, Wandi Xiong, Hao Jia, Ai-Lin Liu, Guan-Hua D. DL0410 Ameliorates Memory and Cognitive Impairments Induced by Scopolamine via Increasing Cholinergic Neurotransmission in Mice. Molecules (Basel, Switzerland). vol 22. issue 3. 2017-05-18. PMID:28272324. |
in the present study, the capability of dl0410 in ameliorating the amnesia induced by scopolamine was investigated, and its effect on the cholinergic system in the hippocampus and its binding mode in the active site of ache was also explored. |
2017-05-18 |
2023-08-13 |
mouse |
| Javier Del Pino, Paula Moyano, María José Anadon, José Manuel García, María Jesús Díaz, Gloria Gómez, Jimena García, María Teresa Frej. SN56 basal forebrain cholinergic neuronal loss after acute and long-term chlorpyrifos exposure through oxidative stress generation; P75(NTR) and α7-nAChRs alterations mediated partially by AChE variants disruption. Toxicology. vol 353-354. 2017-05-10. PMID:27163631. |
sn56 basal forebrain cholinergic neuronal loss after acute and long-term chlorpyrifos exposure through oxidative stress generation; p75(ntr) and α7-nachrs alterations mediated partially by ache variants disruption. |
2017-05-10 |
2023-08-13 |
rat |
| Javier Del Pino, Paula Moyano, María José Anadon, José Manuel García, María Jesús Díaz, Gloria Gómez, Jimena García, María Teresa Frej. SN56 basal forebrain cholinergic neuronal loss after acute and long-term chlorpyrifos exposure through oxidative stress generation; P75(NTR) and α7-nAChRs alterations mediated partially by AChE variants disruption. Toxicology. vol 353-354. 2017-05-10. PMID:27163631. |
according to these data, we hypothesized that cpf induces basal forebrain cholinergic neuronal loss through induction of oxidative stress produced by p75(ntr) and α7-nachrs altered expression, which could mediate this action in part through ache variants disruption. |
2017-05-10 |
2023-08-13 |
rat |
| Javier Del Pino, Gabriela Zeballos, María José Anadon, María Jesús Díaz, Paula Moyano, Gloria Gómez Díaz, Jimena García, Margarita Lobo, María Teresa Frej. Muscarinic M1 receptor partially modulates higher sensitivity to cadmium-induced cell death in primary basal forebrain cholinergic neurons: A cholinesterase variants dependent mechanism. Toxicology. vol 361-362. 2017-05-01. PMID:27377441. |
it also induces cell death in sn56 cholinergic neurons from the basal forebrain through m1r blockage, alterations in the expression of ache variants and gsk-3β, and an increase in aβ and total and phosphorylated tau protein levels. |
2017-05-01 |
2023-08-13 |
Not clear |
| Javier Del Pino, Gabriela Zeballos, María José Anadon, María Jesús Díaz, Paula Moyano, Gloria Gómez Díaz, Jimena García, Margarita Lobo, María Teresa Frej. Muscarinic M1 receptor partially modulates higher sensitivity to cadmium-induced cell death in primary basal forebrain cholinergic neurons: A cholinesterase variants dependent mechanism. Toxicology. vol 361-362. 2017-05-01. PMID:27377441. |
accordingly, we hypothesized that cholinergic transmission blockage and higher sensitivity to cadmium-induced cell death of primary basal forebrain cholinergic neurons is mediated by m1r blockage, which triggers this effect through alteration of the expression of ache variants. |
2017-05-01 |
2023-08-13 |
Not clear |
| Javier Del Pino, Gabriela Zeballos, María José Anadon, María Jesús Díaz, Paula Moyano, Gloria Gómez Díaz, Jimena García, Margarita Lobo, María Teresa Frej. Muscarinic M1 receptor partially modulates higher sensitivity to cadmium-induced cell death in primary basal forebrain cholinergic neurons: A cholinesterase variants dependent mechanism. Toxicology. vol 361-362. 2017-05-01. PMID:27377441. |
to prove this hypothesis, we evaluated, in primary culture from the basal forebrain region, whether m1r silencing induces greater cell death in cholinergic neurons than cadmium does, and whether in sn56 cells m1r mediates the mechanisms described so as to play a part in the cadmium induction of cholinergic transmission blockage and cell death in this cell line through alteration of the expression of ache variants. |
2017-05-01 |
2023-08-13 |
Not clear |
| Javier Del Pino, Gabriela Zeballos, María José Anadon, María Jesús Díaz, Paula Moyano, Gloria Gómez Díaz, Jimena García, Margarita Lobo, María Teresa Frej. Muscarinic M1 receptor partially modulates higher sensitivity to cadmium-induced cell death in primary basal forebrain cholinergic neurons: A cholinesterase variants dependent mechanism. Toxicology. vol 361-362. 2017-05-01. PMID:27377441. |
moreover, all previously described mechanisms for blocking cholinergic transmission and inducing cell death on sn56 cells after cadmium exposure are partially mediated by m1r through the alteration of ache expression. |
2017-05-01 |
2023-08-13 |
Not clear |
| G A Toledo-Ibarra, K J G Díaz-Resendiz, L Pavón-Romero, A E Rojas-García, I M Medina-Díaz, M I Girón-Pére. Effects of diazinon on the lymphocytic cholinergic system of Nile tilapia fish (Oreochromis niloticus). Veterinary immunology and immunopathology. vol 176. 2017-04-07. PMID:27260186. |
the obtained results indicate that acute exposure to diazinon induces an increase in ach concentration and a decrease in nachr and machr concentrations and ache activity in fish immune cells, this suggests that the non-neuronal lymphocytic cholinergic system may be the main target in the mechanism of op immunotoxicity. |
2017-04-07 |
2023-08-13 |
Not clear |
| Ganiyu Oboh, Omodesola O Ogunruku, Sunday I Oyeleye, Tosin A Olasehinde, Ayokunle O Ademosun, Aline Augusti Boligo. Phenolic Extracts from Clerodendrum volubile Leaves Inhibit Cholinergic and Monoaminergic Enzymes Relevant to the Management of Some Neurodegenerative Diseases. Journal of dietary supplements. vol 14. issue 3. 2017-04-03. PMID:27753518. |
this study investigated the inhibitory effects of phenolic-rich extracts from clerodendrum volubile leaves on cholinergic [acetylcholinesterase (ache) and butyrylcholinesterase (bche)] and monoaminergic [monoamine oxidase (mao)] enzymes' activities and pro-oxidants [fe |
2017-04-03 |
2023-08-13 |
Not clear |
| Matheus D Baldissera, Carine F Souza, Pedro Henrique Doleski, Guerino B Júnior, Agueda C de Vargas, Bernardo Baldisserott. Involvement of cholinergic and purinergic systems during the inflammatory response caused by Aeromonas hydrophila in Rhamdia quelen. Microbial pathogenesis. vol 99. 2017-03-27. PMID:27521226. |
the aim of this study was to evaluate the cholinergic (acetylcholinesterase (ache) and butyrylcholinesterase (bche)) and purinergic (adenosine deaminase (ada)) systems in head kidney, spleen, total blood and serum samples in experimentally infected fish with a. hydrophila, and the involvement of these systems during the inflammatory process. |
2017-03-27 |
2023-08-13 |
Not clear |
| Matheus D Baldissera, Carine F Souza, Thirssa H Grando, Aleksandro S da Silva, Silvia G Monteir. Involvement of oxidative stress, cholinergic and adenosinergic systems on renal damage caused by Trypanosoma evansi infection: Relationship with lipid peroxidation. Microbial pathogenesis. vol 99. 2017-03-27. PMID:27565091. |
the aim of this study was to evaluate the oxidative stress variables, and enzymes of cholinergic (acetylcholinesterase (ache) and butyrylcholinesterase (bche)) and adenosinergic (adenosine deaminase (ada)) systems in renal tissue, as well as the relationship between these systems and lipid peroxidation. |
2017-03-27 |
2023-08-13 |
cat |
| Willyan Franco Hilario, Alice Laschuk Herlinger, Lorena Bianchine Areal, Lívia Silveira de Moraes, Tamara Andrea Alarcon Ferreira, Tassiane Emanuelle Servane Andrade, Cristina Martins-Silva, Rita Gomes Wanderley Pire. Cholinergic and Dopaminergic Alterations in Nigrostriatal Neurons Are Involved in Environmental Enrichment Motor Protection in a Mouse Model of Parkinson's Disease. Journal of molecular neuroscience : MN. vol 60. issue 4. 2017-03-23. PMID:27660217. |
as for the cholinergic system, mptp led to a decrease in the chat gene expression while increasing the expression of both ache and m1r. |
2017-03-23 |
2023-08-13 |
mouse |