| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Amrita A Chowdhury, Nitin B Gawali, Renuka Munshi, Archana R Juveka. Trigonelline insulates against oxidative stress, proinflammatory cytokines and restores BDNF levels in lipopolysaccharide induced cognitive impairment in adult mice. Metabolic brain disease. vol 33. issue 3. 2019-02-05. PMID:29277879. |
cholinergic involvement during neuroinflammation was evaluated by measuring levels of acetylcholinesterase (ache) enzyme. |
2019-02-05 |
2023-08-13 |
mouse |
| Tim Anderson, Jing Liu, Scott McMurry, Carey Pop. Comparative in vitro and in vivo effects of chlorpyrifos oxon in the outbred CD-1 mouse (Mus musculus) and great plains toad (Anaxyrus cognatus). Environmental toxicology and chemistry. vol 37. issue 7. 2019-02-04. PMID:29573455. |
these data suggest that the relatively low sensitivity of toads to cholinergic toxicity is based on the low sensitivity of brain ache, which in turn may be attributable to more effective target-site detoxification. |
2019-02-04 |
2023-08-13 |
mouse |
| Jonathan R de Almeida, Micheli Figueiro, Wanda Pereira Almeida, Carlos Henrique Tomich de Paula da Silv. Discovery of novel dual acetylcholinesterase inhibitors with antifibrillogenic activity related to Alzheimer's disease. Future medicinal chemistry. vol 10. issue 9. 2019-02-04. PMID:29676170. |
the current pharmacological approach is based on the improvement of cholinergic neurotransmission by inhibiting acetylcholinesterase (ache) with ache inhibitors. |
2019-02-04 |
2023-08-13 |
Not clear |
| Caio R D Assis, Amanda G Linhares, Mariana P Cabrera, Vagne M Oliveira, Kaline C C Silva, Marina Marcuschi, Elba V M Maciel Carvalho, Ranilson S Bezerra, Luiz B Carvalh. Erythrocyte acetylcholinesterase as biomarker of pesticide exposure: new and forgotten insights. Environmental science and pollution research international. vol 25. issue 19. 2018-12-20. PMID:29797194. |
acetylcholinesterase (ache) acts on the hydrolysis of acetylcholine, rapidly removing this neurotransmitter at cholinergic synapses and neuromuscular junctions as well as in neuronal growth and differentiation, modulation of cell adhesion ("electrotactins") and aryl-acylamidase activity (aaa). |
2018-12-20 |
2023-08-13 |
Not clear |
| Marlyete Chagas Araújo, Caio Rodrigo Dias Assis, Kaline Catiely Campos Silva, Kelma Sirleide Souza, Rafael Souto Azevedo, Maria Helena Menezes Estevam Alves, Luciano Clemente Silva, Valdir Luna Silva, Mônica Lúcia Adam, Luiz Bezerra Carvalho Junior, Ranilson Souza Bezerra, Maria Betânia Melo Oliveir. Characterization of brain acetylcholinesterase of bentonic fish Hoplosternum littorale: Perspectives of application in pesticides and metal ions biomonitoring. Aquatic toxicology (Amsterdam, Netherlands). vol 205. 2018-12-12. PMID:30408655. |
acetylcholinesterase (ache; ec 3.1.1.7) is a serine hydrolase, whose main function is to modulate neurotransmission at cholinergic synapses. |
2018-12-12 |
2023-08-13 |
Not clear |
| Zuzana Gazova, Ondrej Soukup, Vendula Sepsova, Katarina Siposova, Lucie Drtinova, Petr Jost, Katarina Spilovska, Jan Korabecny, Eugenie Nepovimova, Diana Fedunova, Martin Horak, Martina Kaniakova, Ze-Jun Wang, Ayman K Hamouda, Kamil Kuc. Multi-target-directed therapeutic potential of 7-methoxytacrine-adamantylamine heterodimers in the Alzheimer's disease treatment. Biochimica et biophysica acta. Molecular basis of disease. vol 1863. issue 2. 2018-12-11. PMID:27865910. |
moreover, they have ache inhibitory potency but they could not potentiate cholinergic transmission via direct interaction with cholinergic receptors. |
2018-12-11 |
2023-08-13 |
Not clear |
| Vivitri Prasasty, Muhammad Radifar, Enade Istyaston. Natural Peptides in Drug Discovery Targeting Acetylcholinesterase. Molecules (Basel, Switzerland). vol 23. issue 9. 2018-12-11. PMID:30217053. |
acetylcholinesterase-inhibitory peptide has gained much importance since it can inhibit acetylcholinesterase (ache) and increase the availability of acetylcholine in cholinergic synapses, enhancing cholinergic transmission in pharmacological treatment of alzheimer's disease (ad). |
2018-12-11 |
2023-08-13 |
Not clear |
| Marcella Reale, Erica Costantini, Marta Di Nicola, Chiara D'Angelo, Sara Franchi, Marco D'Aurora, Maria Di Bari, Viviana Orlando, Sabrina Galizia, Serena Ruggieri, Liborio Stuppia, Claudio Gasperini, Ada Maria Tata, Valentina Gatt. Butyrylcholinesterase and Acetylcholinesterase polymorphisms in Multiple Sclerosis patients: implication in peripheral inflammation. Scientific reports. vol 8. issue 1. 2018-11-21. PMID:29358722. |
the aim of the present research was to assess the associations between bche and ache genetic variations and serum cholinergic and inflammatory profiles in 102 relapsing remitting-ms patients and 117 healthy controls. |
2018-11-21 |
2023-08-13 |
Not clear |
| Marcella Reale, Erica Costantini, Marta Di Nicola, Chiara D'Angelo, Sara Franchi, Marco D'Aurora, Maria Di Bari, Viviana Orlando, Sabrina Galizia, Serena Ruggieri, Liborio Stuppia, Claudio Gasperini, Ada Maria Tata, Valentina Gatt. Butyrylcholinesterase and Acetylcholinesterase polymorphisms in Multiple Sclerosis patients: implication in peripheral inflammation. Scientific reports. vol 8. issue 1. 2018-11-21. PMID:29358722. |
we propose that serum bche and ache activity may be used as a secondary markers to assess the role of non-neuronal cholinergic system in regulating peripheral inflammation via ach regulation. |
2018-11-21 |
2023-08-13 |
Not clear |
| M D Baldissera, C F Souza, P H Doleski, K L S Moreira, M L da Veiga, M I U M da Rocha, R C V Santos, B Baldisserott. Involvement of cholinergic and adenosinergic systems on the branchial immune response of experimentally infected silver catfish with Streptococcus agalactiae. Journal of fish diseases. vol 41. issue 1. 2018-11-08. PMID:28699699. |
it has been recognized that the cholinergic and adenosinergic systems have an essential role in immune and inflammatory responses during bacterial fish pathogens, such as the enzymes acetylcholinesterase (ache) and adenosine deaminase (ada), which are responsible for catalysis of the anti-inflammatory molecules acetylcholine (ach) and adenosine (ado) respectively. |
2018-11-08 |
2023-08-13 |
Not clear |
| M D Baldissera, C F Souza, P H Doleski, K L S Moreira, M L da Veiga, M I U M da Rocha, R C V Santos, B Baldisserott. Involvement of cholinergic and adenosinergic systems on the branchial immune response of experimentally infected silver catfish with Streptococcus agalactiae. Journal of fish diseases. vol 41. issue 1. 2018-11-08. PMID:28699699. |
based on this evidence, we concluded that infection by s. agalactiae in silver catfish alters the cholinergic and adenosinergic systems, suggesting the involvement of ache and ada activities on immune and inflammatory responses, regulating the ach and ado levels. |
2018-11-08 |
2023-08-13 |
Not clear |
| Felipe Rocha, Letícia Yumi Sugahara, Fernanda Vitória Leimann, Sara Marchesan de Oliveira, Evelyne da Silva Brum, Ricardo Costa Calhelha, Maria Filomena Barreiro, Isabel C F R Ferreira, Rafael Porto Ineu, Odinei Hess Gonçalve. Nanodispersions of beta-carotene: effects on antioxidant enzymes and cytotoxic properties. Food & function. vol 9. issue 7. 2018-10-29. PMID:29974106. |
the formed nanometric beta-carotene particles resulted in stable colloids, readily dispersed in water, able to modulate acetylcholinesterase (ache) activity, and presenting high potential to control the cholinergic system. |
2018-10-29 |
2023-08-13 |
drosophila_melanogaster |
| Paula Moyano, Mariano de Frias, Margarita Lobo, María José Anadon, Emma Sola, Adela Pelayo, María Jesús Díaz, María Teresa Frejo, Javier Del Pin. Cadmium induced ROS alters M1 and M3 receptors, leading to SN56 cholinergic neuronal loss, through AChE variants disruption. Toxicology. vol 394. 2018-10-19. PMID:29253600. |
cadmium induced ros alters m1 and m3 receptors, leading to sn56 cholinergic neuronal loss, through ache variants disruption. |
2018-10-19 |
2023-08-13 |
Not clear |
| Paula Moyano, Mariano de Frias, Margarita Lobo, María José Anadon, Emma Sola, Adela Pelayo, María Jesús Díaz, María Teresa Frejo, Javier Del Pin. Cadmium induced ROS alters M1 and M3 receptors, leading to SN56 cholinergic neuronal loss, through AChE variants disruption. Toxicology. vol 394. 2018-10-19. PMID:29253600. |
thus, we hypothesized that cadmium induced cell death of bf cholinergic neurons is mediated by oxidative stress generation and this mechanism could produce this effect, in part, through ache variants altered by muscarinic receptors disruption. |
2018-10-19 |
2023-08-13 |
Not clear |
| Paula Moyano, Mariano de Frias, Margarita Lobo, María José Anadon, Emma Sola, Adela Pelayo, María Jesús Díaz, María Teresa Frejo, Javier Del Pin. Cadmium induced ROS alters M1 and M3 receptors, leading to SN56 cholinergic neuronal loss, through AChE variants disruption. Toxicology. vol 394. 2018-10-19. PMID:29253600. |
to prove this, we evaluated in bf sn56 cholinergic neurons, whether cadmium induces oxidative stress and alters muscarinic receptors, and their involvement in the induction of cell death through alteration of ache variants. |
2018-10-19 |
2023-08-13 |
Not clear |
| Haroon Khan, Marya, Surriya Amin, Mohammad Amjad Kamal, Seema Pate. Flavonoids as acetylcholinesterase inhibitors: Current therapeutic standing and future prospects. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 101. 2018-10-02. PMID:29635895. |
acetylcholinesterase (ache), a serine hydrolase, is primarily responsible for the termination of signal transmission in the cholinergic system, owing to its outstanding hydrolyzing potential. |
2018-10-02 |
2023-08-13 |
Not clear |
| Jeong Su Ha, Jong Min Kim, Seon Kyeong Park, Jin Yong Kang, Du Sang Lee, Uk Lee, Dae-Ok Kim, Sung-Gil Choi, Ho Jin He. Anti-amyloidogenic properties of an ethyl acetate fraction from Actinidia arguta in Aβ Food & function. vol 9. issue 6. 2018-10-01. PMID:29786737. |
furthermore, efaa showed the ameliorating effect of cholinergic functions by increasing acetylcholine (ach) levels and decreasing acetylcholinesterase (ache) activity, and protected antioxidant systems by increasing superoxide dismutase (sod) and decreasing the oxidized glutathione (gsh)/total gsh and malondialdehyde (mda) in the brain. |
2018-10-01 |
2023-08-13 |
mouse |
| Robert Zdanowski, Monika Leśniak, Urszula Karczmarczyk, Marek Saracyn, Marek Bilski, Anna Kiepura, Jacek Z Kubiak, Sławomir Lewick. The Effects of Isopropyl Methylphosphono-Fluoridate (IMPF) Poisoning on Tumor Growth and Angiogenesis in BALB/C Mice. Annals of transplantation. vol 23. 2018-09-18. PMID:29422483. |
background acetylcholinesterase (ache) and cholinergic receptors have an important role in the immune system and angiogenesis. |
2018-09-18 |
2023-08-13 |
mouse |
| Flávia V Soares, Alexandre A de Castro, Ander F Pereira, Daniel H S Leal, Daiana T Mancini, Ondrej Krejcar, Teodorico C Ramalho, Elaine F F da Cunha, Kamil Kuc. Theoretical Studies Applied to the Evaluation of the DFPase Bioremediation Potential against Chemical Warfare Agents Intoxication. International journal of molecular sciences. vol 19. issue 4. 2018-09-17. PMID:29690585. |
they are called neurotoxic agents because of their action on the nervous system, inhibiting the acetylcholinesterase (ache) enzyme and resulting in a cholinergic crisis. |
2018-09-17 |
2023-08-13 |
Not clear |
| Samuel Legeay, Nicolas Clere, Véronique Apaire-Marchais, Sébastien Faure, Bruno Lapie. Unusual modes of action of the repellent DEET in insects highlight some human side effects. European journal of pharmacology. vol 825. 2018-09-06. PMID:29477656. |
according to emerging literature reports, deet side effects in humans involve new molecular targets including the cholinergic system, acetylcholinesterase (ache), muscarinic m1 and m3 receptor and the participation of the second messenger nitric oxide (no). |
2018-09-06 |
2023-08-13 |
human |