| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shreesh Raj Sammi, Shalini Trivedi, Srikanta Kumar Rath, Abhishek Nagar, Sudeep Tandon, Alok Kalra, Rakesh Pande. 1-Methyl-4-propan-2-ylbenzene from Thymus vulgaris Attenuates Cholinergic Dysfunction. Molecular neurobiology. vol 54. issue 7. 2018-05-18. PMID:27599497. |
to this date, the therapeutic management of cholinergic dysfunction is limited to provide symptomatic relief through the use of acetylcholinesterase (ache) inhibitors only. |
2018-05-18 |
2023-08-13 |
Not clear |
| Qiqing Chen, Daqiang Yin, Yunlu Jia, Sabrina Schiwy, Jessica Legradi, Shouye Yang, Henner Holler. Enhanced uptake of BPA in the presence of nanoplastics can lead to neurotoxic effects in adult zebrafish. The Science of the total environment. vol 609. 2018-05-10. PMID:28793400. |
however, ache activity was no more inhibited in the co-exposure treatment, which implies that solely ache measurement may not be sufficient to identify neurotoxic effects in the cholinergic system. |
2018-05-10 |
2023-08-13 |
zebrafish |
| Anders Allgardsson, C David Andersson, Christine Akfur, Franz Worek, Anna Linusson, Fredrik Ekströ. An Unusual Dimeric Inhibitor of Acetylcholinesterase: Cooperative Binding of Crystal Violet. Molecules (Basel, Switzerland). vol 22. issue 9. 2018-05-08. PMID:28867801. |
acetylcholinesterase (ache) is an essential enzyme that terminates cholinergic transmission by a rapid hydrolysis of the neurotransmitter acetylcholine. |
2018-05-08 |
2023-08-13 |
Not clear |
| Anders Allgardsson, C David Andersson, Christine Akfur, Franz Worek, Anna Linusson, Fredrik Ekströ. An Unusual Dimeric Inhibitor of Acetylcholinesterase: Cooperative Binding of Crystal Violet. Molecules (Basel, Switzerland). vol 22. issue 9. 2018-05-08. PMID:28867801. |
ache is an important target for treatment of various cholinergic deficiencies, including alzheimer's disease and myasthenia gravis. |
2018-05-08 |
2023-08-13 |
Not clear |
| Katarina Mis, Zoran Grubic, Paola Lorenzon, Marina Sciancalepore, Tomaz Mars, Sergej Pirkmaje. In Vitro Innervation as an Experimental Model to Study the Expression and Functions of Acetylcholinesterase and Agrin in Human Skeletal Muscle. Molecules (Basel, Switzerland). vol 22. issue 9. 2018-05-01. PMID:28846617. |
acetylcholinesterase (ache) and agrin, a heparan-sulfate proteoglycan, reside in the basal lamina of the neuromuscular junction (nmj) and play key roles in cholinergic transmission and synaptogenesis. |
2018-05-01 |
2023-08-13 |
human |
| Richa Choudhary, Udayabanu Malairaman, Anju Katya. Inhibition of 12/15 LOX ameliorates cognitive and cholinergic dysfunction in mouse model of hypobaric hypoxia via. attenuation of oxidative/nitrosative stress. Neuroscience. vol 359. 2018-04-30. PMID:28720379. |
12/15lox inhibition could effectively modulate central cholinergic indices during hypobaric hypoxia by restoring machr-1, α7nachr expression and ache, chat activity in the hippocampus comparable to normal mice. |
2018-04-30 |
2023-08-13 |
mouse |
| Danielle Hagstrom, Hideto Hirokawa, Limin Zhang, Zoran Radic, Palmer Taylor, Eva-Maria S Collin. Planarian cholinesterase: in vitro characterization of an evolutionarily ancient enzyme to study organophosphorus pesticide toxicity and reactivation. Archives of toxicology. vol 91. issue 8. 2018-04-12. PMID:27990564. |
while previous activity staining of d. japonica, which possess a discrete cholinergic nervous system, has shown acylthiocholine catalysis, it is unknown whether this is accomplished through an acetylcholinesterase (ache), butyrylcholinesterase (bche), or a hybrid esterase and how op exposure affects esterase activity. |
2018-04-12 |
2023-08-13 |
human |
| Yaowen Zhang, Bin Han, Yating He, Daojing Li, Xiaofeng Ma, Qiang Liu, Junwei Ha. MicroRNA-132 attenuates neurobehavioral and neuropathological changes associated with intracerebral hemorrhage in mice. Neurochemistry international. vol 107. 2018-04-03. PMID:27940326. |
recent studies suggest that microrna-132 (mir-132) potentiates the cholinergic blockade of inflammatory reactions by targeting acetylcholinesterase (ache) and affords robust protection against ischemia-induced neuronal death. |
2018-04-03 |
2023-08-13 |
mouse |
| Maria-Letizia Campanari, Francisco Navarrete, Stephen D Ginsberg, Jorge Manzanares, Javier Sáez-Valero, María-Salud García-Aylló. Increased Expression of Readthrough Acetylcholinesterase Variants in the Brains of Alzheimer's Disease Patients. Journal of Alzheimer's disease : JAD. vol 53. issue 3. 2018-01-26. PMID:27258420. |
ache is expressed as multiple splice variants, which may serve both cholinergic degradative functions and non-cholinergic functions unrelated with their capacity to hydrolyze acetylcholine. |
2018-01-26 |
2023-08-13 |
human |
| Maria-Letizia Campanari, Francisco Navarrete, Stephen D Ginsberg, Jorge Manzanares, Javier Sáez-Valero, María-Salud García-Aylló. Increased Expression of Readthrough Acetylcholinesterase Variants in the Brains of Alzheimer's Disease Patients. Journal of Alzheimer's disease : JAD. vol 53. issue 3. 2018-01-26. PMID:27258420. |
therefore, differential expression of ache variants in ad may reflect changes in the pathophysiological role of ache, independent of cholinergic impairment or its role in degrading acetylcholine. |
2018-01-26 |
2023-08-13 |
human |
| Sadudee Chotirat, Tawit Suriyo, Marianne Hokland, Peter Hokland, Jutamaad Satayavivad, Chirayu U Auewaraku. Cholinergic activation enhances retinoic acid-induced differentiation in the human NB-4 acute promyelocytic leukemia cell line. Blood cells, molecules & diseases. vol 59. 2018-01-12. PMID:27282572. |
we determined the expression of cholinergic components in leukemic cell lines by western blotting and in normal leukocyte subsets by flow cytometry and found a heterogeneous expression of choline acetyltransferase (chat), acetylcholinesterase (ache), choline transporter (cht), m3 muscarinic acetylcholine receptor (m3-machr) and α7 nicotinic acetylcholine receptor (α7-nachr). |
2018-01-12 |
2023-08-13 |
human |
| Ramu Venkatesan, Lalita Subedi, Eui-Ju Yeo, Sun Yeou Ki. Lactucopicrin ameliorates oxidative stress mediated by scopolamine-induced neurotoxicity through activation of the NRF2 pathway. Neurochemistry international. vol 99. 2018-01-03. PMID:27346436. |
the current study aimed to investigate the molecular mechanisms underlying scopolamine-induced cholinergic neuronal dysfunction and the neuroprotective effect of lactucopicrin, an inhibitor of acetylcholine esterase (ache). |
2018-01-03 |
2023-08-13 |
Not clear |
| Cong Lu, Liming Dong, Jingwei Lv, Yan Wang, Bei Fan, Fengzhong Wang, Xinmin Li. 20(S)-protopanaxadiol (PPD) alleviates scopolamine-induced memory impairment via regulation of cholinergic and antioxidant systems, and expression of Egr-1, c-Fos and c-Jun in mice. Chemico-biological interactions. vol 279. 2018-01-03. PMID:29133030. |
ppd regulated cholinergic function by inhibiting scop-induced elevation of acetylcholinesterase (ache) activity, decline of choline acetyltransferase (chat) activity and decrease of acetylcholine (ach) level. |
2018-01-03 |
2023-08-13 |
mouse |
| Umit M Kocyigit, Parham Taslimi, Hayreddin Gezegen, İlhami Gulçin, Mustafa Ceyla. Evaluation of acetylcholinesterase and carbonic anhydrase inhibition profiles of 1,2,3,4,6-pentasubstituted-4-hydroxy-cyclohexanes. Journal of biochemical and molecular toxicology. vol 31. issue 9. 2018-01-02. PMID:28613396. |
prevalent drugs for the symptomatic therapy of dementia are significant in increasing the associated cholinergic deficiency by inhibiting acetylcholinesterase (ache). |
2018-01-02 |
2023-08-13 |
human |
| Jong Min Kim, Seon Kyeong Park, Tian Jiao Guo, Jin Yong Kang, Jeong Su Ha, Du Sang Lee, Uk Lee, Ho Jin He. Anti-amnesic effect of Dendropanax morbifera via JNK signaling pathway on cognitive dysfunction in high-fat diet-induced diabetic mice. Behavioural brain research. vol 312. 2017-12-19. PMID:27288590. |
in animal experiments using y-maze, passive avoidance and morris water maze tests, the cognitive and behavioral disorders in hfd-induced diabetic mice were considerably recovered by regulating cholinergic systems, including acetylcholine (ach) levels and acetylcholinesterase (ache) inhibition, and antioxidant systems, including superoxide dismutase (sod), glutathione (gsh), oxidized gsh, and malondialdehyde (mda) levels. |
2017-12-19 |
2023-08-13 |
mouse |
| Bo Feng, Xiao-Yang Zhao, Yi-Zhou Song, Wen-Na Liang, Ji-Liang Li. Sarsasapogenin reverses depressive-like behaviors and nicotinic acetylcholine receptors induced by olfactory bulbectomy. Neuroscience letters. vol 639. 2017-12-19. PMID:27988349. |
we examined ob-induced changes in cholinergic signalling, as well as ache, α4-nachr, and α7-nachr expression in the hippocampus. |
2017-12-19 |
2023-08-13 |
rat |
| Guozhen Qiu, Shengqiang Chen, Jialing Guo, Jie Wu, Yong-Hong Y. Alpha-asarone improves striatal cholinergic function and locomotor hyperactivity in Fmr1 knockout mice. Behavioural brain research. vol 312. 2017-12-13. PMID:27316341. |
to elucidate the mechanism underlying this improvement, we evaluated the expressions of various cholinergic markers, as well as acetylcholinesterase (ache) activity and acetylcholine (ach) levels, in the striatum of fmr1 ko mice. |
2017-12-13 |
2023-08-13 |
mouse |
| Madhavan Nampoothiri, Grandhi Venkata Ramalingayya, Nampurath Gopalan Kutty, Nandakumar Krishnadas, Chamallamudi Mallikarjuna Ra. Insulin Combined with Glucose Improves Spatial Learning and Memory in Aluminum Chloride-Induced Dementia in Rats. Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer. vol 36. issue 2. 2017-12-07. PMID:29199596. |
behavioral parameters (morris water maze test) along with biochemical parameters (hippocampus and frontal cortex) such as acetylcholinesterase (ache), catalase, and glutathione (gsh) levels were assessed to correlate cognitive function with cholinergic transmission and oxidative stress. |
2017-12-07 |
2023-08-13 |
rat |
| Tamara Lazarevic-Pasti, Andreja Leskovac, Tatjana Momic, Sandra Petrovic, Vesna Vasi. Modulators of Acetylcholinesterase Activity: From Alzheimer's Disease to Anti-Cancer Drugs. Current medicinal chemistry. vol 24. issue 30. 2017-11-29. PMID:28685687. |
acetylcholinesterase (ache) is involved in the termination of impulse transmission by rapid hydrolysis of the neurotransmitter acetylcholine in numerous cholinergic pathways in the central and peripheral nervous systems. |
2017-11-29 |
2023-08-13 |
Not clear |
| D K Rieger, A A Dos Santos, C Suñol, M Farin. Involvement of superoxide in malaoxon-induced toxicity in primary cultures of cortical neurons. Journal of toxicology and environmental health. Part A. vol 80. issue 19-21. 2017-11-16. PMID:28849997. |
the neurotoxic effects are attributed mainly to acetylcholinesterase (ache) enzyme inhibition, which is responsible for cholinergic manifestations in individuals acutely exposed to op. |
2017-11-16 |
2023-08-13 |
mouse |