| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M D Baldissera, C F Souza, P H Doleski, K L S Moreira, M L da Veiga, M I U M da Rocha, R C V Santos, B Baldisserott. Involvement of cholinergic and adenosinergic systems on the branchial immune response of experimentally infected silver catfish with Streptococcus agalactiae. Journal of fish diseases. vol 41. issue 1. 2018-11-08. PMID:28699699. |
it has been recognized that the cholinergic and adenosinergic systems have an essential role in immune and inflammatory responses during bacterial fish pathogens, such as the enzymes acetylcholinesterase (ache) and adenosine deaminase (ada), which are responsible for catalysis of the anti-inflammatory molecules acetylcholine (ach) and adenosine (ado) respectively. |
2018-11-08 |
2023-08-13 |
Not clear |
| M D Baldissera, C F Souza, P H Doleski, K L S Moreira, M L da Veiga, M I U M da Rocha, R C V Santos, B Baldisserott. Involvement of cholinergic and adenosinergic systems on the branchial immune response of experimentally infected silver catfish with Streptococcus agalactiae. Journal of fish diseases. vol 41. issue 1. 2018-11-08. PMID:28699699. |
based on this evidence, we concluded that infection by s. agalactiae in silver catfish alters the cholinergic and adenosinergic systems, suggesting the involvement of ache and ada activities on immune and inflammatory responses, regulating the ach and ado levels. |
2018-11-08 |
2023-08-13 |
Not clear |
| Felipe Rocha, Letícia Yumi Sugahara, Fernanda Vitória Leimann, Sara Marchesan de Oliveira, Evelyne da Silva Brum, Ricardo Costa Calhelha, Maria Filomena Barreiro, Isabel C F R Ferreira, Rafael Porto Ineu, Odinei Hess Gonçalve. Nanodispersions of beta-carotene: effects on antioxidant enzymes and cytotoxic properties. Food & function. vol 9. issue 7. 2018-10-29. PMID:29974106. |
the formed nanometric beta-carotene particles resulted in stable colloids, readily dispersed in water, able to modulate acetylcholinesterase (ache) activity, and presenting high potential to control the cholinergic system. |
2018-10-29 |
2023-08-13 |
drosophila_melanogaster |
| Paula Moyano, Mariano de Frias, Margarita Lobo, María José Anadon, Emma Sola, Adela Pelayo, María Jesús Díaz, María Teresa Frejo, Javier Del Pin. Cadmium induced ROS alters M1 and M3 receptors, leading to SN56 cholinergic neuronal loss, through AChE variants disruption. Toxicology. vol 394. 2018-10-19. PMID:29253600. |
cadmium induced ros alters m1 and m3 receptors, leading to sn56 cholinergic neuronal loss, through ache variants disruption. |
2018-10-19 |
2023-08-13 |
Not clear |
| Paula Moyano, Mariano de Frias, Margarita Lobo, María José Anadon, Emma Sola, Adela Pelayo, María Jesús Díaz, María Teresa Frejo, Javier Del Pin. Cadmium induced ROS alters M1 and M3 receptors, leading to SN56 cholinergic neuronal loss, through AChE variants disruption. Toxicology. vol 394. 2018-10-19. PMID:29253600. |
thus, we hypothesized that cadmium induced cell death of bf cholinergic neurons is mediated by oxidative stress generation and this mechanism could produce this effect, in part, through ache variants altered by muscarinic receptors disruption. |
2018-10-19 |
2023-08-13 |
Not clear |
| Paula Moyano, Mariano de Frias, Margarita Lobo, María José Anadon, Emma Sola, Adela Pelayo, María Jesús Díaz, María Teresa Frejo, Javier Del Pin. Cadmium induced ROS alters M1 and M3 receptors, leading to SN56 cholinergic neuronal loss, through AChE variants disruption. Toxicology. vol 394. 2018-10-19. PMID:29253600. |
to prove this, we evaluated in bf sn56 cholinergic neurons, whether cadmium induces oxidative stress and alters muscarinic receptors, and their involvement in the induction of cell death through alteration of ache variants. |
2018-10-19 |
2023-08-13 |
Not clear |
| Haroon Khan, Marya, Surriya Amin, Mohammad Amjad Kamal, Seema Pate. Flavonoids as acetylcholinesterase inhibitors: Current therapeutic standing and future prospects. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 101. 2018-10-02. PMID:29635895. |
acetylcholinesterase (ache), a serine hydrolase, is primarily responsible for the termination of signal transmission in the cholinergic system, owing to its outstanding hydrolyzing potential. |
2018-10-02 |
2023-08-13 |
Not clear |
| Jeong Su Ha, Jong Min Kim, Seon Kyeong Park, Jin Yong Kang, Du Sang Lee, Uk Lee, Dae-Ok Kim, Sung-Gil Choi, Ho Jin He. Anti-amyloidogenic properties of an ethyl acetate fraction from Actinidia arguta in Aβ Food & function. vol 9. issue 6. 2018-10-01. PMID:29786737. |
furthermore, efaa showed the ameliorating effect of cholinergic functions by increasing acetylcholine (ach) levels and decreasing acetylcholinesterase (ache) activity, and protected antioxidant systems by increasing superoxide dismutase (sod) and decreasing the oxidized glutathione (gsh)/total gsh and malondialdehyde (mda) in the brain. |
2018-10-01 |
2023-08-13 |
mouse |
| Robert Zdanowski, Monika Leśniak, Urszula Karczmarczyk, Marek Saracyn, Marek Bilski, Anna Kiepura, Jacek Z Kubiak, Sławomir Lewick. The Effects of Isopropyl Methylphosphono-Fluoridate (IMPF) Poisoning on Tumor Growth and Angiogenesis in BALB/C Mice. Annals of transplantation. vol 23. 2018-09-18. PMID:29422483. |
background acetylcholinesterase (ache) and cholinergic receptors have an important role in the immune system and angiogenesis. |
2018-09-18 |
2023-08-13 |
mouse |
| Flávia V Soares, Alexandre A de Castro, Ander F Pereira, Daniel H S Leal, Daiana T Mancini, Ondrej Krejcar, Teodorico C Ramalho, Elaine F F da Cunha, Kamil Kuc. Theoretical Studies Applied to the Evaluation of the DFPase Bioremediation Potential against Chemical Warfare Agents Intoxication. International journal of molecular sciences. vol 19. issue 4. 2018-09-17. PMID:29690585. |
they are called neurotoxic agents because of their action on the nervous system, inhibiting the acetylcholinesterase (ache) enzyme and resulting in a cholinergic crisis. |
2018-09-17 |
2023-08-13 |
Not clear |
| Samuel Legeay, Nicolas Clere, Véronique Apaire-Marchais, Sébastien Faure, Bruno Lapie. Unusual modes of action of the repellent DEET in insects highlight some human side effects. European journal of pharmacology. vol 825. 2018-09-06. PMID:29477656. |
according to emerging literature reports, deet side effects in humans involve new molecular targets including the cholinergic system, acetylcholinesterase (ache), muscarinic m1 and m3 receptor and the participation of the second messenger nitric oxide (no). |
2018-09-06 |
2023-08-13 |
human |
| A Kroth, V Mackedanz, C Matté, A T S Wyse, M F M Ribeiro, W A Partat. Effect of Sciatic Nerve Transection on acetylcholinesterase activity in spinal cord and skeletal muscles of the bullfrog Lithobates catesbeianus. Brazilian journal of biology = Revista brasleira de biologia. vol 78. issue 2. 2018-09-05. PMID:28977043. |
in some vertebrate tissues, this condition decreases acetylcholinesterase (ache) activity, the enzyme responsible for fast hydrolysis of released acetylcholine in cholinergic synapses. |
2018-09-05 |
2023-08-13 |
rat |
| Oluwafemi Adeleke Ojo, Adebola Busola Ojo, Basiru Olaitan Ajiboye, Babatunji Emmanuel Oyinloye, Ayodele Jacob Akinyemi, Mary Abiola Okesola, Aline Augusti Boligon, Marli Matiko Anraku de Campo. Chromatographic fingerprint analysis, antioxidant properties, and inhibition of cholinergic enzymes (acetylcholinesterase and butyrylcholinesterase) of phenolic extracts from Irvingia gabonensis (Aubry-Lecomte ex O'Rorke) Baill bark. Journal of basic and clinical physiology and pharmacology. vol 29. issue 2. 2018-08-29. PMID:29381472. |
this work characterized the phenolic composition, evaluated the cholinergic enzymes (acetylcholinesterase, ache and butyrylcholinesterase, bche) inhibition, and assessed the antioxidant activity of phenolic extracts from i. gabonensis (aubry-lecomte ex o'rorke) baill bark. |
2018-08-29 |
2023-08-13 |
Not clear |
| Won Yong Jung, Haneul Kim, Se Jin Jeon, Hye Jin Park, Hyuck Jai Choi, Nam Jae Kim, Dong Hyun Kim, Dae Sik Jang, Jong Hoon Ry. Eclalbasaponin II Ameliorates the Cognitive Impairment Induced by Cholinergic Blockade in Mice. Neurochemical research. vol 43. issue 2. 2018-08-16. PMID:29164430. |
these results suggest that eclalbasaponin ii ameliorates cholinergic blockade-induced cognitive impairment via ache inhibition, ltp formation and the activation of akt-gsk-3β signaling, and that eclalbasaponin ii may be a useful to treat cognitive impairment derived from cholinergic dysfunction. |
2018-08-16 |
2023-08-13 |
mouse |
| Mihaela-Liliana Ţînţaş, Vincent Gembus, Florent Alix, Anaïs Barré, Gaël Coadou, Lina Truong, Muriel Sebban, Cyril Papamicaël, Hassan Oulyadi, Vincent Levache. Rational design of carbamate-based dual binding site and central AChE inhibitors by a "biooxidisable" prodrug approach: Synthesis, in vitro evaluation and docking studies. European journal of medicinal chemistry. vol 155. 2018-08-08. PMID:29886321. |
herein, we report a new class of dual binding site ache inhibitor 4 designed to exert a central cholinergic activation thanks to a redox-activation step of a prodrug precursor 3. |
2018-08-08 |
2023-08-13 |
Not clear |
| Shreesh Raj Sammi, Jitendra K Rawat, Neetu Raghav, Ajay Kumar, Subhadeep Roy, Manjari Singh, Swetlana Gautam, Rajnish K Yadav, Uma Devi, Rakesh Pandey, Gaurav Kaithwa. Galantamine attenuates N,N-dimethyl hydrazine induced neoplastic colon damage by inhibiting acetylcholinesterase and bimodal regulation of nicotinic cholinergic neurotransmission. European journal of pharmacology. vol 818. 2018-08-06. PMID:29074413. |
gal by inhibiting ache and regulating alpha7nach activity can improve cholinergic neurotransmission. |
2018-08-06 |
2023-08-13 |
rat |
| Júlia Relat, Belén Pérez, Pelayo Camps, Diego Muñoz-Torrero, Albert Badia, M Victòria Clo. Huprine X Attenuates The Neurotoxicity Induced by Kainic Acid, Especially Brain Inflammation. Basic & clinical pharmacology & toxicology. vol 122. issue 1. 2018-07-30. PMID:28724203. |
huprine x (hx) is a synthetic anticholinesterasic compound that exerts a potent inhibitory action on acetylcholinesterase (ache) activity, an agonist effect on cholinergic receptors, neuroprotective activity in different neurotoxicity models in vivo and in vitro and cognition enhancing effects in non-transgenic (c57bl/6) and transgenic (3xtg-ad, appswe) mice. |
2018-07-30 |
2023-08-13 |
mouse |
| Terrone L Rosenberry, Xavier Brazzolotto, Ian R Macdonald, Marielle Wandhammer, Marie Trovaslet-Leroy, Sultan Darvesh, Florian Nacho. Comparison of the Binding of Reversible Inhibitors to Human Butyrylcholinesterase and Acetylcholinesterase: A Crystallographic, Kinetic and Calorimetric Study. Molecules (Basel, Switzerland). vol 22. issue 12. 2018-07-17. PMID:29186056. |
acetylcholinesterase (ache) and butyrylcholinesterase (bche) hydrolyze the neurotransmitter acetylcholine and, thereby, function as coregulators of cholinergic neurotransmission. |
2018-07-17 |
2023-08-13 |
human |
| Yvonne J Rosenberg, Jerry Wang, Tara Ooms, Narayanan Rajendran, Lingjun Mao, Xiaoming Jiang, Jonathan Lees, Lori Urban, Jeremiah D Momper, Yadira Sepulveda, Yan-Jye Shyong, Palmer Taylo. Post-exposure treatment with the oxime RS194B rapidly reactivates and reverses advanced symptoms of lethal inhaled paraoxon in macaques. Toxicology letters. vol 293. 2018-06-04. PMID:29129799. |
like nerve agents, insecticides are neurotoxins which target and inhibit acetylcholinesterases (ache) in central and peripheral synapses in the cholinergic nervous system. |
2018-06-04 |
2023-08-13 |
human |
| Jie Gao, Sean X Naughton, Wayne D Beck, Caterina M Hernandez, Guangyu Wu, Zhe Wei, Xiangkun Yang, Michael G Bartlett, Alvin V Terr. Chlorpyrifos and chlorpyrifos oxon impair the transport of membrane bound organelles in rat cortical axons. Neurotoxicology. vol 62. 2018-05-30. PMID:28600141. |
while the insecticidal actions and acute toxicity of cpf are attributed to its oxon metabolite (cpo) which potently inhibits the cholinergic enzyme acetylcholinesterase (ache), there is significant evidence that cpf, cpo, and other organophosphates may affect a variety of neuronal targets and processes that are not directly related to ache. |
2018-05-30 |
2023-08-13 |
rat |