| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Muhammed Khairujjaman Mazumder, Shuvasish Choudhur. Tea polyphenols as multi-target therapeutics for Alzheimer's disease: An in silico study. Medical hypotheses. vol 125. 2019-08-27. PMID:30902161. |
with neurodegeneration, the level of the neurotransmitter acetylcholine (ach), as well as acetylcholinesterase (ache), decreases in the synaptic cleft, called cholinergic deficiency. |
2019-08-27 |
2023-08-13 |
Not clear |
| Rui Sha, Yangsheng Chen, Yali Luo, Yiyun Liu, Li Xu, Heidi Qunhui Xie, Bin Zha. Effects of astrocyte conditioned medium on neuronal AChE expression upon 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure. Chemico-biological interactions. vol 309. 2019-08-19. PMID:31152735. |
acetylcholinesterase (ec3.1.1.7; ache) is a key enzyme in the cholinergic system. |
2019-08-19 |
2023-08-13 |
human |
| b' Maja D Vitorovi\\xc4\\x87-Todorovi\\xc4\\x87, Franz Worek, Andrej Perdih, Sonja \\xc4\\x90 Bauk, Tamara B Vujatovi\\xc4\\x87, Ilija N Cvijeti\\xc4\\x8. The in vitro protective effects of the three novel nanomolar reversible inhibitors of human cholinesterases against irreversible inhibition by organophosphorous chemical warfare agents. Chemico-biological interactions. vol 309. 2019-08-19. PMID:31228470.' |
acetylcholinesterase (ache) is an enzyme which terminates the cholinergic neurotransmission, by hydrolyzing acetylcholine at the nerve and nerve-muscle junctions. |
2019-08-19 |
2023-08-13 |
human |
| Lucieli K F Müller, Aleksandro S DA Silva, Nathieli B Bottari, Janio M Santurio, Vera M Morsch, Manoela M Piva, Ricardo E Mendes, Eduardo M Gloria, Diovani Paian. Effects of fed mycotoxin contaminated diets supplemented with spray-dried porcine plasma on cholinergic response and behavior in piglets. Anais da Academia Brasileira de Ciencias. vol 91. issue 2. 2019-07-26. PMID:31269106. |
taken together, the data suggest changes in ache and bche activities may indicate alterations in cholinergic neurotransmission and consequently in the behavior of piglets. |
2019-07-26 |
2023-08-13 |
Not clear |
| Yali Luo, Heidi Qunhui Xie, Yangsheng Chen, Yingjie Xia, Rui Sha, Yiyun Liu, Yongchao Ma, Tong Xu, Li Xu, Karl Wah-Keung Tsim, Bin Zha. Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure on acetylcholinesterase during myogenic differentiation of contractile rat primary skeletal muscle cells. Chemico-biological interactions. vol 308. 2019-07-22. PMID:31100272. |
acetylcholinesterase (ec3.1.1.7; ache), an enzyme critical for cholinergic neurotransmission, is abundantly expressed in neurons and mature myotubes, and we recently found that muscle ache expression was suppressed in parallel with the inhibition of myogenic differentiation upon tcdd treatment in mouse c2c12 cells. |
2019-07-22 |
2023-08-13 |
mouse |
| Tahira Javed, Rabia Habib, Sania Ghafoor, Baseerat Rumman, Sliha Awan, Leonel J M Ntepe, Sajida Batool, Syed M Nurulai. Association of status of acetylcholinesterase and ACHE gene 3' UTR variants (rs17228602, rs17228616) with drug addiction vulnerability in pakistani population. Chemico-biological interactions. vol 308. 2019-07-22. PMID:31129131. |
acetylecholine (ach), a cholinergic neurotransmitter hydrolyzed by acetylcholinesterase (ache), is an essential neurotransmitter and neuromodulator in central and peripheral nervous system and has regulatory influence on numerous neuronal functions including addiction. |
2019-07-22 |
2023-08-13 |
human |
| Tahira Javed, Rabia Habib, Sania Ghafoor, Baseerat Rumman, Sliha Awan, Leonel J M Ntepe, Sajida Batool, Syed M Nurulai. Association of status of acetylcholinesterase and ACHE gene 3' UTR variants (rs17228602, rs17228616) with drug addiction vulnerability in pakistani population. Chemico-biological interactions. vol 308. 2019-07-22. PMID:31129131. |
further studies with larger sample size and other variants of ache are recommended to identify novel therapeutic approaches for cholinergic based treatment of addiction. |
2019-07-22 |
2023-08-13 |
human |
| Miranda L Xu, Wilson K W Luk, Etta Y L Liu, Xiang P Kong, Qi Y Wu, Ying J Xia, Tina T X Dong, Karl W K Tsi. Differentiation of erythroblast requires the dimeric form of acetylcholinesterase: Interference with erythropoietin receptor. Chemico-biological interactions. vol 308. 2019-07-22. PMID:31170385. |
acetylcholinesterase (ache) hydrolyzes acetylcholine at cholinergic synapses, and which has various isoforms of ache, i.e. |
2019-07-22 |
2023-08-13 |
Not clear |
| Miranda L Xu, Wilson K W Luk, Cathy W C Bi, Etta Y L Liu, Kevin Q Y Wu, Ping Yao, Tina T X Dong, Karl W K Tsi. Erythropoietin regulates the expression of dimeric form of acetylcholinesterase during differentiation of erythroblast. Journal of neurochemistry. vol 146. issue 4. 2019-06-26. PMID:29675901. |
acetylcholinesterase (ache; ec 3.1.1.7) is known to hydrolyze acetylcholine at cholinergic synapses. |
2019-06-26 |
2023-08-13 |
Not clear |
| Etta Y L Liu, Miranda L Xu, Yingjie Xia, Xiangpeng Kong, Qiyun Wu, Tina T X Dong, Karl W K Tsi. Activation of G protein-coupled receptor 30 by flavonoids leads to expression of acetylcholinesterase in cultured PC12 cells. Chemico-biological interactions. vol 306. 2019-06-05. PMID:31034797. |
the role of flavonoids in induction of a cholinergic enzyme, acetylcholinesterase (ache), was being explored here. |
2019-06-05 |
2023-08-13 |
Not clear |
| Kanzal Iman, Muhammad Usman Mirza, Nauman Mazhar, Michiel Vanmeert, Imran Irshad, Mohammad A Kama. In silico Structure-based Identification of Novel Acetylcholinesterase Inhibitors Against Alzheimer's Disease. CNS & neurological disorders drug targets. vol 17. issue 1. 2019-05-31. PMID:29336270. |
therapeutic interventions in ad are largely focused upon ache inhibitors designed essentially to prevent the loss of cholinergic function. |
2019-05-31 |
2023-08-13 |
Not clear |
| Raj P Kapur, Philipp W Raess, Samuel Hwang, Conrad Winte. Choline Transporter Immunohistochemistry: An Effective Substitute for Acetylcholinesterase Histochemistry to Diagnose Hirschsprung Disease With Formalin-fixed Paraffin-embedded Rectal Biopsies. Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society. vol 20. issue 4. 2019-05-29. PMID:28649946. |
acetylcholinesterase enzymatic histochemistry (ache ehc), which highlights abnormal cholinergic nerves in the mucosa of aganglionic bowel, has been used for decades to evaluate rectal biopsies for hirschsprung disease (hscr). |
2019-05-29 |
2023-08-13 |
Not clear |
| Paula Moyano, José Manuel García, María José Anadon, Margarita Lobo, Jimena García, María Teresa Frejo, Emma Sola, Adela Pelayo, Javier Del Pin. Manganese induced ROS and AChE variants alteration leads to SN56 basal forebrain cholinergic neuronal loss after acute and long-term treatment. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 125. 2019-05-20. PMID:30738988. |
manganese induced ros and ache variants alteration leads to sn56 basal forebrain cholinergic neuronal loss after acute and long-term treatment. |
2019-05-20 |
2023-08-13 |
Not clear |
| Paula Moyano, José Manuel García, María José Anadon, Margarita Lobo, Jimena García, María Teresa Frejo, Emma Sola, Adela Pelayo, Javier Del Pin. Manganese induced ROS and AChE variants alteration leads to SN56 basal forebrain cholinergic neuronal loss after acute and long-term treatment. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 125. 2019-05-20. PMID:30738988. |
we hypothesized that mn could induce bf cholinergic neuronal loss through oxidative stress generation, cholinergic transmission and ache variants alteration that could explain mn cognitive disorders. |
2019-05-20 |
2023-08-13 |
Not clear |
| Paula Moyano, José Manuel García, María José Anadon, Margarita Lobo, Jimena García, María Teresa Frejo, Emma Sola, Adela Pelayo, Javier Del Pin. Manganese induced ROS and AChE variants alteration leads to SN56 basal forebrain cholinergic neuronal loss after acute and long-term treatment. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 125. 2019-05-20. PMID:30738988. |
this study shows that mn impaired cholinergic transmission in sn56 cholinergic neurons from bf through alteration of ache and chat activity and cht expression. |
2019-05-20 |
2023-08-13 |
Not clear |
| Paula Moyano, José Manuel García, María José Anadon, Margarita Lobo, Jimena García, María Teresa Frejo, Emma Sola, Adela Pelayo, Javier Del Pin. Manganese induced ROS and AChE variants alteration leads to SN56 basal forebrain cholinergic neuronal loss after acute and long-term treatment. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 125. 2019-05-20. PMID:30738988. |
finally, mn induces cell death on sn56 cholinergic neurons and this effect is independent of cholinergic transmission alteration, but was mediated partially by oxidative stress generation and ache variants alteration. |
2019-05-20 |
2023-08-13 |
Not clear |
| Abdul Mannan Baig, Zohaib Rana, Sumayya Tariq, Salima Lalani, H R Ahma. Traced on the Timeline: Discovery of Acetylcholine and the Components of the Human Cholinergic System in a Primitive Unicellular Eukaryote Acanthamoeba spp. ACS chemical neuroscience. vol 9. issue 3. 2019-05-07. PMID:29058403. |
we show the evidence for the presence of homology of evolutionary conserved key enzymes of the cholinergic system like choline acetyltransferase (chat) and acetylcholinesterase (ache) in a. castellanii spp., which were found to be near identical to their human counterparts. |
2019-05-07 |
2023-08-13 |
human |
| Bruno Nune. Acute ecotoxicological effects of salicylic acid on the Polychaeta species Hediste diversicolor: evidences of low to moderate pro-oxidative effects. Environmental science and pollution research international. vol 26. issue 8. 2019-05-06. PMID:30684172. |
in order to determine the potential ecotoxicological effects caused by sa, individuals of the marine polychaeta species hediste diversicolor were exposed for 96 h to ecologically relevant concentrations of this compound, and several biochemical endpoints were evaluated, namely the activity of the antioxidant enzymes glutathione peroxidase (gpx) and catalase (cat), the phase ii biotransformation isoenzymes glutathione s-transferases (gsts), the cholinergic enzyme acetylcholinesterase (ache), and the determination of lipoperoxidative damage (thiobarbituric acid-reactive substances (tbars) assay). |
2019-05-06 |
2023-08-13 |
human |
| A M da Rocha, L W Kist, E A Almeida, D G H Silva, C D Bonan, S Altenhofen, C G Kaufmann, M R Bogo, D M Barros, S Oliveira, V Geraldo, R G Lacerda, A S Ferlauto, Luiz Orlando Ladeira, J M Monserra. Neurotoxicity in zebrafish exposed to carbon nanotubes: Effects on neurotransmitters levels and antioxidant system. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. vol 218. 2019-04-01. PMID:30543862. |
cholinergic, serotonergic, and dopaminergic systems, through ache activity and serotonin and dopamine levels, respectively were affected by swcnt in the zebrafish brain. |
2019-04-01 |
2023-08-13 |
zebrafish |
| Chanika Alahakoon, Tharaka L Dassanayake, Indika B Gawarammana, E Michael Sedgwick, Vajira S Weerasinghe, Ahmed Abdalla, Michael S Roberts, Nicholas A Buckle. Prediction of organophosphorus insecticide-induced intermediate syndrome with stimulated concentric needle single fibre electromyography. PloS one. vol 13. issue 9. 2019-02-25. PMID:30261032. |
ops inhibit acetylcholine esterase (ache), leading to over-activity of muscarinic and nicotinic cholinergic circuits. |
2019-02-25 |
2023-08-13 |
Not clear |